left and right sided diverticular ... - dr. falk pharma · presentation ---chronic right •...

Left and Right Sided Diverticular DiseaseTwo Entities?

Mr Richard CohenSt. Mark’s Hospital, Harrow

University College Hospital, London

Diverticular Disease

• Solitary Caecal Diverticulum

• Left Sided Diverticular Disease

• Right Sided Diverticular Disease

• Pan Colonic (Total) Diverticular Disease

Diverticular Disease

Diverticular Disease?Normal

DIVERTICULOSIS

Presentation ---Acute

Right• Bleeding• RIF Pain

– Peritonitis– Phlegmon– Abscess

Left• LIF Pain

– Obstruction– Phlegmon– Peritonitis– Abscess

• Bleeding

Presentation ---Chronic

Right• Anaemia

Left• Anaemia• Constipation• Pain• Fistulation

Diverticular disease - uncomplicated

Diverticular disease - pericolic abscess

Solitary Caecal Diverticulum• 1 in 1000 emergency laparotomies• First recorded: 1912 Potier

» 52% anterior» 15% posterior» 14% lateral wall» 7% medially (Wagner and Zollinger 1961)

• “True” diverticula (muscle fibres in wall)– Parker and Seargent 1957– Anscombe 1967

• Congenital• Only present with complication

Classification at OperationGreaney and Snyder 1957Am J. Surg

• Grade I and II– Inflammation of

diverticulum or DD Mass

• Grade III and IV– Pus or

perforation

Country Studies n Caecum Ascending Transverse Descending Sigmoid Total Colon Colon Colon Colon Colon

UK 2 627 1.5 6.5 6 20 58.5 7.5USA 6 5384 3 4 4.7 17.5 69.2 7.5Norway 1 90 3 6 5 23 63Sweden 1 546 0 2 4 14 78 3Finland 2 458 0 6.5 10.5 26.5 56 1.5Japanese 1 82 81 R Colon 11 L Colon 8Hong Kong 1 215 13 36 20 17 13Israel 1 112 2 15 5 24 38 16Australia 1 90 6 R Colon 79 L Colon

Diverticular Disease Worldwide

World Distribution of DD

RIGHT SIDE

• Japan• Korea• China• Singapore• Taiwan• Tailand

LEFT SIDE

• Europe• USA• Brazil• South Africa• Australia• India

Mechanism of Left sided DD• Abnormal thickening

with ageing• Collagen abnormality• Increased intraluminal

pressure • Segmentation

Mechanism of Left sided DD

• Mucosa and submucosa herniate

• Locus minorisresistentia

Ageing and Diet

• Uncommon under 40• 60% over 70 have DD• Environment of the colon rather than its age

(Painter and Burkitt 1975)

• Fibre43881 USA males– Fibre associated with marked decrease risk of symptomatic DD

• Meat3105 colonoscopies with dietary interviews– Right sided diverticulosis correlates with past meat consumption

Mechanism of Right Sided DD

Japan• Large increase in detection

– 1050’s…..1%– 1970’s…..20%

• Younger age

• Decrease in fibre– 1946…..25.0g/day– 1991…..14.5g/day

Correlation with dietary fibre intakeMunakattaA et al, Tohoku J Exp Med 1993

Site of Involvement by Age GroupYoshidaY, Inoue M

Birth cohort analysis Hirosaki University Hospital Nakaji et al. Int J Colorectal Dis (2002)

• 1945-54 ♦

• 1935-44• 1915-24• 1905-14

Intraluminal Pressure Right DD

Colonoscopy with catheter tip transducer• 13 R sided DD• 10 Normal• Injection of neostigmine more frequent high pressure waves• Higher motility index Sugihara K et al Gut 1983

Ascending colon pressure higher with right sided DD than sigmoid DD

Sasaki et al. Nankodo, Tokyo 1990

Intraluminal pressure higher in right colon in patients with right sided DD than those without diverticula

Pathological Features Right Sided DD

• Almost all are pseudodiverticula• Abnormal thickness of colon wall• Number of haustra per constant distance of

ascending colon is greater than controls• Abnormal shortening of colon• Right sided DD are at points where artery

penetrates colon wall

Detection rates of DD in Hawaiian Japanese and Mainland JapaneseNakaji et al. Int J Colorectal Dis (2002)

Nakaji, Danjo et al In J Colorectal Dis 2002

∑ vs“Omicroid Colon”

Clinical Behavior of Left Sided DD

Infective Complications• Diverticulitis• Diverticular Phlegmon• Diverticular Abscess• Diverticular Perforation

Clinical Behavior of Left Sided DD

Other Complications• Fistulation

– Bladder – Vagina

Clinical Behavior of Left Sided DD

Other Complications• Stricture formation• Obstruction• Bleeding

Clinical Behavior of Right Sided DD

Singapore General Hospital Wong,Soong-Kuan et al. DCR 1997

• 188 Patients• Mean Age 65.1 (SEM 13.9)• Women presented 8.4 years later than men• Right sided DD 42%• Left sided DD 34%• Pan colonic DD 24%

Clinical Behavior of Right Sided DD

Massive Rectal Bleeding (n=85)• Right sided DD 49.4%• Left sided DD 16.5%• R + L DD 34.1%Surgery for bleeding• Right sided DD 41%• Left sided DD 7%

Clinical Behavior of Right Sided DD

Diverticulitis (n=65)• Right sided DD 38.5%• Left sided DD 49.2%• R + L DD 12.3%

Surgery more common for left sided diverticulitis

Fistulation, rare, but predominantly left sided DD

Clinical Behavior of Right Sided DDObstruction (n=21)• Right sided DD 38.1%• L sided DD 42.9%• R + L DD 19%

Management of Diverticulosis

Right Side• ? Fibre• Laparoscopic resection

Right hemicolectomy

Left Side• Fibre and advice• Laparoscopic resection

Left Hemicolectomy

Management of DiverticulitisRight Side• Often get surgery as mimic

appendicitis unless CT • If known conservative

– Drip– Suck– Antibiotics– Monitor

Failure of conservative Rx leads to surgery

Right Hemicolectomy

Left Side• Conservative

– Drip– Suck– Antibiotics– Monitor

• CT drain abscessFailure of conservative Rx

leads to surgeryHartmannsAnterior resection

Management of Diverticular Bleeding

• Resuscitation• Assessment• Angiography• Right Hemicolectomy• Left HemicolectomyIF IN DOUBTTAKE IT ALL OUT• Sub Total Colectomy and Ileostomy

Caecal Mass/ Sigmoid Phlegmon

Conservative treatmentUnless• Rising pulse• Worsening sepsis• Increasing pain• Generalised tenderness• Exclude cancer? Interval laparoscopic resection

Different Entities?

CongenitalAcquiredGenetics

YoungOld Age

CommonRareBleeding

UnusualCommonInflammatory Complication

Slightly higherAbnormally high

IntraluminalPressure

AbsentRemarkableMuscle Abnormality

Right SidedLeft Sided