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Nanotechnology

Outline

3

What is nano?

4

Examples of nanomaterials

5

Nanoparticles in daily life

6

Nanoparticles

7

Products

8

Products

9

Companies and nanotechnology

10

Nanomaterials

11

Nanoparticle exposure

12

Nanoparticles for medicine

13

Medical applications

14

Evolving landscapes

Medical applications

15

Clinical grade products

16

Nanoproducts

17

Immunotherapy

18

Benefits: Gene therapy

19

Benefits: Vaccines

20

Benefits: Lymphatic delivery

21

Benefits: Image guided surgery

22

Toxicity

Nanoparticles

Terminology

Immune system

Particle size

Nanoparticles

Structure activity relationship

Immune system

Bidirectional communication

Protein binding

Biodistribution

MPS uptake

Macrophage polarization

Hemolysis

Hemolysis

Coagulation system

Undesirable effects

Zeta potential

Platelets

Endothelial cells

Complement activation

Fibrous carriers

IL-1 induction

Cationic liposomes

Chemokine induction

IFN induction

IFN induction

API immunotoxicity

Platform selection

Infusion reactions

2nd generation liposomes

Allergenicity

Immunogenicity

Anti-PEG antibody

Anti-inflammatory properties

Immunosuppression

Take home message

Nanotechnology characterization lab

Future directions

NCL team

NCL immunology team