Pharmacology Training Programsin the Future

Major Accomplishments in Pharmacology andImpact of other disciplines.

(partly from ASPET’s “Significant events in Pharmacology”)

1978 - Discovery of G proteins - biochemistry1981-1983 - ANP - physiology/biochemistry1988 - ANP receptor Guanylyl Cyclase - biochem/mol. biology1987 - Zidovudine effective against HIV - virology/immunologyLate 80’s to 90’s - Structures of G proteins (ras, Gi, Gs, G)

biochem/structural biol1997 - structure of adenylyl cyclase - biochem/structural biol2000 - structure of rhodopsin (GPCR) - biochem/structural biol90’s - current - transgenics and knock outs - genetics/mol.

biol./physiol/pathology.

Pharmacology

SystemsBiology

Proteomics

Mathematical ModelingPharmacogenomics

Biochemistry Molecular Biology

ImmunologyMicrobiology

Physiology

Chemistry Cell Biology

GeneticsStructural Biology

Astrophysics

PharmacologyStudents/Postdocs

Industry AcademiaGovt.(CDC

NIH, etc.)

Administration Science(R&D)

Teaching

Other (writingPatent law, etc)

Needs on curriculum: How much do we teach? What do we teach?

More Biochemistry? Proteomics?

Systems Biology/ Computational Biology (Mathematical Modeling)? - Collaborations with biology/math depts. - joint programs?

Small molecule screens? (interactions with industry)

Intellectual Property and Patenting? (ditto)

More genomics/genetics?

Structure based inhibitors/activators? Structural Biology?

Administration? Ph.D/MBA programs?

Enhance the translational side of research

Collaborations with Clinicians (co-mentors/committee members) - insights into clinical trials

Collaborations/Partership with Industry (scholarships/fellowships) Co-mentors in Industry?Advantages: Learn hands-on the processes that contribute

to drug development - analyses of clinical trial data Gain insights into the nuances of how Industry

works - from data books, proprietary rights, to researchpriorities.

Make informed decisions about careers in industry.

Hurdles: Time away from primary lab Delay in publications! Commitment on part of industry? - investment?