robert scranton© 2008. 5 cardinal signs of inflammation heat redness swelling/ edema pain loss of...

Robert Scranton© 2008

5 Cardinal Signs of InflammationHeatRednessSwelling/ EdemaPainLoss of Function

Vascular DilationVascular DilationExudateAfferent InformationA result of the

edema and pain

Caused By?

InflammationAcute Chronic

Neutrophil

No

Neutrophil

Lymphocytes, monocytes, eosinophils

Yes

Lymphocytes (also macrophages)

Cell type:

Angiogenesis:

Hallmark:

InflammationMast Cell NeutrophilIgE

Heparin, Histamine & SRS-A

Around small bv, external epithelia

IgG & complement

Primary granules= Lysozyme & myeloperoxidaseSecondary Granules= alkaline phosphataseTertiary Granules= gelatinase

• intravascular

Receptor:

Contents

Location

Special Neutrophil infoLife span?When dead after

responding to inflammation, they become?

How do neutrophils survive in devascularized tissue?

Explain the process by which they get into the area of inflammation.

Margination

Rolling

Diapedesis

MacrophageDerived from?Surface receptor

types?Activated

macrophages look ________.

What happens when many macrophages surround large foreign bodies?

Functions

LymphocytesNuclear/cytoplasmic

ratio?Cell mediated=?Humoral= ?

EosinophilsPhagocytic activitySurface receptors

for?How does it attack

parasites?Granules, what type?

=

BasophilsReceptors forDiscuss slow and fast

granule releaseGranules contain?

ReconstructionDays?Fibroblasts+

vascular endothelial cells= ?

What are the characteristics of granulation tissue?

What happens after reconstruction?

Primary v. secondary union

RemodelingTime periodTypical maximal

tensile strength of the CT is?