vuos partner for cooperation 2 where you can find us

VUOS PARTNER FOR COOPERATION2

Where you can find usWhere you can find us

VUOS PARTNER FOR COOPERATION3

VUOS VUOS ownershipownership

AGROFERT HOLDING,a.s..

SYNTHESIA, a.s.

VÝZKUMNÝ ÚSTAVORGANICKÝCH

SYNTÉZ a.s.

(VUOS

100%

100%

VUOS PARTNER FOR COOPERATION4

HistoryHistory

1941 1952 1992 1997 2004 2009

Foundation of Research Laboratories

Voucher Privatisation

New name – VUOS

Affiliation of Synthesia´s R&D 100% daughter

company of Synthesia a.s.

VUOS PARTNER FOR COOPERATION5

VUOS VUOS main businessesmain businesses

1. R&D and Production of Fine Chemicals

2. Toxicology and Analytics

Employees Sales in %

VUOS PARTNER FOR COOPERATION6

The Certificates of VUOSThe Certificates of VUOS

• ISO 9001:2008

• Certificates of Good Laboratory Practice

• Certificate of Accreditation for Certification of Products No. 229/2002 (EN 45011:1998)

• Certificate of Accreditation No. 230/2002 Testing Laboratory No. 1057 (EN ISO/IEC 17025:2005)

• Certificate on Compliance with Principles of Good Manufacturing Practice in laboratory

VUOS PARTNER FOR COOPERATION7

• Education structure of employees

•VUOS is located in area of long-lasting . chemical tradition with complete infrastructure

•Cooperation with University of Pardubice

Strong PointsStrong Points

VUOS PARTNER FOR COOPERATION8

R&D, up scalingR&D, up scaling

• pharmaceutical intermediates

• intermediates for microelectronics

• custom syntheses of chemical specialities

• dyes and pigments for special application

VUOS PARTNER FOR COOPERATION9

R&D, up scalingR&D, up scaling

Wide range of quantities

Grams – in laboratory

Kilograms – in kilolab unit

Metric tons – in VUOS production plant

Hundreds of MT –

VUOS PARTNER FOR COOPERATION10

VUOS's key chemistry

VUOS's key technology

Adamantane derivates

N-Heterocycles

Hydrogenation Phosgenation

API Building Blocks

VUOS PARTNER FOR COOPERATION11

VUOS's technology/manufacture expertise includes:

acetylationaldolisationamidation alkylationaminationamoxidationalkali fusionarylhydrazines synthesesazocoupling benzoylationchiral synthesischlorinationchlorosulfonationcyclisationClaisen condensationdecarboxylation

dehydrohalogenationdiazotisationeliminationesterificationFriedel-Crafts reactionheterocyclic synthesishydrolysis reactionsneutralisationnitrationnitriles synthesesoxidation – catalytic/chemical oxidation in liquid phase rearrangementreduction with hydrazine and sodium borohydridesulfonation

VUOS PARTNER FOR COOPERATION12

Kilolab UnitKilolab Unit

Phosgenation

2x reactors, 250 and 650 l

2x High performance rectification columns

Laboratory phosgenation units from 1 to 30 litres

VUOS PARTNER FOR COOPERATION13

Kilolab UnitKilolab Unit

Hydrogenation

3x autoclaves 100 l each, 60, 120 and 130 bar, up to 200˚C, Hastelloy C clad

1x autoclave 300 l, 120 bar, 140˚C, Hastelloy C clad

1x autoclave 700 l, 100 bar,

200oC, stainless steel

1x autoclave 1,000 l, 10 bar, 140˚C, stainless steel

many autoclaves up to 10 l

VUOS PARTNER FOR COOPERATION14

Kilolab UnitKilolab Unit

Low temperature, RLi, RMgX, NaH

1 x glass reactor 50 l cooled down to – 80˚C

1x glasslined reactor for NaH reactions (250 l)

3x glass reactors 100l for RLi, Grignard reactions

VUOS PARTNER FOR COOPERATION15

Kilolab UnitKilolab Unit

20x glass reactors, 100 l each

6x glass lined reactors (200 – 1,500 l)

2x evaporators 50 l / h

4x stainless steel reactors (300 – 1,500 l)

sufficient filtration and distillation capacity

Multipurpose chemistry

VUOS PARTNER FOR COOPERATION16

Production Unit

Production EquipmentProduction Equipment

45x glass lined reactors, total vol. 70,000 l (500 – 5,000 l)

13x stainless steel reactors, total vol. 22,000 l (1,000 – 3,000 l)

8x High performance rectification columns

sufficient filtration capacity (nutsches, centrifuges)

computer controlled

VUOS PARTNER FOR COOPERATION17

Toxicology, Ecology and Toxicology, Ecology and AnalyticsAnalytics

VUOS PARTNER FOR COOPERATION18

• Toxicology / ecotoxicology testing

• Sampling, analysing, evaluation of production waste streams (air pollution, effluents, solid

wastes hazards)

• Environmental Impact Assessment

• Development/validation of new specialised analytical methods

Toxicology, Ecology and Toxicology, Ecology and AnalyticsAnalytics

VUOS PARTNER FOR COOPERATION19

Analytical techniques:• NMR Spectroscopy• Mass Spectrometry (LC/GC-MS)• ICP-AES• IR Spectroscopy• Chromatography (HPLC, GC)• UV-Vis

Toxicology, Ecology and Toxicology, Ecology and AnalyticsAnalytics

VUOS PARTNER FOR COOPERATION20

Toxicology, Ecology and Toxicology, Ecology and AnalyticsAnalytics

Toxicology:

In vivo and in vitro testing according to the OECD or EU methods:

• Acute toxicity test• Skin and eye irritation• Sensibilization• Repeated dose tests• Reproduction toxicity tests• Carcinogenicity• Mutagenicicty

VUOS PARTNER FOR COOPERATION21

Toxicology, Ecology and Toxicology, Ecology and AnalyticsAnalytics

Ecotoxicological testing:

In vivo and in vitro testing according to the OECD or EU methods:

• Aquatic toxicity• Biotic degradation – Ready biodegradability• Inherent biodegradability• Abiotic degradation

VUOS PARTNER FOR COOPERATION22

Complete Offer of Services

by VUOS

CONSULTING

TESTING

EXPERT WORKS

REGISTRATION

REACHREACHand other legislative provisions and other legislative provisions

VUOS PARTNER FOR COOPERATION23

ContactContactss

General Manager: Dr. Karel NovákPhone: +420 46 682 2550 fax:+420 46 682 2976 e-mail:

karel.novak@vuos.com 

Sales Manager: Miloš Jesenský,Ph.D.Phone: +420 46 682 3300 fax:+420 46 682 2976 e-mail:milos.jesensky@vuos.com 

R&D : Alois Koloničný, Ph.D.Phone:+420 46 682 3156 fax: +420 46 682 3900 e-mail:alois.kolonicny@vuos.com

Toxicology and Analytics: Viktor Mejstřík,Ph.D.Phone:+420 46 682 3127 fax:+420 46 682 2975 e-mail:viktor.mejstrik@vuos.com

Process Engineering: Luboš Víšek Phone:+420 46 682 5790 fax:+420 46 682 3900 e-mail:lubos.visek@vuos.com