andropause: exploring the causes and hormone free ...caue of andropause: elevations in shbg review...
TRANSCRIPT
Andropause exploring the causes
and hormone free evidence based
nutrients and botanicals for
treatment
Dr Eugene R Zampieron
ND RH(AHG)
Financial Disclosure Receives royalties from Restorative Formulations
Urologe A 2013 Jun 12 Testosterone deficiency - an
underestimated risk for men Prevalence of
hypogonadism
bull RESULTS
bull Pathologically low testosterone levels (ltthinsp25 ngml) were found in 152thinsp of subjects while 374thinsp had a testosterone level lower than 35 ngml Decreased testosterone levels were not associated with age In addition the proportion of men with decreased serum testosterone levels was comparable in all age groups The average serum testosterone level decreased slightly in all age groups during the period before midday
bull CONCLUSIONS
bull The data reveal high rates of testosterone deficiency in men independent of patient age As decreased serum testosterone levels may be the consequence of several diseases and can be causally involved in the pathogenesis of further diseases it is strongly recommended that serum testosterone measurement should be included in the diagnostic arsenal especially when symptoms such as loss of libido erectile dysfunction lack of concentration depression lethargy irritability and sleep disturbance are present
I would add high lipids
weak legs chronic low
back amp weight gain here
httpwwwhealthyfellowcomimages2009testoste
rone-age-chartgif
httpwwwendotextorgmalemale2figures2figure2jpg
httpwww2mstdkudgivpublications2007978-87-7052-538-1htmlimagesfig03gif
Effects of restoring Test Levels
bull In a controlled study 13 healthy men aged 57 to 76 years with low or borderline low blood testosterone were administered testosterone therapy at the University of Washington The men received either testosterone or placebo for three-month time periods The men were not supposed to know when they were receiving testosterone or a placebo but at any given time 12 out of the 13 were able to ascertain they were receiving testosterone based on increases in their libido aggressiveness in business transactions or an improvement in their sense of well-being
bull Tenover JS Effects of testosterone supplementation in the aging male J Clin Endocrinol Metab 1992 Oct75(4)1092-8
Researchers measured free testosterone and 25-hydroxyvitamin D
blood levels in a large group (2069) men who were referred for
coronary angiography The results were nothing short of startling for
those who fail to maintain optimal blood ranges of vitamin D and
testosteronehelliphellip
These are most of
the men who go to
holistic physicians
Expanded Causes of Andropause
Restorative Medicine Model
bull Precursor steal due to Dis-Stresselevating cortisol and reducing lsquoYinrsquo Neurotransmitters
bull Adrenal medulla exhaustionrarrlowDOPAMINErarrwith elevations in ProlactinrarrLow Test
bull ObesityBMI issues
bull Lack of activity
bull Excess aromatase
bull Hypothalamic damage due to high cortisol
bull Hypothalamic damage due to high ROS stress
bull 5 alpha reductase activity
bull SHBG activity
bull Nutrient deficiencies
Free radical and ROS stress to testesleydig cells from multiple agents
bull Low Growth Hormone production
bull Endocrine disruptors and increased toxic load
bull Malabsorption of minerals like zinc leading to low T
bull Kidney disease
bull OTHERS
CAUSES of ANDROPAUSESTRESSeffect on adrenals
Precursor steal
ldquohellipChronically increased cortisol
level as seen during
prolonged stress may reduce
the functional activity of
leuteinizing hormonemdashrelease
hormone (LHRH) pulse
generator which may lead to
decrease in gonadotropin and
testosterone levelshelliprdquo
Science 1984 May
4224(4648)452-9
Stress hormones their
interaction and regulation
Axelrod J et al
Causes of Andropause
Obesity Estrogen cycle
ldquoMen with obesity
and Syndrome X
develop
low
Testosteronehelliprdquo
Adipokines increase
IL-6 which increases
inflammation and
decreases
testosterone
CAUSES of ANDROPAUSE
INSULIN RESISTANCEhttpimgmedscapecomarticle719489719489-fig14jpg
Even surgical loss of
fat increases
testosterone
Causes of Andropause
Prolactin and Andropausebull Physiologic levels of prolactin in males enhance in LH receptors in
Leydig cells resulting in testosterone secretion which leads to spermatogenesis
bull Highly elevated levels of prolactin decrease the levels of sex hormones mdashestrogen in women and Testosterone in men
bull Very Low Prolactin also effects serum testosterone
bull httpwwwmayocliniccomhealthprolactinomaDS00532
bull Gonzales GF Velasquez G Garcia-Hjarles M (1989) Hypoprolactinemia as related to seminal quality and serum testosterone Arch Androl 23 (3) 259ndash65 Rev Urol 2000 Winter 2(1) 39ndash42
bull Hyperprolactinemia and Erectile Dysfunction
bull Scott I Zeitlin MD Rev Urol 2000 Winter 2(1) 39ndash42
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Lay off the brew
bull The consumption of beer unlike other alcoholic beverages increases serum prolactin a hormone necessary for milk production but not good for andropausal men (Carlson Wasser amp Reidelberger 1985 De Rosa Corsello Ruffilli Della Casa amp Pasargiklian 1981 Grossman 1987)
Causes of Andropause
Aromatase activity
Caue of Andropause Elevations in SHBG review
of physiology
bull Sex hormone binding globulin (SHBG) is a glycoprotein which binds to human sex hormones These binding proteins are most often found bound to the primary male and female sex hormones
bull Major production of sex hormone binding globulin occurs in the liver but it may also be produced in the brainuterus testes and in the placenta during pregnancy
bull The function of this protein is to limit the levels of active unbound sex hormones in the body Very high or very low levels of the protein in the body can indicate a variety of health conditions in both women and men
bull Most sex hormones within the bloodstream are biochemically bound to sex hormone binding globulins Only a tiny portion of sex hormones are free and able to enter cells where they bind to hormone receptors Therefore the availability of sex hormones in the human body is directly linked to the amount of SHBG the body produces
bull When produced by the testes SHBG is instead known as an androgen-binding protein a protein that is produced in the Sertoli cells High levels of androgen-binding protein in the testes allow sperm cells to mature in spermatogenesis
Causes of ANDROPAUSE
5 apha reductase
5 alpha
reductase
CAUSES of Andropause
Toxinseffect on Testes
CAUSES of Andropause
Toxinseffect on Testeshttpwwwsiumededu~dbhaleslabimagesresear2gif
CAUSES of Andropause
Toxinseffect on Testeshttpwwwoneresultcomsitesdefaultfilesu3Prohormones20Chart_1png
Michael Phelps amp Co at high risk of low
testosterone
bull A 2011 paper that was
published in the
International Journal of
Andrology by Nickmilder
et al a clear-cut
association with early life
exposure to chlorinated
indoor-pool water and low
testosterone levels in
adolescence and
probably later in life
(Nickmilder 2011)
I wonder if
therersquos an
issue with
Bromine
too
Amaral S et al Front Biosci (Schol Ed) 2013 Jan 15181-97
Aging and male reproductive function
a mitochondrial perspective
bull Researching the effects of aging in the male reproductive system is not trivial Not only are multiple changes at molecular cellular and endocrine levels involved but any findings must be discussed with variable individual characteristics as well as with lifestyle and environmental factors Age-related changes in the reproductive system include any aspect of reproductive function from deregulation of the hypothalamic-pituitary-gonadal axis and of local autoparacrine interactions to effects on testicular stem cells defects in testicular architecture and spermatogenesis or sperm with decreased functionality Several theories place mitochondria at the hub of cellular events related to aging namely regarding the accumulation of oxidative damage to cells and tissues a process in which these organelles play a prominent role although alternative theories have also emerged However oxidative stress is not the only process involved in mitochondrial-related aging mitochondrial energy metabolism changes in mitochondrial DNA or in mitochondrial-dependent testosterone production are also important Crucially all these issues are likely interdependent We will review evidence that suggests that mitochondria constitute a common link between aging and fertility loss
Damage to Leydig cells cause low
testosterone
Are toxin avoidance antioxidants
and depuration a key
bull Biomed Environ Sci 2013 Jun26(6)474-84 doi 1039670895-3988201306008
bull Effects of Environmental Lead Pollution on Blood Lead and Sex Hormone Levels among Occupationally Exposed Group in An E-waste Dismantling Area
bull Yang Y Lu XS Li DL Yu YJ
bull Source
bull School of Environmental amp Safety Engineering Changzhou University Changzhou 213164 Jiangsu China
bull Abstract
bull OBJECTIVE
bull To study the effects of environmental multi-media lead pollution on blood lead and sex hormone levels among lead exposed males engaged in E-waste dismantling and the correlation between confounding factors and sex hormone levels
bull METHODS
bull An E-waste dismantling area in Taizhou of Zhejiang Province was selected as the research site One hundred and fifty two samples were collected from the groundwater soil rice corn chicken and pork in the dismantling area The effects of the multi-media lead pollution on the male blood lead and sex hormone levels of FSH LH and T as well as the correlation with confounding factors were studied
bull RESULTS
bull The blood lead concentrations in the males aged under 31 from 31 to 45 and from 46 to 60 were 9855 10023 and 10145 μgL respectively Of all the environmental media lead exposures the groundwater rice and soil were main contributing factors to the lead accumulation in humans FSH and LH levels increased with the age while the T levels decreased with the age instead There was a significant correlation between the FSH and LH levels and wearing masks
bull CONCLUSION
bull There was correlation between the FSH LH and T levels and the mean values of lead concentrations in environmental media and the sex hormone levels were correlated with the confounding factor of wearing masks
Workup up the Andropausal male Exam PEBlood SalivaUrine
BMI
Chemistry and health profile with all hormones VAP
Free Total and Bioavailable Testosterone amp DHT
Estradiol (Ultrasens)
DHEA Uncong and S
Cardivascular CRP and Homocysteine
Fibrinogen amp D-Dimer
Delta PSA amp Free to Total
Vit D and other Nutrients
IGF-1
bull LH and FSH
bull Prolactin
bull SHBG
bull Cortisol X 4
bull Neurotransmitters
bull Amino acids
bull Hair analysis
bull RBC mineral levels
bull Liver detox profile
bull Pregnenolone
bull Cytokine panel
bull Fasting GlusocseInsulin HAIC amp Fructosamine
Natural non-hormonal
interventions for
trteating the underlying
causes of Andropause
and Low T syndrome
Work on your patients response to the stressttpwwwcursoercomenwp-contentuploads201202people-man-stress-Fotolia_8150434_XSjpg
Put the Adrenals to
BedhellipBotanically
bull Mild relaxants
ndash Chamomila
ndash Vervain
ndash Oats (Avena)
ndash Motherwort
bull Stronger Relaxants
ndash Passiflora
ndash Scutellaria
ndash Valerian
ndash Humulus (Hops)
ndash Eschscholtzia
bull Potent relaxants
ndash Jamaican Dogwood
ndash Corydalis
ndash Wild lettuce
Nervine trophorestoratives
-- St Johnrsquos wort
ADAPTOGENS
bull David Winston in his book ADAPTOGENS Herbs for strength stamina and stress relief states the following lsquoadaptogens can be used for helping the body respond to an excess of adrenal hormones and prevent oxidation damage to the adrenalsrsquo
bull Eleuthero
bull American Ginseng
bull Ashwagandha
bull Asian ginseng
bull Cordyceps
bull Reishi
bull Rhaponticum
bull Rhodiola
bull Schizandra
Make adrenal deposits
Adrenal tonic herbs
Exercise and Testosterone
Exercise helps (even in obese
men to raise) testosterone
Squats 4 sets of 10
reps increased
testosterone the
greatest
Treating Andropause Better sleep
Flavonoids
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Urologe A 2013 Jun 12 Testosterone deficiency - an
underestimated risk for men Prevalence of
hypogonadism
bull RESULTS
bull Pathologically low testosterone levels (ltthinsp25 ngml) were found in 152thinsp of subjects while 374thinsp had a testosterone level lower than 35 ngml Decreased testosterone levels were not associated with age In addition the proportion of men with decreased serum testosterone levels was comparable in all age groups The average serum testosterone level decreased slightly in all age groups during the period before midday
bull CONCLUSIONS
bull The data reveal high rates of testosterone deficiency in men independent of patient age As decreased serum testosterone levels may be the consequence of several diseases and can be causally involved in the pathogenesis of further diseases it is strongly recommended that serum testosterone measurement should be included in the diagnostic arsenal especially when symptoms such as loss of libido erectile dysfunction lack of concentration depression lethargy irritability and sleep disturbance are present
I would add high lipids
weak legs chronic low
back amp weight gain here
httpwwwhealthyfellowcomimages2009testoste
rone-age-chartgif
httpwwwendotextorgmalemale2figures2figure2jpg
httpwww2mstdkudgivpublications2007978-87-7052-538-1htmlimagesfig03gif
Effects of restoring Test Levels
bull In a controlled study 13 healthy men aged 57 to 76 years with low or borderline low blood testosterone were administered testosterone therapy at the University of Washington The men received either testosterone or placebo for three-month time periods The men were not supposed to know when they were receiving testosterone or a placebo but at any given time 12 out of the 13 were able to ascertain they were receiving testosterone based on increases in their libido aggressiveness in business transactions or an improvement in their sense of well-being
bull Tenover JS Effects of testosterone supplementation in the aging male J Clin Endocrinol Metab 1992 Oct75(4)1092-8
Researchers measured free testosterone and 25-hydroxyvitamin D
blood levels in a large group (2069) men who were referred for
coronary angiography The results were nothing short of startling for
those who fail to maintain optimal blood ranges of vitamin D and
testosteronehelliphellip
These are most of
the men who go to
holistic physicians
Expanded Causes of Andropause
Restorative Medicine Model
bull Precursor steal due to Dis-Stresselevating cortisol and reducing lsquoYinrsquo Neurotransmitters
bull Adrenal medulla exhaustionrarrlowDOPAMINErarrwith elevations in ProlactinrarrLow Test
bull ObesityBMI issues
bull Lack of activity
bull Excess aromatase
bull Hypothalamic damage due to high cortisol
bull Hypothalamic damage due to high ROS stress
bull 5 alpha reductase activity
bull SHBG activity
bull Nutrient deficiencies
Free radical and ROS stress to testesleydig cells from multiple agents
bull Low Growth Hormone production
bull Endocrine disruptors and increased toxic load
bull Malabsorption of minerals like zinc leading to low T
bull Kidney disease
bull OTHERS
CAUSES of ANDROPAUSESTRESSeffect on adrenals
Precursor steal
ldquohellipChronically increased cortisol
level as seen during
prolonged stress may reduce
the functional activity of
leuteinizing hormonemdashrelease
hormone (LHRH) pulse
generator which may lead to
decrease in gonadotropin and
testosterone levelshelliprdquo
Science 1984 May
4224(4648)452-9
Stress hormones their
interaction and regulation
Axelrod J et al
Causes of Andropause
Obesity Estrogen cycle
ldquoMen with obesity
and Syndrome X
develop
low
Testosteronehelliprdquo
Adipokines increase
IL-6 which increases
inflammation and
decreases
testosterone
CAUSES of ANDROPAUSE
INSULIN RESISTANCEhttpimgmedscapecomarticle719489719489-fig14jpg
Even surgical loss of
fat increases
testosterone
Causes of Andropause
Prolactin and Andropausebull Physiologic levels of prolactin in males enhance in LH receptors in
Leydig cells resulting in testosterone secretion which leads to spermatogenesis
bull Highly elevated levels of prolactin decrease the levels of sex hormones mdashestrogen in women and Testosterone in men
bull Very Low Prolactin also effects serum testosterone
bull httpwwwmayocliniccomhealthprolactinomaDS00532
bull Gonzales GF Velasquez G Garcia-Hjarles M (1989) Hypoprolactinemia as related to seminal quality and serum testosterone Arch Androl 23 (3) 259ndash65 Rev Urol 2000 Winter 2(1) 39ndash42
bull Hyperprolactinemia and Erectile Dysfunction
bull Scott I Zeitlin MD Rev Urol 2000 Winter 2(1) 39ndash42
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Lay off the brew
bull The consumption of beer unlike other alcoholic beverages increases serum prolactin a hormone necessary for milk production but not good for andropausal men (Carlson Wasser amp Reidelberger 1985 De Rosa Corsello Ruffilli Della Casa amp Pasargiklian 1981 Grossman 1987)
Causes of Andropause
Aromatase activity
Caue of Andropause Elevations in SHBG review
of physiology
bull Sex hormone binding globulin (SHBG) is a glycoprotein which binds to human sex hormones These binding proteins are most often found bound to the primary male and female sex hormones
bull Major production of sex hormone binding globulin occurs in the liver but it may also be produced in the brainuterus testes and in the placenta during pregnancy
bull The function of this protein is to limit the levels of active unbound sex hormones in the body Very high or very low levels of the protein in the body can indicate a variety of health conditions in both women and men
bull Most sex hormones within the bloodstream are biochemically bound to sex hormone binding globulins Only a tiny portion of sex hormones are free and able to enter cells where they bind to hormone receptors Therefore the availability of sex hormones in the human body is directly linked to the amount of SHBG the body produces
bull When produced by the testes SHBG is instead known as an androgen-binding protein a protein that is produced in the Sertoli cells High levels of androgen-binding protein in the testes allow sperm cells to mature in spermatogenesis
Causes of ANDROPAUSE
5 apha reductase
5 alpha
reductase
CAUSES of Andropause
Toxinseffect on Testes
CAUSES of Andropause
Toxinseffect on Testeshttpwwwsiumededu~dbhaleslabimagesresear2gif
CAUSES of Andropause
Toxinseffect on Testeshttpwwwoneresultcomsitesdefaultfilesu3Prohormones20Chart_1png
Michael Phelps amp Co at high risk of low
testosterone
bull A 2011 paper that was
published in the
International Journal of
Andrology by Nickmilder
et al a clear-cut
association with early life
exposure to chlorinated
indoor-pool water and low
testosterone levels in
adolescence and
probably later in life
(Nickmilder 2011)
I wonder if
therersquos an
issue with
Bromine
too
Amaral S et al Front Biosci (Schol Ed) 2013 Jan 15181-97
Aging and male reproductive function
a mitochondrial perspective
bull Researching the effects of aging in the male reproductive system is not trivial Not only are multiple changes at molecular cellular and endocrine levels involved but any findings must be discussed with variable individual characteristics as well as with lifestyle and environmental factors Age-related changes in the reproductive system include any aspect of reproductive function from deregulation of the hypothalamic-pituitary-gonadal axis and of local autoparacrine interactions to effects on testicular stem cells defects in testicular architecture and spermatogenesis or sperm with decreased functionality Several theories place mitochondria at the hub of cellular events related to aging namely regarding the accumulation of oxidative damage to cells and tissues a process in which these organelles play a prominent role although alternative theories have also emerged However oxidative stress is not the only process involved in mitochondrial-related aging mitochondrial energy metabolism changes in mitochondrial DNA or in mitochondrial-dependent testosterone production are also important Crucially all these issues are likely interdependent We will review evidence that suggests that mitochondria constitute a common link between aging and fertility loss
Damage to Leydig cells cause low
testosterone
Are toxin avoidance antioxidants
and depuration a key
bull Biomed Environ Sci 2013 Jun26(6)474-84 doi 1039670895-3988201306008
bull Effects of Environmental Lead Pollution on Blood Lead and Sex Hormone Levels among Occupationally Exposed Group in An E-waste Dismantling Area
bull Yang Y Lu XS Li DL Yu YJ
bull Source
bull School of Environmental amp Safety Engineering Changzhou University Changzhou 213164 Jiangsu China
bull Abstract
bull OBJECTIVE
bull To study the effects of environmental multi-media lead pollution on blood lead and sex hormone levels among lead exposed males engaged in E-waste dismantling and the correlation between confounding factors and sex hormone levels
bull METHODS
bull An E-waste dismantling area in Taizhou of Zhejiang Province was selected as the research site One hundred and fifty two samples were collected from the groundwater soil rice corn chicken and pork in the dismantling area The effects of the multi-media lead pollution on the male blood lead and sex hormone levels of FSH LH and T as well as the correlation with confounding factors were studied
bull RESULTS
bull The blood lead concentrations in the males aged under 31 from 31 to 45 and from 46 to 60 were 9855 10023 and 10145 μgL respectively Of all the environmental media lead exposures the groundwater rice and soil were main contributing factors to the lead accumulation in humans FSH and LH levels increased with the age while the T levels decreased with the age instead There was a significant correlation between the FSH and LH levels and wearing masks
bull CONCLUSION
bull There was correlation between the FSH LH and T levels and the mean values of lead concentrations in environmental media and the sex hormone levels were correlated with the confounding factor of wearing masks
Workup up the Andropausal male Exam PEBlood SalivaUrine
BMI
Chemistry and health profile with all hormones VAP
Free Total and Bioavailable Testosterone amp DHT
Estradiol (Ultrasens)
DHEA Uncong and S
Cardivascular CRP and Homocysteine
Fibrinogen amp D-Dimer
Delta PSA amp Free to Total
Vit D and other Nutrients
IGF-1
bull LH and FSH
bull Prolactin
bull SHBG
bull Cortisol X 4
bull Neurotransmitters
bull Amino acids
bull Hair analysis
bull RBC mineral levels
bull Liver detox profile
bull Pregnenolone
bull Cytokine panel
bull Fasting GlusocseInsulin HAIC amp Fructosamine
Natural non-hormonal
interventions for
trteating the underlying
causes of Andropause
and Low T syndrome
Work on your patients response to the stressttpwwwcursoercomenwp-contentuploads201202people-man-stress-Fotolia_8150434_XSjpg
Put the Adrenals to
BedhellipBotanically
bull Mild relaxants
ndash Chamomila
ndash Vervain
ndash Oats (Avena)
ndash Motherwort
bull Stronger Relaxants
ndash Passiflora
ndash Scutellaria
ndash Valerian
ndash Humulus (Hops)
ndash Eschscholtzia
bull Potent relaxants
ndash Jamaican Dogwood
ndash Corydalis
ndash Wild lettuce
Nervine trophorestoratives
-- St Johnrsquos wort
ADAPTOGENS
bull David Winston in his book ADAPTOGENS Herbs for strength stamina and stress relief states the following lsquoadaptogens can be used for helping the body respond to an excess of adrenal hormones and prevent oxidation damage to the adrenalsrsquo
bull Eleuthero
bull American Ginseng
bull Ashwagandha
bull Asian ginseng
bull Cordyceps
bull Reishi
bull Rhaponticum
bull Rhodiola
bull Schizandra
Make adrenal deposits
Adrenal tonic herbs
Exercise and Testosterone
Exercise helps (even in obese
men to raise) testosterone
Squats 4 sets of 10
reps increased
testosterone the
greatest
Treating Andropause Better sleep
Flavonoids
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
httpwwwhealthyfellowcomimages2009testoste
rone-age-chartgif
httpwwwendotextorgmalemale2figures2figure2jpg
httpwww2mstdkudgivpublications2007978-87-7052-538-1htmlimagesfig03gif
Effects of restoring Test Levels
bull In a controlled study 13 healthy men aged 57 to 76 years with low or borderline low blood testosterone were administered testosterone therapy at the University of Washington The men received either testosterone or placebo for three-month time periods The men were not supposed to know when they were receiving testosterone or a placebo but at any given time 12 out of the 13 were able to ascertain they were receiving testosterone based on increases in their libido aggressiveness in business transactions or an improvement in their sense of well-being
bull Tenover JS Effects of testosterone supplementation in the aging male J Clin Endocrinol Metab 1992 Oct75(4)1092-8
Researchers measured free testosterone and 25-hydroxyvitamin D
blood levels in a large group (2069) men who were referred for
coronary angiography The results were nothing short of startling for
those who fail to maintain optimal blood ranges of vitamin D and
testosteronehelliphellip
These are most of
the men who go to
holistic physicians
Expanded Causes of Andropause
Restorative Medicine Model
bull Precursor steal due to Dis-Stresselevating cortisol and reducing lsquoYinrsquo Neurotransmitters
bull Adrenal medulla exhaustionrarrlowDOPAMINErarrwith elevations in ProlactinrarrLow Test
bull ObesityBMI issues
bull Lack of activity
bull Excess aromatase
bull Hypothalamic damage due to high cortisol
bull Hypothalamic damage due to high ROS stress
bull 5 alpha reductase activity
bull SHBG activity
bull Nutrient deficiencies
Free radical and ROS stress to testesleydig cells from multiple agents
bull Low Growth Hormone production
bull Endocrine disruptors and increased toxic load
bull Malabsorption of minerals like zinc leading to low T
bull Kidney disease
bull OTHERS
CAUSES of ANDROPAUSESTRESSeffect on adrenals
Precursor steal
ldquohellipChronically increased cortisol
level as seen during
prolonged stress may reduce
the functional activity of
leuteinizing hormonemdashrelease
hormone (LHRH) pulse
generator which may lead to
decrease in gonadotropin and
testosterone levelshelliprdquo
Science 1984 May
4224(4648)452-9
Stress hormones their
interaction and regulation
Axelrod J et al
Causes of Andropause
Obesity Estrogen cycle
ldquoMen with obesity
and Syndrome X
develop
low
Testosteronehelliprdquo
Adipokines increase
IL-6 which increases
inflammation and
decreases
testosterone
CAUSES of ANDROPAUSE
INSULIN RESISTANCEhttpimgmedscapecomarticle719489719489-fig14jpg
Even surgical loss of
fat increases
testosterone
Causes of Andropause
Prolactin and Andropausebull Physiologic levels of prolactin in males enhance in LH receptors in
Leydig cells resulting in testosterone secretion which leads to spermatogenesis
bull Highly elevated levels of prolactin decrease the levels of sex hormones mdashestrogen in women and Testosterone in men
bull Very Low Prolactin also effects serum testosterone
bull httpwwwmayocliniccomhealthprolactinomaDS00532
bull Gonzales GF Velasquez G Garcia-Hjarles M (1989) Hypoprolactinemia as related to seminal quality and serum testosterone Arch Androl 23 (3) 259ndash65 Rev Urol 2000 Winter 2(1) 39ndash42
bull Hyperprolactinemia and Erectile Dysfunction
bull Scott I Zeitlin MD Rev Urol 2000 Winter 2(1) 39ndash42
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Lay off the brew
bull The consumption of beer unlike other alcoholic beverages increases serum prolactin a hormone necessary for milk production but not good for andropausal men (Carlson Wasser amp Reidelberger 1985 De Rosa Corsello Ruffilli Della Casa amp Pasargiklian 1981 Grossman 1987)
Causes of Andropause
Aromatase activity
Caue of Andropause Elevations in SHBG review
of physiology
bull Sex hormone binding globulin (SHBG) is a glycoprotein which binds to human sex hormones These binding proteins are most often found bound to the primary male and female sex hormones
bull Major production of sex hormone binding globulin occurs in the liver but it may also be produced in the brainuterus testes and in the placenta during pregnancy
bull The function of this protein is to limit the levels of active unbound sex hormones in the body Very high or very low levels of the protein in the body can indicate a variety of health conditions in both women and men
bull Most sex hormones within the bloodstream are biochemically bound to sex hormone binding globulins Only a tiny portion of sex hormones are free and able to enter cells where they bind to hormone receptors Therefore the availability of sex hormones in the human body is directly linked to the amount of SHBG the body produces
bull When produced by the testes SHBG is instead known as an androgen-binding protein a protein that is produced in the Sertoli cells High levels of androgen-binding protein in the testes allow sperm cells to mature in spermatogenesis
Causes of ANDROPAUSE
5 apha reductase
5 alpha
reductase
CAUSES of Andropause
Toxinseffect on Testes
CAUSES of Andropause
Toxinseffect on Testeshttpwwwsiumededu~dbhaleslabimagesresear2gif
CAUSES of Andropause
Toxinseffect on Testeshttpwwwoneresultcomsitesdefaultfilesu3Prohormones20Chart_1png
Michael Phelps amp Co at high risk of low
testosterone
bull A 2011 paper that was
published in the
International Journal of
Andrology by Nickmilder
et al a clear-cut
association with early life
exposure to chlorinated
indoor-pool water and low
testosterone levels in
adolescence and
probably later in life
(Nickmilder 2011)
I wonder if
therersquos an
issue with
Bromine
too
Amaral S et al Front Biosci (Schol Ed) 2013 Jan 15181-97
Aging and male reproductive function
a mitochondrial perspective
bull Researching the effects of aging in the male reproductive system is not trivial Not only are multiple changes at molecular cellular and endocrine levels involved but any findings must be discussed with variable individual characteristics as well as with lifestyle and environmental factors Age-related changes in the reproductive system include any aspect of reproductive function from deregulation of the hypothalamic-pituitary-gonadal axis and of local autoparacrine interactions to effects on testicular stem cells defects in testicular architecture and spermatogenesis or sperm with decreased functionality Several theories place mitochondria at the hub of cellular events related to aging namely regarding the accumulation of oxidative damage to cells and tissues a process in which these organelles play a prominent role although alternative theories have also emerged However oxidative stress is not the only process involved in mitochondrial-related aging mitochondrial energy metabolism changes in mitochondrial DNA or in mitochondrial-dependent testosterone production are also important Crucially all these issues are likely interdependent We will review evidence that suggests that mitochondria constitute a common link between aging and fertility loss
Damage to Leydig cells cause low
testosterone
Are toxin avoidance antioxidants
and depuration a key
bull Biomed Environ Sci 2013 Jun26(6)474-84 doi 1039670895-3988201306008
bull Effects of Environmental Lead Pollution on Blood Lead and Sex Hormone Levels among Occupationally Exposed Group in An E-waste Dismantling Area
bull Yang Y Lu XS Li DL Yu YJ
bull Source
bull School of Environmental amp Safety Engineering Changzhou University Changzhou 213164 Jiangsu China
bull Abstract
bull OBJECTIVE
bull To study the effects of environmental multi-media lead pollution on blood lead and sex hormone levels among lead exposed males engaged in E-waste dismantling and the correlation between confounding factors and sex hormone levels
bull METHODS
bull An E-waste dismantling area in Taizhou of Zhejiang Province was selected as the research site One hundred and fifty two samples were collected from the groundwater soil rice corn chicken and pork in the dismantling area The effects of the multi-media lead pollution on the male blood lead and sex hormone levels of FSH LH and T as well as the correlation with confounding factors were studied
bull RESULTS
bull The blood lead concentrations in the males aged under 31 from 31 to 45 and from 46 to 60 were 9855 10023 and 10145 μgL respectively Of all the environmental media lead exposures the groundwater rice and soil were main contributing factors to the lead accumulation in humans FSH and LH levels increased with the age while the T levels decreased with the age instead There was a significant correlation between the FSH and LH levels and wearing masks
bull CONCLUSION
bull There was correlation between the FSH LH and T levels and the mean values of lead concentrations in environmental media and the sex hormone levels were correlated with the confounding factor of wearing masks
Workup up the Andropausal male Exam PEBlood SalivaUrine
BMI
Chemistry and health profile with all hormones VAP
Free Total and Bioavailable Testosterone amp DHT
Estradiol (Ultrasens)
DHEA Uncong and S
Cardivascular CRP and Homocysteine
Fibrinogen amp D-Dimer
Delta PSA amp Free to Total
Vit D and other Nutrients
IGF-1
bull LH and FSH
bull Prolactin
bull SHBG
bull Cortisol X 4
bull Neurotransmitters
bull Amino acids
bull Hair analysis
bull RBC mineral levels
bull Liver detox profile
bull Pregnenolone
bull Cytokine panel
bull Fasting GlusocseInsulin HAIC amp Fructosamine
Natural non-hormonal
interventions for
trteating the underlying
causes of Andropause
and Low T syndrome
Work on your patients response to the stressttpwwwcursoercomenwp-contentuploads201202people-man-stress-Fotolia_8150434_XSjpg
Put the Adrenals to
BedhellipBotanically
bull Mild relaxants
ndash Chamomila
ndash Vervain
ndash Oats (Avena)
ndash Motherwort
bull Stronger Relaxants
ndash Passiflora
ndash Scutellaria
ndash Valerian
ndash Humulus (Hops)
ndash Eschscholtzia
bull Potent relaxants
ndash Jamaican Dogwood
ndash Corydalis
ndash Wild lettuce
Nervine trophorestoratives
-- St Johnrsquos wort
ADAPTOGENS
bull David Winston in his book ADAPTOGENS Herbs for strength stamina and stress relief states the following lsquoadaptogens can be used for helping the body respond to an excess of adrenal hormones and prevent oxidation damage to the adrenalsrsquo
bull Eleuthero
bull American Ginseng
bull Ashwagandha
bull Asian ginseng
bull Cordyceps
bull Reishi
bull Rhaponticum
bull Rhodiola
bull Schizandra
Make adrenal deposits
Adrenal tonic herbs
Exercise and Testosterone
Exercise helps (even in obese
men to raise) testosterone
Squats 4 sets of 10
reps increased
testosterone the
greatest
Treating Andropause Better sleep
Flavonoids
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
httpwwwendotextorgmalemale2figures2figure2jpg
httpwww2mstdkudgivpublications2007978-87-7052-538-1htmlimagesfig03gif
Effects of restoring Test Levels
bull In a controlled study 13 healthy men aged 57 to 76 years with low or borderline low blood testosterone were administered testosterone therapy at the University of Washington The men received either testosterone or placebo for three-month time periods The men were not supposed to know when they were receiving testosterone or a placebo but at any given time 12 out of the 13 were able to ascertain they were receiving testosterone based on increases in their libido aggressiveness in business transactions or an improvement in their sense of well-being
bull Tenover JS Effects of testosterone supplementation in the aging male J Clin Endocrinol Metab 1992 Oct75(4)1092-8
Researchers measured free testosterone and 25-hydroxyvitamin D
blood levels in a large group (2069) men who were referred for
coronary angiography The results were nothing short of startling for
those who fail to maintain optimal blood ranges of vitamin D and
testosteronehelliphellip
These are most of
the men who go to
holistic physicians
Expanded Causes of Andropause
Restorative Medicine Model
bull Precursor steal due to Dis-Stresselevating cortisol and reducing lsquoYinrsquo Neurotransmitters
bull Adrenal medulla exhaustionrarrlowDOPAMINErarrwith elevations in ProlactinrarrLow Test
bull ObesityBMI issues
bull Lack of activity
bull Excess aromatase
bull Hypothalamic damage due to high cortisol
bull Hypothalamic damage due to high ROS stress
bull 5 alpha reductase activity
bull SHBG activity
bull Nutrient deficiencies
Free radical and ROS stress to testesleydig cells from multiple agents
bull Low Growth Hormone production
bull Endocrine disruptors and increased toxic load
bull Malabsorption of minerals like zinc leading to low T
bull Kidney disease
bull OTHERS
CAUSES of ANDROPAUSESTRESSeffect on adrenals
Precursor steal
ldquohellipChronically increased cortisol
level as seen during
prolonged stress may reduce
the functional activity of
leuteinizing hormonemdashrelease
hormone (LHRH) pulse
generator which may lead to
decrease in gonadotropin and
testosterone levelshelliprdquo
Science 1984 May
4224(4648)452-9
Stress hormones their
interaction and regulation
Axelrod J et al
Causes of Andropause
Obesity Estrogen cycle
ldquoMen with obesity
and Syndrome X
develop
low
Testosteronehelliprdquo
Adipokines increase
IL-6 which increases
inflammation and
decreases
testosterone
CAUSES of ANDROPAUSE
INSULIN RESISTANCEhttpimgmedscapecomarticle719489719489-fig14jpg
Even surgical loss of
fat increases
testosterone
Causes of Andropause
Prolactin and Andropausebull Physiologic levels of prolactin in males enhance in LH receptors in
Leydig cells resulting in testosterone secretion which leads to spermatogenesis
bull Highly elevated levels of prolactin decrease the levels of sex hormones mdashestrogen in women and Testosterone in men
bull Very Low Prolactin also effects serum testosterone
bull httpwwwmayocliniccomhealthprolactinomaDS00532
bull Gonzales GF Velasquez G Garcia-Hjarles M (1989) Hypoprolactinemia as related to seminal quality and serum testosterone Arch Androl 23 (3) 259ndash65 Rev Urol 2000 Winter 2(1) 39ndash42
bull Hyperprolactinemia and Erectile Dysfunction
bull Scott I Zeitlin MD Rev Urol 2000 Winter 2(1) 39ndash42
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Lay off the brew
bull The consumption of beer unlike other alcoholic beverages increases serum prolactin a hormone necessary for milk production but not good for andropausal men (Carlson Wasser amp Reidelberger 1985 De Rosa Corsello Ruffilli Della Casa amp Pasargiklian 1981 Grossman 1987)
Causes of Andropause
Aromatase activity
Caue of Andropause Elevations in SHBG review
of physiology
bull Sex hormone binding globulin (SHBG) is a glycoprotein which binds to human sex hormones These binding proteins are most often found bound to the primary male and female sex hormones
bull Major production of sex hormone binding globulin occurs in the liver but it may also be produced in the brainuterus testes and in the placenta during pregnancy
bull The function of this protein is to limit the levels of active unbound sex hormones in the body Very high or very low levels of the protein in the body can indicate a variety of health conditions in both women and men
bull Most sex hormones within the bloodstream are biochemically bound to sex hormone binding globulins Only a tiny portion of sex hormones are free and able to enter cells where they bind to hormone receptors Therefore the availability of sex hormones in the human body is directly linked to the amount of SHBG the body produces
bull When produced by the testes SHBG is instead known as an androgen-binding protein a protein that is produced in the Sertoli cells High levels of androgen-binding protein in the testes allow sperm cells to mature in spermatogenesis
Causes of ANDROPAUSE
5 apha reductase
5 alpha
reductase
CAUSES of Andropause
Toxinseffect on Testes
CAUSES of Andropause
Toxinseffect on Testeshttpwwwsiumededu~dbhaleslabimagesresear2gif
CAUSES of Andropause
Toxinseffect on Testeshttpwwwoneresultcomsitesdefaultfilesu3Prohormones20Chart_1png
Michael Phelps amp Co at high risk of low
testosterone
bull A 2011 paper that was
published in the
International Journal of
Andrology by Nickmilder
et al a clear-cut
association with early life
exposure to chlorinated
indoor-pool water and low
testosterone levels in
adolescence and
probably later in life
(Nickmilder 2011)
I wonder if
therersquos an
issue with
Bromine
too
Amaral S et al Front Biosci (Schol Ed) 2013 Jan 15181-97
Aging and male reproductive function
a mitochondrial perspective
bull Researching the effects of aging in the male reproductive system is not trivial Not only are multiple changes at molecular cellular and endocrine levels involved but any findings must be discussed with variable individual characteristics as well as with lifestyle and environmental factors Age-related changes in the reproductive system include any aspect of reproductive function from deregulation of the hypothalamic-pituitary-gonadal axis and of local autoparacrine interactions to effects on testicular stem cells defects in testicular architecture and spermatogenesis or sperm with decreased functionality Several theories place mitochondria at the hub of cellular events related to aging namely regarding the accumulation of oxidative damage to cells and tissues a process in which these organelles play a prominent role although alternative theories have also emerged However oxidative stress is not the only process involved in mitochondrial-related aging mitochondrial energy metabolism changes in mitochondrial DNA or in mitochondrial-dependent testosterone production are also important Crucially all these issues are likely interdependent We will review evidence that suggests that mitochondria constitute a common link between aging and fertility loss
Damage to Leydig cells cause low
testosterone
Are toxin avoidance antioxidants
and depuration a key
bull Biomed Environ Sci 2013 Jun26(6)474-84 doi 1039670895-3988201306008
bull Effects of Environmental Lead Pollution on Blood Lead and Sex Hormone Levels among Occupationally Exposed Group in An E-waste Dismantling Area
bull Yang Y Lu XS Li DL Yu YJ
bull Source
bull School of Environmental amp Safety Engineering Changzhou University Changzhou 213164 Jiangsu China
bull Abstract
bull OBJECTIVE
bull To study the effects of environmental multi-media lead pollution on blood lead and sex hormone levels among lead exposed males engaged in E-waste dismantling and the correlation between confounding factors and sex hormone levels
bull METHODS
bull An E-waste dismantling area in Taizhou of Zhejiang Province was selected as the research site One hundred and fifty two samples were collected from the groundwater soil rice corn chicken and pork in the dismantling area The effects of the multi-media lead pollution on the male blood lead and sex hormone levels of FSH LH and T as well as the correlation with confounding factors were studied
bull RESULTS
bull The blood lead concentrations in the males aged under 31 from 31 to 45 and from 46 to 60 were 9855 10023 and 10145 μgL respectively Of all the environmental media lead exposures the groundwater rice and soil were main contributing factors to the lead accumulation in humans FSH and LH levels increased with the age while the T levels decreased with the age instead There was a significant correlation between the FSH and LH levels and wearing masks
bull CONCLUSION
bull There was correlation between the FSH LH and T levels and the mean values of lead concentrations in environmental media and the sex hormone levels were correlated with the confounding factor of wearing masks
Workup up the Andropausal male Exam PEBlood SalivaUrine
BMI
Chemistry and health profile with all hormones VAP
Free Total and Bioavailable Testosterone amp DHT
Estradiol (Ultrasens)
DHEA Uncong and S
Cardivascular CRP and Homocysteine
Fibrinogen amp D-Dimer
Delta PSA amp Free to Total
Vit D and other Nutrients
IGF-1
bull LH and FSH
bull Prolactin
bull SHBG
bull Cortisol X 4
bull Neurotransmitters
bull Amino acids
bull Hair analysis
bull RBC mineral levels
bull Liver detox profile
bull Pregnenolone
bull Cytokine panel
bull Fasting GlusocseInsulin HAIC amp Fructosamine
Natural non-hormonal
interventions for
trteating the underlying
causes of Andropause
and Low T syndrome
Work on your patients response to the stressttpwwwcursoercomenwp-contentuploads201202people-man-stress-Fotolia_8150434_XSjpg
Put the Adrenals to
BedhellipBotanically
bull Mild relaxants
ndash Chamomila
ndash Vervain
ndash Oats (Avena)
ndash Motherwort
bull Stronger Relaxants
ndash Passiflora
ndash Scutellaria
ndash Valerian
ndash Humulus (Hops)
ndash Eschscholtzia
bull Potent relaxants
ndash Jamaican Dogwood
ndash Corydalis
ndash Wild lettuce
Nervine trophorestoratives
-- St Johnrsquos wort
ADAPTOGENS
bull David Winston in his book ADAPTOGENS Herbs for strength stamina and stress relief states the following lsquoadaptogens can be used for helping the body respond to an excess of adrenal hormones and prevent oxidation damage to the adrenalsrsquo
bull Eleuthero
bull American Ginseng
bull Ashwagandha
bull Asian ginseng
bull Cordyceps
bull Reishi
bull Rhaponticum
bull Rhodiola
bull Schizandra
Make adrenal deposits
Adrenal tonic herbs
Exercise and Testosterone
Exercise helps (even in obese
men to raise) testosterone
Squats 4 sets of 10
reps increased
testosterone the
greatest
Treating Andropause Better sleep
Flavonoids
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
httpwww2mstdkudgivpublications2007978-87-7052-538-1htmlimagesfig03gif
Effects of restoring Test Levels
bull In a controlled study 13 healthy men aged 57 to 76 years with low or borderline low blood testosterone were administered testosterone therapy at the University of Washington The men received either testosterone or placebo for three-month time periods The men were not supposed to know when they were receiving testosterone or a placebo but at any given time 12 out of the 13 were able to ascertain they were receiving testosterone based on increases in their libido aggressiveness in business transactions or an improvement in their sense of well-being
bull Tenover JS Effects of testosterone supplementation in the aging male J Clin Endocrinol Metab 1992 Oct75(4)1092-8
Researchers measured free testosterone and 25-hydroxyvitamin D
blood levels in a large group (2069) men who were referred for
coronary angiography The results were nothing short of startling for
those who fail to maintain optimal blood ranges of vitamin D and
testosteronehelliphellip
These are most of
the men who go to
holistic physicians
Expanded Causes of Andropause
Restorative Medicine Model
bull Precursor steal due to Dis-Stresselevating cortisol and reducing lsquoYinrsquo Neurotransmitters
bull Adrenal medulla exhaustionrarrlowDOPAMINErarrwith elevations in ProlactinrarrLow Test
bull ObesityBMI issues
bull Lack of activity
bull Excess aromatase
bull Hypothalamic damage due to high cortisol
bull Hypothalamic damage due to high ROS stress
bull 5 alpha reductase activity
bull SHBG activity
bull Nutrient deficiencies
Free radical and ROS stress to testesleydig cells from multiple agents
bull Low Growth Hormone production
bull Endocrine disruptors and increased toxic load
bull Malabsorption of minerals like zinc leading to low T
bull Kidney disease
bull OTHERS
CAUSES of ANDROPAUSESTRESSeffect on adrenals
Precursor steal
ldquohellipChronically increased cortisol
level as seen during
prolonged stress may reduce
the functional activity of
leuteinizing hormonemdashrelease
hormone (LHRH) pulse
generator which may lead to
decrease in gonadotropin and
testosterone levelshelliprdquo
Science 1984 May
4224(4648)452-9
Stress hormones their
interaction and regulation
Axelrod J et al
Causes of Andropause
Obesity Estrogen cycle
ldquoMen with obesity
and Syndrome X
develop
low
Testosteronehelliprdquo
Adipokines increase
IL-6 which increases
inflammation and
decreases
testosterone
CAUSES of ANDROPAUSE
INSULIN RESISTANCEhttpimgmedscapecomarticle719489719489-fig14jpg
Even surgical loss of
fat increases
testosterone
Causes of Andropause
Prolactin and Andropausebull Physiologic levels of prolactin in males enhance in LH receptors in
Leydig cells resulting in testosterone secretion which leads to spermatogenesis
bull Highly elevated levels of prolactin decrease the levels of sex hormones mdashestrogen in women and Testosterone in men
bull Very Low Prolactin also effects serum testosterone
bull httpwwwmayocliniccomhealthprolactinomaDS00532
bull Gonzales GF Velasquez G Garcia-Hjarles M (1989) Hypoprolactinemia as related to seminal quality and serum testosterone Arch Androl 23 (3) 259ndash65 Rev Urol 2000 Winter 2(1) 39ndash42
bull Hyperprolactinemia and Erectile Dysfunction
bull Scott I Zeitlin MD Rev Urol 2000 Winter 2(1) 39ndash42
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Lay off the brew
bull The consumption of beer unlike other alcoholic beverages increases serum prolactin a hormone necessary for milk production but not good for andropausal men (Carlson Wasser amp Reidelberger 1985 De Rosa Corsello Ruffilli Della Casa amp Pasargiklian 1981 Grossman 1987)
Causes of Andropause
Aromatase activity
Caue of Andropause Elevations in SHBG review
of physiology
bull Sex hormone binding globulin (SHBG) is a glycoprotein which binds to human sex hormones These binding proteins are most often found bound to the primary male and female sex hormones
bull Major production of sex hormone binding globulin occurs in the liver but it may also be produced in the brainuterus testes and in the placenta during pregnancy
bull The function of this protein is to limit the levels of active unbound sex hormones in the body Very high or very low levels of the protein in the body can indicate a variety of health conditions in both women and men
bull Most sex hormones within the bloodstream are biochemically bound to sex hormone binding globulins Only a tiny portion of sex hormones are free and able to enter cells where they bind to hormone receptors Therefore the availability of sex hormones in the human body is directly linked to the amount of SHBG the body produces
bull When produced by the testes SHBG is instead known as an androgen-binding protein a protein that is produced in the Sertoli cells High levels of androgen-binding protein in the testes allow sperm cells to mature in spermatogenesis
Causes of ANDROPAUSE
5 apha reductase
5 alpha
reductase
CAUSES of Andropause
Toxinseffect on Testes
CAUSES of Andropause
Toxinseffect on Testeshttpwwwsiumededu~dbhaleslabimagesresear2gif
CAUSES of Andropause
Toxinseffect on Testeshttpwwwoneresultcomsitesdefaultfilesu3Prohormones20Chart_1png
Michael Phelps amp Co at high risk of low
testosterone
bull A 2011 paper that was
published in the
International Journal of
Andrology by Nickmilder
et al a clear-cut
association with early life
exposure to chlorinated
indoor-pool water and low
testosterone levels in
adolescence and
probably later in life
(Nickmilder 2011)
I wonder if
therersquos an
issue with
Bromine
too
Amaral S et al Front Biosci (Schol Ed) 2013 Jan 15181-97
Aging and male reproductive function
a mitochondrial perspective
bull Researching the effects of aging in the male reproductive system is not trivial Not only are multiple changes at molecular cellular and endocrine levels involved but any findings must be discussed with variable individual characteristics as well as with lifestyle and environmental factors Age-related changes in the reproductive system include any aspect of reproductive function from deregulation of the hypothalamic-pituitary-gonadal axis and of local autoparacrine interactions to effects on testicular stem cells defects in testicular architecture and spermatogenesis or sperm with decreased functionality Several theories place mitochondria at the hub of cellular events related to aging namely regarding the accumulation of oxidative damage to cells and tissues a process in which these organelles play a prominent role although alternative theories have also emerged However oxidative stress is not the only process involved in mitochondrial-related aging mitochondrial energy metabolism changes in mitochondrial DNA or in mitochondrial-dependent testosterone production are also important Crucially all these issues are likely interdependent We will review evidence that suggests that mitochondria constitute a common link between aging and fertility loss
Damage to Leydig cells cause low
testosterone
Are toxin avoidance antioxidants
and depuration a key
bull Biomed Environ Sci 2013 Jun26(6)474-84 doi 1039670895-3988201306008
bull Effects of Environmental Lead Pollution on Blood Lead and Sex Hormone Levels among Occupationally Exposed Group in An E-waste Dismantling Area
bull Yang Y Lu XS Li DL Yu YJ
bull Source
bull School of Environmental amp Safety Engineering Changzhou University Changzhou 213164 Jiangsu China
bull Abstract
bull OBJECTIVE
bull To study the effects of environmental multi-media lead pollution on blood lead and sex hormone levels among lead exposed males engaged in E-waste dismantling and the correlation between confounding factors and sex hormone levels
bull METHODS
bull An E-waste dismantling area in Taizhou of Zhejiang Province was selected as the research site One hundred and fifty two samples were collected from the groundwater soil rice corn chicken and pork in the dismantling area The effects of the multi-media lead pollution on the male blood lead and sex hormone levels of FSH LH and T as well as the correlation with confounding factors were studied
bull RESULTS
bull The blood lead concentrations in the males aged under 31 from 31 to 45 and from 46 to 60 were 9855 10023 and 10145 μgL respectively Of all the environmental media lead exposures the groundwater rice and soil were main contributing factors to the lead accumulation in humans FSH and LH levels increased with the age while the T levels decreased with the age instead There was a significant correlation between the FSH and LH levels and wearing masks
bull CONCLUSION
bull There was correlation between the FSH LH and T levels and the mean values of lead concentrations in environmental media and the sex hormone levels were correlated with the confounding factor of wearing masks
Workup up the Andropausal male Exam PEBlood SalivaUrine
BMI
Chemistry and health profile with all hormones VAP
Free Total and Bioavailable Testosterone amp DHT
Estradiol (Ultrasens)
DHEA Uncong and S
Cardivascular CRP and Homocysteine
Fibrinogen amp D-Dimer
Delta PSA amp Free to Total
Vit D and other Nutrients
IGF-1
bull LH and FSH
bull Prolactin
bull SHBG
bull Cortisol X 4
bull Neurotransmitters
bull Amino acids
bull Hair analysis
bull RBC mineral levels
bull Liver detox profile
bull Pregnenolone
bull Cytokine panel
bull Fasting GlusocseInsulin HAIC amp Fructosamine
Natural non-hormonal
interventions for
trteating the underlying
causes of Andropause
and Low T syndrome
Work on your patients response to the stressttpwwwcursoercomenwp-contentuploads201202people-man-stress-Fotolia_8150434_XSjpg
Put the Adrenals to
BedhellipBotanically
bull Mild relaxants
ndash Chamomila
ndash Vervain
ndash Oats (Avena)
ndash Motherwort
bull Stronger Relaxants
ndash Passiflora
ndash Scutellaria
ndash Valerian
ndash Humulus (Hops)
ndash Eschscholtzia
bull Potent relaxants
ndash Jamaican Dogwood
ndash Corydalis
ndash Wild lettuce
Nervine trophorestoratives
-- St Johnrsquos wort
ADAPTOGENS
bull David Winston in his book ADAPTOGENS Herbs for strength stamina and stress relief states the following lsquoadaptogens can be used for helping the body respond to an excess of adrenal hormones and prevent oxidation damage to the adrenalsrsquo
bull Eleuthero
bull American Ginseng
bull Ashwagandha
bull Asian ginseng
bull Cordyceps
bull Reishi
bull Rhaponticum
bull Rhodiola
bull Schizandra
Make adrenal deposits
Adrenal tonic herbs
Exercise and Testosterone
Exercise helps (even in obese
men to raise) testosterone
Squats 4 sets of 10
reps increased
testosterone the
greatest
Treating Andropause Better sleep
Flavonoids
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Effects of restoring Test Levels
bull In a controlled study 13 healthy men aged 57 to 76 years with low or borderline low blood testosterone were administered testosterone therapy at the University of Washington The men received either testosterone or placebo for three-month time periods The men were not supposed to know when they were receiving testosterone or a placebo but at any given time 12 out of the 13 were able to ascertain they were receiving testosterone based on increases in their libido aggressiveness in business transactions or an improvement in their sense of well-being
bull Tenover JS Effects of testosterone supplementation in the aging male J Clin Endocrinol Metab 1992 Oct75(4)1092-8
Researchers measured free testosterone and 25-hydroxyvitamin D
blood levels in a large group (2069) men who were referred for
coronary angiography The results were nothing short of startling for
those who fail to maintain optimal blood ranges of vitamin D and
testosteronehelliphellip
These are most of
the men who go to
holistic physicians
Expanded Causes of Andropause
Restorative Medicine Model
bull Precursor steal due to Dis-Stresselevating cortisol and reducing lsquoYinrsquo Neurotransmitters
bull Adrenal medulla exhaustionrarrlowDOPAMINErarrwith elevations in ProlactinrarrLow Test
bull ObesityBMI issues
bull Lack of activity
bull Excess aromatase
bull Hypothalamic damage due to high cortisol
bull Hypothalamic damage due to high ROS stress
bull 5 alpha reductase activity
bull SHBG activity
bull Nutrient deficiencies
Free radical and ROS stress to testesleydig cells from multiple agents
bull Low Growth Hormone production
bull Endocrine disruptors and increased toxic load
bull Malabsorption of minerals like zinc leading to low T
bull Kidney disease
bull OTHERS
CAUSES of ANDROPAUSESTRESSeffect on adrenals
Precursor steal
ldquohellipChronically increased cortisol
level as seen during
prolonged stress may reduce
the functional activity of
leuteinizing hormonemdashrelease
hormone (LHRH) pulse
generator which may lead to
decrease in gonadotropin and
testosterone levelshelliprdquo
Science 1984 May
4224(4648)452-9
Stress hormones their
interaction and regulation
Axelrod J et al
Causes of Andropause
Obesity Estrogen cycle
ldquoMen with obesity
and Syndrome X
develop
low
Testosteronehelliprdquo
Adipokines increase
IL-6 which increases
inflammation and
decreases
testosterone
CAUSES of ANDROPAUSE
INSULIN RESISTANCEhttpimgmedscapecomarticle719489719489-fig14jpg
Even surgical loss of
fat increases
testosterone
Causes of Andropause
Prolactin and Andropausebull Physiologic levels of prolactin in males enhance in LH receptors in
Leydig cells resulting in testosterone secretion which leads to spermatogenesis
bull Highly elevated levels of prolactin decrease the levels of sex hormones mdashestrogen in women and Testosterone in men
bull Very Low Prolactin also effects serum testosterone
bull httpwwwmayocliniccomhealthprolactinomaDS00532
bull Gonzales GF Velasquez G Garcia-Hjarles M (1989) Hypoprolactinemia as related to seminal quality and serum testosterone Arch Androl 23 (3) 259ndash65 Rev Urol 2000 Winter 2(1) 39ndash42
bull Hyperprolactinemia and Erectile Dysfunction
bull Scott I Zeitlin MD Rev Urol 2000 Winter 2(1) 39ndash42
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Lay off the brew
bull The consumption of beer unlike other alcoholic beverages increases serum prolactin a hormone necessary for milk production but not good for andropausal men (Carlson Wasser amp Reidelberger 1985 De Rosa Corsello Ruffilli Della Casa amp Pasargiklian 1981 Grossman 1987)
Causes of Andropause
Aromatase activity
Caue of Andropause Elevations in SHBG review
of physiology
bull Sex hormone binding globulin (SHBG) is a glycoprotein which binds to human sex hormones These binding proteins are most often found bound to the primary male and female sex hormones
bull Major production of sex hormone binding globulin occurs in the liver but it may also be produced in the brainuterus testes and in the placenta during pregnancy
bull The function of this protein is to limit the levels of active unbound sex hormones in the body Very high or very low levels of the protein in the body can indicate a variety of health conditions in both women and men
bull Most sex hormones within the bloodstream are biochemically bound to sex hormone binding globulins Only a tiny portion of sex hormones are free and able to enter cells where they bind to hormone receptors Therefore the availability of sex hormones in the human body is directly linked to the amount of SHBG the body produces
bull When produced by the testes SHBG is instead known as an androgen-binding protein a protein that is produced in the Sertoli cells High levels of androgen-binding protein in the testes allow sperm cells to mature in spermatogenesis
Causes of ANDROPAUSE
5 apha reductase
5 alpha
reductase
CAUSES of Andropause
Toxinseffect on Testes
CAUSES of Andropause
Toxinseffect on Testeshttpwwwsiumededu~dbhaleslabimagesresear2gif
CAUSES of Andropause
Toxinseffect on Testeshttpwwwoneresultcomsitesdefaultfilesu3Prohormones20Chart_1png
Michael Phelps amp Co at high risk of low
testosterone
bull A 2011 paper that was
published in the
International Journal of
Andrology by Nickmilder
et al a clear-cut
association with early life
exposure to chlorinated
indoor-pool water and low
testosterone levels in
adolescence and
probably later in life
(Nickmilder 2011)
I wonder if
therersquos an
issue with
Bromine
too
Amaral S et al Front Biosci (Schol Ed) 2013 Jan 15181-97
Aging and male reproductive function
a mitochondrial perspective
bull Researching the effects of aging in the male reproductive system is not trivial Not only are multiple changes at molecular cellular and endocrine levels involved but any findings must be discussed with variable individual characteristics as well as with lifestyle and environmental factors Age-related changes in the reproductive system include any aspect of reproductive function from deregulation of the hypothalamic-pituitary-gonadal axis and of local autoparacrine interactions to effects on testicular stem cells defects in testicular architecture and spermatogenesis or sperm with decreased functionality Several theories place mitochondria at the hub of cellular events related to aging namely regarding the accumulation of oxidative damage to cells and tissues a process in which these organelles play a prominent role although alternative theories have also emerged However oxidative stress is not the only process involved in mitochondrial-related aging mitochondrial energy metabolism changes in mitochondrial DNA or in mitochondrial-dependent testosterone production are also important Crucially all these issues are likely interdependent We will review evidence that suggests that mitochondria constitute a common link between aging and fertility loss
Damage to Leydig cells cause low
testosterone
Are toxin avoidance antioxidants
and depuration a key
bull Biomed Environ Sci 2013 Jun26(6)474-84 doi 1039670895-3988201306008
bull Effects of Environmental Lead Pollution on Blood Lead and Sex Hormone Levels among Occupationally Exposed Group in An E-waste Dismantling Area
bull Yang Y Lu XS Li DL Yu YJ
bull Source
bull School of Environmental amp Safety Engineering Changzhou University Changzhou 213164 Jiangsu China
bull Abstract
bull OBJECTIVE
bull To study the effects of environmental multi-media lead pollution on blood lead and sex hormone levels among lead exposed males engaged in E-waste dismantling and the correlation between confounding factors and sex hormone levels
bull METHODS
bull An E-waste dismantling area in Taizhou of Zhejiang Province was selected as the research site One hundred and fifty two samples were collected from the groundwater soil rice corn chicken and pork in the dismantling area The effects of the multi-media lead pollution on the male blood lead and sex hormone levels of FSH LH and T as well as the correlation with confounding factors were studied
bull RESULTS
bull The blood lead concentrations in the males aged under 31 from 31 to 45 and from 46 to 60 were 9855 10023 and 10145 μgL respectively Of all the environmental media lead exposures the groundwater rice and soil were main contributing factors to the lead accumulation in humans FSH and LH levels increased with the age while the T levels decreased with the age instead There was a significant correlation between the FSH and LH levels and wearing masks
bull CONCLUSION
bull There was correlation between the FSH LH and T levels and the mean values of lead concentrations in environmental media and the sex hormone levels were correlated with the confounding factor of wearing masks
Workup up the Andropausal male Exam PEBlood SalivaUrine
BMI
Chemistry and health profile with all hormones VAP
Free Total and Bioavailable Testosterone amp DHT
Estradiol (Ultrasens)
DHEA Uncong and S
Cardivascular CRP and Homocysteine
Fibrinogen amp D-Dimer
Delta PSA amp Free to Total
Vit D and other Nutrients
IGF-1
bull LH and FSH
bull Prolactin
bull SHBG
bull Cortisol X 4
bull Neurotransmitters
bull Amino acids
bull Hair analysis
bull RBC mineral levels
bull Liver detox profile
bull Pregnenolone
bull Cytokine panel
bull Fasting GlusocseInsulin HAIC amp Fructosamine
Natural non-hormonal
interventions for
trteating the underlying
causes of Andropause
and Low T syndrome
Work on your patients response to the stressttpwwwcursoercomenwp-contentuploads201202people-man-stress-Fotolia_8150434_XSjpg
Put the Adrenals to
BedhellipBotanically
bull Mild relaxants
ndash Chamomila
ndash Vervain
ndash Oats (Avena)
ndash Motherwort
bull Stronger Relaxants
ndash Passiflora
ndash Scutellaria
ndash Valerian
ndash Humulus (Hops)
ndash Eschscholtzia
bull Potent relaxants
ndash Jamaican Dogwood
ndash Corydalis
ndash Wild lettuce
Nervine trophorestoratives
-- St Johnrsquos wort
ADAPTOGENS
bull David Winston in his book ADAPTOGENS Herbs for strength stamina and stress relief states the following lsquoadaptogens can be used for helping the body respond to an excess of adrenal hormones and prevent oxidation damage to the adrenalsrsquo
bull Eleuthero
bull American Ginseng
bull Ashwagandha
bull Asian ginseng
bull Cordyceps
bull Reishi
bull Rhaponticum
bull Rhodiola
bull Schizandra
Make adrenal deposits
Adrenal tonic herbs
Exercise and Testosterone
Exercise helps (even in obese
men to raise) testosterone
Squats 4 sets of 10
reps increased
testosterone the
greatest
Treating Andropause Better sleep
Flavonoids
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Researchers measured free testosterone and 25-hydroxyvitamin D
blood levels in a large group (2069) men who were referred for
coronary angiography The results were nothing short of startling for
those who fail to maintain optimal blood ranges of vitamin D and
testosteronehelliphellip
These are most of
the men who go to
holistic physicians
Expanded Causes of Andropause
Restorative Medicine Model
bull Precursor steal due to Dis-Stresselevating cortisol and reducing lsquoYinrsquo Neurotransmitters
bull Adrenal medulla exhaustionrarrlowDOPAMINErarrwith elevations in ProlactinrarrLow Test
bull ObesityBMI issues
bull Lack of activity
bull Excess aromatase
bull Hypothalamic damage due to high cortisol
bull Hypothalamic damage due to high ROS stress
bull 5 alpha reductase activity
bull SHBG activity
bull Nutrient deficiencies
Free radical and ROS stress to testesleydig cells from multiple agents
bull Low Growth Hormone production
bull Endocrine disruptors and increased toxic load
bull Malabsorption of minerals like zinc leading to low T
bull Kidney disease
bull OTHERS
CAUSES of ANDROPAUSESTRESSeffect on adrenals
Precursor steal
ldquohellipChronically increased cortisol
level as seen during
prolonged stress may reduce
the functional activity of
leuteinizing hormonemdashrelease
hormone (LHRH) pulse
generator which may lead to
decrease in gonadotropin and
testosterone levelshelliprdquo
Science 1984 May
4224(4648)452-9
Stress hormones their
interaction and regulation
Axelrod J et al
Causes of Andropause
Obesity Estrogen cycle
ldquoMen with obesity
and Syndrome X
develop
low
Testosteronehelliprdquo
Adipokines increase
IL-6 which increases
inflammation and
decreases
testosterone
CAUSES of ANDROPAUSE
INSULIN RESISTANCEhttpimgmedscapecomarticle719489719489-fig14jpg
Even surgical loss of
fat increases
testosterone
Causes of Andropause
Prolactin and Andropausebull Physiologic levels of prolactin in males enhance in LH receptors in
Leydig cells resulting in testosterone secretion which leads to spermatogenesis
bull Highly elevated levels of prolactin decrease the levels of sex hormones mdashestrogen in women and Testosterone in men
bull Very Low Prolactin also effects serum testosterone
bull httpwwwmayocliniccomhealthprolactinomaDS00532
bull Gonzales GF Velasquez G Garcia-Hjarles M (1989) Hypoprolactinemia as related to seminal quality and serum testosterone Arch Androl 23 (3) 259ndash65 Rev Urol 2000 Winter 2(1) 39ndash42
bull Hyperprolactinemia and Erectile Dysfunction
bull Scott I Zeitlin MD Rev Urol 2000 Winter 2(1) 39ndash42
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Lay off the brew
bull The consumption of beer unlike other alcoholic beverages increases serum prolactin a hormone necessary for milk production but not good for andropausal men (Carlson Wasser amp Reidelberger 1985 De Rosa Corsello Ruffilli Della Casa amp Pasargiklian 1981 Grossman 1987)
Causes of Andropause
Aromatase activity
Caue of Andropause Elevations in SHBG review
of physiology
bull Sex hormone binding globulin (SHBG) is a glycoprotein which binds to human sex hormones These binding proteins are most often found bound to the primary male and female sex hormones
bull Major production of sex hormone binding globulin occurs in the liver but it may also be produced in the brainuterus testes and in the placenta during pregnancy
bull The function of this protein is to limit the levels of active unbound sex hormones in the body Very high or very low levels of the protein in the body can indicate a variety of health conditions in both women and men
bull Most sex hormones within the bloodstream are biochemically bound to sex hormone binding globulins Only a tiny portion of sex hormones are free and able to enter cells where they bind to hormone receptors Therefore the availability of sex hormones in the human body is directly linked to the amount of SHBG the body produces
bull When produced by the testes SHBG is instead known as an androgen-binding protein a protein that is produced in the Sertoli cells High levels of androgen-binding protein in the testes allow sperm cells to mature in spermatogenesis
Causes of ANDROPAUSE
5 apha reductase
5 alpha
reductase
CAUSES of Andropause
Toxinseffect on Testes
CAUSES of Andropause
Toxinseffect on Testeshttpwwwsiumededu~dbhaleslabimagesresear2gif
CAUSES of Andropause
Toxinseffect on Testeshttpwwwoneresultcomsitesdefaultfilesu3Prohormones20Chart_1png
Michael Phelps amp Co at high risk of low
testosterone
bull A 2011 paper that was
published in the
International Journal of
Andrology by Nickmilder
et al a clear-cut
association with early life
exposure to chlorinated
indoor-pool water and low
testosterone levels in
adolescence and
probably later in life
(Nickmilder 2011)
I wonder if
therersquos an
issue with
Bromine
too
Amaral S et al Front Biosci (Schol Ed) 2013 Jan 15181-97
Aging and male reproductive function
a mitochondrial perspective
bull Researching the effects of aging in the male reproductive system is not trivial Not only are multiple changes at molecular cellular and endocrine levels involved but any findings must be discussed with variable individual characteristics as well as with lifestyle and environmental factors Age-related changes in the reproductive system include any aspect of reproductive function from deregulation of the hypothalamic-pituitary-gonadal axis and of local autoparacrine interactions to effects on testicular stem cells defects in testicular architecture and spermatogenesis or sperm with decreased functionality Several theories place mitochondria at the hub of cellular events related to aging namely regarding the accumulation of oxidative damage to cells and tissues a process in which these organelles play a prominent role although alternative theories have also emerged However oxidative stress is not the only process involved in mitochondrial-related aging mitochondrial energy metabolism changes in mitochondrial DNA or in mitochondrial-dependent testosterone production are also important Crucially all these issues are likely interdependent We will review evidence that suggests that mitochondria constitute a common link between aging and fertility loss
Damage to Leydig cells cause low
testosterone
Are toxin avoidance antioxidants
and depuration a key
bull Biomed Environ Sci 2013 Jun26(6)474-84 doi 1039670895-3988201306008
bull Effects of Environmental Lead Pollution on Blood Lead and Sex Hormone Levels among Occupationally Exposed Group in An E-waste Dismantling Area
bull Yang Y Lu XS Li DL Yu YJ
bull Source
bull School of Environmental amp Safety Engineering Changzhou University Changzhou 213164 Jiangsu China
bull Abstract
bull OBJECTIVE
bull To study the effects of environmental multi-media lead pollution on blood lead and sex hormone levels among lead exposed males engaged in E-waste dismantling and the correlation between confounding factors and sex hormone levels
bull METHODS
bull An E-waste dismantling area in Taizhou of Zhejiang Province was selected as the research site One hundred and fifty two samples were collected from the groundwater soil rice corn chicken and pork in the dismantling area The effects of the multi-media lead pollution on the male blood lead and sex hormone levels of FSH LH and T as well as the correlation with confounding factors were studied
bull RESULTS
bull The blood lead concentrations in the males aged under 31 from 31 to 45 and from 46 to 60 were 9855 10023 and 10145 μgL respectively Of all the environmental media lead exposures the groundwater rice and soil were main contributing factors to the lead accumulation in humans FSH and LH levels increased with the age while the T levels decreased with the age instead There was a significant correlation between the FSH and LH levels and wearing masks
bull CONCLUSION
bull There was correlation between the FSH LH and T levels and the mean values of lead concentrations in environmental media and the sex hormone levels were correlated with the confounding factor of wearing masks
Workup up the Andropausal male Exam PEBlood SalivaUrine
BMI
Chemistry and health profile with all hormones VAP
Free Total and Bioavailable Testosterone amp DHT
Estradiol (Ultrasens)
DHEA Uncong and S
Cardivascular CRP and Homocysteine
Fibrinogen amp D-Dimer
Delta PSA amp Free to Total
Vit D and other Nutrients
IGF-1
bull LH and FSH
bull Prolactin
bull SHBG
bull Cortisol X 4
bull Neurotransmitters
bull Amino acids
bull Hair analysis
bull RBC mineral levels
bull Liver detox profile
bull Pregnenolone
bull Cytokine panel
bull Fasting GlusocseInsulin HAIC amp Fructosamine
Natural non-hormonal
interventions for
trteating the underlying
causes of Andropause
and Low T syndrome
Work on your patients response to the stressttpwwwcursoercomenwp-contentuploads201202people-man-stress-Fotolia_8150434_XSjpg
Put the Adrenals to
BedhellipBotanically
bull Mild relaxants
ndash Chamomila
ndash Vervain
ndash Oats (Avena)
ndash Motherwort
bull Stronger Relaxants
ndash Passiflora
ndash Scutellaria
ndash Valerian
ndash Humulus (Hops)
ndash Eschscholtzia
bull Potent relaxants
ndash Jamaican Dogwood
ndash Corydalis
ndash Wild lettuce
Nervine trophorestoratives
-- St Johnrsquos wort
ADAPTOGENS
bull David Winston in his book ADAPTOGENS Herbs for strength stamina and stress relief states the following lsquoadaptogens can be used for helping the body respond to an excess of adrenal hormones and prevent oxidation damage to the adrenalsrsquo
bull Eleuthero
bull American Ginseng
bull Ashwagandha
bull Asian ginseng
bull Cordyceps
bull Reishi
bull Rhaponticum
bull Rhodiola
bull Schizandra
Make adrenal deposits
Adrenal tonic herbs
Exercise and Testosterone
Exercise helps (even in obese
men to raise) testosterone
Squats 4 sets of 10
reps increased
testosterone the
greatest
Treating Andropause Better sleep
Flavonoids
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
These are most of
the men who go to
holistic physicians
Expanded Causes of Andropause
Restorative Medicine Model
bull Precursor steal due to Dis-Stresselevating cortisol and reducing lsquoYinrsquo Neurotransmitters
bull Adrenal medulla exhaustionrarrlowDOPAMINErarrwith elevations in ProlactinrarrLow Test
bull ObesityBMI issues
bull Lack of activity
bull Excess aromatase
bull Hypothalamic damage due to high cortisol
bull Hypothalamic damage due to high ROS stress
bull 5 alpha reductase activity
bull SHBG activity
bull Nutrient deficiencies
Free radical and ROS stress to testesleydig cells from multiple agents
bull Low Growth Hormone production
bull Endocrine disruptors and increased toxic load
bull Malabsorption of minerals like zinc leading to low T
bull Kidney disease
bull OTHERS
CAUSES of ANDROPAUSESTRESSeffect on adrenals
Precursor steal
ldquohellipChronically increased cortisol
level as seen during
prolonged stress may reduce
the functional activity of
leuteinizing hormonemdashrelease
hormone (LHRH) pulse
generator which may lead to
decrease in gonadotropin and
testosterone levelshelliprdquo
Science 1984 May
4224(4648)452-9
Stress hormones their
interaction and regulation
Axelrod J et al
Causes of Andropause
Obesity Estrogen cycle
ldquoMen with obesity
and Syndrome X
develop
low
Testosteronehelliprdquo
Adipokines increase
IL-6 which increases
inflammation and
decreases
testosterone
CAUSES of ANDROPAUSE
INSULIN RESISTANCEhttpimgmedscapecomarticle719489719489-fig14jpg
Even surgical loss of
fat increases
testosterone
Causes of Andropause
Prolactin and Andropausebull Physiologic levels of prolactin in males enhance in LH receptors in
Leydig cells resulting in testosterone secretion which leads to spermatogenesis
bull Highly elevated levels of prolactin decrease the levels of sex hormones mdashestrogen in women and Testosterone in men
bull Very Low Prolactin also effects serum testosterone
bull httpwwwmayocliniccomhealthprolactinomaDS00532
bull Gonzales GF Velasquez G Garcia-Hjarles M (1989) Hypoprolactinemia as related to seminal quality and serum testosterone Arch Androl 23 (3) 259ndash65 Rev Urol 2000 Winter 2(1) 39ndash42
bull Hyperprolactinemia and Erectile Dysfunction
bull Scott I Zeitlin MD Rev Urol 2000 Winter 2(1) 39ndash42
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Lay off the brew
bull The consumption of beer unlike other alcoholic beverages increases serum prolactin a hormone necessary for milk production but not good for andropausal men (Carlson Wasser amp Reidelberger 1985 De Rosa Corsello Ruffilli Della Casa amp Pasargiklian 1981 Grossman 1987)
Causes of Andropause
Aromatase activity
Caue of Andropause Elevations in SHBG review
of physiology
bull Sex hormone binding globulin (SHBG) is a glycoprotein which binds to human sex hormones These binding proteins are most often found bound to the primary male and female sex hormones
bull Major production of sex hormone binding globulin occurs in the liver but it may also be produced in the brainuterus testes and in the placenta during pregnancy
bull The function of this protein is to limit the levels of active unbound sex hormones in the body Very high or very low levels of the protein in the body can indicate a variety of health conditions in both women and men
bull Most sex hormones within the bloodstream are biochemically bound to sex hormone binding globulins Only a tiny portion of sex hormones are free and able to enter cells where they bind to hormone receptors Therefore the availability of sex hormones in the human body is directly linked to the amount of SHBG the body produces
bull When produced by the testes SHBG is instead known as an androgen-binding protein a protein that is produced in the Sertoli cells High levels of androgen-binding protein in the testes allow sperm cells to mature in spermatogenesis
Causes of ANDROPAUSE
5 apha reductase
5 alpha
reductase
CAUSES of Andropause
Toxinseffect on Testes
CAUSES of Andropause
Toxinseffect on Testeshttpwwwsiumededu~dbhaleslabimagesresear2gif
CAUSES of Andropause
Toxinseffect on Testeshttpwwwoneresultcomsitesdefaultfilesu3Prohormones20Chart_1png
Michael Phelps amp Co at high risk of low
testosterone
bull A 2011 paper that was
published in the
International Journal of
Andrology by Nickmilder
et al a clear-cut
association with early life
exposure to chlorinated
indoor-pool water and low
testosterone levels in
adolescence and
probably later in life
(Nickmilder 2011)
I wonder if
therersquos an
issue with
Bromine
too
Amaral S et al Front Biosci (Schol Ed) 2013 Jan 15181-97
Aging and male reproductive function
a mitochondrial perspective
bull Researching the effects of aging in the male reproductive system is not trivial Not only are multiple changes at molecular cellular and endocrine levels involved but any findings must be discussed with variable individual characteristics as well as with lifestyle and environmental factors Age-related changes in the reproductive system include any aspect of reproductive function from deregulation of the hypothalamic-pituitary-gonadal axis and of local autoparacrine interactions to effects on testicular stem cells defects in testicular architecture and spermatogenesis or sperm with decreased functionality Several theories place mitochondria at the hub of cellular events related to aging namely regarding the accumulation of oxidative damage to cells and tissues a process in which these organelles play a prominent role although alternative theories have also emerged However oxidative stress is not the only process involved in mitochondrial-related aging mitochondrial energy metabolism changes in mitochondrial DNA or in mitochondrial-dependent testosterone production are also important Crucially all these issues are likely interdependent We will review evidence that suggests that mitochondria constitute a common link between aging and fertility loss
Damage to Leydig cells cause low
testosterone
Are toxin avoidance antioxidants
and depuration a key
bull Biomed Environ Sci 2013 Jun26(6)474-84 doi 1039670895-3988201306008
bull Effects of Environmental Lead Pollution on Blood Lead and Sex Hormone Levels among Occupationally Exposed Group in An E-waste Dismantling Area
bull Yang Y Lu XS Li DL Yu YJ
bull Source
bull School of Environmental amp Safety Engineering Changzhou University Changzhou 213164 Jiangsu China
bull Abstract
bull OBJECTIVE
bull To study the effects of environmental multi-media lead pollution on blood lead and sex hormone levels among lead exposed males engaged in E-waste dismantling and the correlation between confounding factors and sex hormone levels
bull METHODS
bull An E-waste dismantling area in Taizhou of Zhejiang Province was selected as the research site One hundred and fifty two samples were collected from the groundwater soil rice corn chicken and pork in the dismantling area The effects of the multi-media lead pollution on the male blood lead and sex hormone levels of FSH LH and T as well as the correlation with confounding factors were studied
bull RESULTS
bull The blood lead concentrations in the males aged under 31 from 31 to 45 and from 46 to 60 were 9855 10023 and 10145 μgL respectively Of all the environmental media lead exposures the groundwater rice and soil were main contributing factors to the lead accumulation in humans FSH and LH levels increased with the age while the T levels decreased with the age instead There was a significant correlation between the FSH and LH levels and wearing masks
bull CONCLUSION
bull There was correlation between the FSH LH and T levels and the mean values of lead concentrations in environmental media and the sex hormone levels were correlated with the confounding factor of wearing masks
Workup up the Andropausal male Exam PEBlood SalivaUrine
BMI
Chemistry and health profile with all hormones VAP
Free Total and Bioavailable Testosterone amp DHT
Estradiol (Ultrasens)
DHEA Uncong and S
Cardivascular CRP and Homocysteine
Fibrinogen amp D-Dimer
Delta PSA amp Free to Total
Vit D and other Nutrients
IGF-1
bull LH and FSH
bull Prolactin
bull SHBG
bull Cortisol X 4
bull Neurotransmitters
bull Amino acids
bull Hair analysis
bull RBC mineral levels
bull Liver detox profile
bull Pregnenolone
bull Cytokine panel
bull Fasting GlusocseInsulin HAIC amp Fructosamine
Natural non-hormonal
interventions for
trteating the underlying
causes of Andropause
and Low T syndrome
Work on your patients response to the stressttpwwwcursoercomenwp-contentuploads201202people-man-stress-Fotolia_8150434_XSjpg
Put the Adrenals to
BedhellipBotanically
bull Mild relaxants
ndash Chamomila
ndash Vervain
ndash Oats (Avena)
ndash Motherwort
bull Stronger Relaxants
ndash Passiflora
ndash Scutellaria
ndash Valerian
ndash Humulus (Hops)
ndash Eschscholtzia
bull Potent relaxants
ndash Jamaican Dogwood
ndash Corydalis
ndash Wild lettuce
Nervine trophorestoratives
-- St Johnrsquos wort
ADAPTOGENS
bull David Winston in his book ADAPTOGENS Herbs for strength stamina and stress relief states the following lsquoadaptogens can be used for helping the body respond to an excess of adrenal hormones and prevent oxidation damage to the adrenalsrsquo
bull Eleuthero
bull American Ginseng
bull Ashwagandha
bull Asian ginseng
bull Cordyceps
bull Reishi
bull Rhaponticum
bull Rhodiola
bull Schizandra
Make adrenal deposits
Adrenal tonic herbs
Exercise and Testosterone
Exercise helps (even in obese
men to raise) testosterone
Squats 4 sets of 10
reps increased
testosterone the
greatest
Treating Andropause Better sleep
Flavonoids
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Expanded Causes of Andropause
Restorative Medicine Model
bull Precursor steal due to Dis-Stresselevating cortisol and reducing lsquoYinrsquo Neurotransmitters
bull Adrenal medulla exhaustionrarrlowDOPAMINErarrwith elevations in ProlactinrarrLow Test
bull ObesityBMI issues
bull Lack of activity
bull Excess aromatase
bull Hypothalamic damage due to high cortisol
bull Hypothalamic damage due to high ROS stress
bull 5 alpha reductase activity
bull SHBG activity
bull Nutrient deficiencies
Free radical and ROS stress to testesleydig cells from multiple agents
bull Low Growth Hormone production
bull Endocrine disruptors and increased toxic load
bull Malabsorption of minerals like zinc leading to low T
bull Kidney disease
bull OTHERS
CAUSES of ANDROPAUSESTRESSeffect on adrenals
Precursor steal
ldquohellipChronically increased cortisol
level as seen during
prolonged stress may reduce
the functional activity of
leuteinizing hormonemdashrelease
hormone (LHRH) pulse
generator which may lead to
decrease in gonadotropin and
testosterone levelshelliprdquo
Science 1984 May
4224(4648)452-9
Stress hormones their
interaction and regulation
Axelrod J et al
Causes of Andropause
Obesity Estrogen cycle
ldquoMen with obesity
and Syndrome X
develop
low
Testosteronehelliprdquo
Adipokines increase
IL-6 which increases
inflammation and
decreases
testosterone
CAUSES of ANDROPAUSE
INSULIN RESISTANCEhttpimgmedscapecomarticle719489719489-fig14jpg
Even surgical loss of
fat increases
testosterone
Causes of Andropause
Prolactin and Andropausebull Physiologic levels of prolactin in males enhance in LH receptors in
Leydig cells resulting in testosterone secretion which leads to spermatogenesis
bull Highly elevated levels of prolactin decrease the levels of sex hormones mdashestrogen in women and Testosterone in men
bull Very Low Prolactin also effects serum testosterone
bull httpwwwmayocliniccomhealthprolactinomaDS00532
bull Gonzales GF Velasquez G Garcia-Hjarles M (1989) Hypoprolactinemia as related to seminal quality and serum testosterone Arch Androl 23 (3) 259ndash65 Rev Urol 2000 Winter 2(1) 39ndash42
bull Hyperprolactinemia and Erectile Dysfunction
bull Scott I Zeitlin MD Rev Urol 2000 Winter 2(1) 39ndash42
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Lay off the brew
bull The consumption of beer unlike other alcoholic beverages increases serum prolactin a hormone necessary for milk production but not good for andropausal men (Carlson Wasser amp Reidelberger 1985 De Rosa Corsello Ruffilli Della Casa amp Pasargiklian 1981 Grossman 1987)
Causes of Andropause
Aromatase activity
Caue of Andropause Elevations in SHBG review
of physiology
bull Sex hormone binding globulin (SHBG) is a glycoprotein which binds to human sex hormones These binding proteins are most often found bound to the primary male and female sex hormones
bull Major production of sex hormone binding globulin occurs in the liver but it may also be produced in the brainuterus testes and in the placenta during pregnancy
bull The function of this protein is to limit the levels of active unbound sex hormones in the body Very high or very low levels of the protein in the body can indicate a variety of health conditions in both women and men
bull Most sex hormones within the bloodstream are biochemically bound to sex hormone binding globulins Only a tiny portion of sex hormones are free and able to enter cells where they bind to hormone receptors Therefore the availability of sex hormones in the human body is directly linked to the amount of SHBG the body produces
bull When produced by the testes SHBG is instead known as an androgen-binding protein a protein that is produced in the Sertoli cells High levels of androgen-binding protein in the testes allow sperm cells to mature in spermatogenesis
Causes of ANDROPAUSE
5 apha reductase
5 alpha
reductase
CAUSES of Andropause
Toxinseffect on Testes
CAUSES of Andropause
Toxinseffect on Testeshttpwwwsiumededu~dbhaleslabimagesresear2gif
CAUSES of Andropause
Toxinseffect on Testeshttpwwwoneresultcomsitesdefaultfilesu3Prohormones20Chart_1png
Michael Phelps amp Co at high risk of low
testosterone
bull A 2011 paper that was
published in the
International Journal of
Andrology by Nickmilder
et al a clear-cut
association with early life
exposure to chlorinated
indoor-pool water and low
testosterone levels in
adolescence and
probably later in life
(Nickmilder 2011)
I wonder if
therersquos an
issue with
Bromine
too
Amaral S et al Front Biosci (Schol Ed) 2013 Jan 15181-97
Aging and male reproductive function
a mitochondrial perspective
bull Researching the effects of aging in the male reproductive system is not trivial Not only are multiple changes at molecular cellular and endocrine levels involved but any findings must be discussed with variable individual characteristics as well as with lifestyle and environmental factors Age-related changes in the reproductive system include any aspect of reproductive function from deregulation of the hypothalamic-pituitary-gonadal axis and of local autoparacrine interactions to effects on testicular stem cells defects in testicular architecture and spermatogenesis or sperm with decreased functionality Several theories place mitochondria at the hub of cellular events related to aging namely regarding the accumulation of oxidative damage to cells and tissues a process in which these organelles play a prominent role although alternative theories have also emerged However oxidative stress is not the only process involved in mitochondrial-related aging mitochondrial energy metabolism changes in mitochondrial DNA or in mitochondrial-dependent testosterone production are also important Crucially all these issues are likely interdependent We will review evidence that suggests that mitochondria constitute a common link between aging and fertility loss
Damage to Leydig cells cause low
testosterone
Are toxin avoidance antioxidants
and depuration a key
bull Biomed Environ Sci 2013 Jun26(6)474-84 doi 1039670895-3988201306008
bull Effects of Environmental Lead Pollution on Blood Lead and Sex Hormone Levels among Occupationally Exposed Group in An E-waste Dismantling Area
bull Yang Y Lu XS Li DL Yu YJ
bull Source
bull School of Environmental amp Safety Engineering Changzhou University Changzhou 213164 Jiangsu China
bull Abstract
bull OBJECTIVE
bull To study the effects of environmental multi-media lead pollution on blood lead and sex hormone levels among lead exposed males engaged in E-waste dismantling and the correlation between confounding factors and sex hormone levels
bull METHODS
bull An E-waste dismantling area in Taizhou of Zhejiang Province was selected as the research site One hundred and fifty two samples were collected from the groundwater soil rice corn chicken and pork in the dismantling area The effects of the multi-media lead pollution on the male blood lead and sex hormone levels of FSH LH and T as well as the correlation with confounding factors were studied
bull RESULTS
bull The blood lead concentrations in the males aged under 31 from 31 to 45 and from 46 to 60 were 9855 10023 and 10145 μgL respectively Of all the environmental media lead exposures the groundwater rice and soil were main contributing factors to the lead accumulation in humans FSH and LH levels increased with the age while the T levels decreased with the age instead There was a significant correlation between the FSH and LH levels and wearing masks
bull CONCLUSION
bull There was correlation between the FSH LH and T levels and the mean values of lead concentrations in environmental media and the sex hormone levels were correlated with the confounding factor of wearing masks
Workup up the Andropausal male Exam PEBlood SalivaUrine
BMI
Chemistry and health profile with all hormones VAP
Free Total and Bioavailable Testosterone amp DHT
Estradiol (Ultrasens)
DHEA Uncong and S
Cardivascular CRP and Homocysteine
Fibrinogen amp D-Dimer
Delta PSA amp Free to Total
Vit D and other Nutrients
IGF-1
bull LH and FSH
bull Prolactin
bull SHBG
bull Cortisol X 4
bull Neurotransmitters
bull Amino acids
bull Hair analysis
bull RBC mineral levels
bull Liver detox profile
bull Pregnenolone
bull Cytokine panel
bull Fasting GlusocseInsulin HAIC amp Fructosamine
Natural non-hormonal
interventions for
trteating the underlying
causes of Andropause
and Low T syndrome
Work on your patients response to the stressttpwwwcursoercomenwp-contentuploads201202people-man-stress-Fotolia_8150434_XSjpg
Put the Adrenals to
BedhellipBotanically
bull Mild relaxants
ndash Chamomila
ndash Vervain
ndash Oats (Avena)
ndash Motherwort
bull Stronger Relaxants
ndash Passiflora
ndash Scutellaria
ndash Valerian
ndash Humulus (Hops)
ndash Eschscholtzia
bull Potent relaxants
ndash Jamaican Dogwood
ndash Corydalis
ndash Wild lettuce
Nervine trophorestoratives
-- St Johnrsquos wort
ADAPTOGENS
bull David Winston in his book ADAPTOGENS Herbs for strength stamina and stress relief states the following lsquoadaptogens can be used for helping the body respond to an excess of adrenal hormones and prevent oxidation damage to the adrenalsrsquo
bull Eleuthero
bull American Ginseng
bull Ashwagandha
bull Asian ginseng
bull Cordyceps
bull Reishi
bull Rhaponticum
bull Rhodiola
bull Schizandra
Make adrenal deposits
Adrenal tonic herbs
Exercise and Testosterone
Exercise helps (even in obese
men to raise) testosterone
Squats 4 sets of 10
reps increased
testosterone the
greatest
Treating Andropause Better sleep
Flavonoids
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
CAUSES of ANDROPAUSESTRESSeffect on adrenals
Precursor steal
ldquohellipChronically increased cortisol
level as seen during
prolonged stress may reduce
the functional activity of
leuteinizing hormonemdashrelease
hormone (LHRH) pulse
generator which may lead to
decrease in gonadotropin and
testosterone levelshelliprdquo
Science 1984 May
4224(4648)452-9
Stress hormones their
interaction and regulation
Axelrod J et al
Causes of Andropause
Obesity Estrogen cycle
ldquoMen with obesity
and Syndrome X
develop
low
Testosteronehelliprdquo
Adipokines increase
IL-6 which increases
inflammation and
decreases
testosterone
CAUSES of ANDROPAUSE
INSULIN RESISTANCEhttpimgmedscapecomarticle719489719489-fig14jpg
Even surgical loss of
fat increases
testosterone
Causes of Andropause
Prolactin and Andropausebull Physiologic levels of prolactin in males enhance in LH receptors in
Leydig cells resulting in testosterone secretion which leads to spermatogenesis
bull Highly elevated levels of prolactin decrease the levels of sex hormones mdashestrogen in women and Testosterone in men
bull Very Low Prolactin also effects serum testosterone
bull httpwwwmayocliniccomhealthprolactinomaDS00532
bull Gonzales GF Velasquez G Garcia-Hjarles M (1989) Hypoprolactinemia as related to seminal quality and serum testosterone Arch Androl 23 (3) 259ndash65 Rev Urol 2000 Winter 2(1) 39ndash42
bull Hyperprolactinemia and Erectile Dysfunction
bull Scott I Zeitlin MD Rev Urol 2000 Winter 2(1) 39ndash42
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Lay off the brew
bull The consumption of beer unlike other alcoholic beverages increases serum prolactin a hormone necessary for milk production but not good for andropausal men (Carlson Wasser amp Reidelberger 1985 De Rosa Corsello Ruffilli Della Casa amp Pasargiklian 1981 Grossman 1987)
Causes of Andropause
Aromatase activity
Caue of Andropause Elevations in SHBG review
of physiology
bull Sex hormone binding globulin (SHBG) is a glycoprotein which binds to human sex hormones These binding proteins are most often found bound to the primary male and female sex hormones
bull Major production of sex hormone binding globulin occurs in the liver but it may also be produced in the brainuterus testes and in the placenta during pregnancy
bull The function of this protein is to limit the levels of active unbound sex hormones in the body Very high or very low levels of the protein in the body can indicate a variety of health conditions in both women and men
bull Most sex hormones within the bloodstream are biochemically bound to sex hormone binding globulins Only a tiny portion of sex hormones are free and able to enter cells where they bind to hormone receptors Therefore the availability of sex hormones in the human body is directly linked to the amount of SHBG the body produces
bull When produced by the testes SHBG is instead known as an androgen-binding protein a protein that is produced in the Sertoli cells High levels of androgen-binding protein in the testes allow sperm cells to mature in spermatogenesis
Causes of ANDROPAUSE
5 apha reductase
5 alpha
reductase
CAUSES of Andropause
Toxinseffect on Testes
CAUSES of Andropause
Toxinseffect on Testeshttpwwwsiumededu~dbhaleslabimagesresear2gif
CAUSES of Andropause
Toxinseffect on Testeshttpwwwoneresultcomsitesdefaultfilesu3Prohormones20Chart_1png
Michael Phelps amp Co at high risk of low
testosterone
bull A 2011 paper that was
published in the
International Journal of
Andrology by Nickmilder
et al a clear-cut
association with early life
exposure to chlorinated
indoor-pool water and low
testosterone levels in
adolescence and
probably later in life
(Nickmilder 2011)
I wonder if
therersquos an
issue with
Bromine
too
Amaral S et al Front Biosci (Schol Ed) 2013 Jan 15181-97
Aging and male reproductive function
a mitochondrial perspective
bull Researching the effects of aging in the male reproductive system is not trivial Not only are multiple changes at molecular cellular and endocrine levels involved but any findings must be discussed with variable individual characteristics as well as with lifestyle and environmental factors Age-related changes in the reproductive system include any aspect of reproductive function from deregulation of the hypothalamic-pituitary-gonadal axis and of local autoparacrine interactions to effects on testicular stem cells defects in testicular architecture and spermatogenesis or sperm with decreased functionality Several theories place mitochondria at the hub of cellular events related to aging namely regarding the accumulation of oxidative damage to cells and tissues a process in which these organelles play a prominent role although alternative theories have also emerged However oxidative stress is not the only process involved in mitochondrial-related aging mitochondrial energy metabolism changes in mitochondrial DNA or in mitochondrial-dependent testosterone production are also important Crucially all these issues are likely interdependent We will review evidence that suggests that mitochondria constitute a common link between aging and fertility loss
Damage to Leydig cells cause low
testosterone
Are toxin avoidance antioxidants
and depuration a key
bull Biomed Environ Sci 2013 Jun26(6)474-84 doi 1039670895-3988201306008
bull Effects of Environmental Lead Pollution on Blood Lead and Sex Hormone Levels among Occupationally Exposed Group in An E-waste Dismantling Area
bull Yang Y Lu XS Li DL Yu YJ
bull Source
bull School of Environmental amp Safety Engineering Changzhou University Changzhou 213164 Jiangsu China
bull Abstract
bull OBJECTIVE
bull To study the effects of environmental multi-media lead pollution on blood lead and sex hormone levels among lead exposed males engaged in E-waste dismantling and the correlation between confounding factors and sex hormone levels
bull METHODS
bull An E-waste dismantling area in Taizhou of Zhejiang Province was selected as the research site One hundred and fifty two samples were collected from the groundwater soil rice corn chicken and pork in the dismantling area The effects of the multi-media lead pollution on the male blood lead and sex hormone levels of FSH LH and T as well as the correlation with confounding factors were studied
bull RESULTS
bull The blood lead concentrations in the males aged under 31 from 31 to 45 and from 46 to 60 were 9855 10023 and 10145 μgL respectively Of all the environmental media lead exposures the groundwater rice and soil were main contributing factors to the lead accumulation in humans FSH and LH levels increased with the age while the T levels decreased with the age instead There was a significant correlation between the FSH and LH levels and wearing masks
bull CONCLUSION
bull There was correlation between the FSH LH and T levels and the mean values of lead concentrations in environmental media and the sex hormone levels were correlated with the confounding factor of wearing masks
Workup up the Andropausal male Exam PEBlood SalivaUrine
BMI
Chemistry and health profile with all hormones VAP
Free Total and Bioavailable Testosterone amp DHT
Estradiol (Ultrasens)
DHEA Uncong and S
Cardivascular CRP and Homocysteine
Fibrinogen amp D-Dimer
Delta PSA amp Free to Total
Vit D and other Nutrients
IGF-1
bull LH and FSH
bull Prolactin
bull SHBG
bull Cortisol X 4
bull Neurotransmitters
bull Amino acids
bull Hair analysis
bull RBC mineral levels
bull Liver detox profile
bull Pregnenolone
bull Cytokine panel
bull Fasting GlusocseInsulin HAIC amp Fructosamine
Natural non-hormonal
interventions for
trteating the underlying
causes of Andropause
and Low T syndrome
Work on your patients response to the stressttpwwwcursoercomenwp-contentuploads201202people-man-stress-Fotolia_8150434_XSjpg
Put the Adrenals to
BedhellipBotanically
bull Mild relaxants
ndash Chamomila
ndash Vervain
ndash Oats (Avena)
ndash Motherwort
bull Stronger Relaxants
ndash Passiflora
ndash Scutellaria
ndash Valerian
ndash Humulus (Hops)
ndash Eschscholtzia
bull Potent relaxants
ndash Jamaican Dogwood
ndash Corydalis
ndash Wild lettuce
Nervine trophorestoratives
-- St Johnrsquos wort
ADAPTOGENS
bull David Winston in his book ADAPTOGENS Herbs for strength stamina and stress relief states the following lsquoadaptogens can be used for helping the body respond to an excess of adrenal hormones and prevent oxidation damage to the adrenalsrsquo
bull Eleuthero
bull American Ginseng
bull Ashwagandha
bull Asian ginseng
bull Cordyceps
bull Reishi
bull Rhaponticum
bull Rhodiola
bull Schizandra
Make adrenal deposits
Adrenal tonic herbs
Exercise and Testosterone
Exercise helps (even in obese
men to raise) testosterone
Squats 4 sets of 10
reps increased
testosterone the
greatest
Treating Andropause Better sleep
Flavonoids
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Causes of Andropause
Obesity Estrogen cycle
ldquoMen with obesity
and Syndrome X
develop
low
Testosteronehelliprdquo
Adipokines increase
IL-6 which increases
inflammation and
decreases
testosterone
CAUSES of ANDROPAUSE
INSULIN RESISTANCEhttpimgmedscapecomarticle719489719489-fig14jpg
Even surgical loss of
fat increases
testosterone
Causes of Andropause
Prolactin and Andropausebull Physiologic levels of prolactin in males enhance in LH receptors in
Leydig cells resulting in testosterone secretion which leads to spermatogenesis
bull Highly elevated levels of prolactin decrease the levels of sex hormones mdashestrogen in women and Testosterone in men
bull Very Low Prolactin also effects serum testosterone
bull httpwwwmayocliniccomhealthprolactinomaDS00532
bull Gonzales GF Velasquez G Garcia-Hjarles M (1989) Hypoprolactinemia as related to seminal quality and serum testosterone Arch Androl 23 (3) 259ndash65 Rev Urol 2000 Winter 2(1) 39ndash42
bull Hyperprolactinemia and Erectile Dysfunction
bull Scott I Zeitlin MD Rev Urol 2000 Winter 2(1) 39ndash42
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Lay off the brew
bull The consumption of beer unlike other alcoholic beverages increases serum prolactin a hormone necessary for milk production but not good for andropausal men (Carlson Wasser amp Reidelberger 1985 De Rosa Corsello Ruffilli Della Casa amp Pasargiklian 1981 Grossman 1987)
Causes of Andropause
Aromatase activity
Caue of Andropause Elevations in SHBG review
of physiology
bull Sex hormone binding globulin (SHBG) is a glycoprotein which binds to human sex hormones These binding proteins are most often found bound to the primary male and female sex hormones
bull Major production of sex hormone binding globulin occurs in the liver but it may also be produced in the brainuterus testes and in the placenta during pregnancy
bull The function of this protein is to limit the levels of active unbound sex hormones in the body Very high or very low levels of the protein in the body can indicate a variety of health conditions in both women and men
bull Most sex hormones within the bloodstream are biochemically bound to sex hormone binding globulins Only a tiny portion of sex hormones are free and able to enter cells where they bind to hormone receptors Therefore the availability of sex hormones in the human body is directly linked to the amount of SHBG the body produces
bull When produced by the testes SHBG is instead known as an androgen-binding protein a protein that is produced in the Sertoli cells High levels of androgen-binding protein in the testes allow sperm cells to mature in spermatogenesis
Causes of ANDROPAUSE
5 apha reductase
5 alpha
reductase
CAUSES of Andropause
Toxinseffect on Testes
CAUSES of Andropause
Toxinseffect on Testeshttpwwwsiumededu~dbhaleslabimagesresear2gif
CAUSES of Andropause
Toxinseffect on Testeshttpwwwoneresultcomsitesdefaultfilesu3Prohormones20Chart_1png
Michael Phelps amp Co at high risk of low
testosterone
bull A 2011 paper that was
published in the
International Journal of
Andrology by Nickmilder
et al a clear-cut
association with early life
exposure to chlorinated
indoor-pool water and low
testosterone levels in
adolescence and
probably later in life
(Nickmilder 2011)
I wonder if
therersquos an
issue with
Bromine
too
Amaral S et al Front Biosci (Schol Ed) 2013 Jan 15181-97
Aging and male reproductive function
a mitochondrial perspective
bull Researching the effects of aging in the male reproductive system is not trivial Not only are multiple changes at molecular cellular and endocrine levels involved but any findings must be discussed with variable individual characteristics as well as with lifestyle and environmental factors Age-related changes in the reproductive system include any aspect of reproductive function from deregulation of the hypothalamic-pituitary-gonadal axis and of local autoparacrine interactions to effects on testicular stem cells defects in testicular architecture and spermatogenesis or sperm with decreased functionality Several theories place mitochondria at the hub of cellular events related to aging namely regarding the accumulation of oxidative damage to cells and tissues a process in which these organelles play a prominent role although alternative theories have also emerged However oxidative stress is not the only process involved in mitochondrial-related aging mitochondrial energy metabolism changes in mitochondrial DNA or in mitochondrial-dependent testosterone production are also important Crucially all these issues are likely interdependent We will review evidence that suggests that mitochondria constitute a common link between aging and fertility loss
Damage to Leydig cells cause low
testosterone
Are toxin avoidance antioxidants
and depuration a key
bull Biomed Environ Sci 2013 Jun26(6)474-84 doi 1039670895-3988201306008
bull Effects of Environmental Lead Pollution on Blood Lead and Sex Hormone Levels among Occupationally Exposed Group in An E-waste Dismantling Area
bull Yang Y Lu XS Li DL Yu YJ
bull Source
bull School of Environmental amp Safety Engineering Changzhou University Changzhou 213164 Jiangsu China
bull Abstract
bull OBJECTIVE
bull To study the effects of environmental multi-media lead pollution on blood lead and sex hormone levels among lead exposed males engaged in E-waste dismantling and the correlation between confounding factors and sex hormone levels
bull METHODS
bull An E-waste dismantling area in Taizhou of Zhejiang Province was selected as the research site One hundred and fifty two samples were collected from the groundwater soil rice corn chicken and pork in the dismantling area The effects of the multi-media lead pollution on the male blood lead and sex hormone levels of FSH LH and T as well as the correlation with confounding factors were studied
bull RESULTS
bull The blood lead concentrations in the males aged under 31 from 31 to 45 and from 46 to 60 were 9855 10023 and 10145 μgL respectively Of all the environmental media lead exposures the groundwater rice and soil were main contributing factors to the lead accumulation in humans FSH and LH levels increased with the age while the T levels decreased with the age instead There was a significant correlation between the FSH and LH levels and wearing masks
bull CONCLUSION
bull There was correlation between the FSH LH and T levels and the mean values of lead concentrations in environmental media and the sex hormone levels were correlated with the confounding factor of wearing masks
Workup up the Andropausal male Exam PEBlood SalivaUrine
BMI
Chemistry and health profile with all hormones VAP
Free Total and Bioavailable Testosterone amp DHT
Estradiol (Ultrasens)
DHEA Uncong and S
Cardivascular CRP and Homocysteine
Fibrinogen amp D-Dimer
Delta PSA amp Free to Total
Vit D and other Nutrients
IGF-1
bull LH and FSH
bull Prolactin
bull SHBG
bull Cortisol X 4
bull Neurotransmitters
bull Amino acids
bull Hair analysis
bull RBC mineral levels
bull Liver detox profile
bull Pregnenolone
bull Cytokine panel
bull Fasting GlusocseInsulin HAIC amp Fructosamine
Natural non-hormonal
interventions for
trteating the underlying
causes of Andropause
and Low T syndrome
Work on your patients response to the stressttpwwwcursoercomenwp-contentuploads201202people-man-stress-Fotolia_8150434_XSjpg
Put the Adrenals to
BedhellipBotanically
bull Mild relaxants
ndash Chamomila
ndash Vervain
ndash Oats (Avena)
ndash Motherwort
bull Stronger Relaxants
ndash Passiflora
ndash Scutellaria
ndash Valerian
ndash Humulus (Hops)
ndash Eschscholtzia
bull Potent relaxants
ndash Jamaican Dogwood
ndash Corydalis
ndash Wild lettuce
Nervine trophorestoratives
-- St Johnrsquos wort
ADAPTOGENS
bull David Winston in his book ADAPTOGENS Herbs for strength stamina and stress relief states the following lsquoadaptogens can be used for helping the body respond to an excess of adrenal hormones and prevent oxidation damage to the adrenalsrsquo
bull Eleuthero
bull American Ginseng
bull Ashwagandha
bull Asian ginseng
bull Cordyceps
bull Reishi
bull Rhaponticum
bull Rhodiola
bull Schizandra
Make adrenal deposits
Adrenal tonic herbs
Exercise and Testosterone
Exercise helps (even in obese
men to raise) testosterone
Squats 4 sets of 10
reps increased
testosterone the
greatest
Treating Andropause Better sleep
Flavonoids
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Adipokines increase
IL-6 which increases
inflammation and
decreases
testosterone
CAUSES of ANDROPAUSE
INSULIN RESISTANCEhttpimgmedscapecomarticle719489719489-fig14jpg
Even surgical loss of
fat increases
testosterone
Causes of Andropause
Prolactin and Andropausebull Physiologic levels of prolactin in males enhance in LH receptors in
Leydig cells resulting in testosterone secretion which leads to spermatogenesis
bull Highly elevated levels of prolactin decrease the levels of sex hormones mdashestrogen in women and Testosterone in men
bull Very Low Prolactin also effects serum testosterone
bull httpwwwmayocliniccomhealthprolactinomaDS00532
bull Gonzales GF Velasquez G Garcia-Hjarles M (1989) Hypoprolactinemia as related to seminal quality and serum testosterone Arch Androl 23 (3) 259ndash65 Rev Urol 2000 Winter 2(1) 39ndash42
bull Hyperprolactinemia and Erectile Dysfunction
bull Scott I Zeitlin MD Rev Urol 2000 Winter 2(1) 39ndash42
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Lay off the brew
bull The consumption of beer unlike other alcoholic beverages increases serum prolactin a hormone necessary for milk production but not good for andropausal men (Carlson Wasser amp Reidelberger 1985 De Rosa Corsello Ruffilli Della Casa amp Pasargiklian 1981 Grossman 1987)
Causes of Andropause
Aromatase activity
Caue of Andropause Elevations in SHBG review
of physiology
bull Sex hormone binding globulin (SHBG) is a glycoprotein which binds to human sex hormones These binding proteins are most often found bound to the primary male and female sex hormones
bull Major production of sex hormone binding globulin occurs in the liver but it may also be produced in the brainuterus testes and in the placenta during pregnancy
bull The function of this protein is to limit the levels of active unbound sex hormones in the body Very high or very low levels of the protein in the body can indicate a variety of health conditions in both women and men
bull Most sex hormones within the bloodstream are biochemically bound to sex hormone binding globulins Only a tiny portion of sex hormones are free and able to enter cells where they bind to hormone receptors Therefore the availability of sex hormones in the human body is directly linked to the amount of SHBG the body produces
bull When produced by the testes SHBG is instead known as an androgen-binding protein a protein that is produced in the Sertoli cells High levels of androgen-binding protein in the testes allow sperm cells to mature in spermatogenesis
Causes of ANDROPAUSE
5 apha reductase
5 alpha
reductase
CAUSES of Andropause
Toxinseffect on Testes
CAUSES of Andropause
Toxinseffect on Testeshttpwwwsiumededu~dbhaleslabimagesresear2gif
CAUSES of Andropause
Toxinseffect on Testeshttpwwwoneresultcomsitesdefaultfilesu3Prohormones20Chart_1png
Michael Phelps amp Co at high risk of low
testosterone
bull A 2011 paper that was
published in the
International Journal of
Andrology by Nickmilder
et al a clear-cut
association with early life
exposure to chlorinated
indoor-pool water and low
testosterone levels in
adolescence and
probably later in life
(Nickmilder 2011)
I wonder if
therersquos an
issue with
Bromine
too
Amaral S et al Front Biosci (Schol Ed) 2013 Jan 15181-97
Aging and male reproductive function
a mitochondrial perspective
bull Researching the effects of aging in the male reproductive system is not trivial Not only are multiple changes at molecular cellular and endocrine levels involved but any findings must be discussed with variable individual characteristics as well as with lifestyle and environmental factors Age-related changes in the reproductive system include any aspect of reproductive function from deregulation of the hypothalamic-pituitary-gonadal axis and of local autoparacrine interactions to effects on testicular stem cells defects in testicular architecture and spermatogenesis or sperm with decreased functionality Several theories place mitochondria at the hub of cellular events related to aging namely regarding the accumulation of oxidative damage to cells and tissues a process in which these organelles play a prominent role although alternative theories have also emerged However oxidative stress is not the only process involved in mitochondrial-related aging mitochondrial energy metabolism changes in mitochondrial DNA or in mitochondrial-dependent testosterone production are also important Crucially all these issues are likely interdependent We will review evidence that suggests that mitochondria constitute a common link between aging and fertility loss
Damage to Leydig cells cause low
testosterone
Are toxin avoidance antioxidants
and depuration a key
bull Biomed Environ Sci 2013 Jun26(6)474-84 doi 1039670895-3988201306008
bull Effects of Environmental Lead Pollution on Blood Lead and Sex Hormone Levels among Occupationally Exposed Group in An E-waste Dismantling Area
bull Yang Y Lu XS Li DL Yu YJ
bull Source
bull School of Environmental amp Safety Engineering Changzhou University Changzhou 213164 Jiangsu China
bull Abstract
bull OBJECTIVE
bull To study the effects of environmental multi-media lead pollution on blood lead and sex hormone levels among lead exposed males engaged in E-waste dismantling and the correlation between confounding factors and sex hormone levels
bull METHODS
bull An E-waste dismantling area in Taizhou of Zhejiang Province was selected as the research site One hundred and fifty two samples were collected from the groundwater soil rice corn chicken and pork in the dismantling area The effects of the multi-media lead pollution on the male blood lead and sex hormone levels of FSH LH and T as well as the correlation with confounding factors were studied
bull RESULTS
bull The blood lead concentrations in the males aged under 31 from 31 to 45 and from 46 to 60 were 9855 10023 and 10145 μgL respectively Of all the environmental media lead exposures the groundwater rice and soil were main contributing factors to the lead accumulation in humans FSH and LH levels increased with the age while the T levels decreased with the age instead There was a significant correlation between the FSH and LH levels and wearing masks
bull CONCLUSION
bull There was correlation between the FSH LH and T levels and the mean values of lead concentrations in environmental media and the sex hormone levels were correlated with the confounding factor of wearing masks
Workup up the Andropausal male Exam PEBlood SalivaUrine
BMI
Chemistry and health profile with all hormones VAP
Free Total and Bioavailable Testosterone amp DHT
Estradiol (Ultrasens)
DHEA Uncong and S
Cardivascular CRP and Homocysteine
Fibrinogen amp D-Dimer
Delta PSA amp Free to Total
Vit D and other Nutrients
IGF-1
bull LH and FSH
bull Prolactin
bull SHBG
bull Cortisol X 4
bull Neurotransmitters
bull Amino acids
bull Hair analysis
bull RBC mineral levels
bull Liver detox profile
bull Pregnenolone
bull Cytokine panel
bull Fasting GlusocseInsulin HAIC amp Fructosamine
Natural non-hormonal
interventions for
trteating the underlying
causes of Andropause
and Low T syndrome
Work on your patients response to the stressttpwwwcursoercomenwp-contentuploads201202people-man-stress-Fotolia_8150434_XSjpg
Put the Adrenals to
BedhellipBotanically
bull Mild relaxants
ndash Chamomila
ndash Vervain
ndash Oats (Avena)
ndash Motherwort
bull Stronger Relaxants
ndash Passiflora
ndash Scutellaria
ndash Valerian
ndash Humulus (Hops)
ndash Eschscholtzia
bull Potent relaxants
ndash Jamaican Dogwood
ndash Corydalis
ndash Wild lettuce
Nervine trophorestoratives
-- St Johnrsquos wort
ADAPTOGENS
bull David Winston in his book ADAPTOGENS Herbs for strength stamina and stress relief states the following lsquoadaptogens can be used for helping the body respond to an excess of adrenal hormones and prevent oxidation damage to the adrenalsrsquo
bull Eleuthero
bull American Ginseng
bull Ashwagandha
bull Asian ginseng
bull Cordyceps
bull Reishi
bull Rhaponticum
bull Rhodiola
bull Schizandra
Make adrenal deposits
Adrenal tonic herbs
Exercise and Testosterone
Exercise helps (even in obese
men to raise) testosterone
Squats 4 sets of 10
reps increased
testosterone the
greatest
Treating Andropause Better sleep
Flavonoids
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
CAUSES of ANDROPAUSE
INSULIN RESISTANCEhttpimgmedscapecomarticle719489719489-fig14jpg
Even surgical loss of
fat increases
testosterone
Causes of Andropause
Prolactin and Andropausebull Physiologic levels of prolactin in males enhance in LH receptors in
Leydig cells resulting in testosterone secretion which leads to spermatogenesis
bull Highly elevated levels of prolactin decrease the levels of sex hormones mdashestrogen in women and Testosterone in men
bull Very Low Prolactin also effects serum testosterone
bull httpwwwmayocliniccomhealthprolactinomaDS00532
bull Gonzales GF Velasquez G Garcia-Hjarles M (1989) Hypoprolactinemia as related to seminal quality and serum testosterone Arch Androl 23 (3) 259ndash65 Rev Urol 2000 Winter 2(1) 39ndash42
bull Hyperprolactinemia and Erectile Dysfunction
bull Scott I Zeitlin MD Rev Urol 2000 Winter 2(1) 39ndash42
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Lay off the brew
bull The consumption of beer unlike other alcoholic beverages increases serum prolactin a hormone necessary for milk production but not good for andropausal men (Carlson Wasser amp Reidelberger 1985 De Rosa Corsello Ruffilli Della Casa amp Pasargiklian 1981 Grossman 1987)
Causes of Andropause
Aromatase activity
Caue of Andropause Elevations in SHBG review
of physiology
bull Sex hormone binding globulin (SHBG) is a glycoprotein which binds to human sex hormones These binding proteins are most often found bound to the primary male and female sex hormones
bull Major production of sex hormone binding globulin occurs in the liver but it may also be produced in the brainuterus testes and in the placenta during pregnancy
bull The function of this protein is to limit the levels of active unbound sex hormones in the body Very high or very low levels of the protein in the body can indicate a variety of health conditions in both women and men
bull Most sex hormones within the bloodstream are biochemically bound to sex hormone binding globulins Only a tiny portion of sex hormones are free and able to enter cells where they bind to hormone receptors Therefore the availability of sex hormones in the human body is directly linked to the amount of SHBG the body produces
bull When produced by the testes SHBG is instead known as an androgen-binding protein a protein that is produced in the Sertoli cells High levels of androgen-binding protein in the testes allow sperm cells to mature in spermatogenesis
Causes of ANDROPAUSE
5 apha reductase
5 alpha
reductase
CAUSES of Andropause
Toxinseffect on Testes
CAUSES of Andropause
Toxinseffect on Testeshttpwwwsiumededu~dbhaleslabimagesresear2gif
CAUSES of Andropause
Toxinseffect on Testeshttpwwwoneresultcomsitesdefaultfilesu3Prohormones20Chart_1png
Michael Phelps amp Co at high risk of low
testosterone
bull A 2011 paper that was
published in the
International Journal of
Andrology by Nickmilder
et al a clear-cut
association with early life
exposure to chlorinated
indoor-pool water and low
testosterone levels in
adolescence and
probably later in life
(Nickmilder 2011)
I wonder if
therersquos an
issue with
Bromine
too
Amaral S et al Front Biosci (Schol Ed) 2013 Jan 15181-97
Aging and male reproductive function
a mitochondrial perspective
bull Researching the effects of aging in the male reproductive system is not trivial Not only are multiple changes at molecular cellular and endocrine levels involved but any findings must be discussed with variable individual characteristics as well as with lifestyle and environmental factors Age-related changes in the reproductive system include any aspect of reproductive function from deregulation of the hypothalamic-pituitary-gonadal axis and of local autoparacrine interactions to effects on testicular stem cells defects in testicular architecture and spermatogenesis or sperm with decreased functionality Several theories place mitochondria at the hub of cellular events related to aging namely regarding the accumulation of oxidative damage to cells and tissues a process in which these organelles play a prominent role although alternative theories have also emerged However oxidative stress is not the only process involved in mitochondrial-related aging mitochondrial energy metabolism changes in mitochondrial DNA or in mitochondrial-dependent testosterone production are also important Crucially all these issues are likely interdependent We will review evidence that suggests that mitochondria constitute a common link between aging and fertility loss
Damage to Leydig cells cause low
testosterone
Are toxin avoidance antioxidants
and depuration a key
bull Biomed Environ Sci 2013 Jun26(6)474-84 doi 1039670895-3988201306008
bull Effects of Environmental Lead Pollution on Blood Lead and Sex Hormone Levels among Occupationally Exposed Group in An E-waste Dismantling Area
bull Yang Y Lu XS Li DL Yu YJ
bull Source
bull School of Environmental amp Safety Engineering Changzhou University Changzhou 213164 Jiangsu China
bull Abstract
bull OBJECTIVE
bull To study the effects of environmental multi-media lead pollution on blood lead and sex hormone levels among lead exposed males engaged in E-waste dismantling and the correlation between confounding factors and sex hormone levels
bull METHODS
bull An E-waste dismantling area in Taizhou of Zhejiang Province was selected as the research site One hundred and fifty two samples were collected from the groundwater soil rice corn chicken and pork in the dismantling area The effects of the multi-media lead pollution on the male blood lead and sex hormone levels of FSH LH and T as well as the correlation with confounding factors were studied
bull RESULTS
bull The blood lead concentrations in the males aged under 31 from 31 to 45 and from 46 to 60 were 9855 10023 and 10145 μgL respectively Of all the environmental media lead exposures the groundwater rice and soil were main contributing factors to the lead accumulation in humans FSH and LH levels increased with the age while the T levels decreased with the age instead There was a significant correlation between the FSH and LH levels and wearing masks
bull CONCLUSION
bull There was correlation between the FSH LH and T levels and the mean values of lead concentrations in environmental media and the sex hormone levels were correlated with the confounding factor of wearing masks
Workup up the Andropausal male Exam PEBlood SalivaUrine
BMI
Chemistry and health profile with all hormones VAP
Free Total and Bioavailable Testosterone amp DHT
Estradiol (Ultrasens)
DHEA Uncong and S
Cardivascular CRP and Homocysteine
Fibrinogen amp D-Dimer
Delta PSA amp Free to Total
Vit D and other Nutrients
IGF-1
bull LH and FSH
bull Prolactin
bull SHBG
bull Cortisol X 4
bull Neurotransmitters
bull Amino acids
bull Hair analysis
bull RBC mineral levels
bull Liver detox profile
bull Pregnenolone
bull Cytokine panel
bull Fasting GlusocseInsulin HAIC amp Fructosamine
Natural non-hormonal
interventions for
trteating the underlying
causes of Andropause
and Low T syndrome
Work on your patients response to the stressttpwwwcursoercomenwp-contentuploads201202people-man-stress-Fotolia_8150434_XSjpg
Put the Adrenals to
BedhellipBotanically
bull Mild relaxants
ndash Chamomila
ndash Vervain
ndash Oats (Avena)
ndash Motherwort
bull Stronger Relaxants
ndash Passiflora
ndash Scutellaria
ndash Valerian
ndash Humulus (Hops)
ndash Eschscholtzia
bull Potent relaxants
ndash Jamaican Dogwood
ndash Corydalis
ndash Wild lettuce
Nervine trophorestoratives
-- St Johnrsquos wort
ADAPTOGENS
bull David Winston in his book ADAPTOGENS Herbs for strength stamina and stress relief states the following lsquoadaptogens can be used for helping the body respond to an excess of adrenal hormones and prevent oxidation damage to the adrenalsrsquo
bull Eleuthero
bull American Ginseng
bull Ashwagandha
bull Asian ginseng
bull Cordyceps
bull Reishi
bull Rhaponticum
bull Rhodiola
bull Schizandra
Make adrenal deposits
Adrenal tonic herbs
Exercise and Testosterone
Exercise helps (even in obese
men to raise) testosterone
Squats 4 sets of 10
reps increased
testosterone the
greatest
Treating Andropause Better sleep
Flavonoids
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Even surgical loss of
fat increases
testosterone
Causes of Andropause
Prolactin and Andropausebull Physiologic levels of prolactin in males enhance in LH receptors in
Leydig cells resulting in testosterone secretion which leads to spermatogenesis
bull Highly elevated levels of prolactin decrease the levels of sex hormones mdashestrogen in women and Testosterone in men
bull Very Low Prolactin also effects serum testosterone
bull httpwwwmayocliniccomhealthprolactinomaDS00532
bull Gonzales GF Velasquez G Garcia-Hjarles M (1989) Hypoprolactinemia as related to seminal quality and serum testosterone Arch Androl 23 (3) 259ndash65 Rev Urol 2000 Winter 2(1) 39ndash42
bull Hyperprolactinemia and Erectile Dysfunction
bull Scott I Zeitlin MD Rev Urol 2000 Winter 2(1) 39ndash42
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Lay off the brew
bull The consumption of beer unlike other alcoholic beverages increases serum prolactin a hormone necessary for milk production but not good for andropausal men (Carlson Wasser amp Reidelberger 1985 De Rosa Corsello Ruffilli Della Casa amp Pasargiklian 1981 Grossman 1987)
Causes of Andropause
Aromatase activity
Caue of Andropause Elevations in SHBG review
of physiology
bull Sex hormone binding globulin (SHBG) is a glycoprotein which binds to human sex hormones These binding proteins are most often found bound to the primary male and female sex hormones
bull Major production of sex hormone binding globulin occurs in the liver but it may also be produced in the brainuterus testes and in the placenta during pregnancy
bull The function of this protein is to limit the levels of active unbound sex hormones in the body Very high or very low levels of the protein in the body can indicate a variety of health conditions in both women and men
bull Most sex hormones within the bloodstream are biochemically bound to sex hormone binding globulins Only a tiny portion of sex hormones are free and able to enter cells where they bind to hormone receptors Therefore the availability of sex hormones in the human body is directly linked to the amount of SHBG the body produces
bull When produced by the testes SHBG is instead known as an androgen-binding protein a protein that is produced in the Sertoli cells High levels of androgen-binding protein in the testes allow sperm cells to mature in spermatogenesis
Causes of ANDROPAUSE
5 apha reductase
5 alpha
reductase
CAUSES of Andropause
Toxinseffect on Testes
CAUSES of Andropause
Toxinseffect on Testeshttpwwwsiumededu~dbhaleslabimagesresear2gif
CAUSES of Andropause
Toxinseffect on Testeshttpwwwoneresultcomsitesdefaultfilesu3Prohormones20Chart_1png
Michael Phelps amp Co at high risk of low
testosterone
bull A 2011 paper that was
published in the
International Journal of
Andrology by Nickmilder
et al a clear-cut
association with early life
exposure to chlorinated
indoor-pool water and low
testosterone levels in
adolescence and
probably later in life
(Nickmilder 2011)
I wonder if
therersquos an
issue with
Bromine
too
Amaral S et al Front Biosci (Schol Ed) 2013 Jan 15181-97
Aging and male reproductive function
a mitochondrial perspective
bull Researching the effects of aging in the male reproductive system is not trivial Not only are multiple changes at molecular cellular and endocrine levels involved but any findings must be discussed with variable individual characteristics as well as with lifestyle and environmental factors Age-related changes in the reproductive system include any aspect of reproductive function from deregulation of the hypothalamic-pituitary-gonadal axis and of local autoparacrine interactions to effects on testicular stem cells defects in testicular architecture and spermatogenesis or sperm with decreased functionality Several theories place mitochondria at the hub of cellular events related to aging namely regarding the accumulation of oxidative damage to cells and tissues a process in which these organelles play a prominent role although alternative theories have also emerged However oxidative stress is not the only process involved in mitochondrial-related aging mitochondrial energy metabolism changes in mitochondrial DNA or in mitochondrial-dependent testosterone production are also important Crucially all these issues are likely interdependent We will review evidence that suggests that mitochondria constitute a common link between aging and fertility loss
Damage to Leydig cells cause low
testosterone
Are toxin avoidance antioxidants
and depuration a key
bull Biomed Environ Sci 2013 Jun26(6)474-84 doi 1039670895-3988201306008
bull Effects of Environmental Lead Pollution on Blood Lead and Sex Hormone Levels among Occupationally Exposed Group in An E-waste Dismantling Area
bull Yang Y Lu XS Li DL Yu YJ
bull Source
bull School of Environmental amp Safety Engineering Changzhou University Changzhou 213164 Jiangsu China
bull Abstract
bull OBJECTIVE
bull To study the effects of environmental multi-media lead pollution on blood lead and sex hormone levels among lead exposed males engaged in E-waste dismantling and the correlation between confounding factors and sex hormone levels
bull METHODS
bull An E-waste dismantling area in Taizhou of Zhejiang Province was selected as the research site One hundred and fifty two samples were collected from the groundwater soil rice corn chicken and pork in the dismantling area The effects of the multi-media lead pollution on the male blood lead and sex hormone levels of FSH LH and T as well as the correlation with confounding factors were studied
bull RESULTS
bull The blood lead concentrations in the males aged under 31 from 31 to 45 and from 46 to 60 were 9855 10023 and 10145 μgL respectively Of all the environmental media lead exposures the groundwater rice and soil were main contributing factors to the lead accumulation in humans FSH and LH levels increased with the age while the T levels decreased with the age instead There was a significant correlation between the FSH and LH levels and wearing masks
bull CONCLUSION
bull There was correlation between the FSH LH and T levels and the mean values of lead concentrations in environmental media and the sex hormone levels were correlated with the confounding factor of wearing masks
Workup up the Andropausal male Exam PEBlood SalivaUrine
BMI
Chemistry and health profile with all hormones VAP
Free Total and Bioavailable Testosterone amp DHT
Estradiol (Ultrasens)
DHEA Uncong and S
Cardivascular CRP and Homocysteine
Fibrinogen amp D-Dimer
Delta PSA amp Free to Total
Vit D and other Nutrients
IGF-1
bull LH and FSH
bull Prolactin
bull SHBG
bull Cortisol X 4
bull Neurotransmitters
bull Amino acids
bull Hair analysis
bull RBC mineral levels
bull Liver detox profile
bull Pregnenolone
bull Cytokine panel
bull Fasting GlusocseInsulin HAIC amp Fructosamine
Natural non-hormonal
interventions for
trteating the underlying
causes of Andropause
and Low T syndrome
Work on your patients response to the stressttpwwwcursoercomenwp-contentuploads201202people-man-stress-Fotolia_8150434_XSjpg
Put the Adrenals to
BedhellipBotanically
bull Mild relaxants
ndash Chamomila
ndash Vervain
ndash Oats (Avena)
ndash Motherwort
bull Stronger Relaxants
ndash Passiflora
ndash Scutellaria
ndash Valerian
ndash Humulus (Hops)
ndash Eschscholtzia
bull Potent relaxants
ndash Jamaican Dogwood
ndash Corydalis
ndash Wild lettuce
Nervine trophorestoratives
-- St Johnrsquos wort
ADAPTOGENS
bull David Winston in his book ADAPTOGENS Herbs for strength stamina and stress relief states the following lsquoadaptogens can be used for helping the body respond to an excess of adrenal hormones and prevent oxidation damage to the adrenalsrsquo
bull Eleuthero
bull American Ginseng
bull Ashwagandha
bull Asian ginseng
bull Cordyceps
bull Reishi
bull Rhaponticum
bull Rhodiola
bull Schizandra
Make adrenal deposits
Adrenal tonic herbs
Exercise and Testosterone
Exercise helps (even in obese
men to raise) testosterone
Squats 4 sets of 10
reps increased
testosterone the
greatest
Treating Andropause Better sleep
Flavonoids
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Causes of Andropause
Prolactin and Andropausebull Physiologic levels of prolactin in males enhance in LH receptors in
Leydig cells resulting in testosterone secretion which leads to spermatogenesis
bull Highly elevated levels of prolactin decrease the levels of sex hormones mdashestrogen in women and Testosterone in men
bull Very Low Prolactin also effects serum testosterone
bull httpwwwmayocliniccomhealthprolactinomaDS00532
bull Gonzales GF Velasquez G Garcia-Hjarles M (1989) Hypoprolactinemia as related to seminal quality and serum testosterone Arch Androl 23 (3) 259ndash65 Rev Urol 2000 Winter 2(1) 39ndash42
bull Hyperprolactinemia and Erectile Dysfunction
bull Scott I Zeitlin MD Rev Urol 2000 Winter 2(1) 39ndash42
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Lay off the brew
bull The consumption of beer unlike other alcoholic beverages increases serum prolactin a hormone necessary for milk production but not good for andropausal men (Carlson Wasser amp Reidelberger 1985 De Rosa Corsello Ruffilli Della Casa amp Pasargiklian 1981 Grossman 1987)
Causes of Andropause
Aromatase activity
Caue of Andropause Elevations in SHBG review
of physiology
bull Sex hormone binding globulin (SHBG) is a glycoprotein which binds to human sex hormones These binding proteins are most often found bound to the primary male and female sex hormones
bull Major production of sex hormone binding globulin occurs in the liver but it may also be produced in the brainuterus testes and in the placenta during pregnancy
bull The function of this protein is to limit the levels of active unbound sex hormones in the body Very high or very low levels of the protein in the body can indicate a variety of health conditions in both women and men
bull Most sex hormones within the bloodstream are biochemically bound to sex hormone binding globulins Only a tiny portion of sex hormones are free and able to enter cells where they bind to hormone receptors Therefore the availability of sex hormones in the human body is directly linked to the amount of SHBG the body produces
bull When produced by the testes SHBG is instead known as an androgen-binding protein a protein that is produced in the Sertoli cells High levels of androgen-binding protein in the testes allow sperm cells to mature in spermatogenesis
Causes of ANDROPAUSE
5 apha reductase
5 alpha
reductase
CAUSES of Andropause
Toxinseffect on Testes
CAUSES of Andropause
Toxinseffect on Testeshttpwwwsiumededu~dbhaleslabimagesresear2gif
CAUSES of Andropause
Toxinseffect on Testeshttpwwwoneresultcomsitesdefaultfilesu3Prohormones20Chart_1png
Michael Phelps amp Co at high risk of low
testosterone
bull A 2011 paper that was
published in the
International Journal of
Andrology by Nickmilder
et al a clear-cut
association with early life
exposure to chlorinated
indoor-pool water and low
testosterone levels in
adolescence and
probably later in life
(Nickmilder 2011)
I wonder if
therersquos an
issue with
Bromine
too
Amaral S et al Front Biosci (Schol Ed) 2013 Jan 15181-97
Aging and male reproductive function
a mitochondrial perspective
bull Researching the effects of aging in the male reproductive system is not trivial Not only are multiple changes at molecular cellular and endocrine levels involved but any findings must be discussed with variable individual characteristics as well as with lifestyle and environmental factors Age-related changes in the reproductive system include any aspect of reproductive function from deregulation of the hypothalamic-pituitary-gonadal axis and of local autoparacrine interactions to effects on testicular stem cells defects in testicular architecture and spermatogenesis or sperm with decreased functionality Several theories place mitochondria at the hub of cellular events related to aging namely regarding the accumulation of oxidative damage to cells and tissues a process in which these organelles play a prominent role although alternative theories have also emerged However oxidative stress is not the only process involved in mitochondrial-related aging mitochondrial energy metabolism changes in mitochondrial DNA or in mitochondrial-dependent testosterone production are also important Crucially all these issues are likely interdependent We will review evidence that suggests that mitochondria constitute a common link between aging and fertility loss
Damage to Leydig cells cause low
testosterone
Are toxin avoidance antioxidants
and depuration a key
bull Biomed Environ Sci 2013 Jun26(6)474-84 doi 1039670895-3988201306008
bull Effects of Environmental Lead Pollution on Blood Lead and Sex Hormone Levels among Occupationally Exposed Group in An E-waste Dismantling Area
bull Yang Y Lu XS Li DL Yu YJ
bull Source
bull School of Environmental amp Safety Engineering Changzhou University Changzhou 213164 Jiangsu China
bull Abstract
bull OBJECTIVE
bull To study the effects of environmental multi-media lead pollution on blood lead and sex hormone levels among lead exposed males engaged in E-waste dismantling and the correlation between confounding factors and sex hormone levels
bull METHODS
bull An E-waste dismantling area in Taizhou of Zhejiang Province was selected as the research site One hundred and fifty two samples were collected from the groundwater soil rice corn chicken and pork in the dismantling area The effects of the multi-media lead pollution on the male blood lead and sex hormone levels of FSH LH and T as well as the correlation with confounding factors were studied
bull RESULTS
bull The blood lead concentrations in the males aged under 31 from 31 to 45 and from 46 to 60 were 9855 10023 and 10145 μgL respectively Of all the environmental media lead exposures the groundwater rice and soil were main contributing factors to the lead accumulation in humans FSH and LH levels increased with the age while the T levels decreased with the age instead There was a significant correlation between the FSH and LH levels and wearing masks
bull CONCLUSION
bull There was correlation between the FSH LH and T levels and the mean values of lead concentrations in environmental media and the sex hormone levels were correlated with the confounding factor of wearing masks
Workup up the Andropausal male Exam PEBlood SalivaUrine
BMI
Chemistry and health profile with all hormones VAP
Free Total and Bioavailable Testosterone amp DHT
Estradiol (Ultrasens)
DHEA Uncong and S
Cardivascular CRP and Homocysteine
Fibrinogen amp D-Dimer
Delta PSA amp Free to Total
Vit D and other Nutrients
IGF-1
bull LH and FSH
bull Prolactin
bull SHBG
bull Cortisol X 4
bull Neurotransmitters
bull Amino acids
bull Hair analysis
bull RBC mineral levels
bull Liver detox profile
bull Pregnenolone
bull Cytokine panel
bull Fasting GlusocseInsulin HAIC amp Fructosamine
Natural non-hormonal
interventions for
trteating the underlying
causes of Andropause
and Low T syndrome
Work on your patients response to the stressttpwwwcursoercomenwp-contentuploads201202people-man-stress-Fotolia_8150434_XSjpg
Put the Adrenals to
BedhellipBotanically
bull Mild relaxants
ndash Chamomila
ndash Vervain
ndash Oats (Avena)
ndash Motherwort
bull Stronger Relaxants
ndash Passiflora
ndash Scutellaria
ndash Valerian
ndash Humulus (Hops)
ndash Eschscholtzia
bull Potent relaxants
ndash Jamaican Dogwood
ndash Corydalis
ndash Wild lettuce
Nervine trophorestoratives
-- St Johnrsquos wort
ADAPTOGENS
bull David Winston in his book ADAPTOGENS Herbs for strength stamina and stress relief states the following lsquoadaptogens can be used for helping the body respond to an excess of adrenal hormones and prevent oxidation damage to the adrenalsrsquo
bull Eleuthero
bull American Ginseng
bull Ashwagandha
bull Asian ginseng
bull Cordyceps
bull Reishi
bull Rhaponticum
bull Rhodiola
bull Schizandra
Make adrenal deposits
Adrenal tonic herbs
Exercise and Testosterone
Exercise helps (even in obese
men to raise) testosterone
Squats 4 sets of 10
reps increased
testosterone the
greatest
Treating Andropause Better sleep
Flavonoids
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Lay off the brew
bull The consumption of beer unlike other alcoholic beverages increases serum prolactin a hormone necessary for milk production but not good for andropausal men (Carlson Wasser amp Reidelberger 1985 De Rosa Corsello Ruffilli Della Casa amp Pasargiklian 1981 Grossman 1987)
Causes of Andropause
Aromatase activity
Caue of Andropause Elevations in SHBG review
of physiology
bull Sex hormone binding globulin (SHBG) is a glycoprotein which binds to human sex hormones These binding proteins are most often found bound to the primary male and female sex hormones
bull Major production of sex hormone binding globulin occurs in the liver but it may also be produced in the brainuterus testes and in the placenta during pregnancy
bull The function of this protein is to limit the levels of active unbound sex hormones in the body Very high or very low levels of the protein in the body can indicate a variety of health conditions in both women and men
bull Most sex hormones within the bloodstream are biochemically bound to sex hormone binding globulins Only a tiny portion of sex hormones are free and able to enter cells where they bind to hormone receptors Therefore the availability of sex hormones in the human body is directly linked to the amount of SHBG the body produces
bull When produced by the testes SHBG is instead known as an androgen-binding protein a protein that is produced in the Sertoli cells High levels of androgen-binding protein in the testes allow sperm cells to mature in spermatogenesis
Causes of ANDROPAUSE
5 apha reductase
5 alpha
reductase
CAUSES of Andropause
Toxinseffect on Testes
CAUSES of Andropause
Toxinseffect on Testeshttpwwwsiumededu~dbhaleslabimagesresear2gif
CAUSES of Andropause
Toxinseffect on Testeshttpwwwoneresultcomsitesdefaultfilesu3Prohormones20Chart_1png
Michael Phelps amp Co at high risk of low
testosterone
bull A 2011 paper that was
published in the
International Journal of
Andrology by Nickmilder
et al a clear-cut
association with early life
exposure to chlorinated
indoor-pool water and low
testosterone levels in
adolescence and
probably later in life
(Nickmilder 2011)
I wonder if
therersquos an
issue with
Bromine
too
Amaral S et al Front Biosci (Schol Ed) 2013 Jan 15181-97
Aging and male reproductive function
a mitochondrial perspective
bull Researching the effects of aging in the male reproductive system is not trivial Not only are multiple changes at molecular cellular and endocrine levels involved but any findings must be discussed with variable individual characteristics as well as with lifestyle and environmental factors Age-related changes in the reproductive system include any aspect of reproductive function from deregulation of the hypothalamic-pituitary-gonadal axis and of local autoparacrine interactions to effects on testicular stem cells defects in testicular architecture and spermatogenesis or sperm with decreased functionality Several theories place mitochondria at the hub of cellular events related to aging namely regarding the accumulation of oxidative damage to cells and tissues a process in which these organelles play a prominent role although alternative theories have also emerged However oxidative stress is not the only process involved in mitochondrial-related aging mitochondrial energy metabolism changes in mitochondrial DNA or in mitochondrial-dependent testosterone production are also important Crucially all these issues are likely interdependent We will review evidence that suggests that mitochondria constitute a common link between aging and fertility loss
Damage to Leydig cells cause low
testosterone
Are toxin avoidance antioxidants
and depuration a key
bull Biomed Environ Sci 2013 Jun26(6)474-84 doi 1039670895-3988201306008
bull Effects of Environmental Lead Pollution on Blood Lead and Sex Hormone Levels among Occupationally Exposed Group in An E-waste Dismantling Area
bull Yang Y Lu XS Li DL Yu YJ
bull Source
bull School of Environmental amp Safety Engineering Changzhou University Changzhou 213164 Jiangsu China
bull Abstract
bull OBJECTIVE
bull To study the effects of environmental multi-media lead pollution on blood lead and sex hormone levels among lead exposed males engaged in E-waste dismantling and the correlation between confounding factors and sex hormone levels
bull METHODS
bull An E-waste dismantling area in Taizhou of Zhejiang Province was selected as the research site One hundred and fifty two samples were collected from the groundwater soil rice corn chicken and pork in the dismantling area The effects of the multi-media lead pollution on the male blood lead and sex hormone levels of FSH LH and T as well as the correlation with confounding factors were studied
bull RESULTS
bull The blood lead concentrations in the males aged under 31 from 31 to 45 and from 46 to 60 were 9855 10023 and 10145 μgL respectively Of all the environmental media lead exposures the groundwater rice and soil were main contributing factors to the lead accumulation in humans FSH and LH levels increased with the age while the T levels decreased with the age instead There was a significant correlation between the FSH and LH levels and wearing masks
bull CONCLUSION
bull There was correlation between the FSH LH and T levels and the mean values of lead concentrations in environmental media and the sex hormone levels were correlated with the confounding factor of wearing masks
Workup up the Andropausal male Exam PEBlood SalivaUrine
BMI
Chemistry and health profile with all hormones VAP
Free Total and Bioavailable Testosterone amp DHT
Estradiol (Ultrasens)
DHEA Uncong and S
Cardivascular CRP and Homocysteine
Fibrinogen amp D-Dimer
Delta PSA amp Free to Total
Vit D and other Nutrients
IGF-1
bull LH and FSH
bull Prolactin
bull SHBG
bull Cortisol X 4
bull Neurotransmitters
bull Amino acids
bull Hair analysis
bull RBC mineral levels
bull Liver detox profile
bull Pregnenolone
bull Cytokine panel
bull Fasting GlusocseInsulin HAIC amp Fructosamine
Natural non-hormonal
interventions for
trteating the underlying
causes of Andropause
and Low T syndrome
Work on your patients response to the stressttpwwwcursoercomenwp-contentuploads201202people-man-stress-Fotolia_8150434_XSjpg
Put the Adrenals to
BedhellipBotanically
bull Mild relaxants
ndash Chamomila
ndash Vervain
ndash Oats (Avena)
ndash Motherwort
bull Stronger Relaxants
ndash Passiflora
ndash Scutellaria
ndash Valerian
ndash Humulus (Hops)
ndash Eschscholtzia
bull Potent relaxants
ndash Jamaican Dogwood
ndash Corydalis
ndash Wild lettuce
Nervine trophorestoratives
-- St Johnrsquos wort
ADAPTOGENS
bull David Winston in his book ADAPTOGENS Herbs for strength stamina and stress relief states the following lsquoadaptogens can be used for helping the body respond to an excess of adrenal hormones and prevent oxidation damage to the adrenalsrsquo
bull Eleuthero
bull American Ginseng
bull Ashwagandha
bull Asian ginseng
bull Cordyceps
bull Reishi
bull Rhaponticum
bull Rhodiola
bull Schizandra
Make adrenal deposits
Adrenal tonic herbs
Exercise and Testosterone
Exercise helps (even in obese
men to raise) testosterone
Squats 4 sets of 10
reps increased
testosterone the
greatest
Treating Andropause Better sleep
Flavonoids
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Lay off the brew
bull The consumption of beer unlike other alcoholic beverages increases serum prolactin a hormone necessary for milk production but not good for andropausal men (Carlson Wasser amp Reidelberger 1985 De Rosa Corsello Ruffilli Della Casa amp Pasargiklian 1981 Grossman 1987)
Causes of Andropause
Aromatase activity
Caue of Andropause Elevations in SHBG review
of physiology
bull Sex hormone binding globulin (SHBG) is a glycoprotein which binds to human sex hormones These binding proteins are most often found bound to the primary male and female sex hormones
bull Major production of sex hormone binding globulin occurs in the liver but it may also be produced in the brainuterus testes and in the placenta during pregnancy
bull The function of this protein is to limit the levels of active unbound sex hormones in the body Very high or very low levels of the protein in the body can indicate a variety of health conditions in both women and men
bull Most sex hormones within the bloodstream are biochemically bound to sex hormone binding globulins Only a tiny portion of sex hormones are free and able to enter cells where they bind to hormone receptors Therefore the availability of sex hormones in the human body is directly linked to the amount of SHBG the body produces
bull When produced by the testes SHBG is instead known as an androgen-binding protein a protein that is produced in the Sertoli cells High levels of androgen-binding protein in the testes allow sperm cells to mature in spermatogenesis
Causes of ANDROPAUSE
5 apha reductase
5 alpha
reductase
CAUSES of Andropause
Toxinseffect on Testes
CAUSES of Andropause
Toxinseffect on Testeshttpwwwsiumededu~dbhaleslabimagesresear2gif
CAUSES of Andropause
Toxinseffect on Testeshttpwwwoneresultcomsitesdefaultfilesu3Prohormones20Chart_1png
Michael Phelps amp Co at high risk of low
testosterone
bull A 2011 paper that was
published in the
International Journal of
Andrology by Nickmilder
et al a clear-cut
association with early life
exposure to chlorinated
indoor-pool water and low
testosterone levels in
adolescence and
probably later in life
(Nickmilder 2011)
I wonder if
therersquos an
issue with
Bromine
too
Amaral S et al Front Biosci (Schol Ed) 2013 Jan 15181-97
Aging and male reproductive function
a mitochondrial perspective
bull Researching the effects of aging in the male reproductive system is not trivial Not only are multiple changes at molecular cellular and endocrine levels involved but any findings must be discussed with variable individual characteristics as well as with lifestyle and environmental factors Age-related changes in the reproductive system include any aspect of reproductive function from deregulation of the hypothalamic-pituitary-gonadal axis and of local autoparacrine interactions to effects on testicular stem cells defects in testicular architecture and spermatogenesis or sperm with decreased functionality Several theories place mitochondria at the hub of cellular events related to aging namely regarding the accumulation of oxidative damage to cells and tissues a process in which these organelles play a prominent role although alternative theories have also emerged However oxidative stress is not the only process involved in mitochondrial-related aging mitochondrial energy metabolism changes in mitochondrial DNA or in mitochondrial-dependent testosterone production are also important Crucially all these issues are likely interdependent We will review evidence that suggests that mitochondria constitute a common link between aging and fertility loss
Damage to Leydig cells cause low
testosterone
Are toxin avoidance antioxidants
and depuration a key
bull Biomed Environ Sci 2013 Jun26(6)474-84 doi 1039670895-3988201306008
bull Effects of Environmental Lead Pollution on Blood Lead and Sex Hormone Levels among Occupationally Exposed Group in An E-waste Dismantling Area
bull Yang Y Lu XS Li DL Yu YJ
bull Source
bull School of Environmental amp Safety Engineering Changzhou University Changzhou 213164 Jiangsu China
bull Abstract
bull OBJECTIVE
bull To study the effects of environmental multi-media lead pollution on blood lead and sex hormone levels among lead exposed males engaged in E-waste dismantling and the correlation between confounding factors and sex hormone levels
bull METHODS
bull An E-waste dismantling area in Taizhou of Zhejiang Province was selected as the research site One hundred and fifty two samples were collected from the groundwater soil rice corn chicken and pork in the dismantling area The effects of the multi-media lead pollution on the male blood lead and sex hormone levels of FSH LH and T as well as the correlation with confounding factors were studied
bull RESULTS
bull The blood lead concentrations in the males aged under 31 from 31 to 45 and from 46 to 60 were 9855 10023 and 10145 μgL respectively Of all the environmental media lead exposures the groundwater rice and soil were main contributing factors to the lead accumulation in humans FSH and LH levels increased with the age while the T levels decreased with the age instead There was a significant correlation between the FSH and LH levels and wearing masks
bull CONCLUSION
bull There was correlation between the FSH LH and T levels and the mean values of lead concentrations in environmental media and the sex hormone levels were correlated with the confounding factor of wearing masks
Workup up the Andropausal male Exam PEBlood SalivaUrine
BMI
Chemistry and health profile with all hormones VAP
Free Total and Bioavailable Testosterone amp DHT
Estradiol (Ultrasens)
DHEA Uncong and S
Cardivascular CRP and Homocysteine
Fibrinogen amp D-Dimer
Delta PSA amp Free to Total
Vit D and other Nutrients
IGF-1
bull LH and FSH
bull Prolactin
bull SHBG
bull Cortisol X 4
bull Neurotransmitters
bull Amino acids
bull Hair analysis
bull RBC mineral levels
bull Liver detox profile
bull Pregnenolone
bull Cytokine panel
bull Fasting GlusocseInsulin HAIC amp Fructosamine
Natural non-hormonal
interventions for
trteating the underlying
causes of Andropause
and Low T syndrome
Work on your patients response to the stressttpwwwcursoercomenwp-contentuploads201202people-man-stress-Fotolia_8150434_XSjpg
Put the Adrenals to
BedhellipBotanically
bull Mild relaxants
ndash Chamomila
ndash Vervain
ndash Oats (Avena)
ndash Motherwort
bull Stronger Relaxants
ndash Passiflora
ndash Scutellaria
ndash Valerian
ndash Humulus (Hops)
ndash Eschscholtzia
bull Potent relaxants
ndash Jamaican Dogwood
ndash Corydalis
ndash Wild lettuce
Nervine trophorestoratives
-- St Johnrsquos wort
ADAPTOGENS
bull David Winston in his book ADAPTOGENS Herbs for strength stamina and stress relief states the following lsquoadaptogens can be used for helping the body respond to an excess of adrenal hormones and prevent oxidation damage to the adrenalsrsquo
bull Eleuthero
bull American Ginseng
bull Ashwagandha
bull Asian ginseng
bull Cordyceps
bull Reishi
bull Rhaponticum
bull Rhodiola
bull Schizandra
Make adrenal deposits
Adrenal tonic herbs
Exercise and Testosterone
Exercise helps (even in obese
men to raise) testosterone
Squats 4 sets of 10
reps increased
testosterone the
greatest
Treating Andropause Better sleep
Flavonoids
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Causes of Andropause
Aromatase activity
Caue of Andropause Elevations in SHBG review
of physiology
bull Sex hormone binding globulin (SHBG) is a glycoprotein which binds to human sex hormones These binding proteins are most often found bound to the primary male and female sex hormones
bull Major production of sex hormone binding globulin occurs in the liver but it may also be produced in the brainuterus testes and in the placenta during pregnancy
bull The function of this protein is to limit the levels of active unbound sex hormones in the body Very high or very low levels of the protein in the body can indicate a variety of health conditions in both women and men
bull Most sex hormones within the bloodstream are biochemically bound to sex hormone binding globulins Only a tiny portion of sex hormones are free and able to enter cells where they bind to hormone receptors Therefore the availability of sex hormones in the human body is directly linked to the amount of SHBG the body produces
bull When produced by the testes SHBG is instead known as an androgen-binding protein a protein that is produced in the Sertoli cells High levels of androgen-binding protein in the testes allow sperm cells to mature in spermatogenesis
Causes of ANDROPAUSE
5 apha reductase
5 alpha
reductase
CAUSES of Andropause
Toxinseffect on Testes
CAUSES of Andropause
Toxinseffect on Testeshttpwwwsiumededu~dbhaleslabimagesresear2gif
CAUSES of Andropause
Toxinseffect on Testeshttpwwwoneresultcomsitesdefaultfilesu3Prohormones20Chart_1png
Michael Phelps amp Co at high risk of low
testosterone
bull A 2011 paper that was
published in the
International Journal of
Andrology by Nickmilder
et al a clear-cut
association with early life
exposure to chlorinated
indoor-pool water and low
testosterone levels in
adolescence and
probably later in life
(Nickmilder 2011)
I wonder if
therersquos an
issue with
Bromine
too
Amaral S et al Front Biosci (Schol Ed) 2013 Jan 15181-97
Aging and male reproductive function
a mitochondrial perspective
bull Researching the effects of aging in the male reproductive system is not trivial Not only are multiple changes at molecular cellular and endocrine levels involved but any findings must be discussed with variable individual characteristics as well as with lifestyle and environmental factors Age-related changes in the reproductive system include any aspect of reproductive function from deregulation of the hypothalamic-pituitary-gonadal axis and of local autoparacrine interactions to effects on testicular stem cells defects in testicular architecture and spermatogenesis or sperm with decreased functionality Several theories place mitochondria at the hub of cellular events related to aging namely regarding the accumulation of oxidative damage to cells and tissues a process in which these organelles play a prominent role although alternative theories have also emerged However oxidative stress is not the only process involved in mitochondrial-related aging mitochondrial energy metabolism changes in mitochondrial DNA or in mitochondrial-dependent testosterone production are also important Crucially all these issues are likely interdependent We will review evidence that suggests that mitochondria constitute a common link between aging and fertility loss
Damage to Leydig cells cause low
testosterone
Are toxin avoidance antioxidants
and depuration a key
bull Biomed Environ Sci 2013 Jun26(6)474-84 doi 1039670895-3988201306008
bull Effects of Environmental Lead Pollution on Blood Lead and Sex Hormone Levels among Occupationally Exposed Group in An E-waste Dismantling Area
bull Yang Y Lu XS Li DL Yu YJ
bull Source
bull School of Environmental amp Safety Engineering Changzhou University Changzhou 213164 Jiangsu China
bull Abstract
bull OBJECTIVE
bull To study the effects of environmental multi-media lead pollution on blood lead and sex hormone levels among lead exposed males engaged in E-waste dismantling and the correlation between confounding factors and sex hormone levels
bull METHODS
bull An E-waste dismantling area in Taizhou of Zhejiang Province was selected as the research site One hundred and fifty two samples were collected from the groundwater soil rice corn chicken and pork in the dismantling area The effects of the multi-media lead pollution on the male blood lead and sex hormone levels of FSH LH and T as well as the correlation with confounding factors were studied
bull RESULTS
bull The blood lead concentrations in the males aged under 31 from 31 to 45 and from 46 to 60 were 9855 10023 and 10145 μgL respectively Of all the environmental media lead exposures the groundwater rice and soil were main contributing factors to the lead accumulation in humans FSH and LH levels increased with the age while the T levels decreased with the age instead There was a significant correlation between the FSH and LH levels and wearing masks
bull CONCLUSION
bull There was correlation between the FSH LH and T levels and the mean values of lead concentrations in environmental media and the sex hormone levels were correlated with the confounding factor of wearing masks
Workup up the Andropausal male Exam PEBlood SalivaUrine
BMI
Chemistry and health profile with all hormones VAP
Free Total and Bioavailable Testosterone amp DHT
Estradiol (Ultrasens)
DHEA Uncong and S
Cardivascular CRP and Homocysteine
Fibrinogen amp D-Dimer
Delta PSA amp Free to Total
Vit D and other Nutrients
IGF-1
bull LH and FSH
bull Prolactin
bull SHBG
bull Cortisol X 4
bull Neurotransmitters
bull Amino acids
bull Hair analysis
bull RBC mineral levels
bull Liver detox profile
bull Pregnenolone
bull Cytokine panel
bull Fasting GlusocseInsulin HAIC amp Fructosamine
Natural non-hormonal
interventions for
trteating the underlying
causes of Andropause
and Low T syndrome
Work on your patients response to the stressttpwwwcursoercomenwp-contentuploads201202people-man-stress-Fotolia_8150434_XSjpg
Put the Adrenals to
BedhellipBotanically
bull Mild relaxants
ndash Chamomila
ndash Vervain
ndash Oats (Avena)
ndash Motherwort
bull Stronger Relaxants
ndash Passiflora
ndash Scutellaria
ndash Valerian
ndash Humulus (Hops)
ndash Eschscholtzia
bull Potent relaxants
ndash Jamaican Dogwood
ndash Corydalis
ndash Wild lettuce
Nervine trophorestoratives
-- St Johnrsquos wort
ADAPTOGENS
bull David Winston in his book ADAPTOGENS Herbs for strength stamina and stress relief states the following lsquoadaptogens can be used for helping the body respond to an excess of adrenal hormones and prevent oxidation damage to the adrenalsrsquo
bull Eleuthero
bull American Ginseng
bull Ashwagandha
bull Asian ginseng
bull Cordyceps
bull Reishi
bull Rhaponticum
bull Rhodiola
bull Schizandra
Make adrenal deposits
Adrenal tonic herbs
Exercise and Testosterone
Exercise helps (even in obese
men to raise) testosterone
Squats 4 sets of 10
reps increased
testosterone the
greatest
Treating Andropause Better sleep
Flavonoids
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Caue of Andropause Elevations in SHBG review
of physiology
bull Sex hormone binding globulin (SHBG) is a glycoprotein which binds to human sex hormones These binding proteins are most often found bound to the primary male and female sex hormones
bull Major production of sex hormone binding globulin occurs in the liver but it may also be produced in the brainuterus testes and in the placenta during pregnancy
bull The function of this protein is to limit the levels of active unbound sex hormones in the body Very high or very low levels of the protein in the body can indicate a variety of health conditions in both women and men
bull Most sex hormones within the bloodstream are biochemically bound to sex hormone binding globulins Only a tiny portion of sex hormones are free and able to enter cells where they bind to hormone receptors Therefore the availability of sex hormones in the human body is directly linked to the amount of SHBG the body produces
bull When produced by the testes SHBG is instead known as an androgen-binding protein a protein that is produced in the Sertoli cells High levels of androgen-binding protein in the testes allow sperm cells to mature in spermatogenesis
Causes of ANDROPAUSE
5 apha reductase
5 alpha
reductase
CAUSES of Andropause
Toxinseffect on Testes
CAUSES of Andropause
Toxinseffect on Testeshttpwwwsiumededu~dbhaleslabimagesresear2gif
CAUSES of Andropause
Toxinseffect on Testeshttpwwwoneresultcomsitesdefaultfilesu3Prohormones20Chart_1png
Michael Phelps amp Co at high risk of low
testosterone
bull A 2011 paper that was
published in the
International Journal of
Andrology by Nickmilder
et al a clear-cut
association with early life
exposure to chlorinated
indoor-pool water and low
testosterone levels in
adolescence and
probably later in life
(Nickmilder 2011)
I wonder if
therersquos an
issue with
Bromine
too
Amaral S et al Front Biosci (Schol Ed) 2013 Jan 15181-97
Aging and male reproductive function
a mitochondrial perspective
bull Researching the effects of aging in the male reproductive system is not trivial Not only are multiple changes at molecular cellular and endocrine levels involved but any findings must be discussed with variable individual characteristics as well as with lifestyle and environmental factors Age-related changes in the reproductive system include any aspect of reproductive function from deregulation of the hypothalamic-pituitary-gonadal axis and of local autoparacrine interactions to effects on testicular stem cells defects in testicular architecture and spermatogenesis or sperm with decreased functionality Several theories place mitochondria at the hub of cellular events related to aging namely regarding the accumulation of oxidative damage to cells and tissues a process in which these organelles play a prominent role although alternative theories have also emerged However oxidative stress is not the only process involved in mitochondrial-related aging mitochondrial energy metabolism changes in mitochondrial DNA or in mitochondrial-dependent testosterone production are also important Crucially all these issues are likely interdependent We will review evidence that suggests that mitochondria constitute a common link between aging and fertility loss
Damage to Leydig cells cause low
testosterone
Are toxin avoidance antioxidants
and depuration a key
bull Biomed Environ Sci 2013 Jun26(6)474-84 doi 1039670895-3988201306008
bull Effects of Environmental Lead Pollution on Blood Lead and Sex Hormone Levels among Occupationally Exposed Group in An E-waste Dismantling Area
bull Yang Y Lu XS Li DL Yu YJ
bull Source
bull School of Environmental amp Safety Engineering Changzhou University Changzhou 213164 Jiangsu China
bull Abstract
bull OBJECTIVE
bull To study the effects of environmental multi-media lead pollution on blood lead and sex hormone levels among lead exposed males engaged in E-waste dismantling and the correlation between confounding factors and sex hormone levels
bull METHODS
bull An E-waste dismantling area in Taizhou of Zhejiang Province was selected as the research site One hundred and fifty two samples were collected from the groundwater soil rice corn chicken and pork in the dismantling area The effects of the multi-media lead pollution on the male blood lead and sex hormone levels of FSH LH and T as well as the correlation with confounding factors were studied
bull RESULTS
bull The blood lead concentrations in the males aged under 31 from 31 to 45 and from 46 to 60 were 9855 10023 and 10145 μgL respectively Of all the environmental media lead exposures the groundwater rice and soil were main contributing factors to the lead accumulation in humans FSH and LH levels increased with the age while the T levels decreased with the age instead There was a significant correlation between the FSH and LH levels and wearing masks
bull CONCLUSION
bull There was correlation between the FSH LH and T levels and the mean values of lead concentrations in environmental media and the sex hormone levels were correlated with the confounding factor of wearing masks
Workup up the Andropausal male Exam PEBlood SalivaUrine
BMI
Chemistry and health profile with all hormones VAP
Free Total and Bioavailable Testosterone amp DHT
Estradiol (Ultrasens)
DHEA Uncong and S
Cardivascular CRP and Homocysteine
Fibrinogen amp D-Dimer
Delta PSA amp Free to Total
Vit D and other Nutrients
IGF-1
bull LH and FSH
bull Prolactin
bull SHBG
bull Cortisol X 4
bull Neurotransmitters
bull Amino acids
bull Hair analysis
bull RBC mineral levels
bull Liver detox profile
bull Pregnenolone
bull Cytokine panel
bull Fasting GlusocseInsulin HAIC amp Fructosamine
Natural non-hormonal
interventions for
trteating the underlying
causes of Andropause
and Low T syndrome
Work on your patients response to the stressttpwwwcursoercomenwp-contentuploads201202people-man-stress-Fotolia_8150434_XSjpg
Put the Adrenals to
BedhellipBotanically
bull Mild relaxants
ndash Chamomila
ndash Vervain
ndash Oats (Avena)
ndash Motherwort
bull Stronger Relaxants
ndash Passiflora
ndash Scutellaria
ndash Valerian
ndash Humulus (Hops)
ndash Eschscholtzia
bull Potent relaxants
ndash Jamaican Dogwood
ndash Corydalis
ndash Wild lettuce
Nervine trophorestoratives
-- St Johnrsquos wort
ADAPTOGENS
bull David Winston in his book ADAPTOGENS Herbs for strength stamina and stress relief states the following lsquoadaptogens can be used for helping the body respond to an excess of adrenal hormones and prevent oxidation damage to the adrenalsrsquo
bull Eleuthero
bull American Ginseng
bull Ashwagandha
bull Asian ginseng
bull Cordyceps
bull Reishi
bull Rhaponticum
bull Rhodiola
bull Schizandra
Make adrenal deposits
Adrenal tonic herbs
Exercise and Testosterone
Exercise helps (even in obese
men to raise) testosterone
Squats 4 sets of 10
reps increased
testosterone the
greatest
Treating Andropause Better sleep
Flavonoids
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Causes of ANDROPAUSE
5 apha reductase
5 alpha
reductase
CAUSES of Andropause
Toxinseffect on Testes
CAUSES of Andropause
Toxinseffect on Testeshttpwwwsiumededu~dbhaleslabimagesresear2gif
CAUSES of Andropause
Toxinseffect on Testeshttpwwwoneresultcomsitesdefaultfilesu3Prohormones20Chart_1png
Michael Phelps amp Co at high risk of low
testosterone
bull A 2011 paper that was
published in the
International Journal of
Andrology by Nickmilder
et al a clear-cut
association with early life
exposure to chlorinated
indoor-pool water and low
testosterone levels in
adolescence and
probably later in life
(Nickmilder 2011)
I wonder if
therersquos an
issue with
Bromine
too
Amaral S et al Front Biosci (Schol Ed) 2013 Jan 15181-97
Aging and male reproductive function
a mitochondrial perspective
bull Researching the effects of aging in the male reproductive system is not trivial Not only are multiple changes at molecular cellular and endocrine levels involved but any findings must be discussed with variable individual characteristics as well as with lifestyle and environmental factors Age-related changes in the reproductive system include any aspect of reproductive function from deregulation of the hypothalamic-pituitary-gonadal axis and of local autoparacrine interactions to effects on testicular stem cells defects in testicular architecture and spermatogenesis or sperm with decreased functionality Several theories place mitochondria at the hub of cellular events related to aging namely regarding the accumulation of oxidative damage to cells and tissues a process in which these organelles play a prominent role although alternative theories have also emerged However oxidative stress is not the only process involved in mitochondrial-related aging mitochondrial energy metabolism changes in mitochondrial DNA or in mitochondrial-dependent testosterone production are also important Crucially all these issues are likely interdependent We will review evidence that suggests that mitochondria constitute a common link between aging and fertility loss
Damage to Leydig cells cause low
testosterone
Are toxin avoidance antioxidants
and depuration a key
bull Biomed Environ Sci 2013 Jun26(6)474-84 doi 1039670895-3988201306008
bull Effects of Environmental Lead Pollution on Blood Lead and Sex Hormone Levels among Occupationally Exposed Group in An E-waste Dismantling Area
bull Yang Y Lu XS Li DL Yu YJ
bull Source
bull School of Environmental amp Safety Engineering Changzhou University Changzhou 213164 Jiangsu China
bull Abstract
bull OBJECTIVE
bull To study the effects of environmental multi-media lead pollution on blood lead and sex hormone levels among lead exposed males engaged in E-waste dismantling and the correlation between confounding factors and sex hormone levels
bull METHODS
bull An E-waste dismantling area in Taizhou of Zhejiang Province was selected as the research site One hundred and fifty two samples were collected from the groundwater soil rice corn chicken and pork in the dismantling area The effects of the multi-media lead pollution on the male blood lead and sex hormone levels of FSH LH and T as well as the correlation with confounding factors were studied
bull RESULTS
bull The blood lead concentrations in the males aged under 31 from 31 to 45 and from 46 to 60 were 9855 10023 and 10145 μgL respectively Of all the environmental media lead exposures the groundwater rice and soil were main contributing factors to the lead accumulation in humans FSH and LH levels increased with the age while the T levels decreased with the age instead There was a significant correlation between the FSH and LH levels and wearing masks
bull CONCLUSION
bull There was correlation between the FSH LH and T levels and the mean values of lead concentrations in environmental media and the sex hormone levels were correlated with the confounding factor of wearing masks
Workup up the Andropausal male Exam PEBlood SalivaUrine
BMI
Chemistry and health profile with all hormones VAP
Free Total and Bioavailable Testosterone amp DHT
Estradiol (Ultrasens)
DHEA Uncong and S
Cardivascular CRP and Homocysteine
Fibrinogen amp D-Dimer
Delta PSA amp Free to Total
Vit D and other Nutrients
IGF-1
bull LH and FSH
bull Prolactin
bull SHBG
bull Cortisol X 4
bull Neurotransmitters
bull Amino acids
bull Hair analysis
bull RBC mineral levels
bull Liver detox profile
bull Pregnenolone
bull Cytokine panel
bull Fasting GlusocseInsulin HAIC amp Fructosamine
Natural non-hormonal
interventions for
trteating the underlying
causes of Andropause
and Low T syndrome
Work on your patients response to the stressttpwwwcursoercomenwp-contentuploads201202people-man-stress-Fotolia_8150434_XSjpg
Put the Adrenals to
BedhellipBotanically
bull Mild relaxants
ndash Chamomila
ndash Vervain
ndash Oats (Avena)
ndash Motherwort
bull Stronger Relaxants
ndash Passiflora
ndash Scutellaria
ndash Valerian
ndash Humulus (Hops)
ndash Eschscholtzia
bull Potent relaxants
ndash Jamaican Dogwood
ndash Corydalis
ndash Wild lettuce
Nervine trophorestoratives
-- St Johnrsquos wort
ADAPTOGENS
bull David Winston in his book ADAPTOGENS Herbs for strength stamina and stress relief states the following lsquoadaptogens can be used for helping the body respond to an excess of adrenal hormones and prevent oxidation damage to the adrenalsrsquo
bull Eleuthero
bull American Ginseng
bull Ashwagandha
bull Asian ginseng
bull Cordyceps
bull Reishi
bull Rhaponticum
bull Rhodiola
bull Schizandra
Make adrenal deposits
Adrenal tonic herbs
Exercise and Testosterone
Exercise helps (even in obese
men to raise) testosterone
Squats 4 sets of 10
reps increased
testosterone the
greatest
Treating Andropause Better sleep
Flavonoids
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
CAUSES of Andropause
Toxinseffect on Testes
CAUSES of Andropause
Toxinseffect on Testeshttpwwwsiumededu~dbhaleslabimagesresear2gif
CAUSES of Andropause
Toxinseffect on Testeshttpwwwoneresultcomsitesdefaultfilesu3Prohormones20Chart_1png
Michael Phelps amp Co at high risk of low
testosterone
bull A 2011 paper that was
published in the
International Journal of
Andrology by Nickmilder
et al a clear-cut
association with early life
exposure to chlorinated
indoor-pool water and low
testosterone levels in
adolescence and
probably later in life
(Nickmilder 2011)
I wonder if
therersquos an
issue with
Bromine
too
Amaral S et al Front Biosci (Schol Ed) 2013 Jan 15181-97
Aging and male reproductive function
a mitochondrial perspective
bull Researching the effects of aging in the male reproductive system is not trivial Not only are multiple changes at molecular cellular and endocrine levels involved but any findings must be discussed with variable individual characteristics as well as with lifestyle and environmental factors Age-related changes in the reproductive system include any aspect of reproductive function from deregulation of the hypothalamic-pituitary-gonadal axis and of local autoparacrine interactions to effects on testicular stem cells defects in testicular architecture and spermatogenesis or sperm with decreased functionality Several theories place mitochondria at the hub of cellular events related to aging namely regarding the accumulation of oxidative damage to cells and tissues a process in which these organelles play a prominent role although alternative theories have also emerged However oxidative stress is not the only process involved in mitochondrial-related aging mitochondrial energy metabolism changes in mitochondrial DNA or in mitochondrial-dependent testosterone production are also important Crucially all these issues are likely interdependent We will review evidence that suggests that mitochondria constitute a common link between aging and fertility loss
Damage to Leydig cells cause low
testosterone
Are toxin avoidance antioxidants
and depuration a key
bull Biomed Environ Sci 2013 Jun26(6)474-84 doi 1039670895-3988201306008
bull Effects of Environmental Lead Pollution on Blood Lead and Sex Hormone Levels among Occupationally Exposed Group in An E-waste Dismantling Area
bull Yang Y Lu XS Li DL Yu YJ
bull Source
bull School of Environmental amp Safety Engineering Changzhou University Changzhou 213164 Jiangsu China
bull Abstract
bull OBJECTIVE
bull To study the effects of environmental multi-media lead pollution on blood lead and sex hormone levels among lead exposed males engaged in E-waste dismantling and the correlation between confounding factors and sex hormone levels
bull METHODS
bull An E-waste dismantling area in Taizhou of Zhejiang Province was selected as the research site One hundred and fifty two samples were collected from the groundwater soil rice corn chicken and pork in the dismantling area The effects of the multi-media lead pollution on the male blood lead and sex hormone levels of FSH LH and T as well as the correlation with confounding factors were studied
bull RESULTS
bull The blood lead concentrations in the males aged under 31 from 31 to 45 and from 46 to 60 were 9855 10023 and 10145 μgL respectively Of all the environmental media lead exposures the groundwater rice and soil were main contributing factors to the lead accumulation in humans FSH and LH levels increased with the age while the T levels decreased with the age instead There was a significant correlation between the FSH and LH levels and wearing masks
bull CONCLUSION
bull There was correlation between the FSH LH and T levels and the mean values of lead concentrations in environmental media and the sex hormone levels were correlated with the confounding factor of wearing masks
Workup up the Andropausal male Exam PEBlood SalivaUrine
BMI
Chemistry and health profile with all hormones VAP
Free Total and Bioavailable Testosterone amp DHT
Estradiol (Ultrasens)
DHEA Uncong and S
Cardivascular CRP and Homocysteine
Fibrinogen amp D-Dimer
Delta PSA amp Free to Total
Vit D and other Nutrients
IGF-1
bull LH and FSH
bull Prolactin
bull SHBG
bull Cortisol X 4
bull Neurotransmitters
bull Amino acids
bull Hair analysis
bull RBC mineral levels
bull Liver detox profile
bull Pregnenolone
bull Cytokine panel
bull Fasting GlusocseInsulin HAIC amp Fructosamine
Natural non-hormonal
interventions for
trteating the underlying
causes of Andropause
and Low T syndrome
Work on your patients response to the stressttpwwwcursoercomenwp-contentuploads201202people-man-stress-Fotolia_8150434_XSjpg
Put the Adrenals to
BedhellipBotanically
bull Mild relaxants
ndash Chamomila
ndash Vervain
ndash Oats (Avena)
ndash Motherwort
bull Stronger Relaxants
ndash Passiflora
ndash Scutellaria
ndash Valerian
ndash Humulus (Hops)
ndash Eschscholtzia
bull Potent relaxants
ndash Jamaican Dogwood
ndash Corydalis
ndash Wild lettuce
Nervine trophorestoratives
-- St Johnrsquos wort
ADAPTOGENS
bull David Winston in his book ADAPTOGENS Herbs for strength stamina and stress relief states the following lsquoadaptogens can be used for helping the body respond to an excess of adrenal hormones and prevent oxidation damage to the adrenalsrsquo
bull Eleuthero
bull American Ginseng
bull Ashwagandha
bull Asian ginseng
bull Cordyceps
bull Reishi
bull Rhaponticum
bull Rhodiola
bull Schizandra
Make adrenal deposits
Adrenal tonic herbs
Exercise and Testosterone
Exercise helps (even in obese
men to raise) testosterone
Squats 4 sets of 10
reps increased
testosterone the
greatest
Treating Andropause Better sleep
Flavonoids
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
CAUSES of Andropause
Toxinseffect on Testeshttpwwwsiumededu~dbhaleslabimagesresear2gif
CAUSES of Andropause
Toxinseffect on Testeshttpwwwoneresultcomsitesdefaultfilesu3Prohormones20Chart_1png
Michael Phelps amp Co at high risk of low
testosterone
bull A 2011 paper that was
published in the
International Journal of
Andrology by Nickmilder
et al a clear-cut
association with early life
exposure to chlorinated
indoor-pool water and low
testosterone levels in
adolescence and
probably later in life
(Nickmilder 2011)
I wonder if
therersquos an
issue with
Bromine
too
Amaral S et al Front Biosci (Schol Ed) 2013 Jan 15181-97
Aging and male reproductive function
a mitochondrial perspective
bull Researching the effects of aging in the male reproductive system is not trivial Not only are multiple changes at molecular cellular and endocrine levels involved but any findings must be discussed with variable individual characteristics as well as with lifestyle and environmental factors Age-related changes in the reproductive system include any aspect of reproductive function from deregulation of the hypothalamic-pituitary-gonadal axis and of local autoparacrine interactions to effects on testicular stem cells defects in testicular architecture and spermatogenesis or sperm with decreased functionality Several theories place mitochondria at the hub of cellular events related to aging namely regarding the accumulation of oxidative damage to cells and tissues a process in which these organelles play a prominent role although alternative theories have also emerged However oxidative stress is not the only process involved in mitochondrial-related aging mitochondrial energy metabolism changes in mitochondrial DNA or in mitochondrial-dependent testosterone production are also important Crucially all these issues are likely interdependent We will review evidence that suggests that mitochondria constitute a common link between aging and fertility loss
Damage to Leydig cells cause low
testosterone
Are toxin avoidance antioxidants
and depuration a key
bull Biomed Environ Sci 2013 Jun26(6)474-84 doi 1039670895-3988201306008
bull Effects of Environmental Lead Pollution on Blood Lead and Sex Hormone Levels among Occupationally Exposed Group in An E-waste Dismantling Area
bull Yang Y Lu XS Li DL Yu YJ
bull Source
bull School of Environmental amp Safety Engineering Changzhou University Changzhou 213164 Jiangsu China
bull Abstract
bull OBJECTIVE
bull To study the effects of environmental multi-media lead pollution on blood lead and sex hormone levels among lead exposed males engaged in E-waste dismantling and the correlation between confounding factors and sex hormone levels
bull METHODS
bull An E-waste dismantling area in Taizhou of Zhejiang Province was selected as the research site One hundred and fifty two samples were collected from the groundwater soil rice corn chicken and pork in the dismantling area The effects of the multi-media lead pollution on the male blood lead and sex hormone levels of FSH LH and T as well as the correlation with confounding factors were studied
bull RESULTS
bull The blood lead concentrations in the males aged under 31 from 31 to 45 and from 46 to 60 were 9855 10023 and 10145 μgL respectively Of all the environmental media lead exposures the groundwater rice and soil were main contributing factors to the lead accumulation in humans FSH and LH levels increased with the age while the T levels decreased with the age instead There was a significant correlation between the FSH and LH levels and wearing masks
bull CONCLUSION
bull There was correlation between the FSH LH and T levels and the mean values of lead concentrations in environmental media and the sex hormone levels were correlated with the confounding factor of wearing masks
Workup up the Andropausal male Exam PEBlood SalivaUrine
BMI
Chemistry and health profile with all hormones VAP
Free Total and Bioavailable Testosterone amp DHT
Estradiol (Ultrasens)
DHEA Uncong and S
Cardivascular CRP and Homocysteine
Fibrinogen amp D-Dimer
Delta PSA amp Free to Total
Vit D and other Nutrients
IGF-1
bull LH and FSH
bull Prolactin
bull SHBG
bull Cortisol X 4
bull Neurotransmitters
bull Amino acids
bull Hair analysis
bull RBC mineral levels
bull Liver detox profile
bull Pregnenolone
bull Cytokine panel
bull Fasting GlusocseInsulin HAIC amp Fructosamine
Natural non-hormonal
interventions for
trteating the underlying
causes of Andropause
and Low T syndrome
Work on your patients response to the stressttpwwwcursoercomenwp-contentuploads201202people-man-stress-Fotolia_8150434_XSjpg
Put the Adrenals to
BedhellipBotanically
bull Mild relaxants
ndash Chamomila
ndash Vervain
ndash Oats (Avena)
ndash Motherwort
bull Stronger Relaxants
ndash Passiflora
ndash Scutellaria
ndash Valerian
ndash Humulus (Hops)
ndash Eschscholtzia
bull Potent relaxants
ndash Jamaican Dogwood
ndash Corydalis
ndash Wild lettuce
Nervine trophorestoratives
-- St Johnrsquos wort
ADAPTOGENS
bull David Winston in his book ADAPTOGENS Herbs for strength stamina and stress relief states the following lsquoadaptogens can be used for helping the body respond to an excess of adrenal hormones and prevent oxidation damage to the adrenalsrsquo
bull Eleuthero
bull American Ginseng
bull Ashwagandha
bull Asian ginseng
bull Cordyceps
bull Reishi
bull Rhaponticum
bull Rhodiola
bull Schizandra
Make adrenal deposits
Adrenal tonic herbs
Exercise and Testosterone
Exercise helps (even in obese
men to raise) testosterone
Squats 4 sets of 10
reps increased
testosterone the
greatest
Treating Andropause Better sleep
Flavonoids
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
CAUSES of Andropause
Toxinseffect on Testeshttpwwwoneresultcomsitesdefaultfilesu3Prohormones20Chart_1png
Michael Phelps amp Co at high risk of low
testosterone
bull A 2011 paper that was
published in the
International Journal of
Andrology by Nickmilder
et al a clear-cut
association with early life
exposure to chlorinated
indoor-pool water and low
testosterone levels in
adolescence and
probably later in life
(Nickmilder 2011)
I wonder if
therersquos an
issue with
Bromine
too
Amaral S et al Front Biosci (Schol Ed) 2013 Jan 15181-97
Aging and male reproductive function
a mitochondrial perspective
bull Researching the effects of aging in the male reproductive system is not trivial Not only are multiple changes at molecular cellular and endocrine levels involved but any findings must be discussed with variable individual characteristics as well as with lifestyle and environmental factors Age-related changes in the reproductive system include any aspect of reproductive function from deregulation of the hypothalamic-pituitary-gonadal axis and of local autoparacrine interactions to effects on testicular stem cells defects in testicular architecture and spermatogenesis or sperm with decreased functionality Several theories place mitochondria at the hub of cellular events related to aging namely regarding the accumulation of oxidative damage to cells and tissues a process in which these organelles play a prominent role although alternative theories have also emerged However oxidative stress is not the only process involved in mitochondrial-related aging mitochondrial energy metabolism changes in mitochondrial DNA or in mitochondrial-dependent testosterone production are also important Crucially all these issues are likely interdependent We will review evidence that suggests that mitochondria constitute a common link between aging and fertility loss
Damage to Leydig cells cause low
testosterone
Are toxin avoidance antioxidants
and depuration a key
bull Biomed Environ Sci 2013 Jun26(6)474-84 doi 1039670895-3988201306008
bull Effects of Environmental Lead Pollution on Blood Lead and Sex Hormone Levels among Occupationally Exposed Group in An E-waste Dismantling Area
bull Yang Y Lu XS Li DL Yu YJ
bull Source
bull School of Environmental amp Safety Engineering Changzhou University Changzhou 213164 Jiangsu China
bull Abstract
bull OBJECTIVE
bull To study the effects of environmental multi-media lead pollution on blood lead and sex hormone levels among lead exposed males engaged in E-waste dismantling and the correlation between confounding factors and sex hormone levels
bull METHODS
bull An E-waste dismantling area in Taizhou of Zhejiang Province was selected as the research site One hundred and fifty two samples were collected from the groundwater soil rice corn chicken and pork in the dismantling area The effects of the multi-media lead pollution on the male blood lead and sex hormone levels of FSH LH and T as well as the correlation with confounding factors were studied
bull RESULTS
bull The blood lead concentrations in the males aged under 31 from 31 to 45 and from 46 to 60 were 9855 10023 and 10145 μgL respectively Of all the environmental media lead exposures the groundwater rice and soil were main contributing factors to the lead accumulation in humans FSH and LH levels increased with the age while the T levels decreased with the age instead There was a significant correlation between the FSH and LH levels and wearing masks
bull CONCLUSION
bull There was correlation between the FSH LH and T levels and the mean values of lead concentrations in environmental media and the sex hormone levels were correlated with the confounding factor of wearing masks
Workup up the Andropausal male Exam PEBlood SalivaUrine
BMI
Chemistry and health profile with all hormones VAP
Free Total and Bioavailable Testosterone amp DHT
Estradiol (Ultrasens)
DHEA Uncong and S
Cardivascular CRP and Homocysteine
Fibrinogen amp D-Dimer
Delta PSA amp Free to Total
Vit D and other Nutrients
IGF-1
bull LH and FSH
bull Prolactin
bull SHBG
bull Cortisol X 4
bull Neurotransmitters
bull Amino acids
bull Hair analysis
bull RBC mineral levels
bull Liver detox profile
bull Pregnenolone
bull Cytokine panel
bull Fasting GlusocseInsulin HAIC amp Fructosamine
Natural non-hormonal
interventions for
trteating the underlying
causes of Andropause
and Low T syndrome
Work on your patients response to the stressttpwwwcursoercomenwp-contentuploads201202people-man-stress-Fotolia_8150434_XSjpg
Put the Adrenals to
BedhellipBotanically
bull Mild relaxants
ndash Chamomila
ndash Vervain
ndash Oats (Avena)
ndash Motherwort
bull Stronger Relaxants
ndash Passiflora
ndash Scutellaria
ndash Valerian
ndash Humulus (Hops)
ndash Eschscholtzia
bull Potent relaxants
ndash Jamaican Dogwood
ndash Corydalis
ndash Wild lettuce
Nervine trophorestoratives
-- St Johnrsquos wort
ADAPTOGENS
bull David Winston in his book ADAPTOGENS Herbs for strength stamina and stress relief states the following lsquoadaptogens can be used for helping the body respond to an excess of adrenal hormones and prevent oxidation damage to the adrenalsrsquo
bull Eleuthero
bull American Ginseng
bull Ashwagandha
bull Asian ginseng
bull Cordyceps
bull Reishi
bull Rhaponticum
bull Rhodiola
bull Schizandra
Make adrenal deposits
Adrenal tonic herbs
Exercise and Testosterone
Exercise helps (even in obese
men to raise) testosterone
Squats 4 sets of 10
reps increased
testosterone the
greatest
Treating Andropause Better sleep
Flavonoids
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Michael Phelps amp Co at high risk of low
testosterone
bull A 2011 paper that was
published in the
International Journal of
Andrology by Nickmilder
et al a clear-cut
association with early life
exposure to chlorinated
indoor-pool water and low
testosterone levels in
adolescence and
probably later in life
(Nickmilder 2011)
I wonder if
therersquos an
issue with
Bromine
too
Amaral S et al Front Biosci (Schol Ed) 2013 Jan 15181-97
Aging and male reproductive function
a mitochondrial perspective
bull Researching the effects of aging in the male reproductive system is not trivial Not only are multiple changes at molecular cellular and endocrine levels involved but any findings must be discussed with variable individual characteristics as well as with lifestyle and environmental factors Age-related changes in the reproductive system include any aspect of reproductive function from deregulation of the hypothalamic-pituitary-gonadal axis and of local autoparacrine interactions to effects on testicular stem cells defects in testicular architecture and spermatogenesis or sperm with decreased functionality Several theories place mitochondria at the hub of cellular events related to aging namely regarding the accumulation of oxidative damage to cells and tissues a process in which these organelles play a prominent role although alternative theories have also emerged However oxidative stress is not the only process involved in mitochondrial-related aging mitochondrial energy metabolism changes in mitochondrial DNA or in mitochondrial-dependent testosterone production are also important Crucially all these issues are likely interdependent We will review evidence that suggests that mitochondria constitute a common link between aging and fertility loss
Damage to Leydig cells cause low
testosterone
Are toxin avoidance antioxidants
and depuration a key
bull Biomed Environ Sci 2013 Jun26(6)474-84 doi 1039670895-3988201306008
bull Effects of Environmental Lead Pollution on Blood Lead and Sex Hormone Levels among Occupationally Exposed Group in An E-waste Dismantling Area
bull Yang Y Lu XS Li DL Yu YJ
bull Source
bull School of Environmental amp Safety Engineering Changzhou University Changzhou 213164 Jiangsu China
bull Abstract
bull OBJECTIVE
bull To study the effects of environmental multi-media lead pollution on blood lead and sex hormone levels among lead exposed males engaged in E-waste dismantling and the correlation between confounding factors and sex hormone levels
bull METHODS
bull An E-waste dismantling area in Taizhou of Zhejiang Province was selected as the research site One hundred and fifty two samples were collected from the groundwater soil rice corn chicken and pork in the dismantling area The effects of the multi-media lead pollution on the male blood lead and sex hormone levels of FSH LH and T as well as the correlation with confounding factors were studied
bull RESULTS
bull The blood lead concentrations in the males aged under 31 from 31 to 45 and from 46 to 60 were 9855 10023 and 10145 μgL respectively Of all the environmental media lead exposures the groundwater rice and soil were main contributing factors to the lead accumulation in humans FSH and LH levels increased with the age while the T levels decreased with the age instead There was a significant correlation between the FSH and LH levels and wearing masks
bull CONCLUSION
bull There was correlation between the FSH LH and T levels and the mean values of lead concentrations in environmental media and the sex hormone levels were correlated with the confounding factor of wearing masks
Workup up the Andropausal male Exam PEBlood SalivaUrine
BMI
Chemistry and health profile with all hormones VAP
Free Total and Bioavailable Testosterone amp DHT
Estradiol (Ultrasens)
DHEA Uncong and S
Cardivascular CRP and Homocysteine
Fibrinogen amp D-Dimer
Delta PSA amp Free to Total
Vit D and other Nutrients
IGF-1
bull LH and FSH
bull Prolactin
bull SHBG
bull Cortisol X 4
bull Neurotransmitters
bull Amino acids
bull Hair analysis
bull RBC mineral levels
bull Liver detox profile
bull Pregnenolone
bull Cytokine panel
bull Fasting GlusocseInsulin HAIC amp Fructosamine
Natural non-hormonal
interventions for
trteating the underlying
causes of Andropause
and Low T syndrome
Work on your patients response to the stressttpwwwcursoercomenwp-contentuploads201202people-man-stress-Fotolia_8150434_XSjpg
Put the Adrenals to
BedhellipBotanically
bull Mild relaxants
ndash Chamomila
ndash Vervain
ndash Oats (Avena)
ndash Motherwort
bull Stronger Relaxants
ndash Passiflora
ndash Scutellaria
ndash Valerian
ndash Humulus (Hops)
ndash Eschscholtzia
bull Potent relaxants
ndash Jamaican Dogwood
ndash Corydalis
ndash Wild lettuce
Nervine trophorestoratives
-- St Johnrsquos wort
ADAPTOGENS
bull David Winston in his book ADAPTOGENS Herbs for strength stamina and stress relief states the following lsquoadaptogens can be used for helping the body respond to an excess of adrenal hormones and prevent oxidation damage to the adrenalsrsquo
bull Eleuthero
bull American Ginseng
bull Ashwagandha
bull Asian ginseng
bull Cordyceps
bull Reishi
bull Rhaponticum
bull Rhodiola
bull Schizandra
Make adrenal deposits
Adrenal tonic herbs
Exercise and Testosterone
Exercise helps (even in obese
men to raise) testosterone
Squats 4 sets of 10
reps increased
testosterone the
greatest
Treating Andropause Better sleep
Flavonoids
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Amaral S et al Front Biosci (Schol Ed) 2013 Jan 15181-97
Aging and male reproductive function
a mitochondrial perspective
bull Researching the effects of aging in the male reproductive system is not trivial Not only are multiple changes at molecular cellular and endocrine levels involved but any findings must be discussed with variable individual characteristics as well as with lifestyle and environmental factors Age-related changes in the reproductive system include any aspect of reproductive function from deregulation of the hypothalamic-pituitary-gonadal axis and of local autoparacrine interactions to effects on testicular stem cells defects in testicular architecture and spermatogenesis or sperm with decreased functionality Several theories place mitochondria at the hub of cellular events related to aging namely regarding the accumulation of oxidative damage to cells and tissues a process in which these organelles play a prominent role although alternative theories have also emerged However oxidative stress is not the only process involved in mitochondrial-related aging mitochondrial energy metabolism changes in mitochondrial DNA or in mitochondrial-dependent testosterone production are also important Crucially all these issues are likely interdependent We will review evidence that suggests that mitochondria constitute a common link between aging and fertility loss
Damage to Leydig cells cause low
testosterone
Are toxin avoidance antioxidants
and depuration a key
bull Biomed Environ Sci 2013 Jun26(6)474-84 doi 1039670895-3988201306008
bull Effects of Environmental Lead Pollution on Blood Lead and Sex Hormone Levels among Occupationally Exposed Group in An E-waste Dismantling Area
bull Yang Y Lu XS Li DL Yu YJ
bull Source
bull School of Environmental amp Safety Engineering Changzhou University Changzhou 213164 Jiangsu China
bull Abstract
bull OBJECTIVE
bull To study the effects of environmental multi-media lead pollution on blood lead and sex hormone levels among lead exposed males engaged in E-waste dismantling and the correlation between confounding factors and sex hormone levels
bull METHODS
bull An E-waste dismantling area in Taizhou of Zhejiang Province was selected as the research site One hundred and fifty two samples were collected from the groundwater soil rice corn chicken and pork in the dismantling area The effects of the multi-media lead pollution on the male blood lead and sex hormone levels of FSH LH and T as well as the correlation with confounding factors were studied
bull RESULTS
bull The blood lead concentrations in the males aged under 31 from 31 to 45 and from 46 to 60 were 9855 10023 and 10145 μgL respectively Of all the environmental media lead exposures the groundwater rice and soil were main contributing factors to the lead accumulation in humans FSH and LH levels increased with the age while the T levels decreased with the age instead There was a significant correlation between the FSH and LH levels and wearing masks
bull CONCLUSION
bull There was correlation between the FSH LH and T levels and the mean values of lead concentrations in environmental media and the sex hormone levels were correlated with the confounding factor of wearing masks
Workup up the Andropausal male Exam PEBlood SalivaUrine
BMI
Chemistry and health profile with all hormones VAP
Free Total and Bioavailable Testosterone amp DHT
Estradiol (Ultrasens)
DHEA Uncong and S
Cardivascular CRP and Homocysteine
Fibrinogen amp D-Dimer
Delta PSA amp Free to Total
Vit D and other Nutrients
IGF-1
bull LH and FSH
bull Prolactin
bull SHBG
bull Cortisol X 4
bull Neurotransmitters
bull Amino acids
bull Hair analysis
bull RBC mineral levels
bull Liver detox profile
bull Pregnenolone
bull Cytokine panel
bull Fasting GlusocseInsulin HAIC amp Fructosamine
Natural non-hormonal
interventions for
trteating the underlying
causes of Andropause
and Low T syndrome
Work on your patients response to the stressttpwwwcursoercomenwp-contentuploads201202people-man-stress-Fotolia_8150434_XSjpg
Put the Adrenals to
BedhellipBotanically
bull Mild relaxants
ndash Chamomila
ndash Vervain
ndash Oats (Avena)
ndash Motherwort
bull Stronger Relaxants
ndash Passiflora
ndash Scutellaria
ndash Valerian
ndash Humulus (Hops)
ndash Eschscholtzia
bull Potent relaxants
ndash Jamaican Dogwood
ndash Corydalis
ndash Wild lettuce
Nervine trophorestoratives
-- St Johnrsquos wort
ADAPTOGENS
bull David Winston in his book ADAPTOGENS Herbs for strength stamina and stress relief states the following lsquoadaptogens can be used for helping the body respond to an excess of adrenal hormones and prevent oxidation damage to the adrenalsrsquo
bull Eleuthero
bull American Ginseng
bull Ashwagandha
bull Asian ginseng
bull Cordyceps
bull Reishi
bull Rhaponticum
bull Rhodiola
bull Schizandra
Make adrenal deposits
Adrenal tonic herbs
Exercise and Testosterone
Exercise helps (even in obese
men to raise) testosterone
Squats 4 sets of 10
reps increased
testosterone the
greatest
Treating Andropause Better sleep
Flavonoids
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
bull Biomed Environ Sci 2013 Jun26(6)474-84 doi 1039670895-3988201306008
bull Effects of Environmental Lead Pollution on Blood Lead and Sex Hormone Levels among Occupationally Exposed Group in An E-waste Dismantling Area
bull Yang Y Lu XS Li DL Yu YJ
bull Source
bull School of Environmental amp Safety Engineering Changzhou University Changzhou 213164 Jiangsu China
bull Abstract
bull OBJECTIVE
bull To study the effects of environmental multi-media lead pollution on blood lead and sex hormone levels among lead exposed males engaged in E-waste dismantling and the correlation between confounding factors and sex hormone levels
bull METHODS
bull An E-waste dismantling area in Taizhou of Zhejiang Province was selected as the research site One hundred and fifty two samples were collected from the groundwater soil rice corn chicken and pork in the dismantling area The effects of the multi-media lead pollution on the male blood lead and sex hormone levels of FSH LH and T as well as the correlation with confounding factors were studied
bull RESULTS
bull The blood lead concentrations in the males aged under 31 from 31 to 45 and from 46 to 60 were 9855 10023 and 10145 μgL respectively Of all the environmental media lead exposures the groundwater rice and soil were main contributing factors to the lead accumulation in humans FSH and LH levels increased with the age while the T levels decreased with the age instead There was a significant correlation between the FSH and LH levels and wearing masks
bull CONCLUSION
bull There was correlation between the FSH LH and T levels and the mean values of lead concentrations in environmental media and the sex hormone levels were correlated with the confounding factor of wearing masks
Workup up the Andropausal male Exam PEBlood SalivaUrine
BMI
Chemistry and health profile with all hormones VAP
Free Total and Bioavailable Testosterone amp DHT
Estradiol (Ultrasens)
DHEA Uncong and S
Cardivascular CRP and Homocysteine
Fibrinogen amp D-Dimer
Delta PSA amp Free to Total
Vit D and other Nutrients
IGF-1
bull LH and FSH
bull Prolactin
bull SHBG
bull Cortisol X 4
bull Neurotransmitters
bull Amino acids
bull Hair analysis
bull RBC mineral levels
bull Liver detox profile
bull Pregnenolone
bull Cytokine panel
bull Fasting GlusocseInsulin HAIC amp Fructosamine
Natural non-hormonal
interventions for
trteating the underlying
causes of Andropause
and Low T syndrome
Work on your patients response to the stressttpwwwcursoercomenwp-contentuploads201202people-man-stress-Fotolia_8150434_XSjpg
Put the Adrenals to
BedhellipBotanically
bull Mild relaxants
ndash Chamomila
ndash Vervain
ndash Oats (Avena)
ndash Motherwort
bull Stronger Relaxants
ndash Passiflora
ndash Scutellaria
ndash Valerian
ndash Humulus (Hops)
ndash Eschscholtzia
bull Potent relaxants
ndash Jamaican Dogwood
ndash Corydalis
ndash Wild lettuce
Nervine trophorestoratives
-- St Johnrsquos wort
ADAPTOGENS
bull David Winston in his book ADAPTOGENS Herbs for strength stamina and stress relief states the following lsquoadaptogens can be used for helping the body respond to an excess of adrenal hormones and prevent oxidation damage to the adrenalsrsquo
bull Eleuthero
bull American Ginseng
bull Ashwagandha
bull Asian ginseng
bull Cordyceps
bull Reishi
bull Rhaponticum
bull Rhodiola
bull Schizandra
Make adrenal deposits
Adrenal tonic herbs
Exercise and Testosterone
Exercise helps (even in obese
men to raise) testosterone
Squats 4 sets of 10
reps increased
testosterone the
greatest
Treating Andropause Better sleep
Flavonoids
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Workup up the Andropausal male Exam PEBlood SalivaUrine
BMI
Chemistry and health profile with all hormones VAP
Free Total and Bioavailable Testosterone amp DHT
Estradiol (Ultrasens)
DHEA Uncong and S
Cardivascular CRP and Homocysteine
Fibrinogen amp D-Dimer
Delta PSA amp Free to Total
Vit D and other Nutrients
IGF-1
bull LH and FSH
bull Prolactin
bull SHBG
bull Cortisol X 4
bull Neurotransmitters
bull Amino acids
bull Hair analysis
bull RBC mineral levels
bull Liver detox profile
bull Pregnenolone
bull Cytokine panel
bull Fasting GlusocseInsulin HAIC amp Fructosamine
Natural non-hormonal
interventions for
trteating the underlying
causes of Andropause
and Low T syndrome
Work on your patients response to the stressttpwwwcursoercomenwp-contentuploads201202people-man-stress-Fotolia_8150434_XSjpg
Put the Adrenals to
BedhellipBotanically
bull Mild relaxants
ndash Chamomila
ndash Vervain
ndash Oats (Avena)
ndash Motherwort
bull Stronger Relaxants
ndash Passiflora
ndash Scutellaria
ndash Valerian
ndash Humulus (Hops)
ndash Eschscholtzia
bull Potent relaxants
ndash Jamaican Dogwood
ndash Corydalis
ndash Wild lettuce
Nervine trophorestoratives
-- St Johnrsquos wort
ADAPTOGENS
bull David Winston in his book ADAPTOGENS Herbs for strength stamina and stress relief states the following lsquoadaptogens can be used for helping the body respond to an excess of adrenal hormones and prevent oxidation damage to the adrenalsrsquo
bull Eleuthero
bull American Ginseng
bull Ashwagandha
bull Asian ginseng
bull Cordyceps
bull Reishi
bull Rhaponticum
bull Rhodiola
bull Schizandra
Make adrenal deposits
Adrenal tonic herbs
Exercise and Testosterone
Exercise helps (even in obese
men to raise) testosterone
Squats 4 sets of 10
reps increased
testosterone the
greatest
Treating Andropause Better sleep
Flavonoids
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Natural non-hormonal
interventions for
trteating the underlying
causes of Andropause
and Low T syndrome
Work on your patients response to the stressttpwwwcursoercomenwp-contentuploads201202people-man-stress-Fotolia_8150434_XSjpg
Put the Adrenals to
BedhellipBotanically
bull Mild relaxants
ndash Chamomila
ndash Vervain
ndash Oats (Avena)
ndash Motherwort
bull Stronger Relaxants
ndash Passiflora
ndash Scutellaria
ndash Valerian
ndash Humulus (Hops)
ndash Eschscholtzia
bull Potent relaxants
ndash Jamaican Dogwood
ndash Corydalis
ndash Wild lettuce
Nervine trophorestoratives
-- St Johnrsquos wort
ADAPTOGENS
bull David Winston in his book ADAPTOGENS Herbs for strength stamina and stress relief states the following lsquoadaptogens can be used for helping the body respond to an excess of adrenal hormones and prevent oxidation damage to the adrenalsrsquo
bull Eleuthero
bull American Ginseng
bull Ashwagandha
bull Asian ginseng
bull Cordyceps
bull Reishi
bull Rhaponticum
bull Rhodiola
bull Schizandra
Make adrenal deposits
Adrenal tonic herbs
Exercise and Testosterone
Exercise helps (even in obese
men to raise) testosterone
Squats 4 sets of 10
reps increased
testosterone the
greatest
Treating Andropause Better sleep
Flavonoids
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Work on your patients response to the stressttpwwwcursoercomenwp-contentuploads201202people-man-stress-Fotolia_8150434_XSjpg
Put the Adrenals to
BedhellipBotanically
bull Mild relaxants
ndash Chamomila
ndash Vervain
ndash Oats (Avena)
ndash Motherwort
bull Stronger Relaxants
ndash Passiflora
ndash Scutellaria
ndash Valerian
ndash Humulus (Hops)
ndash Eschscholtzia
bull Potent relaxants
ndash Jamaican Dogwood
ndash Corydalis
ndash Wild lettuce
Nervine trophorestoratives
-- St Johnrsquos wort
ADAPTOGENS
bull David Winston in his book ADAPTOGENS Herbs for strength stamina and stress relief states the following lsquoadaptogens can be used for helping the body respond to an excess of adrenal hormones and prevent oxidation damage to the adrenalsrsquo
bull Eleuthero
bull American Ginseng
bull Ashwagandha
bull Asian ginseng
bull Cordyceps
bull Reishi
bull Rhaponticum
bull Rhodiola
bull Schizandra
Make adrenal deposits
Adrenal tonic herbs
Exercise and Testosterone
Exercise helps (even in obese
men to raise) testosterone
Squats 4 sets of 10
reps increased
testosterone the
greatest
Treating Andropause Better sleep
Flavonoids
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Put the Adrenals to
BedhellipBotanically
bull Mild relaxants
ndash Chamomila
ndash Vervain
ndash Oats (Avena)
ndash Motherwort
bull Stronger Relaxants
ndash Passiflora
ndash Scutellaria
ndash Valerian
ndash Humulus (Hops)
ndash Eschscholtzia
bull Potent relaxants
ndash Jamaican Dogwood
ndash Corydalis
ndash Wild lettuce
Nervine trophorestoratives
-- St Johnrsquos wort
ADAPTOGENS
bull David Winston in his book ADAPTOGENS Herbs for strength stamina and stress relief states the following lsquoadaptogens can be used for helping the body respond to an excess of adrenal hormones and prevent oxidation damage to the adrenalsrsquo
bull Eleuthero
bull American Ginseng
bull Ashwagandha
bull Asian ginseng
bull Cordyceps
bull Reishi
bull Rhaponticum
bull Rhodiola
bull Schizandra
Make adrenal deposits
Adrenal tonic herbs
Exercise and Testosterone
Exercise helps (even in obese
men to raise) testosterone
Squats 4 sets of 10
reps increased
testosterone the
greatest
Treating Andropause Better sleep
Flavonoids
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
ADAPTOGENS
bull David Winston in his book ADAPTOGENS Herbs for strength stamina and stress relief states the following lsquoadaptogens can be used for helping the body respond to an excess of adrenal hormones and prevent oxidation damage to the adrenalsrsquo
bull Eleuthero
bull American Ginseng
bull Ashwagandha
bull Asian ginseng
bull Cordyceps
bull Reishi
bull Rhaponticum
bull Rhodiola
bull Schizandra
Make adrenal deposits
Adrenal tonic herbs
Exercise and Testosterone
Exercise helps (even in obese
men to raise) testosterone
Squats 4 sets of 10
reps increased
testosterone the
greatest
Treating Andropause Better sleep
Flavonoids
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Make adrenal deposits
Adrenal tonic herbs
Exercise and Testosterone
Exercise helps (even in obese
men to raise) testosterone
Squats 4 sets of 10
reps increased
testosterone the
greatest
Treating Andropause Better sleep
Flavonoids
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Exercise and Testosterone
Exercise helps (even in obese
men to raise) testosterone
Squats 4 sets of 10
reps increased
testosterone the
greatest
Treating Andropause Better sleep
Flavonoids
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Exercise helps (even in obese
men to raise) testosterone
Squats 4 sets of 10
reps increased
testosterone the
greatest
Treating Andropause Better sleep
Flavonoids
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Squats 4 sets of 10
reps increased
testosterone the
greatest
Treating Andropause Better sleep
Flavonoids
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Treating Andropause Better sleep
Flavonoids
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Flavonoids
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Chrysin and Aromatase
bull Science 1984 Sep 7225(4666)1032-4
bull Inhibition of human estrogen synthetase (aromatase) by flavones
bull Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes These flavones include (in order of decreasing potency) 78-
benzoflavone chrysin apigenin flavone flavanone and quercetin 56-benzoflavone was not inhibitory 78-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
In response to eating certain plant foods the intestine
converts their lignans into compounds called
enterolactones which enter the bloodstream Findings from
human and animal studies indicate that these
enterolactones protect against hormone-dependent
cancers via several well-established mechanisms
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
bull Increasing your intake of fruits vegetables and whole grains helps provide the lignans needed to boost serum enterolactone levels This fact helps explain why men who eat healthier diets enjoy sharply reduced rates of prostate cancer
bull The two most important lignans that most readily convert to beneficial enterolactones in the body are secoisolariciresinol diglucoside and hydroxymatairesinol Extracts obtained from flax and the Norway spruce are now available as concentrated dietary supplements to enable aging men to achieve and maintain higher daily blood levels of enterolactones
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
ParsleyCelery
rosemary oregano
thyme basil and coriander
Chamomile
Cloves amp Lemon Balm
Scute
Apples lemons
limes
many fruits
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Modulate Aromatase with Vit D3bull Steroids 2012 Sep77(11)1107-12 doi 101016jsteroids201206005 Epub 2012 Jul 16
bull The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
bull Krishnan AV Swami S Feldman D
bull Source
bull Division of Endocrinology Department of Medicine Stanford University School of Medicine Stanford CA 94305 United States
bull Abstract
bull Calcitriol (125-dihydroxyvitamin D(3)) the hormonally active form of vitamin D inhibits the growth of many malignant cells including breast cancer (BCa) cells The mechanisms of calcitriol anticancer actions include cell cycle arrest stimulation of apoptosis and inhibition of invasion metastasis and angiogenesis In addition we have discovered new pathways of calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor positive (ER+) BCa cells Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs) Our in vitro and in vivo studies show that calcitriol decreases the expression of aromatase the enzyme that catalyzes estrogen synthesis selectively in BCa cells and in the mammary adipose tissue surrounding BCa by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels of PGs which are major stimulator of aromatase transcription through promoter II Calcitriol down-regulates the expression of ERα and thereby attenuates estrogen signaling in BCa cells including the proliferative stimulus provided by estrogens Thus the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in inhibiting ER+BCa We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention andor treatment of ER+BCa in women
Vit D3
modulates
aromatase
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
I would need 800 mgday of I3C
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
GOAL Lower SHBG with
Radix Urtica spp
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Nettle Root Extract
bull When testosterone binds to SHBG it loses its biological activity and becomes known as ldquobound testosteronerdquo as opposed to the desirable ldquofree testosteronerdquo
bull Nettle inhibits all 3 enzymes which can disable testosterone DHT Aromatase and SGBH
bull Scopoletin may be an active constituent
bull DOSEs 4-6 grams dried rootd
bull 600 -1200 of a 51 extract9 ml of 12 tincture 1 gram herb 2ml liquid
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Nettle and SHBGbull Planta Med 1997 Dec63(6)529-32
bull Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)
bull Polar extracts of the stinging nettle (Urtica dioica L) roots contain the ligans (+)-neoolivil (-)-secoisolariciresinol dehydrodiconiferylalcohol isolariciresinol pinoresinol and 34-divanillyltetrahydrofuran
bull These compounds were either isolated from Urtica roots or obtained semisynthetically Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay In addition the main intestinal transformation products of plant lignans in humans enterodiol and enterolactone together with enterofuranwere checked for their activity All lignans except (-)-pinoresinoldeveloped a binding affinity to SHBG in the in vitro assay The affinity of (-)-34-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH)
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Protect Testes from Oxidative
Damage and Endocrine disrupters
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Se can protect the testes
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Milk Thistle protects the
TESTES too
bull Phytomedicine 2012 Sep 1519(12)1077-84 doi 101016jphymed201206011 Epub 2012 Jul 20
bull Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
bull Malekinejad H Janbaz-Acyabar H Razi M Varasteh S
bull Source
bull Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Urmia University Urmia Iran
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Minerals which
Increase
Testosterone
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Zinc help low T patients increase T but not normal T
patients
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Boron
This is a
High dose
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Magnesium
apply topical
Mag gel before
class + oral
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Evidence Based
BOTANICALS
which Increase
Testosterone
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Macuna pruriens flowerspodsseeds
DOSE 5 grams per day in the literature
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
bull M pruriens seeds are rich source of L-DOPA and its
bull metabolites which include epinephrine and norepinephrine
Therefore an increase in dopamine level in the brain
following M pruriens treatment may not only induce the
activation of sexual behavior but it may also increase
plasma testosterone level It has been reported recently
that L-DOPA and its metabolite dopamine stimulate the
hypothalamus and forebrain to secrete gonadotropic releasing hormone (GnRH)
This in turn upregulates
bull the anterior pituitary gland to secrete follicle
bull stimulating hormone (FSH) and luteinizing hormone
bull (LH) causing increased synthesis of testosterone by
bull Leydig cells of the testis
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
bull Fertil Steril 2009 Dec92(6)1934-40 doi 101016jfertnstert200809045 Epub 2008 Oct 29
bull Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis
bull Shukla KK et al
bull PATIENT(S)
bull Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening
bull MAIN OUTCOME MEASURE(S)
bull Before and after treatment serum T LH FSH PRL dopamine adrenaline and noradrenaline in seminal and blood plasma were measured
bull RESULT(S)
bull Decreased sperm count and motility were seen in infertile subjects Serum T and LH levels as well as seminal plasma and blood levels of dopamine adrenaline and noradrenaline were also decreased in all groups of infertile men This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects Treatment with M pruriens significantly improved T LH dopamine adrenaline and noradrenaline levels in infertile men and reduced levels of FSH and PRL Sperm count and motility were significantly recovered in infertile men after treatment
bull CONCLUSION(S)
bull Treatment with M pruriens regulates steroidogenesis and improves semen quality in infertile men
Treatment with M pruriens
significantly improved T
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
sTAR - Steroidogenic acute
regulating protein protein has
285 amino acids transports
cholesterol to the mitochondria in
the leydig cells
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Ashwagandha Withania somniferaDose 6 grams per day 12 ml of 12 tincture
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Withania improves sperm count and hormones including
LH amp Testosterone lowered FSH amp prolactin versus
controls
Serum T
significantly
increased
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Tong Kat ali akaEurycoma longifolia
Usual Dose 600 mg of 1001 qd or 200-300 of 2001 qd
can be very expensive
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
bull Andrologia 2012 May44 Suppl 1226-30 doi 101111j1439-0272201101168x Epub 2011 Jun 15
bull Standardised water-soluble extract of Eurycoma longifolia Tongkat ali as testosteronebooster for managing men with late-onset hypogonadism
bull Tambi MI et al
bull Source
bull Wellmen Clinic Damai Service Hospital Kuala Lumpur Malaysia dr_tambiyahoocom
bull Abstract
bull In most countries millions of people are relying on herbal medicines as remedy for numerous ailments In South-East Asia Eurycoma longifolia Jack also known as Malaysian ginseng or Tongkat ali is used to combat stress and disease and to improve physical strength Moreover the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat Considering that human studies are not available 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month The Ageing Males Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken Results show that treatment of LOH patients with this Tongkat ali extract significantly (P lt 00001) improved the AMS score as
well as the serum testosterone concentration While before treatment only 105 of the patients did not show any complaint according to the AMS scale and 355 had normal testosterone levels after the completed treatment 717 and 908 of the patients showed normal values respectively Thus Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
TongKat ali improves hormones
in elders 57-72 years oldbull Phytother Res 2013 Jun 11 doi 101002ptr5017 [Epub ahead of print]
bull Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study
bull Henkel RR et al Department of Medical Bioscience University of the Western Cape Bellville 7535 South Africa
bull Abstract
bull Tongkat Ali (Eurycoma longifolia TA) is known to increase testosterone levels and alleviate aging males symptoms This study aimed at investigating TA as an ergogenic supplement for elderly people Thirteen physically active male and 12 physically active female seniors (57-72thinspyears) were supplemented with 400-mg TA extract daily for 5thinspweeks Standard hematological parameters were taken In addition the concentrations of total and free testosterone dihydroepiandrosterone cortisol insulin-like growth factor-1 and sex hormone-binding globulin were analyzed As additional biochemical parameters blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage respectively as well as the muscle strength by a simple handgrip test were determined After treatment hemoglobin testosterone and dihydroepiandrosterone concentrations and the ratio of total testosteronecortisol and muscle force remained significantly lower in female seniors than in male seniors Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations The study affirms the ergogenic benefit of TA through enhanced muscle strength
Significant increases
in total and free
testosterone in men amp
women
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Tribulus amp Testosteronebull Fiziol Zh 200955(5)89-96
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes organism homeostasis
bull Milasius K Dadeliene R Skernevicius J
bull The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes organism homeostase was investigated It was established the positive impact of dietary supplement Tribulus (Optimum Nutrition USA) using per 1 capsule 3 times a day during 20 days on athletes physical power in various energy producing zones anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased Tribulus terrestris extract after 20 days of consuming it did not have essential effect on erythrocytes haemoglobin and thrombocytes indices During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes blood Creatinkinase concentration in athletes blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract The declining tendency of urea cholesterol and bilirubin concentrations has appeared The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment it did not grow during the next 10 days while consuming Tribulus still
This study showed
some increases in
blood testosterone
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Tribulus fails to work in Rugby
playersbull J Strength Cond Res 2007 May21(2)348-53
bull The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players
bull Rogerson S Riches CJ Jennings C Weatherby RP Meir RA Marshall-Gradisnik SM
bull Source
bull School of Exercise Science and Sport Management Southern Cross University Lismore New South Wales Australia srogerson10bigpondcom
bull Abstract
bull Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15 18) Although some manufacturers claim T terrestris will not lead to a positive drug test others have suggested that T terrestris may increase the urinary testosteroneepitestosterone (TE) ratio which may place athletes at risk of a positive drug test The purpose of the study was to determine the effect of T terrestris on strength fat free mass and the urinary TE ratio during 5 weeks of preseason training in elite rugby league players Twenty-two Australian elite male rugby league players (mean +- SD age = 198 +- 29 years weight = 880 +- 95 kg) were match-paired and randomly assigned in a double-blind manner to either a T terrestris (n = 11) or placebo (n = 11) group All subjects performed structured heavy resistance training as part of the clubs preseason preparations A T terrestris extract (450 mgd(-1)) or placebo capsules were consumed once daily for 5 weeks Muscular strength body composition and the urinary TE ratio were monitored prior to and after supplementation After 5 weeks of training strength and fat free mass increased significantly without any between-group differences No between-group differences were noted in the urinary TE ratio It was concluded that T terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days Furthermore T terrestris did not alter the urinary TE ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agencys urinary TE ratio limit of 41
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
PROTOCOL
bull Eurycoma 2001
300 mg
Macuna extract equivalent to 5 Gms per day
Ashwagandha equivalent to 3 Gms per day
Nettle root 2 tsp 12 qd
bull Squats 4 sets of 10day
bull Zinc 100 mgday
bull Ornithine and arginine 3000 mg per day
bull Fresh organic Veggie juice 2 X per day 8 OZ
ndash Kale
ndash Celery
ndash Ginger frac12 inch root
Hair analysis showed Pb toxicityrarrDetox X 6 months
Increase competitive minerals znCamg
Increase flax seed fiber to sequester Pb and act as phytosterol
Liver Detox support formula
Sauna
Homeopathic Pb
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Quest lab values from April to
sept 2018bull Protocol without DHEA and Detoxhellip only botanicals (Tong Kat
Ashwagandha Nettles and minerals used
bull Mucuna 6 grams Ashwagandha 6 grams 101 pine pollen 501 Nettle
root Shilajit Boron 12mg
bull Ashwagandha daily other 5 things rotate daily 4 day rotationTong Kat alirarr use reliable brand
Shilajit shows promise as a
rasayana
Shilajit shows promise as a
rasayana