semiconductor solutions for the healthcare challenge...1994 2000 2010 2025 in 2025 7.3% of the...

Semiconductor Solutions for the Healthcare Challenge

Werner Neumann

electronica Medical Forum

November 11, 2008

Sept 2008 p.2Werner Neumann

STMicroelectronics Solutions for Healthcare November 2008 - p.2

Healthcare – A Challenge

Source: IDF Diabetes Atlas 2006, Wikipedia, Spectaris 2008

• Health cost in Germany 2006: 148B€

• Potential to save 2.7B€ with modern medical electronics

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1994 2000 2010 2025

In 2025 7.3% of the worlds population might suffer from diabetes

Aging pyramid for Germany, Forecast for 2050

Diabetes Impaired Million people ww

Sept 2008 p.3Werner Neumann

STMicroelectronics Solutions for Healthcare November 2008 - p.3

STMicroelectronics’ 3 Pillars in Healthcare

Mass Market ApplicationApproach

• Products ready now

• Development Tools

• Short Time-To-Market

Healthcare Key CTM

Partnership

Develop new dedicated

products and technologies

Government programs,Consortia,Universities

Technology,Investment into

the future

Sept 2008 p.4Werner Neumann

STMicroelectronics Solutions for Healthcare November 2008 - p.4

ST Healthcare Solutions

Hearing Aid, Assembly Tech.

Patient Health Records

Tele-monitoring,Home Health

Imaging

Home HealthImplantsDisposable Healthcare

MolecularDiagnostic

Driving ApplicationsEmerging Applications

Sept 2008 p.5Werner Neumann

STMicroelectronics Solutions for Healthcare November 2008 - p.5

ST Healthcare Solutions

Molecular Diagnostic

MolecularDiagnostic

• Medical Diagnostics – Point of Care

• Environmental Control – Air/Water

• Agro-Industrial Control – Genetically Modified Objects

Sept 2008 p.6Werner Neumann

STMicroelectronics Solutions for Healthcare November 2008 - p.6

ST In-Check™ Platform

Sept 2008 p.7Werner Neumann

STMicroelectronics Solutions for Healthcare November 2008 - p.7

ST Platform Approach To Biotech Market

Expert biologists

Big Central Lab

Automation

Hospital LabIntegration

Quantification

Miniaturization - Automation - Reliability

User friendly

Low cost

Fast

Portable

Sept 2008 p.8Werner Neumann

STMicroelectronics Solutions for Healthcare November 2008 - p.8

In-Check™ Platform: Main Elements

Biochip Core

Reader

Software platform

Thermal Control System

Pathogen A

Pathogen B

Pathogen C

Marker A

Marker B

Biological Content From ST partners

Sept 2008 p.9Werner Neumann

STMicroelectronics Solutions for Healthcare November 2008 - p.9

Core Silicon Chip

Ta/Au electrodes

Thermal Sensors - Al/Si/Cu

Fluidic Inlets - Glass

Buried Channels

Surface Channels - Dry resist

Microarray Detection Area

Sept 2008 p.10Werner Neumann

STMicroelectronics Solutions for Healthcare November 2008 - p.10

Concept & Application

Analysis Time: 1- 2 hours

In-Check is designed as an open platform for fast and highly automated DNA analysis.

Example Screenshot

Sept 2008 p.11Werner Neumann

STMicroelectronics Solutions for Healthcare November 2008 - p.11

Insulin Nanopump™ in MEMS Technology

Disposable

Healthcare

Inlet valve

Pumping chamber

Outlet valveDetector

• Small, Precise, Safe

Sept 2008 p.12Werner Neumann

STMicroelectronics Solutions for Healthcare November 2008 - p.12

European Imaging Project: Megaframe

• Array of diodes in Geiger mode

• One million frames per second imaging

• Count of single photons with a timing resolution of 100ps.

• A new enabler for non-invasivediagnostics with big potential:

– Optical Coherence Tomography (OCT)

– Fluorescence Lifetime Analysis (FLIM)

– Blood glucose metering

– SpO2 Blood oxygen saturation level

– http://www.megaframe.eu

OCT skin analysis video

Sept 2008 p.13Werner Neumann

STMicroelectronics Solutions for Healthcare November 2008 - p.13

Technologies for Implantable Devices

1200V dice

3-D MEMS dice

IGBT

MEMS

HCMOS9 LP/ULL

Low Power CMOSUltra Low Leakage

0.13um CMOS

Selected Technologies

HVG8

High Voltage Gate

0.18um CMOS

High Voltage Switch

ECG Unit(ADC)

HV H-Bridge

HV Control

Switching

High Voltage

Capacitor

Capacitor ChargerControl

CircuitMemory Techno.

Power Management

Communication

MEMS Acce-

lerometer

IPAD Device Integration / Hybrids

Implants

Sept 2008 p.14Werner Neumann

STMicroelectronics Solutions for Healthcare November 2008 - p.14

Solutions For Each Function

PortableHealthcare

• Glucose Meter

• Insulin Pump

• Blood Pressure

• Thermometer

• Fertility Tester

• Sensors

– MEMS accelerometer

– MEMS microphone

– MEMS technology enables implantable sensors

• Analysis

– Low Power Micro / DSP Functionality

– EEPROM Memory

– ADC, Analog Std. product and ASIC

– Power Management

– RF-ASIC/ZigBee/NFC

• Drug Delivery

– Insulin Nanopump

– MCU / Dual Core ASIC

Sept 2008 p.15Werner Neumann

STMicroelectronics Solutions for Healthcare November 2008 - p.15

STM32 Low Power MCU

• ST provides software routines for faster Time-to-market:

• VDE Certified Firmware for STM32 Family according IEC60335 Type B, similar to SIL-2.

• 3DES/AES Encryption Libraries

Sept 2008 p.16Werner Neumann

STMicroelectronics Solutions for Healthcare November 2008 - p.16

Motor Control Solutions

• Respirator

• Wheelchair

• Hospital Drug Delivery

• 8-bit: ST7FMC, 32-bit: STM32Power Electronics

• BLDC, 3ph-Induction, PMSM Motors

• Vector / Field Oriented Control

– FIR and IIR filters, PID controller

– Motor control dedicated PWM peripheral

– Dual 12-bit ADC converter, 1 MS/s with synchronization capabilities

– All libraries available now

• Examples:

– Ultra silent drive

– Voice encoding / decoding for commands

– Fast Fourier Transformation

Sept 2008 p.17Werner Neumann

STMicroelectronics Solutions for Healthcare November 2008 - p.17

STM32-EVALBoard, Small Packages

• Starter Kits from ST, IAR, Keil, Hitex

• Demos for USB, CAN, SD Card etc…available from www.st.com/mcu

• Hotline support

• Ultra small packages available

Sept 2008 p.18Werner Neumann

STMicroelectronics Solutions for Healthcare November 2008 - p.18

EEPROM

• Any Communication interface in any Density:– I2C from 1 Kb to 1 Mb

– SPI from 1 Kb to 1 Mb

– Microwire from 1 Kb to 16 Kb

• On top of standard packages (SO8, SSOP8):– MLP 2x3 up to 128 Kb

– WLCSP for the smallest high density EEPROM in the world

• ST # 1 in EEPROM

• Special Service: custom trimming of key parameter

Sept 2008 p.19Werner Neumann

STMicroelectronics Solutions for Healthcare November 2008 - p.19

Tele-Monitoring: ZigBee, NFC

To continuously monitor variations in:

• Temperature

• Heart rate

• Blood oxygenation

• Respiratory rate

ZigBee SN250 module

Tele-Monitoring,Home Health

Sept 2008 p.20Werner Neumann

STMicroelectronics Solutions for Healthcare November 2008 - p.20

Miniaturized Packages

Stack Die Through Silicon Via

WLCSPWafer Level Chip Scale Package

Bumped die

SIP System in Package

Down to 400µm pitch

µQFN

Assembly Technology

Sept 2008 p.21Werner Neumann

STMicroelectronics Solutions for Healthcare November 2008 - p.21

New ST Micropower Operation Amplifier for Healthcare Analog Front Ends

• Market Leader

– Over 2 Billion units of analog mixed products shipped in 2007

– 6% Market Share WW in 2007

• New Product:

– High merit factor: 5V, 60µA/890kHz

– Low Vio: 1mV max

– Very narrow dispersion of Icc and AC parameters

– Micro Packages: SC70-5, SOT23-8, MSO8-10

• Available in Q1/2009

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NEW

NEW

NEW

NEW

Sept 2008 p.22Werner Neumann

STMicroelectronics Solutions for Healthcare November 2008 - p.22

Summary

• ST is taking care

– Long term research

– Strong partnerships with market leaders

– State of the art products

– Radical innovative technology

• Products are available now

• Demoboards and support hotline for fast development

On-Chip Cell Sorting