pharmacology training programs in the future. major accomplishments in pharmacology and impact of...

Pharmacology Training Programsin the Future

Major Accomplishments in Pharmacology andImpact of other disciplines.

(partly from ASPET’s “Significant events in Pharmacology”)

1978 - Discovery of G proteins - biochemistry1981-1983 - ANP - physiology/biochemistry1988 - ANP receptor Guanylyl Cyclase - biochem/mol. biology1987 - Zidovudine effective against HIV - virology/immunologyLate 80’s to 90’s - Structures of G proteins (ras, Gi, Gs, G)

biochem/structural biol1997 - structure of adenylyl cyclase - biochem/structural biol2000 - structure of rhodopsin (GPCR) - biochem/structural biol90’s - current - transgenics and knock outs - genetics/mol.

biol./physiol/pathology.

Pharmacology

SystemsBiology

Proteomics

Mathematical ModelingPharmacogenomics

Biochemistry Molecular Biology

ImmunologyMicrobiology

Physiology

Chemistry Cell Biology

GeneticsStructural Biology

Astrophysics

PharmacologyStudents/Postdocs

Industry AcademiaGovt.(CDC

NIH, etc.)

Administration Science(R&D)

Teaching

Other (writingPatent law, etc)

Needs on curriculum: How much do we teach? What do we teach?

More Biochemistry? Proteomics?

Systems Biology/ Computational Biology (Mathematical Modeling)? - Collaborations with biology/math depts. - joint programs?

Small molecule screens? (interactions with industry)

Intellectual Property and Patenting? (ditto)

More genomics/genetics?

Structure based inhibitors/activators? Structural Biology?

Administration? Ph.D/MBA programs?

Enhance the translational side of research

Collaborations with Clinicians (co-mentors/committee members) - insights into clinical trials

Collaborations/Partership with Industry (scholarships/fellowships) Co-mentors in Industry?Advantages: Learn hands-on the processes that contribute

to drug development - analyses of clinical trial data Gain insights into the nuances of how Industry

works - from data books, proprietary rights, to researchpriorities.

Make informed decisions about careers in industry.

Hurdles: Time away from primary lab Delay in publications! Commitment on part of industry? - investment?