Animals in Research

Donald B. Casebolt

Director, Department of Animal Resources

Objectives

Responsibilities of the institution Responsibilities of the principal investigator

“The development of knowledge necessary for the improvement of

the health and well-being of humans as well as other animals requires in vivo experimentation

with a wide variety of animal species.”

(United States Office of Science and Technology Policy, 1985)

Federal Laws

Animal Welfare Act US Department of Agriculture

Health Research Extension Act National Institutes of Health

Office of Laboratory Animal

Welfare

Similarities of Two Laws

Institutional Official Institutional Animal Care and Use Committee Program of veterinary care Training of personnel

“Enforced

Self-Regulation”

AAALAC Accreditation

IACUC Membership

Scientist Veterinarian with training and/or experience in

laboratory animal medicine Nonscientist At least one member not affiliated with the

institution (public member)

IACUC Responsibilities

Review the programs of animal care and use Inspect animal facilities and procedure areas Approve, require modifications prior to

approval, or withhold approval of animal use protocols

Approve any changes to animal use protocols The IACUC is authorized to suspend a

protocol

Principal Investigator Responsibilities

Preparation and submission of Animal Use Protocols

Modifications to protocols Justification of animal species and numbers Training of personnel in appropriate methods Occupational health and safety of personnel Avoidance of animal pain and distress Development of humane endpoints Animal euthanasia methods

iStar for IACUC

iStar for IACUC

iStar for IACUC

iStar for IACUC

Training

Species-specific Protocol-specific Web based and hands-on

Questions?