nnt drug - 10 nnt placebo – 2.5

0%

5%

10%

15%

20%

25%

30%

35%

40%

45%

50%

Res

pons

e R

ate%

Drug v Placebo

Active Drug

Placebo

-

0%

5%

10%

15%

20%

25%

30%

35%

40%

Res

pons

e R

ate%

Components of Therapeutic Response: Specific v Non-Specific

Specific

Non-specific

-

NNT Drug - 10

NNT Placebo – 2.5

0%

10%

20%

30%

40%

50%

60%

70%

80%

Res

pons

e R

ate%

Drug v Placebo

Active Drug

Placebo

-

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

Res

pons

e R

ate%

Responders v Others

Drug Responder

Others

1. Olanzapine, quetiapine, risperidone for acute mania

2. Olanzapine, prophylaxis

3. Stop antidepressants

4. Valproate for prophylaxis

5. Treatment for Children

6. Suicide Risk

1. Olanzapine, quetiapine, risperidone for acute mania

2.Olanzapine, prophylaxis

3. Stop antidepressants

4. Valproate for prophylaxis

5. Treatment for Children

6. Suicide Risk

1. Olanzapine quetiapine risperidone for mania

2. Olanzapine, prophylaxis

3.Stop antidepressants

4.Valproate for prophylaxis

5. Treatment for Children

6. Suicide Risk

0

20

40

60

80

100

120

140

Nu

mb

er

1985

1987

1989

1991

1993

1995

1997

1999

2001

2003

2005

Articles on Mood Stabilizers

N

1. Olanzapine, quetiapine, risperidone for mania

2. Olanzapine, prophylaxis

3. Stop antidepressants

4. Valproate for prophylaxis

5.Treatment for Children

6. Suicide Risk

Many of the mothers we interviewed remembered their baby’s excessive activity in utero.  

 1/ While my daughter was in the womb, she kicked so hard and often that I had very little rest… much of the time it felt like she was in a fight - rolling and tumbling around and then, when she was born.. she kept all the other babies up with her screaming. 2/ I too noticed signs that this was an extra-spirited child. In fact, while I was pregnant, I remember saying, “Uh-oh, the baby is angry again.” His kicks would last for an hour as I doubled over in pain..3/ “At 14 weeks the sonographer and obstetrician were unable to get a picture of Ian’s face and could not sample the amniotic fluid due to constant, unpredictable activity.”

1. Olanzapine, quetiapine, risperidone for mania

2. Olanzapine, prophylaxis

3. Stop antidepressants

4. Valproate for prophylaxis

5. Treatment for Children

6.Suicide Risk

Suicide/Suicidal Acts: Mood Stabilizers v Placebo Storosum et al 2005

RR = 2.22

GUIDELINECAPTURE

http://www.healyprozac.com/AcademicStalking/default.htm.

BRAND FASCISM

The Engineer of

Human Souls

Bax: Some of the witnesses we have had have described these guidelines as a framework, within which to work... Does that fit in with how you saw the guidelines? That: They are exactly what they say, guidelines, they are not the law. They are guidelines. Bax: Did they have to be followed? That: Of course they have to be followed, but they are not strict law. That is why they are guidelines and not law and, of course, they have to be applied according to the relevant circumstances. Bax: They are expected to be followed? That: Of course they have to be followed. They need to be followed for what they are, guidelines