and tongue analysis the role of fingernail · · 2013-07-12the role of fingernail and tongue...

Copyright. Chi‟s Enterprise, Inc.

The Role of Fingernail

and Tongue Analysisand Herbal Practice

PREVENTIVE METHODS DEVELOPED

FROM OVER 10,000 PATIENTS‟ RECORDS

Tsu-Tsair Chi, PhD

November 18, 2012 – Mt. Pleasant, MI


LUNULA

TEETH MARKS


• 2010 Hardcover edition

• Over 120 color pictures

2008 Edition


COLOR

VITALITY

MOISTURE

SHAPE

COATING


Tongue Color

1. Pink tongue

2. Pale tongue

3. Red tongue

4. Dark red/Purple


Pink Tongue:

Normal

Light coating

on root of the

tongue


Pale Tongue:

Anemia

Shiny areas on

tongue: Anemia


Red Tongue:

Fever, Heart,

Infection

Spiky tongue:

Real fever


Dark Red or

Purple Tongue:

Blood stasis,

Serious

1


LUNG

TONGUE DIAGNOSIS

GALLBLADDER

LUNG

STOMACH(GI)

SPLEEN

HEART

KIDNEY

LIVER

LIVER


HEART

Elongated

Tongue


STOMACH

ULCER

Cracks on

tongue


Teeth Marks

Hypoglycemia

Lung

White Coating


Purple Dots: Blood Stasis


SPIKY TONGUE

• Tip – Heart/Lung

• Side – Liver/Gallbladder

• Center – Stomach/Intestine


Roadmap-like Tongue

Younger People:Deficiency of Blood,

Hormone and Chi

Older People:Digestion, Lack of

stomach acid


FEVER

Spikes


Inflammation Tongue Ulcer

2

Copyright. Chi‟s Enterprise, Inc. Copyright. Chi‟s Enterprise, Inc.

Tongue Movement vs. Diseases

• Stiff tongue and movement not easy

– Stroke or cognition

• Deviated tongue

– Whiplash, heavy metals, and stroke

• Tongue shrinks and is difficult to stick out

– Very serious condition

• Unable to control tongue, slow movements and/or tongue hangs out:

– Low IQ (since childhood) or stroke


Deviated

Tongue

Whiplash

Heavy Metals

Stroke


Tongue Coating

• Light white: Normal

• White: Lung

• Yellow: Stomach

• Black: Digestion, Kidney, etc.


• Root / No Root

• Wet / Dry

• Greasy / Not Greasy

• Grow / Reduce

• Thick / Thin

Distribution of Coating


Yellowish/White

Coating

FEVER or

LOCAL

INFLAMMATION:

Stomach


Black Coating

• High fever

• Dehydrated

• Chronic infection

• Black/brown keratosis cell

• Digestion and Kidney


DIGESTION

Black Coating

KIDNEY


LIVER

Black, Dry,

Spiky Coating

3


KIDNEYS

Green/Grey

Coating


Mirror-Like Tongue• No coating

• Red color (thirsty, heavy chest, nauseous)

– stomach and gallbladder condition

• Serum albumin low

• Tongue cell metabolism retarded

– Digestion stopped

• Electrolyte imbalance

• Serious health condition


GALLBLADDER

Red, dry,

cracking tongue

STOMACH


Mirror-Like Tongue (Slippery)

Low serum

albumin


Autoimmune

Disease, etc.

SNOW-LIKE

COATING


Coating Location

• Whole tongue: Stomach and Liver.

• Tip (outside): Stomach initiative.

• Roots (inside): Stomach and Intestine

accumulation

• Left side: Inner Organs (difficult to treat)

• Right side: Outside Organs (muscles)

• No root: Stomach, kidney, spleen (serious)


Coating with

No Root

Serious

Condition


Peeling

Coating

Illness becomes

serious


Coating in

Center

Inner organs

problem

4


Coating on

Left Side

Dangerous

condition


SHAPE OR

GROWTH

CHANGE


NAIL CLUBBING

Caused by low oxygen levels in

the blood

Sign of:

• Heart problem

• Lung disease

• Cancer

• Parasites

• Digestive

problem


KOILONYCHIA (spoon nails)

Anemia


Nail growth is

interrupted by

severe illness

(heart attack) or

malnutrition

BEAU’S LINES

Horizontal indentations across the nails


PITTING

• Psoriasis

• Chronic

Dermatitis

• Alopecia

areata

(hair loss)Small

depressions


Psoriasis

Injury

Thyroid

disease

Fungal

disease

Drug

reactions

ONYCHOLYSISNail separates from nail bed


COLOR

CHANGE


TERRY’S NAILS (White nails)Opaque nails with a dark band on tip

Cancer

Congestive

Heart failure

Diabetes

Liver disease

(cirrhosis)

Auto-immune

disease

5


Kidney

Disease

MUEHRCKE’S LINES


Dark

longitudinal

streak(s)

• Melanoma

• Benign

nevus


HALF and HALF NAILS

Renal Failure


RED

LUNULA

Heart Disease

Systemic Lupus

Erymathosus

(SLE)

Rheumatoid

Arthritis


AZURE LUNULA

Silver poisoning, Wilson‟s disease,

quinachrine therapy


Lung/Heart (> 50-60%)

Nail Clubbing Ear Crease

Heart (89%)

Cardiovascular Markers


Heart DiseaseTip of tongue is red, ear crease, nail

clubbing, lunulae on pinky

Poor Circulation

Lack of lunulae, cold hands & feet,

numbness of the limbs (If the condition

improves, the lunulae should reappear)

Atherosclerosis Vertical ridges

Peripheral Artery

DiseaseCentral nail canal (“fir tree” abnormality)

Stroke/Aneurysm Cherry angiomas on forehead

Heavy Metals

Protruding blue veins and/or red/black spots

underneath the tongue. Sometimes there is a

metallic taste.

Cardiovascular Symptoms


Red dots on tip of tongue


Earlobe crease and cardiovascular risk

Chronic circulatory problems allow the vascular

bed in the earlobe to collapse, causing the crease.

1982 study: An earlobe crease plus chest pain,

etc. predicts a heart attack 89% of the time.

Cardiac symptoms without an earlobe crease only

predicts 10% of heart attack cases.

1991 study: patients with diagonal earlobe

creases had higher cardiac mortality rate and

higher number of cardiac events.

6


Nail Clubbing – Lung/Heart


Nail Clubbing and Heart Disease

Source: Journal of the American Academy of Dermatology. 2005; 52(6): 1020-28

Hemiplegia

• Paralysis of half of body

• Of 87 patients, 13.8% had clubbing on the

affected side

Infective Endocarditis

• Inflammation of heart lining

• Of 60 patients, 50% had bilateral clubbing


Lunula on the pinky

Heart Condition

Horizontal ridges

Horizontal Ridges: Heart Condition


Central Nail Canal

“Fir Tree” abnormality

Peripheral Artery Disease


Stroke/AneurysmCherry Angiomas on Forehead

• Cherry angiomas on

forehead,

• Family history of

stroke/aneurysm, and

• Hypertension

Risk is 23 = 8x higher

than average people


Salvia, Carthamus, Paeonia and

Ligusticum Extracts

1991. Japan Health Department.

Symptom 2 weeks 4 weeks 6 weeks 8 weeks

Headache 38.5 69.2 72.7 91.7

Dizziness 40.0 65.0 --- 66.7

Cardiac Flutter 57.1 71.4 75.2 80.0

Cold Hands/Feet 12.5 37.5 --- 53.3

Numb Hands/Feet 11.1 50.0 --- 55.5

on Cardiovascular Symptoms of 300 Patients


Salvia, Carthamus, Paeonia, and Ligusticum

Extracts on Cardiovascular Patients (30days)

28.926.6

38.1 36.8 38.1

0

5

10

15

20

25

30

35

40

Journal of West China University of Medical Sciences. 1999;30:64.

Blo

od

vis

cosi

ty

Fib

rrin

ogen

Mic

roci

rcu

lati

on

Ind

ex o

f th

rom

bla

stro

gra

m

Red

blo

od

cel

l ag

gre

gat

ion

130 patients


• Study from Washington University in St. Louis, MO

• Mitochondrial function decreases in aging cells,

allowing a reactive form of oxygen to leak

• Reactive oxygen causes damage to blood vessel walls

• The body mounts an immune response to repair this

damage

• Immune cells attract a form of cholesterol that sticks

to arterial walls, causing plaque and eventually

atherosclerosis

Aging cells may lead to arterial damage

and plaque

Source: Nature. June 2005, Vol. 435


Hippophae and Rhodiola Extracts

for Heart, Lungs, Energy

• Mitochondrial efficacy to utilize oxygen and glucose for the production of energy (ATP)

• Repairs/Protects vascular endothelial cells from free radical damage (vascular cell damage contributes to cardiovascular disease) LD50 > 40 ml/kg

Reference: Townsend Letter. May 2011; 334.

7


Hippophae and Rhodiola Extracts

TrilinoleinActive constituent of Hippophae

and Rhodiola Extracts

DHA

EPA

Eicosapentaenoic Acid (20:5)

Docosahexaenoic Acid (22:6)


Hippophae and Rhodiola Extracts vs. CoQ10 on Heart, Lung and Energy function

Action Extracts CoQ10

Increases energy within

30 minutes+++

Protects vascular

endothelial cells from

damage

+++ +

Repairs and protect

DNA-damaged cells+++

Eliminates shortness of

breath+++

Relieves choking-like

symptoms+++

Reduces palpitations +++

Minimizes chest

pounding+++

Action Extracts CoQ10

Improves mitochondrial

efficiency+++ +++

Reduces lactic acid +++ +++

Lowers lactate

dehydrogenase (LDH)+++ +++

Reduces malondialdehyde

(MDA)+++ ++

Increases superoxide

dismutase (SOD),

glutathione (GSH)

+++ +++

Anti-hypoxia +++

Reduces cholesterol +++ ++

Reduces triglycerides +++ +


ASPARAGUS EXTRACT CONTAINS:

• ORGANIC FOLATE(9 capsules or 3 bags contains > 400 g of organic folic acid)

• ASPARAGINASE

• ASPARAGOSIDE

• GLUTATHIONE

• VITAMIN B, C, E

• ORGANIC SELENIUM

• ORGANIC ZINC


• The American Journal of Clinical Nutrition. 2002; 76(4):758-65.

• JAMA. 2002; 288:973-979.

39%

28%

0

5

10

15

20

25

30

35

40

Asparagus Extract reduces Cardiovascular

Disease Risk by Reducing Homocysteine Levels

Folic Acid Homocysteine

(4 months)(1 month)


Xanthomas (eyelid plaque) may signal

Atherosclerosis, Ischemic Heart Disease,

Myocardial Infarction, High Cholesterol*

• 48% higher chance of myocardial infarction

• If present in those under 30 years old,

signals arterial plaque

*British Medical Journal. 2011; 343:d5497.


88%80%

84%

65%

0

10

20

30

40

50

60

70

80

90

Wine Extract reduces cholesterol in

155 patients (3 months)

Ath

ero

scle

rosi

s In

dex

Tri

gly

ceri

des

To

tal

Ch

ole

ster

ol

%


• Black- or blue-colored nails

• Dark, protruding veins under the

tongue with red/black spots

• Gum shows dark/blue lines

• Metallic taste in mouth


Blue veins under

the tongue

Heavy metal

deposit in gum


Silver and

Copper

Poisoning

Heavy metal

deposits

8


• Oral chelating herbal supplement

• No Side Effects

• Does not strip essential trace elements.

• Safe for children (3 years and older) to take.

• Kidney patients can take with Asparagus

Extract and use with Bathdetox

• Removes heavy metals through urination and

fecal excretion

• Inexpensive

Smilax, Sargassum, Rheum and

Allium Extracts


Smilax, Sargassum, Rheum and

Allium Extracts on Lead Toxicity

0

0.1

0.2

0.3

0.4

0.5

0.6

0.7

0.8

1st day 10 days

(10 days is one course, 3 courses is a treatment period)

Usage: 3-4 capsules, 3 times a day.

Lea

d i

n U

rin

e (u

mo

le/L

)

0.725

0.097

110 Patients


Smilax, Sargassum, Rheum and Allium

Extracts vs. EDTA: Chelating Power

Pb2+ Cd2+ Hg2+ Zn2+

EDTA ++++ ++++ — ++++

Extracts ++++ +++ +++ —

EDTA cannot recover liver damage caused by lead toxicity.

The herbal extracts recover liver damage and do not inhibit

hemoglobin biosynthesis.


Children with Lead Toxicity Risk of ADHD

Smilax, Sargassum, Rheum and Allium Extracts

chelate lead in children safely and

reduces/eliminates associated symptoms.

• Loss of appetite

• Hyperactivity

• Irregular sleeping habits

• Temper tantrums

• Lack of concentration


Smilax, Sargassum, Rheum, and Allium

Extracts on Lead Toxicity(68 children, ages 3-12)

0.24

0.12

0.0

0.1

0.2

0.3

Day 0 Day 14

g/m

L

2 weeks

Zinc level increased from 4.58 to 4.87 g/ml

Associated symptoms reduced


0.4280.483

0.556

0.270.23

0

0.1

0.2

0.3

0.4

0.5

0.6

0.7

0 7 14 21 28

Mer

cury

in u

rine

(μm

ol/

L)

Normal mercury in urine is < 0.250 μmol/LMetal Flush does not remove essential trace elements and has no side effects

days

50 cases

Smilax, Sargassum, Rheum and Allium

Extracts remove Mercury


Advantages of Smilax, Sargassum,

Rheum and Allium Extracts

• Easy administration

• Inexpensive

• No side effects

• Does not strip essential elements

• Children (ages 3 and

above) can take

• Kidney patients can

take with Asparagus

Extract and use with

Bathdetox


Has a high chance for bypass surgery.

Protocol: Extracts of Salvia, Carthamus, Paeonia and Ligusticum + Asparagus Extract + Extracts of Smilax, Sargassum, Rheum and Allium

Earlobe creaseBlue Veins under Tongue

with Red / Black Spots

Heart (89%)


Your kidneys must be in good condition before undergoing intravenous chelation.

When bubbles are present in the urine or edema is present in the legs, this indicates a kidney problem.

Protocol: •Asparagus Extract

•Extracts of Rosa and Lygodium

•Extracts of Smilax, Sargassum, Rheum and Allium

•Extracts of Eupatorium, Cinnamomum, and Atractylodes

Bubbles in the

urine

Leg Edema

9


ANEMIA

Concave or

“spoon-like”

nails


DEFICIENCY of

BLOOD,

HORMONE and

CHI

Roadmap-like

Tongue in Younger

People


Functions of Angelica, Cyperus,

Astragalus, Salvia Extracts

• Improves anemia and malnutrition

– WBC, especially after

chemotherapy

– RBC, Hemoglobin

• Platelets (ITP) by 81%


Red

spots


Balances estrogen, testosterone, progesterone

90% PMS PAIN

Irregular menstruation (75%)

Abnormal uterine bleeding (93%)

Menopausal Syndrome (NHRT)

Promotes fertility in both women and men

Recommended for pre- and postmenopausal women as well as men

Hormone Balance, Menopause, PMS

Angelica, Cyperus, Astragalus, Salvia

Extracts


Angelica, Cyperus, Astragalus and Salvia

Extracts on 280 Women with

Dysmenorrhea (3 months)

41.07

48.21

10.71

0

10

20

30

40

50

Effective Improved No Effect

Eff

ecti

ve

Rate

(%

)

Overall

Improvement

89%


Angelica, Cyperus, Astragalus and Salvia

Extracts on 60 Women with PMS (3 months)

93.3396.55

100

50

60

70

80

90

100

110

Heavy PMS Intermediate

PMS

Light PMS

Eff

ecti

ve

Rate

(%

)

Overall Effectiveness:

96.67%


Angelica, Cyperus, Astragalus and Salvia on

120 Menopausal Women (3 months)

Symptom % Reduced Symptom % Reduced

Hot Flash 87.37 Painful Intercourse 89.18

Fatigue 62.96 Palpitations 59.60

Headache 55.06 UTI 50.62

Irritability 43.01 Depression 32.26

Joint Pain 29.61 Insomnia 23.72

Malaise 21.63 Dizziness 17.86

Approximately 80% of women over 50 years old will

benefit from the hormone-balancing effect of Chi-F


• In Women: Cysts, Fibroids, Endometriosis,

Fibrocystic breasts, Female organ cancer, etc.

• In Men: BPH, Prostate Cancer, Testicle

Cancer, etc.

• In Both Men and Women: Diabetes, Insulin

Resistance, Cardiovascular risk, Dementia,

Autoimmune conditions, Abdominal fat, etc.

90

10


ESTROGEN

CANCERWEIGHTMANAGEMENT

SEXUALVITALITY CARDIOVASCULAR

HEALTH

AUTOIMMUNEDISEASE

HORMONESDIABETES


Physical Markers of

Estrogen Dominance

• Red dots on the tongue

• Cherry angiomas on the abdomen

• White spots on the nail

• Facial Hyperpigmentation


White

spots

Hormonal Imbalance


Cherry Angiomas on Abdomen

• If > 10 to 15 large ones

– Men: Prostate Cancer risk

– Women: Breast Cancer risk

– Or Liver Cirrhosis in both men and women

94


Facial Hyperpigmentation:

Estrogen dominance

Chloasma, Melasma


Cherry angiomas on the Forehead


Cyperus, Curcuma and

Astragalus Extracts

• Aromatase inhibitor for women and men( Estradiol, Estrone, Testosterone)

• Competes with estradiol at estrogen

receptors

• Belly Fat

• Also for Type II Diabetes patients (with

Diabend and OxyPower


DHEA17-OH Pregne-nolone

Testos-terone

Estradiol

Estrone

Estriol

Pregnenolone

Cholesterol

Proges-

terone

Corticosterone

Aldosterone

17-OH

Progesterone

11-Deoxycortisol

Cortisol Cortisone

Aromatase

Androste-nedione

Aromatase

DHT

5- reductase

17-OH

estrone

16-OH dehydroepi-androsterone

16-OH androsterone

16-OH

estrone

2-OH

estrone

EXTRACTS/

DIM

Extracts of Cyperus, Curcuma, Astragalus

MECHANISM

EXTRACTS


Extracts of Cyperus, Curcuma and

Astragalus reduces Estradiol

Postmenopausal Women with Fibroids/Cysts

74.52

38.84

0

20

40

60

80

Before 10 Days After

60 patients

Postmenopausal women: Estradiol level < 35 pg/ml

11



Astragalus: Aromatase Reducer

• Recommended for pre- and

postmenopausal women

• Recommended for men

• Multiple applications for estrogen-

dominant and hyperaromatization

conditions


Extracts of Cyperus, Curcuma and Astragalus

inhibit aromatase expression in ovarian and

endometrial tissue in rats

Ectopic

endometrium

tissue

Ovarian

tissue

Negative Control

No stains

Positive Control

Tremendous aromatase

expression

Extracts group after

28 days

Aromatase

expression inhibited


Comparison of grayscale values of

aromatase expression in rat endometrial

and ovarian tissues

Group

Ectopic

endometrium

(mean + SD)

Ovary

(mean + SD)

Negative control 48.0 + 8.5 29.7 + 6.4

Positive control 108.9 + 29.03 149.8 + 33.86

Herbal extracts group

(28 days)34.7 + 5.2 47.0 + 9.19

Aromatase reduction

(Herbal extracts)100% 85.6%


AROMATASE INHIBITORSProduct

Administration, Cost

Manufacturer

Approval DateIndication

ARIMIDEX

Oral, $220/month

AstraZeneca

12/27/1995

Breast cancer in

postmenopausal women

AROMASIN

Oral, $224/month

Pharmacia

10/21/1999

Advanced breast cancer in

postmenopausal women after

tamoxifen therapy

FEMARA

Oral, $225/month

Novartis

1/10/2001

Advanced or metastatic breast

cancer in postmenopausal

women

Extracts of Cyperus,

Curcuma, Astragalus

Oral, $45-$90/month

No side effects

Dietary

Supplement

Estrogen-related conditions

(cysts, fibroids, ovarian/breast/

prostate cancer, etc) in men

and women.


57.6

34.1

8.20

10

20

30

40

50

60

Effective Improvement No Change

~ 5 months


Astragalus on 255 Patients with Ovarian

Cysts and Endometriosis

1994 study from Chang Hai Hospital in Shanghai, China

Overall Improvement Rate of 92% within a 5-month period.

%


Extracts of Cyperus, Curcuma, Astragalus +

Extracts of Bolbostemma + Sea cucumber

on 60 patients with Uterine Fibroids

69.2

19.011.8

0

10

20

30

40

50

60

70

Effective Improved No Change

*Those with uterine fibroids over 5cm should add

Revivin and Angiostop for better results.

6 months

%



Astragalus on 100 Patients with

Fibrocystic Breasts

60

30

100

10

20

30

40

50

60


• 90% improved in 6 months

• 94% of the pain associated with cystic fibrosis had disappeared

6 months

%


Factors influencing risk of

Breast/Ovarian Cysts/Cancer in women

I. Long-term Hormone Stimulation

– Among women with fibrocystic breasts for

over 20 years, 17% developed breast cancer

II. Obesity/Belly Fat

III. Xenoestrogens

IV. Hyperaromatization


I. Long-term Hormone Stimulation

• 40% women of childbearing age already

develop fibrocystic breasts

• 42%: First time breast cancer diagnosis at 65

years old

• 1 in 6 American women who reach 80 years

old develop breast cancer

Breast Abnormalities

12


Dense Breast Tissue: Risk for Breast Cancer

• More than half of all women have dense breast tissue

• Risk for breast cancer is 5x greater in women with

dense breast tissue

• Senate Bill 791 (CA) – effective 4/1/2012

Requires that patients be informed of their breast

cancer risk if dense breast tissue is found in

mammogram

Breast Calcification: Precancer• Small clusters of breast calcification is an early warning

sign of breast cancer

• Should be treated immediately

Sources: Int J Bioinform Res Appl. 2010;6(4):418-34; Br J Cancer. 2010 Sep 8;103(7):1034-1039.


Progesterone

• Listed as “Carcinogenic” under California‟s

Prop 65 since 1988

• A listed substance may be natural, synthetic or

even naturally produced in the body

• Progesterone products should have a warning

labelSource: NNFA Today. Sep 2004; 18(9)

Even bio-identical hormones may pose a risk


HRT Increases Breast Cancer Risk

• England Study: If Estrogen + Progesterone are used

together

– 66% increase in breast cancer incidence

– ~15,000 more cases per year

• If only progesterone is used

– 22% increase in breast cancer incidence

• Total of 20,000 more breast cancer cases every year

Source: Family Physician. Sep 2003.


II. Obesity and Cancer

• Breast cancer

– Larger tumor size

– Advanced grade

– Increased nodal

involvement

– Higher mortality

• Prostate Cancer

– More aggressive

tumors

– Higher recurrence

rate

Obese persons have high estradiol,

low testosterone levels



Astragalus for Belly Fat

Aromatase converts testosterone into estrogen.

More estrogen means more fat accumulation,

especially in the belly, which has the highest

amount of aromatase. The herbal extracts reduce

aromatase and consequently reduces belly fat.

For weight loss, take with

Extracts of Raphanus, Crataegus, Alisma,

Garcinia, Paeonia and Tyrosine .


III. Xenoestrogens

• Substances that mimic the effects of estrogen

• Attach to estrogen receptors and disrupt endocrine functions

• Common xenoestrogens: clouding agents, pesticides, phthalates in plastics, dyes

(Environmental Hormones)

Underdeveloped white seeds

in watermelons signify

presence of xenoestrogens


Plasticizers: Xenoestrogens

DEHP, DINP, BBP, DBP

• Plasticizers as clouding agents

found in sports drinks, juices,

tea drinks, fruit jams or syrups,

and tablets or powders

• Causes cancer and damage to the reproductive

system, heart, kidneys and liver

• Men: Has feminizing qualities, reduces sperm

• Women: Early puberty, breast cancer risk


Effect of Xenoestrogens on Men

• Reduces sperm count

– Only ~46 million/ml for men around 20 years old

(Avg 84 million/ml for men 30-50 years old)

– 1940s: avg was 60 million/ml. Now avg is 20 million/ml

• Lowers ejaculation

• Doubles testicular cancer risk

– rate has doubled in the last 40 years

• Increases male breast cancer

– 1973: 86 per 100,000 were twice at risk

– 1998: risk increased 1.08 times

– 2004: 1,600 cases of breast cancer diagnosed


Hugo Rodier, MD, from Utah

recommends the herbal extracts for his

patients who are exposed to

xenoestrogens


Astragalus counteract the effects of

xenoestrogens by competing with

estrogen and binding to estrogen

receptors

13


Testosterone Estradiol (E2)

Estriol (E3)

DHEA

Progesterone

Aromatase

Androste-

nedione

Aromatase

IV. Hyperaromatization of Testosterone

Estrone (E1)

Pregnenolone Cholesterol



People at risk for Hyperaromatization

have the following conditions:

– Overweight (or difficult to lose weight)

– Type 2 Diabetes

• Insulin Resistance Hypertension

• Cholesterol Triglyceride

• Family history of Diabetes

Source: Jonathan Wright, MD. “Bio-Identical Hormone Replacement Therapy:

Common Issues and Solutions.” Townsend Letter. Jan 2010.

(High estradiol, Lower Testosterone)


Symptoms of Hyperaromatization

–Overweight

–Low libido

–Reduced muscle tone

–Gynecomastia

Source: Jonathan Wright, MD. “Bio-Identical Hormone Replacement Therapy:

Common Issues and Solutions.” Townsend Letter. Jan 2010.

(High estradiol, Lower Testosterone)


Any type of Hormone Therapy

Increases Breast Cancer Risk

Risk keeps increasing with longer durations of

use and never tapers off

Estrogen + Progesterone Study

Years of use Risk

10 – 15 88% higher than non-users

15 – 20 Double than those using for 10-15 years

Source: American Association for Cancer Research. April 1, 2012.

Copyright. Chi‟s Enterprise, Inc.122

When on Hormone Replacement

Therapy, including Bio-identical

hormones, and birth control pills,

add Extracts of Cyperus,

Curcuma and Astragalus to avoid

hormone-related side effects


Source: Townsend Letter. Aug/Sep 2010: 54-56.

“Women were more likely to be long-term breast

cancer survivors...if they had more estriol (E3)

than estrone (E1) and estradiol (E2)”

E3 > E1 + E2

Suzanne Somers‟ Interview with

Dr. Jonathan Wright

In any situation, make sure


Jonathan Wright, MD Townsend Letter (Jan 2010)

• Estrogen Quotient (EQ)

– EQ > 1: preponderance of estriol, lower estrogen-related cancer risk

– EQ = E3 / (E1 + E2)• E3 > (E1 + E2)

• 2/16 Hydroxyestrogen Ratio

– 2/16 ratio < 2 is related to cancer risk in men, pre- and postmenopausal women on BHRT

Testosterone Estradiol (E2)

Estriol (E3)

DHEA

Progesterone

Aromatase

Androste-nedione

AromataseEstrone (E1)

2-OH estrone

16-OH estrone

CholesterolPregnenolone

DIM

I3C


Curcuma, Astragalus


Red Dots on the Tongue: Prostate Problems

Estrogen and the Prostate


Cherry Angiomas on Abdomen: Prostate Problems

14


Causes of Abnormal Increase of

Estradiol Levels in Men

• Hyperaromatization of testosterone

• Impaired liver function

• Obesity – increases aromatase expression


Extracts of Melia, Citrus,

Phellodendron and Salvia

Benign Prostatic

Hyperplasia (BPH)

Prostatitis

Hair Loss in men

Add Extracts of Cyperus, Curcuma and

Astragalus for best effects for men


Extracts of Melia, Citrus, Phellodendron, Salvia

+ Extracts of Cyperus, Curcuma and Astragalus

for Prostate Problems

Benign

Prostatic

Hyperplasia

(BPH)

Prostatitis

Hair Loss in

men

DHEATestos-

terone Estradiol

Estrone

Estriol

Androste-

nedione

DHT

5-

reductase


Curcuma, Astragalus

Extracts of Melia, Citrus,

Phellodendron, Salvia

Aromatase

Aromatase

Progesterone

Pregnenolone Cholesterol

Copyright. Chi‟s Enterprise, Inc.130

Biopsy recommended for men

with PSA > 2.5

• 82% missed cases without biopsy:

men < 60 years old

• 65% missed cases without biopsy:

men > 60 years old

Sources: Patient Care. December 2003.

New England Journal of Medicine. 2004; 350(22):2239-46.


Disadvantages of Biopsies

Instead watch for these physical signs

indicating high estrogen and possibly a high

PSA level:

Red dots on the root of the tongue

Cherry angiomas on the abdominal area

• Definite risk of spreading the cancer

• Painful and uncomfortable procedure


Normal Testosterone Level

• Decreased depression

• Improved memory

• Adequate levels of DHT correlated with:

– Improved sexual function

– Less aggressive prostate cancer riskSource: Jonathan Wright, MD. BHRT Symposium. June 25, 2011.

To normalize Testosterone Level, take Extracts of

Cyperus, Curcuma and Astragalus with Extracts of

Melia, Citrus, Phellodendron, Salvia


Ovarian Cysts, Ovarian Cancer Odds Ratio in the US

• 1:500 women develop ovarian cysts within 5 years

after menopause

• 0.2% develop into ovarian cancer

Breast Cancer Odds Ratio in the US

• 1:22 women 50 years ago

• 1:6 women over 80 years old (year 2000)

• Among newborn girls in 2010, 1:3 will get breast

cancer within their lifetime

Prostate Cancer Odds Ratio in the US

• 1:6 men


FUNCTIONS


• Fibrocystic breast Colon polyps

• Endometriosis Cervical cancer

• Ovarian cyst/PCOS Breast cancer

• Uterine fibroid Ovarian cancer

• Thyroid cyst Uterine cancer

• Kidney cyst Prostate cancer

• Liver cyst Testicle cancer

• Neurofibromatosis Lung cancer

• Type II Diabetes Reduces belly fat

• Acne Competes with xenoestrogens,

reducing their effects


Estrogen related to

Diabetes and

Insulin Resistance

Extracts of Gymnema, Morus, Coptis, Astragalus

Extracts of Hippophae, Rhodiola


15


Hypoglycemia

• Tongue is red and has

teeth marks

• Since hypoglycemia is a

precursor to Diabetes, and

vice versa, it is important

to regulate blood glucose

levels

Those who have high iron levels in the blood are

not only likely to develop cancer but are 3 times

more likely to develop diabetes.

Teeth marks


Insulin Resistance, Diabetes, PCOS

Dark, wrinkly

pigmentation

Acanthosis nigricans

Skin tags

80% Type 2 Diabetes risk

May also be a colon problem

Children: Fatty liver

50% chance colon polyps


Extracts of Gymnema, Morus,

Coptis, Astragalus Functions

• Blood glucose

• Glucose tolerance

• Insulin receptor sensitivity

• Beta cells of pancreas to produce

more insulin

• Antioxidant

• Regulates lipoprotein metabolism


Extracts of Gymnema, Morus,

Coptis, Astragalus

for Type II Diabetes (6 months)

Group Total CasesEffective

CasesEffective Rate

Diabend 195 133 68.2%

Control 30 2 7.0%


Insulin Resistance

• Present in at least 1 in 3

men with below-median

serum testosterone

• Associated with

hyperaromatization and

estrogen excess

• If low or below-median

testosterone

(hyperaromatization,

test for insulin

resistance!

• Signs and Symptoms

Sugar or carbohydrate craving

Shaky without food

Obesity, especially belly fat

Skin tags

o 80% risk of Type 2 Diabetes

Osteoarthritis

o ~80% have metabolic syndrome

Source: Jonathan Wright, MD. “Testosterone Evaluation, Treatment, Safety.” BHRT

Symposium. Las Vegas, NV. June 24, 2011.


Dangers of Excess Estrogen in Aging Males

Int J Cancer. 2006; 118(9):2123-31

Annals of the NY Acad Sci. 2006; 1089: 77-193

Minerva Endocrinol. 2006; 31(1):1-12

J Cell Biochem. 2007; 102(4):899-911

Reprod Toxicol. 2007; 23(3): 374-82

FASEB J. 2007 Nov 30 [Epub].

Basic Clin Pharmacol Toxicol. 2008 Feb; 102(2):134-8

• Double the stroke risk

• Heart Attack, Myocardial infarction risk

• Atherosclerosis chance

• Thrombus (blood clot) incidence

• Prostate cancer, BPH riskSources:


Estrogen and Cardiovascular

Disease

Cherry

Angiomas on

Forehead

Stroke or

Aneurysm


• Crack(s) on tongue

• Black line(s) on nails

• Yellow coating on tongue

• Roadmap-like tongue

• Geographic tongue (IBS, Crohn‟s disease)


STOMACH

ULCER

Cracks on

tongue

16


Yellow

Coating

Digestive

problems


Stomach or Esophageal Problem

If GERD is

present

22 = 4x

chance

Auricle cyst


Roadmap-like Tongue

Older People:Digestion, Lack of

stomach acid


The stool will not often show if you have minor bleeding. Stomach bleeding is caused by acid and pepsin secretion. If you have this condition, digestive enzymes should not be used.

Black lines on the fingernails and a

crack on the center of the tongue

often indicate stomach bleeding.


Deep crack Yellow coating

Case Study: R.S., 67 y/o/m, esophageal and stomach issues

Pale and

shiny

tongue


Extracts of Paeonia,

Atractylodes, Poria(For teeth marks & crack in center of tongue)

Digestive Enzymes

Absorption

H. Pylori bacteria

Adjusts stomach/intestinal muscle

contractions

Balances stomach acid

Repairs stomach/intestine membrane


Digestron on Digestive Problems

59.0%

29.1%

11.9%

0%

10%

20%

30%

40%

50%

60%

Effective Improved No Effect

952 cases

Extracts of Paeonia, Atractylodes and

Poria on Digestive Problems


Extracts of Paeonia, Atractylodes and

Poria for Digestive Disorders

ConditionRate (%)

Effective Improved

Gastritis 65.7 28.6

Chronic Atrophic Gastritis 47.7 17.4

Gastric Ulcer 79.7 17.0

Duodenal Ulcer 69.5 28.8

Irritable Bowel Syndrome* 50.5 39.8

Diverticulitis/Colitis* 40.3 18.2

*GI Chi + Psoricaid + Digestron for IBS and Diverticulitis/Colitis

For GERD, take Digestron + Debile


39-year-old male with

Stomach Cancer30% Stomach Cancer

is Stage IV

16% metastasized

stomach cancer is

HER2 +

Need Angiostop

(EGFR inhibitor)

– 35% prolongs life

17


Stomach Cancer

Cancer patients:

Tongue has greasy coating


Markers/Symptoms of Liver Problems

• Dark, branching veins

under the tongue

• Red or dark spots on the

sides of the tongue

(blood stasis spots)

• Thick and wide tongue

• Large cherry angiomas

on the chest and

abdominal area

• Spider veins on the

chest and abdomen

• Dark or red bands on

the tips of the nails

• Red palm

• Bloating, dry mouth,

bitter taste, fatigue

• “Panda eye” (dark

circle around eye)


Dark, branching veins under the tongue


Characteristic of Veins under the

Tongue and Liver Conditions

Liver condition (N) 2 veins >2 veins Thickness Width Length

Hepatitis (60) 90% 10% 5.21+0.31 3.34+0.21 5.45+0.30

Liver Cirrhosis (50) 26% 74% 3.08+0.27 3.78+0.30 5.62+0.1

Liver Cancer (40) 45% 55% 3.10+0.4 4.34+0.21 5.63+0.1

Fatty Liver (60) n/a n/a 3.18+0.27 3.34+0.31 5.71+0.42

Alcohol-induced Fatty Liver: SGOT (AST) level is two times

higher than SGPT (ALT) level. Both levels are moderate-high.


4 or more veins

under the tongue

• Liver cirrhosis

• Liver cancer


Cherry AngiomaAn indication that estrogen attacks

peripheral

blood vessels, causing an aneurysm

Metabolism of too much estrogen causes liver

problems


Cherry angiomas and spider veins


Cherry Angiomas on Abdomen

• If > 10 to 15 large ones

–Men: Prostate Cancer risk

–Women: Breast Cancer risk

–Or Liver condition in both men

and women

162

18


Yellow skin (Jaundice)


Red Palm and Hot


Spider Veins/Skin itching

Liver Cirrhosis


AST (SGOT) ALT (SGPT)

HEPATITIS VIRUS TITER

JAUNDICE BITTER TASTE

Extracts of Schisandra,

Bupleurum, Smilax

LD50: 12.50 g/kg

The herbal extracts stop Hepatitis C RNA

virus replication and expression in 6 days

Fatty Liver, Hepatitis, Liver Cirrhosis


Hepatitis A and B, Fatty Liver Studies

• Hepatitis A and B patients: ALT (SGPT) levels in 47 cases by 73% in 3 months

• Fatty Liver: 100% effective in 7 cases

• Excellent for bloating, bitter and dry mouth, cherry angiomas, fatigue

167


In vitro study (2002):

Extracts of Schisandra, Bupleurum,

Smilax on Hepatitis C

• The herbal extracts have been

proven to inhibit Hepatitis C

RNA virus replication and

expression in 6 days

• The herbal extracts do not have a

toxic effect on normal liver cells


Frenula Cyst (Lower)

Colon/rectum condition


Intestine/upper colon condition

Frenula Cyst (Upper)

19


Serious condition

Multiple Frenula Cysts


3 Factors of Colon Polyps

Those without gallbladder → high chance of

colon cancer

Factor Recommendation

Bowel

irregularityAmorphophallus, Angelica, Lycii Extracts

Excess bile

from liver

Schisandra, Smilax, Bupleurum Extracts

Mentha and Curculigo Extracts

Excess

estrogenCyperus, Curcuma, Astragalus Extracts


Symptoms suggest estrogen affects liver and colon


Extracts of Amorphophallus,

Angelica, Lycii

• Colon, Intestine Detoxifier

• Regular Bowel Movements

• Balances pH of intestines and

promotes good bacterial

growth

• Cholesterol, Weight Control

• Blood Glucose Regulation

• Healthier, Blemish-Free SkinLD50: 45 g/kg


Dark

line(s)

on nails

Internal Bleeding


Inflammatory Bowel Disease related to

Autoimmune Disorders

Studies show that the incidence of autoimmune

problems in people with Crohn‟s disease and

Ulcerative Colitis is greater than those without

these diseases.

For best results, take Extracts of Paeonia,

Atractylodes, Poria with

Extracts of Euphorbia, Sanguisorba, Phellodendron

for Crohn‟s disease and Ulcerative Colitis


Geographic

Tongue

• IBS

• Crohn‟s disease

• Lung

• Sinus/allergy


Extracts of Euphorbia,

Phellodendron and Sanguisorba

Colitis, IBS, Diverticulitis

For gastrointestinal infections,

Use immediately


20


KIDNEY PROBLEM -Black Tongue


Horizontal white line(s) across the fingernail

Kidney problem


Horizontal

white line

30-year-old

Male with

Proteinuria


Proteinuria


IgA Nephritis

Half-and-Half nails


• Puffy face when waking up

• Foamy urine

• Teeth marks on tongue

• Edema in legs/ankles

• Dark color/puffy under eyes

• Half-and-half nails

• Horizontal white line or strips on nails

• Yellow or black coating on root of tongue

Signs of Kidney Problems


Teeth Marks Foamy urine

Proteinuria


Serious Leg Edema


KIDNEY PROGRAM• Asparagus Extract

• Creatinine, Diuretic

• Cordyceps Extract

• BUN

• Extracts of Rosa, Lygodium, Smilax, Centella

• Proteinuria

• Extracts of Eupatorium, Cinnamomum,

Atractylodes

• Edema, BUN, Ereatinine, Skin

Itching

21


• Diuretic Agent

• Creatinine levels

• Renal glomerulus re-absorption

• Kidney function

ASPARAGUS EXTRACT


Cordyceps Extract on Kidney

Function of 349 Patients

Overall 85.9% improvement

24.37

15.26

5.23.5

12.413.5

2.89 3.140

5

10

15

20

25

BUN Creatinine Hemoglobulin RBC

Before

After

(mg/dl) (mg/dl) (g/dl) (m/mm3)


Extracts of Rosa, Lygodium,

Smilax, Centella

Urinary Tract Infection Kidney Stones

Frequent Urination Prostate

Difficulty urinating Gout

Toxicity Study: 480 times of the regular

dose, in mice shows no toxicity


Extracts of Rosa, Lygodium, Smilax and

Centella on Genitourinary Conditions

64.34%

19.78%15.88%

0

10

20

30

40

50

60

70


6,512 cases(3,880)

(1,288)(1,034)


Source: JTCM. 2003; 44(4):311.

Condition N Effective Rate

Frequent urination 172 82.71%

Acute cystitis 984 71.95%

Vaginitis (Trichomoniasis and Candidiasis) 243 65.84%

Kidney stones 221 62.44%

ProteinuriaUrine protein > 3.58 g/L for 2 weeks

Serum albumin < 3.0 g/L, Edema

478 59.41%

UTI 1057 42.48%

Prostatis 288 21.53%

Extracts of Rosa, Lygodium, Smilax, and

Centella on 6,512 cases of

Genitourinary Conditions


Rat

#

Dose

kg-1/d-1

Number of rat survivors

Staphylococcus

aureus

E.

Coli

Bacillus

pycyaneus

Streptococcus

pyogenes Type I

Saline 20 20ml x 7 2 1 1 2

Cephalexin 20 1mg x 7 14 13 12 14

Kidney Chi 20 54mg x 7 12 11 7 10

Kidney Chi 20 18mg x 7 10 10 7 7

Kidney Chi 20 6mg x 7 7 5 5 5

In vivo Antibacterial Study:

Extracts of Rosa, Lygodium, Smilax, Centella

vs. Cephalexin


Those who have

frequent bladder infections

should take

Asparagus Extract with Extracts of

Rosa, Lygodium, Smilax, Centella

for excellent results

Great to have when traveling and also

to prevent sexual disease.

Make it part of your first aid regimen.


Extracts of Eupatorium, Cinnamomum, Atractylodes

SKIN DIALYSIS FORMULA

Detoxifies through the skin without hurting the kidneys and liver

The herbal extracts can remove these biowastesthrough the skin: urea, creatinine, uric Acid, cAMP,

purine compounds, aromatic compounds, polyamines, indoles, phenols, myoinositol, sorbitol,

oxalic acid, etc.


Monoaminoxidase

Kidney

Circulation

Na-,K-,Cl-

Increase

Electrolyte

Balance

Sweat Medium-sized Biowastes***

Urea

Excretion

Cyanate

Urea BUN

Kidney

Medulla

Osmosis

Water

Excretion

EdemaPoison

Body Balance

Lung

Function

Angiotensin I Angiotensin II

Ketone & Anti-Diuretic

Hormones

Norepinephrine

Urine

Reabsorption

Urine

Norepi-

nephrine

***One of the causes of fibromyalgia is the

accumulation of biowastes. These biowastes

can be removed through the blood (use Vein

Lite) or through skin dialysis using

Bathdetox.

Skin Dialysis Mechanism

22


Extracts of Eupatorium,

Cinnamomum, Atractylodes

41%

26%

83%87%

77%

0

10

20

30

40

50

60

70

80

90

BUN Creatinine Proteinuria Edema/ Pain/

Skin Itching Fibromyalgia

Imp

rovem

en

t


Case study: 36 y/o/m with Focal segmental

glomerulosclerosis (Autoimmune disease)

Half and half Nails


For bladder/vaginal area infection

– Extracts of Rosa, Lygodium, Smilax,

Centella

For upper respiratory

(throat/esophagus) area infection

– Bamboo Extract

For gastrointestinal infection

– Sanguisorba, Phellodendron, Euphorbia

INFECTIONS


Lyme Disease• Caused by tick-borne bacteria

Borrelia burgdorferi

• Regular treatment is through

antibioticsDeer tick

Erythema

migrans

Circular/spiral

skin rash

associated with

Lyme disease Rash becomes

bigger


Lyme Disease Symptoms

• Categories

– Skin Musculoskeletal

– Respiratory Gastrointestinal

• Skin itches on the bitten area

• Nearby joint pain, then limb numbness and blurred vision

• Then the infection goes to the blood and the nervous system


Lyme Disease Protocol

Recommendation For infection in the…

Bamboo Extract Respiratory system

Extracts of Rosa,

Lygodium, Smilax,

Centella

Urinary system

Extracts of Eupatorium,

Cinnamomum,

Atractylodes

To remove toxins


• Nail Clubbing

• Geographic tongue

• Vertical ridges on opaque nail

• White coating on tongue

• Tongue inflamed around the edges

Markers of Lung

Problems


NAIL

CLUBBING


Bilateral Nail clubbing and Lung Diseases

Pulmonary Diseases Total cases Cases w/ clubbing %

Cystic Fibrosis 73 73 100

Cirrhosis

(Hepatopulmonary syndrome)14 9 64.3

Hypersensitivity pneumonitis 82 44 53.7

Interstitial Pulmonary Fibrosis 588 289 49.2

Asbestosis 167 72 43.1

Mesothelioma 77 23 29.9

Bronchogenic carcinoma 111 32 28.9

Pulmonary arteriovenous malformation 93 18 19.4

Sarcoidosis 90 11 12.2

Tuberculosis 426 72 16.9

Source: J American Academy of Dermatology. June 2005; 52(6): 1020-28

23


Geographic Tongue

Sinus allergy, Lung Problem


White Coating


Vertical ridges on opaque nails


Tongue inflamed around edges


Extracts of Hippophae and Rhodiola

for the Lungs

• Lung congestion

(as quickly as 20 mins)

• Anti-Hypoxia

• Energy, Anti-Fatigue

• Throat clearing

• Pulmonary and Brain edema


23.4

26.4

30.6

20

24

28

32

Control 0.125 g/kg

Rhodiola

0.125 ml/kg

Extracts

Su

rviv

al t

ime

(min

s)

Anti-Hypoxia Effect: Herbal Extracts vs.

Rhodiola alone in mice


BAMBOO EXTRACTAcute and chronic throat and lung

conditions

Cough with phlegm

Sore throat

Runny nose Asthma

Ear irritation in Children

LD50 > 20g/kg

FIRST AID for upper respiratory conditions


Bamboo Extract + Cephalexin more

effective than Cephalexin alone

*Cephalexin alone is only 6.1% effective

Overall, Bamboo Extract + Cephalexin is 81.2% effective

for all age groups and duration of disease

AgeEffective

Rate

< 40 years old 100%

41-60 years old 81.2%

> 60 years old 32.8%

Duration of

disease

Effective

Rate

> 10 years 81.94%

< 10 years 78.1%


Bamboo Extract for Oral Candida

• People with low immunity such as diabetes

patients, children, the elderly, HIV patients, long-

term steroid users, and cancer patients - More

prone to candida in the mouth and throat

• Antibiotics and/or pain medication are often

unnecessary.

• Instead they should take Bamboo Extract for

candida.

24


Extracts of Astragalus,

Xanthium, Saposhnikovia

• ALLERGIC RHINITIS

• SINUSITIS

Take before the allergy season starts


Extracts of Astragalus, Xanthium,

Saposhnikovia on Allergic Rhinitis

22.9

57.2

19.9

0

10

20

30

40

50

60


%

367 cases


BRONCHITIS PNEUMONIA


EMPHYSEMA


• Only thumbs have

lunulae (80%)

• Physical signs

CANCER

Especially if 8 lunulae were present

and then disappear feel cold


Only thumbs have lunulae


Physical Signs to Determine Early

Signs of Cancer

TYPE OF

CANCERSYMPTOMS

Colorectal

Cancer

• Frenula cyst

• Shape of stool changes, sometimes with blood

• Soft, light-colored hair on the cheeks on adults

Stomach

Cancer

If the digestive symptoms suddenly change with

severe pain

Esophageal

Cancer

GERD patients who feel like food is stuck in the

throat or it goes down very slowly



Signs of CancerTYPE OF

CANCERSYMPTOMS

Breast and

Prostate

Cancer

• Red dots on tongue

• Lots of cherry angiomas (>10 to 15) on

chest, may also be Liver Cancer

Cervical

CancerVaginal bleeding after intercourse

Ovarian/

Uterine

Cancer

Sudden vaginal bleeding in postmenopausal

women



Signs of Cancer

TYPE OF CANCER SYMPTOMS

Kidney Cancer Urinary bleeding with no pain

Lung Cancer

• Nail clubbing with chronic dry cough

• Soft, light-colored hair on the cheeks

on adults

Lymphoma,

Leukemia

• Triangular nails

• Nail clubbing

Nasopharyngeal

Brain Cancer

Ear ringing on one side only (For brain

cancer: also headaches and blurred

vision)

25


Hard lump about 2 inches

above or to the left of the navel

Stomach Esophagus/Stomach

Lump, thickening or wrinkle

on the auricle

2 1

3


Not every RTK drug can target several

cancer processes simultaneously

• Angiogenesis

• Invasion

• Metastasis

• Proliferation

• Inhibition of apoptosis


VEGFR(Avastin, Nexavar,

Sutent, Votrient,

Zactima)

PDGFR(Gleevec, Nexavar,

Sprycel, Sutent,

Votrient)

EGFR(Tarceva, Erbitux,

Herceptin, Iressa,

Tykerb, Zactima)

FGFR(Votrient)

Angiogenesis

Proliferation

Apoptosis

Lymphomagenesis

Tumor Vascular

Maturation

Mitogenesis

Cellular motility

Metastasis

Sea cucumber Extract can inhibit all 4 RTKs and

Associated Cancer Processes


Sea Cucumber

Extract

Neo-Angiogenesis and RTK

Inhibitor

LD50 = 4.3g/kg orally in mice


Inhibition of growth factor signaling

Inhibition of signal

transduction pathway

intermediates

Induction of

apoptosis

Cell

membrane

EGFR, PDGFR, VEGFR, FGFR

AKT /

RAS

Sea Cucumber Extract Mechanism

Nuclear

membrane

Inhibition of DNA’s

Topoisomerase2


Type of CancerVEGFR

(Avastin, Nexavar, Sutent,

Votrient, Zactima)


Sprycel, Sutent, Votrient)


Herceptin, Iressa,

Tykerb, Zactima)

FGFR(Votrient)

Bladder

Bone

Brain (Glioma)

Breast

Colorectal

Esophageal

Gastric

Head and Neck

Kidney

Leukemia

Liver

Sea Cucumber Extract inhibits 4 RTKs, associated cancer types


Type of Cancer

VEGFR(Avastin, Nexavar, Sutent,

Votrient, Zactima)


Sprycel, Sutent, Votrient)


Herceptin, Iressa,

Tykerb, Zactima)

FGFR(Votrient)

Lung

Lymphoma

Melanoma

Meningioma

Myeloma

Nasopharyngeal

Ovarian

Pancreatic

Prostate

Thyroid

Sea Cucumber Extract inhibits 4 RTKs, associated cancer types


4/11/2005 8/24/2005

Sea Cucumber Extract inhibits angiogenesis

as illustrated by thermal imaging

6/28/2005

Between 4/11/05 and 6/28/05, this 42-year-old female patient took no herbs and had a

positive mammogram and ultrasound. Beginning 6/28/05, patient took Sea Cucumber

Extract and results have been remarkable. It appears angiogenesis has receded, which is

the best possible outcome.- Medi-Therm Imaging


Cancer recurrence rate increases after surgery

Breast Cancer

Study : 1,173 breast cancer patients

treated with surgery, 520 had relapse

(20% of premenopausal women relapsed

within 10 months after surgery).

Source: Intl J Surgery. 2005.

Colon and Lung Cancer

Lung and colon cancer surgery linked

to cancer recurrence.

Colon cancer patients who had surgery

had higher relapse rate than invasive

laparoscopy

Source: Lancet. 2002.

Chance of recurrence and metastasis after surgery:

• Within 2 years – 50%

• After 5 years – 5%

Recommendation: Use an angiogenesis inhibitor like Angiostop

before and after surgery to help minimize recurrence

26


Sea Cucumber Extract

• Multiple RTK targets (VEGFR, EGFR, PDGFR,

FGFR): more effective

• Also Topoisomerase2 inhibitor

• Used before and after surgery and biopsy to reduce

recurrence

• As a multiple RTK inhibitor, it can be first-line

treatment for better results

• Can be used by itself or with chemo for better and

faster results

• Reasonable cost compared to cancer drugs


Inhibition of growth factor signaling

Inhibition of signal

transduction pathway

intermediates

Induction of

apoptosis

Cell

membrane

EGFR, PDGFR, VEGFR, FGFR

AKT

Bolbostemma Ext

Sea Cucumber Ext

TARGETS FOR ANTI-CANCER AGENTS

Nuclear

membrane

Inhibition of G1-S transition

G1 S

Inhibition of DNA‟s

topoisomerase2


Bolbostemma/Fritillaria ExtractInhibits G1-S transition in Cell Cycle

A disruption in the cell cycle can cause the cell to multiply

uncontrollably, forming a tumor.

LD50: 10.0g/kg

Uncontrolled cell replication is inhibited

Ensures that damaged or mutated DNA does not get passed on to daughter cells


(Lymphoma, Leukemia, Anemia, etc.)

Shell-Shaped/Triangular Nails

Bone Marrow or Blood Disease

Whenever you have these nails, check your Hgb, WBC, RBC levels


NAIL CLUBBING

Cancer

• Lung cancer

(opaque nails)

• Lymphoma

• Leukemia

• Breast cancer

• Colon cancer, etc


Nail clubbing and Cancer

Neoplastic DiseasesTotal # of

cases

# cases w/

clubbing%

Mesothelioma

(from asbestosis)77 23 29.9

Bronchogeneic carcinoma 111 32 28.9

Pleural Tumors 21 3 14.3

Lymphoma 40 6 15

Intrathoracic Hodgkin‟s in

children5 5 100

Nasopharyngeal carcinoma 90 6 6.7

Source: J American Academy of Dermatology. June 2005; 52(6): 1020-28


Extracts of Hippophae and

Rhodiola

• DNA repair for cancer cells

• Oxygen (Cancer cells cannot grow in aerobic environments)

• Mitochondrial DNA repair

• More energy for cancer patients


• Extracts of Hippophae, Rhodiola (DNA repair)

• Extracts of Salvia, Carthamus, Paeonia, Ligusticum (For cardiovascular conditions)

• Extracts of Cyperus, Curcuma, Astragalus (For estrogen-related problems)

• Lutein, Bilberry, Alisma, Cornus Extracts (Eye health, hearing, bones, hair)

• Asparagus Extract (Kidneys, immunity, heart)

Consumers believe genes and lifestyle affect aging more

than external products

69% of consumers reported the earlier one starts using

age prevention remedies, the betterSource: “„Cause‟meceuticals.” Natural Products Insider. July 18, 2011.


Vertical ridges on nails

• Aging

• Adrenals

• Kidneys

• Vitamin deficiency

• Peripheral blood

vessel disease

• Neurasthenia

27


Mitochondrial Dysfunction

• When mitochondrial function is low, lactic

acid cannot be converted to energy, causing

acidosis

• Not enough cell energy supply leads to:

– Muscle strength - Liver disease

– Retarded growth - Kidney failure

– Induced epilepsy/seizures - Sudden stroke

– Heart enlargement - Kidney failure

– Heart failure - Diabetes


Extracts of Hippophae and Rhodiola promotes

DNA Repair for Anti-Aging, Healing

• Deficiencies in DNA repair show

– premature onset of neurodegenerative

age-related diseases

– shortening of lifespan

• OxyPower prevents DNA damage and

repairs damaged DNA


Extracts of Hippophae and Rhodiola may

protect and repair damaged DNA (Comet Test)

Test shows K2Cr2O7-induced

damage of TK6 human

lymphoblast cells, evident

here as the comet tail

24 hours after the extracts

were added, DNA damage

was repaired, as seen by the

absence of the comet tail


Fingernail easily splits

• Adrenals

–Chi Energy

• Lack of stomach acid

–Digestron


Vertical

ridges like

beads on a

string

OSTEOPOROSIS

ARTHRITIS


Osteoporosis/Osteopenia

Thin Nails


• Improves bone density

• Enhances bone calcium content

• Inhibits calcium loss from bones

• Does not affect estrogen levels

• Recommended for osteoporosis patients who

have or are at risk for estrogen-related

conditions such as cysts, fibroids, breast

cancer, etc

Extracts of Rehmannia, Corydalis,

Dioscorea, Lycium for Osteoporosis


Extracts of Rehmannia, Corydalis,

Dioscorea, Lycium on Osteoporosis

54.17%

44.79%

1.5%

0

10

20

30

40

50

60

70


96 cases


• Pain, Migraine

• Dizziness

• Numbness

• Arthritis

• Blood Pressure

• Fibromyalgia

• Nervous System

• Muscle Ache

• Paralysis

• Intervertebral Disc

Herniation

• Calming effect

Extracts of Gastrodia, Angelica,

Ligusticum Functions

28


Extracts of Gastrodia, Angelica, and

Ligusticum on 1,137 patients with

Neurological Conditions76.2

73.9

66.767.7

70.6

68.8 69.4

72.6

60

64

68

72

76

80

Pain Dizziness Fibromyalgia Tinnitus Lumbar Sciatica Cervical Lumbar Disc

Disease Vertebra Herniation

Source: Beijing Medical University. 1997.

Eff

ecti

ve

rate

(%

)


• Burns/Lesions Infection

• Wrinkles/Acne Skin Cancer

• Psoriasis/Eczema


"The new remedy not only eases pain of burn injuries, according to proponents, but speeds healing, reduces scarring and drastically cuts the cost of saving lives. There is no need for bandages, no topical antibiotics and no sterile isolation. The conventionally treated skin was rough, scarred and marked by patches of excessive or reduced pigmentation. The herbal treated flesh was now "supple and unblemished."

Aloe, Coptis, Phellodendron Ointment

MEDICINE

“A Simpler Way to Save Lives”

Newsweek. May 7, 1990, page 68

Could a new medication from China change the world‟s approach to

treating burn injuries?


Silvadene Whole Skin


Aloe, Coptis, Phellodendron Extracts

(Scar-Free Ointment)

ENDORSED BY

JONATHAN WRIGHT, MD

Make this ointment part of the

FIRST AID regimen in

your home and workplace.


11 days after 15 days after

SILVADENE WHOLE SKIN

30 days after

Whole Skin for Burns


Missed Nail

Diagnosiscould actually be

Squamous Cell

Carcinoma,

Melanoma

“Fungal Masquerades”

Richard K. Scher, MD,

World Congress

of Dermatology

February 2003


MELANOMA

“Amelanotic melanoma occurs more often in the

nail than in the skin.”Richard Scher, MD from the Dermatology Times, Feb.2003, p. 30.


Black mole on

the palm or sole

of the foot:

High chance of

melanoma

29


Melanoma and Estrogen

Ref: Cancer Prev Res. 2012. 5(1): 82-8.

• Elevated estrogenlevels may be implicated in melanoma etiology

• Risk of melanoma was higher for patients who did not receive anti-estrogens

Melanoma (dark colored)

Cherry

Angiomas


MyxomaSquamous Cell

Carcinoma



Prevent Skin

Cancer• Avoid sun

exposure

• Extracts of Aloe, Coptis, Phellodendron

• Asparagus Extract (organic folic acid)

• AGG (Antioxidant)

• Sea Cucumber Ext

• Bolbostemma Ext

• Asparagus Extract

• Reishi Spore Extract

Skin Cancer

Protocol


Extracts of Raphanus, Crataegus, Alisma,

Garcinia

Tyrosine and Paeonia Extract


(for belly fat)


Extracts of Raphanus, Crataegus,

Alisma, and Garcinia

• Removes fat by 51%

–If taken before meals

• Burns fat faster

–If taken before exercise


ENERGY

Exercise: Consume Energy (ATP)

FOR BODILY

ACTIVITY

ATP ADP + P

(INHIBITION)

FAT DEGRADATION

Extracts of Raphanus, Crataegus, Alisma, Garcinia

Removes ADP, Promotes the fat-burning process

to control weight


Tyrosine and Paeonia Extracts

• Increases metabolic rate

• Increases serotonin and norepinephrine levels

• Induces a happy feeling, reducing cravings

for foods and promoting faster fat burning

Extracts of Cyperus, Curcuma,

Astragalus for belly fat

• Reduces abdominal fat by inhibiting aromatase

• The belly has the highest amount of aromatase


Copyright © 2012 Chi‟s Enterprise, Inc.

Reproduction of this work in any form, in whole or in part, by any means,

electronic or mechanical, including photocopying, microfilming, and recording,

or by any information storage and retrieval system, without permission in

writing from Chi‟s Enterprise is strictly prohibited at the risk of legal action.

30

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