esm 15.11.2017, oliver wolf€¦ · “specific collagen peptide supplementation in athletes with...
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Evolution US Sports/ Active Nutrition Sales
$3.2 $3.6 $4.0 $4.5 $4.9 $5.3 $5.7
$6.1 $6.6
$7.1 $7.6
2010 2011 2012 2013 2014 2015 2016E 2017E 2018E 2019E 2020E
Source: Nutrition Business Journal 2017
$ in billions, consumer sales all channels
Key Growth Drivers
• New consumer groups / Shift to everyday
consumers
• Increased focus on active lifestyle
• Evolution of product mix
• Expansion of distribution channels
Expansion of Consumer Group =
Expansion of Expectations towards Active Nutrition
4
• Young
• Male
• Focus on muscle
• Young – Old
• Male & Female
• Different needs and expectations
Performance
Mobility
Protein Intake
Variety / Choice
Appearance
Increasing Protein Intake – A Continuous Mega Trend
5
% of General US Population Who
Seek Out Foods High in Protein
Protein Supplements –
Different Delivery Formats
Source: Natural Marketing Institute,
2015, NBJ
Source: Nutrition Business Journal,
2017, Consumer Sales $mill
Consumers Expectation Towards Protein Quality
6
GELITA Focus Group Research USA, 2016
Consumer expect a consistent experience (‘always the same’) with
consistent quality
Consumer’s definition of a ‘high quality protein powder’:
• Neutral taste, pleasant sensory and mouthfeel
• Highly soluble
• “No mess” use / application (packaging)
Collagen peptides in liquid
applications
Collagen peptides in powder
applications
Collagen Peptides – An Easy To Use Protein Source
7
Collagen Peptides – The ‘Barley There’ Protein Source
8
Viscosity of different collagen
peptides at 25°C
Protein shot (25% collagen
peptides)
Collagen Peptides – Stable in Most Delivery Formats
9
Protein powder (90% collagen
peptides)
Collagen Peptides – For Many Delivery Systems
10
Scientifically substantiated daily dose of 2.5-15g
with Bioactive Collagen Peptides
U.S. Collagen Supplements Sales
11
Source: Nutrition Business Journal ($mill, consumer sales)
Sales grew by
30% in 2017
Expansion of Consumer Group =
Expansion of Expectations towards Active Nutrition
12
• Young
• Male
• Focus on muscle
• Young – Old
• Male & Female
• Different needs and expectations
Performance
Mobility
Protein Intake
Variety / Choice
Appearance
Mobility & Collagen
13
Mobility =
Functioning
Connective
Tissue
Mobility =
Collagen
~30%
© 2018 GELITA AG. 2018 GELITA Symposium. GELITA must authorize any copies.
Collagen Peptides Are Building Blocks of Connective Tissue
14
Adapted from Zdzieblik et al. 2015; internal analytical reports
Conditionally essential AAs
Proline and Glycine
Amino acids:
Non-essential AAs Proline (incl. Pro-OH)
Glycine Essential AAs Leucine
55%
Ligaments
Tendons
Elements of Mobility and Bioactive Collagen Peptides
15
Mobility
Strength
Joint Health
Flexibility
Strong Bones
© 2018 GELITA AG. 2018 GELITA Symposium. GELITA must authorize any copies.
Bioactive Collagen Peptides
16
1
Simple, but specific enzymatic hydrolysis process
Native
CollagenRaw material
Bioactive peptides of different
profiles for specific body functions
Extracted
collagen
Collagen
peptidesSpecific health
benefits
2
3
Important signaling molecules Rich in Proline and Hydroxyproline
Osteoblast
• Synthesizing bone matrix
Mode of Action: Selectively Stimulating Human
Connective Tissue Cells to Increase Anabolism
17
• Connective tissue metabolizing cells as target
• Influence anabolic-catabolic balance
• Increased anabolismOsteoclast
• Degrading bone
matrix
Chondrocyte
• Production and maintenance of cartilaginous matrix
Fibroblast
• Synthesis of collagen extracellular matrix in connective tissue (skin, fascia, ligaments, tendons
Elements of Mobility and Bioactive Collagen Peptides
18
Mobility
Strength
Joint Health
Flexibility
Strong Bones
© 2018 GELITA AG. 2018 GELITA Symposium. GELITA must authorize any copies.
Growing Attention for Collagen Peptides
19
IOC Consensus
Statement (Maughan et al 2018)
Collagen* may support
athletes to train harder
and perform better
*Findings based on research done with
Bioactive Collagen Peptides
© 2018 GELITA AG. 2018 GELITA Symposium. GELITA must authorize any copies.
Bioactive Collagen Peptides for Performance – Feel It!
20© 2018 GELITA AG. 2018 GELITA Symposium. GELITA must authorize any copies.
Mobility and Bioactive Collagen Peptides
21
Mobility
Strength
Joint Health
Flexibility
Strong Bones
© 2018 GELITA AG. 2018 GELITA Symposium. GELITA must authorize any copies.
BODYBALANCE® for Body Toning
22
Increasing Lean Body Mass
(double your training effect)
+ Decreasing Fat Mass
(triple your training effect)
+ Increasing Muscle Strength
In Combination with Resistance Exercise
© 2018 GELITA AG. 2018 GELITA Symposium. GELITA must authorize any copies.
BODYBALANCE® - An Ingredient for Aging Strong
23
Zdzieblik D. et al 2015–BJN
Study with > 50 elderly participants (>70 years) showed significantly increased power
output with BODYBALANCE® supplementation
© 2018 GELITA AG. 2018 GELITA Symposium. GELITA must authorize any copies.
+2.9
+4.2
-3.6
-5.5-6
-4
-2
0
2
4
6
Exercise +
BODYBALANCE®
Exercise +
BODYBALANCE®
Exercise +
Placebo
Exercise +
Placebo
BODYBALANCE® Effect on Body Toning
24
Zdzieblik D. et al 2015–BJN
kg c
om
pare
d to
ba
se
line
∆ Lean Body Mass ∆ Fatx 1.5
Increase your training
effect : gain of lean body
mass and loss of body fat
x 1.5
© 2018 GELITA AG. 2018 GELITA Symposium. GELITA must authorize any copies.
26
Zdzieblik, 2015 BJN and unpublished data
BODYBALANCE® for the Ages
CONFIDENTIAL© 2018 GELITA AG. 2018 GELITA Symposium. GELITA must authorize any copies.
Mobility and Bioactive Collagen Peptides
27
Mobility
Strength
Joint Health
Flexibility
StrongBones
© 2018 GELITA AG. 2018 GELITA Symposium. GELITA must authorize any copies.
Visualized Joint Health Effect
FORTIGEL® supports cartilage tissue regeneration in humans
Proteoglycan density
in the knee joint
cartilage was
significantly
increased after
FORTIGEL®
supplementation
Pla
ce
bo
FO
RT
IGE
L®
Day 1 Week 24 Week 48
Diseased Cartilage Healthy CartilageMcAlindon 2011
© 2018 GELITA AG. 2018 GELITA Symposium. GELITA must authorize any copies. 28
FORTIGEL® in Healthy Subjects
29
Zdzieblik 2017
NEW
DATA
Healthy Student Athletes – 5g FORTIGEL® Daily – 12 Weeks
© 2018 GELITA AG. 2018 GELITA Symposium. GELITA must authorize any copies.
Side Note – Joint Health & Mobility for Pets
30
Osteoarthritis
affects ~20% of
dogs over 1 year
of age
31% of dog owners point out
that bone and joint
problems are an
issue for their pets
(Hansen, 2003)
© 2018 GELITA AG. 2018 GELITA Symposium. GELITA must authorize any copies.
Source: Innova Market Insights: Only the Best for Pets Infographic
Mobility for Pets with PETAGILE®
31
• PETAGILE® Bioactive Collagen Peptides® (BCP), are
specific, highly purified hydrolyzed collagen peptides,
with neutral taste and odor.
• Nutritional supplement for management of osteoarthritis
(OA) and supporting maintenance of joint health in
animals
• Is food and no food additive, and therefore carries no E-
number.
• In compliance with Regulation (EC) 852/2004, 853/
2004, 999/2001
• Is easy to handle in dog food applications.
• Is pure collagen protein
© 2018 GELITA AG. 2018 GELITA Symposium. GELITA must authorize any copies.
PETAGILE® Stimulates Matrix Synthesis
in Canine Chondrocytes
32
Scientific Design:
• Experimental approach with canine
chondrocytes
• Measuring the RNA-expression of
cartilage matrix molecules
RN
A-
exp
ressio
n (
x-fo
ld
of co
ntr
ol)
Collagen type II Aggrecan Bigylcan Decorin Elastin
Cell Stimulation Test in Canine Chondrocytes*
10
Results:
• Statistically significant increase in matrix molecules such as collagen Type II,
aggrecan, biglycan, decorin, and elastin
• Increased accumulation of newly synthesized Type II collagen (+7.5%),
aggrecan (+5.5%) and elastin (+6.3%) at end of 3 week trial period
• Down regulation of degenerative processes
© 2018 GELITA AG. 2018 GELITA Symposium. GELITA must authorize any copies.
PETAGILE® Intervention on Osteoarthritic Dogs with
Treatment-Resistant History
33
Observational study (veterinarian and dog owner) / 22 dogs with clear OA indication
and treatment-resistant history / 12 weeks 5g PETAGILE® daily
Orange line: Lameness of dogs
continuously decreased over trial
period
Blue line: Dog owners observed
increased vitality of their dogs
over trial period
© 2018 GELITA AG. 2018 GELITA Symposium. GELITA must authorize any copies.
Schunck, 2017
…..It Also Works In Horses!
34© 2018 GELITA AG. 2018 GELITA Symposium. GELITA must authorize any copies.
Mobility and Bioactive Collagen Peptides
35
Mobility
Strength
Joint Health
Flexibility
StrongBones
© 2018 GELITA AG. 2018 GELITA Symposium. GELITA must authorize any copies.
Tendons and Ligaments are a Weak Link
36
Musculoskeletal injuries are the most common
complaint in active population.
More than 50% of all injuries in sports can be
classified as sprains, strains, ruptures or breaks
of musculoskeletal tissue.
Shaw, G et. al (2017). “Vitamin C-enriched gelation supplementation before intermittent activity augments collagen synthesis
Collagen is a major component of
tendons and ligaments
© 2018 GELITA AG. 2018 GELITA Symposium. GELITA must authorize any copies.
TENDOFORTE® Supports Faster Return-to-Training
37
Praet et al. (2017) O26: Oral supplementation of specific collagen peptides accelerates improvement in Achilles tendon symptoms and function in
combination with eccentric exercise. South African Journal of Sports Medicine, V 29, Suppl 1.
0123456789
10
Group T-P Group P-T Group T-P Group P-T3 months 6 months
5g TENDOFORTE®
Placebo
Cross-over after
3 months
Group T-P: 3 months TENDOFORTE®, 3 months Placebo
Group P-T: 3 months Placebo, 3 months TENDOFORTE®
Pa
rtic
ipa
nts
retu
rnin
g to
run
nin
g (
n=
20
)
6
3
+1
+2
“Oral supplementation of sCPs may accelerate the clinical benefits of a well-structured calf
strengthening and return-to-running program in patients with chronic Achilles tendinopathy symptoms”
© 2018 GELITA AG. 2018 GELITA Symposium. GELITA must authorize any copies.
5g of TENDOFORTE® for 6 months
significantly improved ankle stability during daily activity and sports
and reduced the incidence of injuries
Parallel design, n= 50 men or women with chronic ankle joint instability. Endpoints: changes in ankle functional status (CAIT), changes in foot and ankle ability measure (FAAM), and incidence of injuries in a 3 month follow-up
period.
Reduced Incidence of Injuries and Improved Ankle Stability
38
Adapted from Dressler et al. 2018. J Sports Sci Med. University of Freiburg.
“Specific collagen peptide supplementation in athletes with chronic ankle instability results in significant improvements in
ankle stability baring clinical relevance, as demonstrated by a reduced re-injury rate of ankle sprains in the follow-up period”
5g TENDOFORTE® Placebo
Reduced ankle sprains
by 62%(<0.001)
96% (n=24)
36% (n=9)
0%
100%
Reduced ankle injuries
by 35%(<0.05)
92% (n=23)
60% (n=15)
0%
100%
Improved ankle stability
by 76%(<0.001)
84% (n=21)
20% (n=5)
0%
100%
© 2018 GELITA AG. 2018 GELITA Symposium. GELITA must authorize any copies.
TENDOFORTE®
39© 2018 GELITA AG. 2018 GELITA Symposium. GELITA must authorize any copies.
TENDOFORTE® The first protein solution for stronger ligaments and tendons in active and performance nutrition
Expansion of Consumer Group =
Expansion of Expectations towards Active Nutrition
40
• Young
• Male
• Focus on muscle
• Young – Old
• Male & Female
• Different needs and expectations
Performance
Mobility
Protein Intake
Variety / Choice
Appearance
Appearance = Beautiful Skin
41
Beauty© 2018 GELITA AG. 2018 GELITA Symposium. GELITA must authorize any copies.
Crazy for Collagen
42
Source: Nutrition Business Journal; Condition Specific Report 2017
US Beauty From
Within Ingredients:
2017
© 2018 GELITA AG. 2018 GELITA Symposium. GELITA must authorize any copies.
VERISOL® For Beauty-from-Within
43
Proksch et al, 2014; Proksch et al, 2014a, Schunck, 2015
Daily dose of 2.5g
VERISOL®
Increased
Skin
Elasticitiy
Wrinkle
Reduction
Improved
Skin Surface
Structure
© 2018 GELITA AG. 2018 GELITA Symposium. GELITA must authorize any copies.
Eye Wrinkle Reduction – With VERISOL®
44
Proksch et al., 2014a
© 2018 GELITA AG. 2018 GELITA Symposium. GELITA must authorize any copies.
Improved Skin Structure with VERISOL®
Ultrasound Evidence of Skin @ 6 months
45
PLACEBO
© 2018 GELITA AG. 2018 GELITA Symposium. GELITA must authorize any copies.
Schunck et al, 2015
Nail Support with VERISOL®
46
Hexsel et al, 2017
Improvement
in nail peeling
Perceived
nails as
longer
Indicated
faster and
longer nail
growth
© 2018 GELITA AG. 2018 GELITA Symposium. GELITA must authorize any copies.
Life…and Bioactive Collagen Peptides
47
47
© 2018 GELITA AG. 2018 GELITA Symposium. GELITA must authorize any copies.
Active Nutrition is a growing and diversifying market segment being exposed to an increasing number of needs and demand for variety in delivery formats.
Bioactive Collagen Peptides are a versatile, clinically studied protein source to help with innovation in this category
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