clr, rlr & cds signaling pathways · clr, rlr & cds signaling pathways iкb p50 p65 p50 p65...
TRANSCRIPT
Dectin-1
P P
P
P
P
P
Apoptosis
DHX29PKR
NEMO
IKKβIKKα
IкBp50 p65
Ub
ZDHHC1
LSP1
IKKε
CYLD
Bcl3
Bcl3
Anti-inflammatory cytokines
NF-кB
Fucose
DC-SIGN
CNK
KSR1
Raf-1
LSP1
Raf-1
p65
STING
cGAMPc-di-GMPc-di-AMPcGAMP
p65
IKKβIKKα
ISRE7
Type I IFNs IFN-l1 IFN-βIL-2
NF-кB
Pro-inflammatory cytokines
Caspase 8
FADD
DAI
DDX41
TRAF6
TBK1
Pro-Casp-1ASC
Caspase-1
AIM2
pro-IL-1β IL-1β
IFI16cGAS
MRE11
MyD88
IRF1IRF3/7 IRF3/7
ISRE1/7
p50 p65
DHX15
DDX3
IKKεTBK1
IRF3/7
IRF7 IRF7 IRF7
IFN-α
ISRE3/7
Pro-inflammatory cytokines
CLR, RLR & CDS Signaling Pathways
IкBp50 p65
p50 p65 Junc-fos
Pro-inflammatory cytokines
NF-кBNFAT
FcRγ
SykFcRγ
Syk
TBK1
IRF3
IRF3 IRF3
ISRE3
c-di-GMPc-di-AMP
AP1
dsRNA
MAVS
MDA-5 RIG-I
LRRFIP1
Ku70
DHX36
IFIX
dsDNA
β-catenin
Pathogen dsDNA Host dsDNA
LGP2
Mitochondrion
Endoplasmic reticulum
DHX9
High mannose
Dectin-2
NEMO
IKKβIKKα
ERK JNK p38
PLC γ
IP3DAG
RNA Virus
Calcineurin
NFAT
CARD9
MALT1Bcl-10
Ca2+PKCδ
β-Glucan
Syk
DC-SIGN
MAPKs
Mincle
α-Mannose, cord factor
High mannose, α-mannan
NF-кB
RNAPol III
The TRUSTED SOURCE for all your CLR, RLR & CDS needsAgonist & Antagonistsreporter cell linesGenes & shRNAs
Antibodies & InhibitorsReporter plasmidsLigand screening service