introduction: maximising the yield

David Price, REG Chairman

2015 REG Winter Summit: Welcome

Welcome!Many Miles

Travelled to be here today.

Thank you for your time &

commitment to REG

Housekeeping & “rules of engagement”• Mobile phones

• Please switch off / to silent• Regular coffee breaks if you do need to pick up emails

• Recording & Photography for:o Internal reference; meeting report; newsletter & (with

consent) website• Toilets / Rest rooms

• TBC on the day• Delegate pack

• Programme• Abstract book – for all thematic sessions & select plenaries• Maps – directions to dinner tonight• Expenses form – emailed for completion on your return

• Sessions • Q&A welcomed – discussion & debate is strongly

encouraged

Looking back; looking forward…

2014 2015

2014: off to a good start…

2015

Arch Supplement• Published by ATS Annals• 7 papers discussing the key

aspects of real-life research:o Guideline limitationso The role of RWEo Standardso Cost-effectiveness

EAACI 2015 Conference proposals accepted• Harnessing primary care databases to unpick the

complexities of allergic obstructive airway disease7 papers discussing the key aspects of real-life research

• From efficacy-based to effectiveness-based guidelines in asthma: a paradigm shift?

Initial wish in 2012/13

“Set up a short-term initiative that will raise the quality and profile of real-life (respiratory) research across the research, political and public arenas”

But… 2014 required REG to recognise its longevity…

2014: REG continued to grow…COLLABORATORS

SUPPORTERS

2014: Recognising our longevity (II)

Initial Structure

Constitution+

2014: Recognising our longevity (II)

More formal structure required: • Oversight

Committee; • Council;

Special Interest Leads;

• Society Leads;

• Regional Leads;

• Guideline Leads;

• Accreditation Committee; Manuscript & Research Review Committees

2014: “Manageable chunks”

2014: Formalised call for research ideas

• Research Pin board• Studies shortlisted for

funding as:1. REG Studies (non-

commercial, with multi-sponsors or hands-off grant);

2. REG Collaborations (single-sponsor, non-commercials study), or

3. Commercial Study (commercial/product-specific study).

2014 Research: understanding real practice• Asthma State of the Union • Rationale: poor control may contribute

significantly to the health and economic consequences of asthma

• A study characterising asthma severity, treatment and control among patients from 153 UK primary care practices. Addresses questions around:o Exacerbation risk at different GINA

treatment stepo Possible over-treatment of patients

(at higher GINA step)o Differential outcomes for smokers/non-

smokers • Submitted to EACCI 2015; Manuscript in

development

TREATMENT

CONTROL

RISK?

2014: June Summit

2014: June Summit

2014 ERS…• Real-life session:

The Evolving Role of Real Life Research in Respiratory Medicine

• Collaborators meeting• 6 abstracts from REG

studies:o REG Endpoint

Validation Study:o Paediatric Asthma

Step-Upo COPD Eosinophil

Study

• Real-life session:The Evolving Role of Real Life Research in Respiratory Medicine

• Collaborators meeting• Real-life research course – run by

Research Education Alliance – materials to be accredited by REG

2014: APSR…

Looking forward…

2014

2015To all who contributed to REG’s many activities and successes

THANK YOU

• ERS session proposal submitted• Session at the ATS – Jerry Krishnan & Barry Make • EAACI sessions• EAACI Taskforce completing its work• Completion & publication of current REG studies:

o Asthma risk predictorso Blood eosinophils in COPDo Longitudinal bi-directional

relationship between ICS adherence and asthma

outcomeso Asthma Endpoint Validationo COPD risk predictiono Devices – iHARP & Critikal

2015: lots to look forward to (I)

• More research• More meetings• PR-activities – make the world start to sit up and take

notice• Possible joint society taskforce application…?• Potential Horizon 2020 bid…?

Next 48 hours – the summit…

• Opportunity to:o Share and learn from each other’s datao Identify new data resources and opportuntieso Strengthen relationships and extend our

networkso Identify new ideas and opportunities for REG

and for your own research interests

• And much more

• Hand over to Dermot Ryan for his opening talk:Maximizing the Yield: towards patient-centred care