colimix 120 sintofarm ( colistin sulphate )
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Colimix 120 Sintofarm
(Colistin sulphate)
Colistin is a polypeptide antibiotic , was obtained from a
fermentation broth inoculated with Bacillus polimyxa
var. colistinus which had been isolated from soil
sampled of Fukushima Prefecture , Japan.
Anti-bacterial spectrum
Gram-negative :
E.Coli
Shigella spp
Salmonella spp
Enterobacter spp
Pseudomonas aeruginosa
Klebsiella pneumoniae
Campylobacter (vibrio) coli .
Colimix 120 Sintofarm
Characteristics :
1)Colistin is effective against Gram – bacteria such as E.Coli and
Salmonella.
2)Colistin does not select resistant bacteria in vivo and its resistance
is not transferred by the R-factor.
3)Colistin is not absorbed from the digestive tract of poultry hence
no residue is observe.
4)Colistin has a synergistic effect against bacteria when used in
combination with Zinc-bacitracin.
5)Colistin is effective as a growth promoter for broiler. It is also used
in the prevention and control of infectious enteritis in broiler.
Colimix 120 Sintofarm
Synergism and Antagonism :
Colistin is compatible with tetracyclines, sulfas, imidazoles,
Lincomycin and common feed additives. Sometimes is
showed a good synergism with some antibiotics particularly
with bacitracin .There are no experiences of antagonist
effects between Colistin and other antibiotics.
Palatability :
No "medicinal taste" to deter sick animals from eating or
drinking.
Colimix 120 Sintofarm
Combination use of Colistin sulphate and Zinc bacitracin
show the followings:
1)They have a mutually compensating antibacterial spectrumn.
2)Synergistic action against many bacteria in the digestive tract
Colimix 120 Sintofarm
+
Zinc bacitracin
Colistin Sulphate premix
Colimix 120 premix is :
For prevention and control of infectious enteritis in broilers and layers .(E.Coli,Salmonella)
For improving feed efficiency and weight gain.
Colimix 120 premix is a barrier against enteritis from E.Coli and Salmonella in poultry
Colimix 120 Sintofarm
Colimix 120 pemix is :
SAFEBecause it is not absorbed Because it leaves no residues in the meatBecause it does not present problem of resistanceBecause it does not present problem of toxicityBecause it can be associated with all other antibiotics and sulfa –drugs
STABLEIn the premix for 12-24 monthsIn the feed for at least 6 monthsIn mineral feed for at least 4 months
Colimix 120 Sintofarm
Effective
Because of its activity against Gram - bacteria , specially E.Coli and Salmonella , even if they are resistant to other antibacterial substances
Because it not only checks but treats the disease
Because it improves animal performance
Because of its bactericide action at low dosage(5-8 mg /kg live weight)
Because it acts rapidly and can be used in periods when the sanitary risk is higher
Colimix 120 Sintofarm
Poultry :
For prevention of intestinal diseases (diarrhea)20-200 g/ton of complete feed .
Poultry :
For therapy 800-1000g/ton of complete feed for 5-15 days
Colimix 120 Sintofarm
Composition for kg :
Colistin sulphate 120 g
Carrier up to 100 g
Withdrawal period : 5 days
Storage : keep in dry place and avoid light
Shelf life : 24 months Packaging : 25 kg bags
Colimix 120 Sintofarm
Colimix 120 premix Sintofarm has :
1)Broad antibiotic spectrum – has strong activity on gram-negative bacteria such as E.Coli , Salmonella ecc.2)Strong bactericidal capacity-its effect mechanism is to block cell membrane selective permeation function.3)Good compatibility- better effectiveness in combination with gram-positive bacteria drug4)Good stability-it is not affected by feed ,enzyme and secretive substance.5)Good security- no side effect , no residue
Colimix 120 Sintofarm
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