the emergence of a novel threat: zika - swedish medical center/media/images/swedish/cme1... ·...

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the emergence of a novel threat:

Zika

June 3, 2016 Swedish Family Medicine

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2015-2016 Brazil

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Unusually large number of babies with microcephaly

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2002-2003 SARS

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2006 Bird Flu: H5N1

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2008-2009: H1N1 Swine Flu Pandemic

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2012-2013 MERS Co-V

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2014 Ebola in West Africa

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2015-2016 Zika

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1947 Zika in Rhesus Macaques

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CDC map of Zika range May 2016

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Range of Ae. aegypti

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Aedes aegypti likes people

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Estimated range of Aedes aegypti in the

US (CDC 2016)

Estimated range of Aedes albopictus in the US (CDC 2016)

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How is Zika transmitted?

Zika can be transmitted through:

– Mosquito bites

– From a pregnant woman to her fetus

– Sexual contact

– Blood transfusion

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Complications of Zika Maternal infection

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Range of neurological problems

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Zika infects glial cells: Guillain-Barré

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Vaccine?

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References:

Duffy MR, Chen, Hancock WT, Powers AM, Kool JL, Lanciotti RS, Pretrick M, Marfel M, Holzbauer S, Dubray C, Guillaumot L, Griggs A, Bel M, Lambert AJ, Laven J, Kosoy O, Panella A, Biggerstaff BJ, Fischer M, Hayes EB. Zika Virus Outbreak on Yap Island, Federated States of Micronesia. 2009 June. The New England Journal of Medicine. 360:2536-43

Musso D, Nilles EJ, Cao-Lormeau VM. Rapid spread of emerging Zika virus in the Pacific area. 2014. Clinical Microbiology and Infection. 20(10):O595-6

Roth A, Mericer A, Lepers C, Hoy D, Duituturanga S, Benyon E, Guillaumot L, Souares Y. Concurrent outbreaks of dengue, chikungunya and Zika virus infections - an unprecedented epidemic wave of mosquito-borne viruses in the Pacific, 2012-2014. 2014. Eurosurveillance. 19(41)

Shinichi N. Mosquito Fauna in the Federated States of Micronesia: A Discussion of the Vector Species of the Dengue Virus. 2014. South Pacific Studies. 34(2):117-27

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Association between Zika virus and microcephaly in French Polynesia, 2013–15: a retrospective study

Published Online: 15 March 2016

Dr Simon Cauchemez, PhD; Marianne Besnard, MD; Priscillia Bompard, MPH; Timothée Dub, MPH; Prisca Guillemette-Artur, MD…

http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2816%2900651-6/abstract?version=meter+at+null&module=meter-Links&pgtype=article&contentId=&mediaId=&referrer=https%3A%2F%2Fwww.google.com%2F&priority=true&action=click&contentCollection=meter-links-click

Zika Virus: Medical Countermeasure Development Challenges

Published: March 2, 2016; Robert W. Malone , et al

James Wilson ,

Zika Response Working Group

http://dx.doi.org/10.1371/journal.pntd.0004530