annual report of research activity 2015 · publication list kkn research groups 2015 95 frontside:...

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Annual Report

of Research Activity 2015

Division of Surgery and Clinical Neuroscience University of Oslo and Oslo University Hospital

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Contents Oslo University Hospital and The University of Oslo 3

From Division Director Olav Røise 3

Research activity at the Division of Surgery and Clinical Neuroscience 3

Research groups at the Division of Surgery and Clinical Neuroscience 5

Department of Physical Medicine and Rehabilitation

Rehabilitation after trauma 7

Painful musculoskeletal disorders 10

Department of Refractory Epilepsy – National Centre for Epilepsy

Complex epilepsy 13

Department for Neurosurgery

Neurovascular‐Hydrocephalus Research Group 17

Oslo Neurosurgical Outcome Study Group (ONOSG) 19

Vilhelm Magnus Laboratory for Neurosurgical Research 21

Department of Neurology

Movement Disorders 25

Cerebrovascular Research Group 28

Epilepsy Research Group ‒ Department of Neurology 30

Multiple Sclerosis (MS) 33

Pain Conditions 38

Department of Psychosomatic Medicine

Neuropsychiatic research group 41 Psycho-neuro-endocrinology. Sex on Brain European Research (SOBER) 45

Department of Orthopaedic Surgery Osteoarthritis Research Group 47

Pediatric Ortopaedics 49

Biomechanics Laboratory 51

CIRRO 55

Hand 60

Norwegian Research Centre for Active Rehabilitation ‒ NAR 62

Oncological Orthopedics 66

Orthopaedic Trauma Research Group 68

Oslo Sports Trauma Research Center 71

Department of Plastic and Reconstructive Surgery

Research in plastic- and reconstructive surgery 75

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Sunnaas Rehabilitation Hospital

Specialized medical rehabilitation – Sunnaas Rehabilitation Hospital 77

Department for Otorhinolaryngology, Head and Neck Surgery

Ear and hearing research group 80

HPV in Head and Neck (merged with Upper airways research) 83

Department of Ophthalmology

Center for Eye Research 85

Clinical Retina Research 90

Retinal Vessel Diameters Research Group 93

Publication list KKN research groups 2015 95

Frontside: Colorbox

Non-credited photos in the report: Colorbox, OUH HF and UiO.

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Oslo University Hospital and The University of Oslo Oslo University Hospital (OUH) is Norway’s largest hospital with over 20 000 employees and a budget of 20 billion NOK. The Hospital has a local function for parts of Oslo's population. It has a regional function for the inhabitants in the South-Eastern Norway Regional Health Authority, and it also has a large number of national functions. The Hospital is responsible for the majority of medical research and education of health personnel in Norway. The University of Oslo (UiO) is Norway's largest research and educational institution with 28 000 students and 7 000 employees. Professional breadth and internationally recognized research environments make UiO an important contributor to society. The Faculty of Medicine was established in 1814 and works for progressive education, research and dissemination for the patients’ and society’s best interests.

From Division Director Olav Røise Being the largest hospital in Norway, Oslo University Hospital provides highly specialized health care

services to the citizens of Oslo and the Southeast health region. In addition, the Hospital has a

nationwide responsibility for a number of national and multi-regional assignments. The Division of

Surgery and Clinical Neuroscience is one of eight medical divisions. It encompasses the fields

orthopedics, neurology, neurosurgery, physical medicine and rehabilitation, oto-rhino-laryngology,

reconstructive plastic surgery, orthodontics and dentofacial orthopedics, neuropsychiatry, and

ophthalmology. The proximity to patients and their medical issues are the cornerstones for the

research conducted at our Hospital and is aimed at improving patient care. High ethical standards

ensure the confidentiality and our goal is to continuously improve diagnostics, treatment and

management for all our patients.

Research activity at the Division of Surgery and Clinical

Neuroscience The Division’s research activity is organized into 29 different research groups covering a broad range

of basic, clinical and epidemiological research with an overall aim to improve patient care with

emphasis on diagnostic, therapeutic and preventive measures. Most group leaders have a combined

position at Oslo University Hospital and the University of Oslo. In total the Division has 30 Professors,

11 Associate Professors, postdoctoral fellowships, several PhD students and administrative and

technical staff. The Division has an advisory research board that in 2015 consisted of: Professor John-

Anker Zwart (leader), Professor Olav Røise, Professor Lars Nordsletten, Professor Per Kristian Eide,

Professor Morten Carstens Moe and Administrative Manager Agnete Hager. In 2015 there were in

total 281 registered peer reviewed publications and 21 PhD dissertations.

John-Anker Zwart

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Research groups at the Division of Surgery and Clinical

Neuroscience

Department of Physical Medicine and Rehabilitation

Rehabilitation after trauma. Group Leader: Nada Andelic

Painful musculoskeletal disorders. Group Leader: Cecilie Røe

Department of Refractory Epilepsy – National Centre for Epilepsy

Complex epilepsy. Group Leader: Morten I. Lossius

Department for Neurosurgery

Neurovascular‐Hydrocephalus Research Group. Group Leader: Per Kristian Eide

Oslo Neurosurgical Outcome Study Group (ONOSG). Group Leader: Eirik Helseth/Torstein Meling

Vilhelm Magnus Laboratory for Neurosurgical Research. Group Leader: Iver A. Langmoen

Department of Neurology

Movement Disorders. Group Leader: Espen Dietrichs

Cerebrovascular Research Group. Group Leader: David Russell

Epilepsy Research Group ‒ Department of Neurology. Group Leader: Erik Taubøll

Multiple Sclerosis (MS). Group Leader: Hanne F. Harbo

Pain Conditions. Group Leader: John-Anker Zwart

Department of Psychosomatic Medicine

Neuropsychiatric research group. Group Leader: Ulrik Malt Psycho-neuro-endocrinology. Sex on Brain European Research (SOBER). Group Leader: Ira Haraldsen

Department of Orthopaedic Surgery Osteoarthritis Research Group. Group Leader: Lars Nordsletten

Pediatric Ortopaedics. Group Leader: Ivan Hvid

Biomechanics Laboratory. Group Leader: Harald Steen

CIRRO. Group Leader: Stephan Röhrl/Lars Nordsletten

Hand. Group Leader: Magne Røkkum

Norwegian Research Centre for Active Rehabilitation ‒ NAR. Group Leader: May Arna Risberg

Oncological Orthopedics. Group Leader: Olga Zaikova

Orthopaedic Trauma Research Group. Group Leader: Jan Erik Madsen

Oslo Sports Trauma Research Center. Group Leader: Lars Engebretsen

Department of Plastic and Reconstructive Surgery

Research in plastic- and reconstructive surgery. Group Leader: Kim A. Tønseth

Sunnaas Rehabilitation Hospital

Specialized medical rehabilitation – Sunnaas Rehabilitation Hospital. Group Leader: Johan Stanghelle

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Department for Otorhinolaryngology, Head and Neck Surgery

Ear and hearing research group. Group Leader: Juha Silvola

HPV in Head and Neck (merged with Upper airways research). Group Leader: Harriet Akre

Department of Ophthalmology

Center for Eye Research. Group Leader: Bjørn Nicolaissen Clinical Retina Research. Group Leader: Ragnheidur Bragadottir

Retinal Vessel Diameters Research Group. Group Leader: Nina CBB Veiby

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Rehabilitation after trauma Group Leader

Nada Andelic, MD/PhD, Researcher, Dept of Nursing Science, UiO

([email protected]) / OUH ([email protected])

Research profile and aims The research group generates knowledge about the mechanisms and consequences of trauma,

patient care, trends and challenges in treatment and rehabilitation including the patients’ healthcare

needs. The main research focus is traumatic brain injuries (TBIs). The research conducted by this

group is multidisciplinary and collaborative, where collaboration between genetics, intensive

medicine, neurosurgery, neuroradiology, neuropsychology and rehabilitation has been established

over the last 10 years. By combining the perspectives and methods of basal, clinical and health care

service research, we may provide unique knowledge on the consequences of injuries, how to

organize effective patient care and improve the functional outcomes after injuries.

The main aims are: 1. To better understand the mechanisms, course and consequences of TBI and multiple

traumas by using translational research strategy. 2. To develop and build evidence based efficient protocols for the rehabilitation

implementation. 3. To strengthen existing and initiate new national and international research collaborations on

trauma/TBI research.

Group members

∙ Cecilie Røe, Professor, UiO ∙ Erik Bautz-Holter, Professor, UiO ∙ Helene Lundgaard Søberg, PhD, Senior researcher, OUH ∙ Unni Sveen, Professor, UiO ∙ Ingerid Kleffegaard, PhD fellow, OUH ∙ Tanja Karic, PhD fellow, UiO ∙ Torgeir Hellstrøm, PhD fellow, UiO ∙ Tonje Haug Nordenmark, PhD, Postdoc, OUH ∙ Marit V. Forslund, PhD fellow, UiO

Associated group members ∙ Line Preede, MS research program, UiO ∙ Cathrine Buaas Tverdal, MSC student, UiO ∙ Øyvor Øistensen Holthe, Cand Psych, Research assistant, OUH ∙ Emilie I. Howe, Cand Psych, Research assistant, OUH

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Ongoing projects ∙ Center-TBI (Collaborative European NeuroTrauma Effectiveness Research in TBI). Principal

investigator at the Oslo University Hospital Study Site of Center-TBI Nada Andelic. ∙ Morphological brain damage and functional impairment following mild traumatic brain

injury. Principal investigators Cecilie Røe and Nada Andelic; PhD fellow Torgeir Hellstrøm. ∙ The course of functional recovery after moderate-to-severe TBI (5, 10 and 20 years after

injury). In collaboration with Sunnaas Rehabilitation hospital. Principal investigator Nada Andelic, PhD fellow Marit Forslund.

∙ Effect of interdisciplinary outpatients' treatment in mild traumatic brain injury, a randomized study. In collaboration with Haukeland Hospital. Principal investigators Cecilie Røe and Jan Sture Skouen; PhD fellow Eirik Vikane.

∙ Vestibular Rehabilitation for Patients with Dizziness and Balance Problems after Traumatic Brain Injury. In collaboration with Oslo and Akershus University College of Applied Sciences (HiOA) Principal investigator Helene L. Søberg; PhD fellow Ingerid Kleffelgård.

∙ Effect of early rehabilitation in patients with acute subarachnoid hemorrhage. Principal investigators Cecilie Røe and Angelika Sorteberg. PhD fellow Tanja Karic.

∙ Transitions in rehabilitation: Biographical reconstruction, experiential knowledge and professional expertise. In collaboration with HiOA. Investigators from OUH Helene L. Søberg and Unni Sveen.

∙ Effect of adapted physical activity and goal-setting on physical and mental health. In collaboration with Beitostølen Health Sport Center. Principal investigators Cecilie Røe and Erik-Bautz Holter, fellow Line Preede.

∙ The family as a resource for improved patient and family functioning after traumatic brain injury. A randomized controlled trial of a family centered intervention. Principal investigator Helene L. Søberg.

Most important national and international collaborators

National International

Oslo Traumatic Brain Injury Outcome and Rehabilitation Research Network (OBIOR- research network) - Hospitals in the South-East Region including Sunnaas Rehabilitation Hospital - The Norwegian University Hospitals - Oslo and Akershus University College of Applied Sciences - Universities of Oslo, Bergen, Trondheim and Tromsø

‐ Karolinska, Uppsala, Umeå and Salgrenska University Hospitals, Sweden

‐ Copenhagen University Hospital and Hammel Rehabilitation and Research Centre, Denmark

‐ Virginia Commonwealth University, Richmond, US ‐ University of Deusto, Bilbao, Spain ‐ University of Gottingen, Germany ‐ CENTER-TBI collaborators across the European

hospitals/universities

Scientific production of the research group in 2015

Peer reviewed original research articles: 23

Other publications: 13

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Invited lectures at international congresses: - Andelic N. CENTER-TBI: International workshop on transitions of TBI care, Oxford (May 8th 2015) - Andelic N. Self-perceived health care needs and delivery of health care services 5 years after

moderate-to-severe traumatic brain injury. The 5th Conference of the European Societies of Neuropsychology and the 12th Nordic Meeting in Neuropsychology, Tampere, Finland, Sept. 2015

- Røe C. Predictors of one year functional outcome in elderly with severe traumatic brain injury. The 5th Conference of the European Societies of Neuropsychology and the 12th Nordic Meeting in Neuropsychology, Tampere, Finland, Sept. 2015

Selected publications: 1. Andelic N, Arango-Lasprilla JC, Perrin PB, Sigurdardottir S, Lu J, Landa LO, Forslund MV, Roe C

(2015). Modeling of Community Integration Trajectories in the First Five Years after Traumatic Brain Injury. J Neurotrauma, 33 (1), 95-100

2. Soberg HL, Bautz-Holter E, Finset A, Roise O, Andelic N (2015). Physical and mental health 10 years after multiple trauma: A prospective cohort study. J Trauma Acute Care Surg, 78 (3), 628-33

3. Røe C, Skandsen T, Manskow U, Ader T, Anke A (2015). Mortality and One-Year Functional Outcome in Elderly and Very Old Patients with Severe Traumatic Brain Injuries: Observed and Predicted. Behav Neurol, 2015, 845491

Funding - European Union's Seventh Framework Programme for Research and Development - Norwegian Research Council - Norwegian Extra Foundation for Health and Rehabilitation - University of Oslo - Oslo University Hospital

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Painful musculoskeletal disorders Group Leader Cecilie Røe, Professor, Head of Dept of Physical Medicine and Rehabilitation, UiO

([email protected])/ OUH ([email protected])

Research profile and aims The research unit generates knowledge regarding diagnostics, treatment and rehabilitation of painful

musculoskeletal conditions. The main focus is on neck, back and shoulder conditions. The research is

multidisciplinary and collaboration with basal, clinical and health care service milieus established.

Based on the framework of the International Classification of Functioning, Disability and Health (ICF)

and the biospychosocial model, interaction between the genetic and other basal disease mechanisms

with psychosocial, personal and environmental factors are studied regarding the course of pain,

functioning and participation. Furthermore, developing and evaluating treatment models in

prospective and randomized studies, aiming to improve functioning and return to work are main

focus areas.

The main aims are:

- To understand the mechanisms, course and consequences of painful musculoskeletal conditions.

- To develop and evaluate treatment models for painful musculoskeletal conditions.

Ongoing projects ∙ Low back pain, workplace absenteeism and disability pensioning – the interaction between

type of occupation, psychosocial risk factors and genetic susceptibility. Principal investigators Cecilie Røe and Johannes Gjerstad, National Institute of Occupational health. PhD fellow Aurora Moen

∙ The long-term course of low back pain and radiculopathy. PhD student Aurora Moen ∙ Reliability of Modic changes. Principal investigator Elina Schistad

Group Members

∙ Erik Bautz-Holter, Professor, UiO ∙ Siri Bjorland, PhD, UiO ∙ Jens Ivar Brox, Professor, UiO ∙ Kaia Beck Engebretsen, PT, PhD, OUH ∙ Aasne Hoksrud, PhD, OUH ∙ Niels-Gunnar Juel MD, OUH ∙ Synnøve Kvalheim, PhD student, UiO ∙ Elisabeth Kvalvaag, PhD student, UiO ∙ Aurora Lie Moen, PhD student, UiO ∙ Kjersti Myhre, , PhD, OUH ∙ Line Preede, Research line student, UiO ∙ Elina Schistad, PhD, postdoctoral student Pain Medicine, UiO

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∙ Efficacy of labral repair, biceps tenodesis and diagnostic arthroscopy for SLAP lesions of the

shoulder, a randomized controlled trial. Principal investigator Jens Ivar Brox. PhD fellow Cecilie Piene Schrøder.

∙ Significance of diagnostics and effect of pressure wave treatment in addition to guided training, head of project Erik Bautz Holter. PhD fellow Elisabeth Kvalvaag.

∙ An investigation of neck/back and shoulder patients expectations to treatment outcome, regarding painreduction and functional improvements. Principal investigator Lars-Petter Granan. PhD fellow Sigrid Skatteboe.

∙ Improving functioning and participation among persons with physical disabilities. Principal investigator Cecilie Røe. Research line student Line Preede.

∙ Clinical course and prognostic factors for shoulder pain patients in primary and specialized care. Principal investigator Kaia Engebretsen.

∙ Frozen shoulder- a prospective study with 4 years follow up. Principal investigator Niels Gunnar Juel.

∙ Antibiotic treatment in patients with chronic low back pain and Modic Changes: randomized trial. Conducted by FORMI. Principal investigator in the research group Jens Ivar Brox, and Elina Schistad.

Most important national and international collaborators National International

‐ Dept of Orthopaedics, OUH ‐ National Institute of Occupational

Health

‐ Dept of Physical medicine and Rehabilitation at St Olavs Hospital / Trondheim University Hospital, University Hospital of North Norway and Haukeland University Hospital

‐ Torsten Gordh, Uppsala University, Sweden ‐ Juan Lu, Paul Perrin, Virginia Commonwealth

University, US

‐ ICF Research Branch, Switzerland ‐ University of Munich, Switzerland ‐ University of Lucerne, Switzerland


Peer reviewed original research articles:


Invited lectures at international congresses: 5

Doctoral dissertation:

Kjersti Myhre: Perceived psychosocial work environment

and effects of a work-focused intervention among

patients with neck and back pain. UiO 16.09.15

Funding ‐ The Research Council of

Norway ‐ South-Eastern Norway

Regional Health Authority ‐ Sofies Minde Ortopedi ‐ Oslo University Hospital

(interaction means)

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Selected publications: Kvalvaag E, Brox JI, Engebretsen KB, Søberg HL, Bautz-Holter E, Røe C (2015)

Is radial Extracorporeal Shock Wave Therapy (rEWST) combined with supervised exercises (SE) more

effective than sham rESWT and SE in patients with subacromial shoulder pain? Study protocol for a

double-blind randomised, sham-controlled trial

BMC Musculoskelet Disord, 16, 248. PubMed 26361756

Myhre K, Lau B, Marchand GH, Leivseth G, Bautz-Holter E, Røe C (2015)

Demand, Control and Support at Work Among Sick-Listed Patients with Neck or Back Pain: A

Prospective Study. J Occup Rehabil (in press). PubMed 26286432

Omair A, Mannion AF, Holden M, Fairbank J, Lie BA, Hägg O, Fritzell P, Brox JI (2015). Catechol-O-methyltransferase (COMT) gene polymorphisms are associated with baseline disability but not long-term treatment outcome in patients with chronic low back pain. Eur Spine J, 24 (11), 2425-31. PubMed 25772090

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Complex epilepsy Group Leader Morten I. Lossius, MD/PhD, Consultant neurologist, National Centre for Epilepsy, OUH

([email protected])

Research profile and aims Clinical research in patients with difficult-to-treat epilepsy, with particular focus on:

1. Characterisation of different epilepsy syndromes (genotype/phenotype)

2. Different diagnostic and treatment options; EEG, pharmacotherapy, surgery, VNS, diets

3. Psychosocial, psychiatric and neurocognitive aspects

4. Psychogenic non-epileptic seizures

Ongoing projects PhD candidates in the UiO PhD program:

∙ Kristin Alfstad: Prevalence of psychiatric symptoms in children and youth with epilepsy and executive dysfunction as a possible predictor of psychiatric disease. (submitting the PhD thesis summer 2015). Supervisor: Morten I. Lossius. Co-supervisor: Leif Gjerstad

Group Members ∙ Karl Otto Nakken, MD/PhD, SSE ∙ Marit Bjørnvold, MD/PhD, SSE ∙ Erik Hessen, Prof dr.philos, SSE, UiO ∙ Ylva Østby, PhD, SSE ∙ Cecilie Johannessen Landmark MSc/PhD, SSE, HIOA

Associated group members ∙ Kristin Alfstad, MD, SSE ∙ Anette Ramm-Pettersen, MD, SSE, UiO ∙ Magnhild Kverneland, MSc, SSE,UiO ∙ Kari Modalsli Aaberg, MD, SSE,UiO ∙ Hilde Karterud, Nurse, Cand.san, SSE,UiO ∙ Antonia Vilagran, MD, SSE,UiO ∙ Charlotte Lunde, MD, SSE ∙ Trude Rath Olsen, MD, SSE

∙ Halvor Torgersen, Psychologist, SSE

∙ Oliver Henning, MD, SSE

∙ Torleiv Svendsen, SSE, SI-L ∙ Anette Huuse Farmen, MD,OUS, SI-L

∙ Silje Syrstad, Educationalist, UiO

http://ous-research.no/home/epilepsy/home/6580

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∙ Anette Ramm-Pettersen: GLUT-1 Deficiency Syndrome ‒ an underdiagnosed cause of difficult-to-treat epilepsy? (defended the PhD thesis June 10, 2015). Supervisor: Kaja Selmer. Co-supervisor: Karl Otto Nakken

∙ Kari Modalsli Aaberg: Epilepsy in young children. Supervisor: Camilla Stoltenberg. Co-supervisors: Pål Suren, Per Magnus, Richard Chin and Morten I. Lossius

∙ Hilde Karterud: Medically unexplained seizures: a qualitative study of the development of patients illness perceptions. Supervisor: Mette Bech Risør. Co-supervisor: Ole Rikard Haavet

∙ Magnhild Kverneland: Effect of modified Atkin’s diet in adult patients with pharmacoresistant focal epilepsy. A randomized controlled study. Supervisor: Karl Otto Nakken. Co-supervisor: Erik Taubøll

∙ Antonia Villagran. Psychiatric comorbidity in patients with psychogenic non-epileptic seizures

(PNES). Supervisor: Morten I. Lossius. Co-supervisor: Roderick Duncan

PhD-candidates not yet in the UiO PhD program:

∙ Charlotte Lunde: Could Computerized Working Memory Training be an alternative to stimulant medication for children and adolescents with attention deficits and epilepsy? A randomized, blinded, controlled trial. Supervisor: Morten I. Lossius. Co-supervisor: Gro Løhaugen

∙ Trude Rath Olsen: Predictors for Sudden Unexpected Death in Epilepsy and the putative importance of antiepileptic medication. Supervisor: Morten I. Lossius. Co-supervisor: Karl Otto Nakken and Torbjørn Tomson

∙ Halvor Torgersen: Neuropsychological functioning among children and adolescents with different types and severity of epilepsy. Supervisor: Erik Hessen. Co-supervisors/co-workers: Morten Lossius and Kristin Alfstad

∙ Torleiv Svendsen: Tolerability and efficacy of new antiepileptic drugs. Supervisor: Cecilie

Johannessen Landmark. Co-supervisors: Ole Morten Rønning and MortenI Lossius

PhD-candidates in the UiO PhD program, associated to the group:

∙ Anette Huuse Farmen. Effect of epilepsy and antiepileptic drugs in pregnancy: cognition, neurodevelopmental symptoms and obstetric outcome in offspring ‒ a prospective cohort study. Supervisor: Morten I. Lossius. Co-supervisor: Merethe Øien

∙ Silje Syrstad. Nocturnal epileptiform activity in EEG and language skills. Supervisor: Solveig Alma Lyster. Co-supervisor: Marit Bjørnvold

Innovation project:

∙ Charlotte Lunde. Selfmotivating computerized working memory training in ADHD. Oslo University Hospital, Oslo Med-Tec, Inven2

International projects:

∙ EURAP study. An International Antiepileptic Drugs and Pregnancy Registry (http://www.eurapinternational.org/) Karl Otto Nakken, National coordinator

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∙ Twin study. An international genetic study of twins with epilepsy. Karl Otto Nakken, co-reseacher

∙ E-PILEPSY. Pan European project, with the primary aim of improving awareness and accessibility of surgery for epilepsy across different countries. Epilepsy surgery is an established treatment in the management of individuals with drug resistant focal epilepsy (http://www.e-pilepsy.eu/). Morten I. Lossius, associated partner

International projects:

∙ EURAP study. An International Antiepileptic Drugs and Pregnancy Registry (http://www.eurapinternational.org/) Karl Otto Nakken, National coordinator.

∙ Twin study. An international genetic study of twins with epilepsy. Karl Otto Nakken, co-reseacher.

∙ E-PILEPSY is a pan European project, with the primary aim of improving awareness and accessibility of surgery for epilepsy across different countries. Epilepsy surgery is an established treatment in the management of individuals with drug resistant focal epilepsy (http://www.e-pilepsy.eu/). Morten I. Lossius, associated partner.


‐ Eylert Brodtkorb, St. Olavs Hospital / Trondheim University Hospital

‐ Erik Taubøll, OUH

‐ Linda Corey, Richmond, Virginia, US. (Twin study)

‐ Torbjørn Tomson, Karolinska Institutet, Stockholm, Sweden. (European Registry of Antiepileptic drugs and Pregnancy)

‐ P Ryvlin (Lyon), H Cross (London), K Braun (Utrecht), P Dimova (Sofia), S Francione (Milano), H Hecimovic (Zagreb), C Helmstaedter (Bonn), V Kimiskidis (Thessaloniki), K Malmgren (Götenburg), P Marusic (Praha), E Trinka (Salzburg), and B Steinhoff (Kork). (The E-PILEPSY project)




Dissertation:

Anette Ramm-Pettersen: “GLUT1 deficiency syndrome in Norway - an epidemiological study of treatable metabolic disease”. June 15, 2015

Funding ‐ South-Eastern Norway Regional

Health Authority ‐ Norwegian ExtraFoundation for

Health and Rehabilitation ‐ Norwegian School of Sport Science ‐ Innlandet Hospital Trust ‐ The Competence Centre for

Mental Delay and Epilepsy ‐ ADHD network research funds ‐ Inven2 ‐ Innovation Norway

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Invited lectures at international congresses: ∙ «Termination of AED treatment in patients in remission». Morten I Lossius: Withdrawal of

antiepileptic drugs- possibilities and consequences. Tampere Finland, April 23, 2015

∙ 5th Eilat International educational course Pharmacological treatment of epilepsy, Jerusalem, Israel October 2015: Svein I. Johannessen: Implementation of therapeutic drug monitoring of antiepileptic drugs + Clinical pharmacokinetic and interactions

∙ 5th Eilat International educational course Pharmacological treatment of epilepsy, Jerusalem, Israel October 2015. Cecilie Johannessen Landmark: Pharmacokinetics of AEDs in special patient populations and Clinical pharmacokinetic and interactions

∙ Differentialdiagnostic challenges in children with PNES incl. Case. Morten I. Lossius: Psychogenic non-epileptic seizures. Treatment, outcome and prognoses. Copenhagen, November 12, 2015

∙ Psychopathology in adults with PNES. Antonia Villagran: Psychogenic non-epileptic seizures Treatment, outcome and prognoses. Copenhagen, November 12, 2015

∙ Differentialdiagnostic challanges in adults with PNES. Oliver Henning: Psychogenic non-epileptic seizures. Treatment, outcome and prognoses. Copenhagen, November 12, 2015

∙ Nordic Ketogenic Meeting. Magnhild Kverneland: Dietary therapy for adults with pharmacoresistant generalized epilepsy - preliminary results. Comwell Sorø, Denmark, May 22, 2015

Selected publications:

Farmen AH, Grundt J, Tomson T, Nakken KO, Nakling J, Mowinchel P, Lossius M. Intrauterine

growth retardation in foetuses of women with epilepsy. Seizure 2015; 28: 76-80.

Lossius MI, Nakken KO, Mowinckel P, Taubøll E, Gjerstad L. Favorable change of lipid profile after

carbamazepine withdrawal. Acta Neurol Scand 2015 [Epub ahead of print]

Syvertsen M, Nakken KO, Edland A, Hansen G, Hellum MK, Koht J. Prevalence and etiology of epilepsy in a Norwegian county-A population based study. Epilepsia 2015; 56(5): 699-706.

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Neurovascular‐Hydrocephalus Research Group Group Leader Per Kristian Eide, Professor, Dept of Neurosurgery, UiO ([email protected])/

Section Chief, Dept of Neurosurgery, OUH ([email protected])

Research profile and aims The research group focuses on clinical and translational neurosurgical research within the fields of

neurovascular disease and cerebrospinal fluid disorders.

1. Cerebrovascular disorders. Cerebral hemodynamics. Focus on intracranial aneurysms and subarachnoid hemorrhage, including neurointensive monitoring and outcome.

2. Brain Monitoring. Several projects study intracranial pathophysiology with a strong focus on intracranial pressure and arterial blood pressure dynamics, and cerebral autoregulation.

3. Hydrocephalus. Studies focus on the pathophysiology of hydrocephalus and alterations in pressure dynamics in hydrocephalus and other brain water disorders. Translational research has been initiated to study molecular-genetic mechanisms of hydrocephalus and diseases involving disorders in brain water homeostasis. Clinical studies focus on outcome of treatment of hydrocephalus.

Group Members

∙ Daniel Dahlberg, PhD fellow, OUH ∙ Per Kristian Eide, professor, OUH ∙ Vigdis A Eidsvåg, PhD fellow, OUH ∙ Øyvind Evju, PhD fellow, UiO ∙ Tanja Karic, PhD fellow, OUH ∙ Karl‐Fredrik Lindegaard, Professor, OUH ∙ Tryggve Lundar, Professor, OUH ∙ Torstein R Meling, dr.med., OUH ∙ Geir A. Ringstad, Senior Consultant, OUH ∙ Tiril Sandell, PhD fellow, OUH ∙ Haldor Slettebø, Senior Consultant, OUH ∙ Angelika Sorteberg, dr.med., OUH ∙ Wilhelm Sorteberg, dr.med., OUH ∙ Terje Sæhle, PhD fellow, OUH ∙ Milo Stanisic, dr.med., OUH ∙ Hampus O. Erixon, stud med. Researcher Line Student, UiO

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Ongoing projects ∙ Pathophysiology by cerebral abscesses ∙ Pathophysiology of hydrocephalus and abnormal brain pressure ∙ Pathophysiology of subarachnoid hemorrhage and subdural hematomas ∙ Outcome of treatment of subarachnoid hemorrhage, vascular compression

syndromes, stroke and hydrocephalus ∙ Bleeding Risks of cerebral aneurysms ∙ Rehabilitation after subarachnoid hemorrhage ∙ Diagnostic Imaging by disturbances in the cerebrospinal fluid circulation


‐ Simula, UiO ‐ Physical medical dept, OUH ‐ Dept of Radiology, OUH ‐ Interventional Centre, OUH ‐ Dept of Informatics, UiO ‐ Dept of Neurology, OUH ‐ Trauma Clinic , OUH ‐ Sunnaas Rehabilitation

Hospital

‐ University of Miami, US (Prof. Alperin) ‐ University of Gothenburg, Sweden (Prof.

Hansson)



Invited lectures at international congresses:>15

Doctoral dissertations:

Tiril Sandell “Microvascular decompression for cranial nerve vascular compression syndromes” ISBN 978-82-8264-949-0. Dissertation 19.3.2015

Selected publications: Dahlberg D, Ivanovic J, Hassel B (2015) Toxic levels of ammonia in human brain abscess. J Neurosurg, 124 (3), 854-60 Eide PK, Sorteberg W (2015) Outcome of Surgery for Idiopathic Normal Pressure Hydrocephalus: Role of Preoperative Static and Pulsatile Intracranial Pressure. World Neurosurg, 86, 186-193.e1 Farahmand D, Sæhle T, Eide PK, Tisell M, Hellström P, Wikkelsö C (2015) A double-blind randomized trial on the clinical effect of different shunt valve settings in idiopathic normal pressure hydrocephalus J Neurosurg, 124 (2), 359-67


Health Authority ‐ European Union

http://www.publika.no/publika?page=scientist&authorid=11404


http://dx.doi.org/10.3171/2015.1.JNS142582



http://dx.doi.org/10.1016/j.wneu.2015.09.067








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Oslo Neurosurgical Outcome Study Group (ONOSG)

Professor Eirik Helseth, MD/PhD. Consultant neurosurgeon, Dept. of

Neurosurgery, Oslo University Hospital and Professor of Neurosurgery, Faculty

of Medicine, University of Oslo ([email protected]) / OUH

([email protected])

Torstein Meling, MD/PhD, Consultant neurosurgeon, Dept of Neurosurgery,

Oslo University Hospital ([email protected]), Assistant Professor of

Neurosurgery, Faculty of Medicine, University of Oslo and Assistant Professor,

Institute of Psychology, University of Oslo ([email protected])

Research profile and aims Main focus on surgical complications and outcome after surgery for:

∙ Intracranial tumors

∙ Intraspinal tumors

∙ Outpatient spinal surgery

∙ Neurotrauma

Ongoing projects ∙ Intraspinal tumors – Charlotte Halvorsen

∙ Cervical trauma – Hege Fredø

∙ Tumor epidemiology – Markus Wiedmann

∙ Pituitary adenomas – Jon-Terje Ramm-Pettersen

∙ Traumatic Brain Injury – Pål Rønning

∙ Intracranial tumors – Benjamin Lassen

Group Members

∙ Petter Brandal, MD/PhD, OUH ∙ Bjarne Lied, MD/PhD, OUH ∙ Tom Børge Johannesen, MD/PhD, OUH ∙ David Scheie, MD/PhD, Rigshospitalet, Copenhagen, Denmark ∙ Mads Aarhus, MD/PhD, OUH ∙ Einar Vik-Mo, MD/PhD, Postdoc, OUH ∙ Charlotte Halvorsen, MD, PhD fellow, OUH ∙ Hege Fredø, MD, PhD fellow, OUH ∙ Markus Wiedmann, MD, PhD fellow, OUH ∙ Jon-Terje Ramm-Pettersen, MD, PhD fellow, OUH ∙ Pål Rønning, MD, PhD fellow, OUH ∙ Benjamin Lassen, MD, PhD fellow, OUH ∙ Marton König, MD, PhD fellow, Sykehuset Østfold Kalnes

mailto:[email protected]

20

∙ Skull base tumors - Marton König

∙ CNS lymphomas – Guro Jahr

∙ Intraoperative control of resection – Einar Vik-Mo

∙ Center-TBI (European multicenter study) – Eirik Helseth

∙ Out-patient spine surgery – Bjarne Lied





Halvorsen CM, Rønning P, Hald J, Johannesen TB, Kolstad F, Langmoen IA, Lied B, Skaar Holme S, Helseth E (2015) The Long-term Outcome After Resection of Intraspinal Nerve Sheath Tumors: Report of 131 Consecutive Cases Neurosurgery, 77 (4), 585-92; discussion 592-3

Helseth Ø, Lied B, Halvorsen CM, Ekseth K, Helseth E (2015) Outpatient Cervical and Lumbar Spine Surgery is Feasible and Safe: A Consecutive Single Center Series of 1449 Patients Neurosurgery, 76 (6), 728-37; discussion 737-8

Ramm-Pettersen J, Halvorsen H, Evang JA, Rønning P, Hol PK, Bollerslev J, Berg-Johnsen J, Helseth E (2015) Low immediate postoperative serum-cortisol nadir predicts the short-term, but not long-term, remission after pituitary surgery for Cushing's disease BMC Endocr Disord, 15, 62

Funding South-Eastern Norway Regional Health Authority

21

Vilhelm Magnus Laboratory for Neurosurgical Research Group Leader Iver A. Langmoen, MD/PhD, Professor, Dept of Neurosurgery, UiO

([email protected]) /Dept of Neurosurgery, OUH ([email protected])

Research profile and aims The Vilhelm Magnus Laboratory (VML) is the translational research group for neurosurgery at Oslo

University Hospital. We explore the biology underlying neurosurgical conditions and our research

efforts encompass both normal and cancer cells from the human brain. The studies on brain cancer

are focused on glioblastoma which is both the most frequent and most deadly brain cancer (median

survival in unselected series ≈10 months).

To characterize human brain stem cells and develop cell types for neurodegenerative

disorders

To characterize glioblastoma stem cells

To develop therapeutic strategies against glioma stem cell

Ongoing projects

Characterization of adult human brain stem cells

A major obstacle in studying adult human neural stem cells has been the very limited amount of

cells available. In keeping with work we have published earlier on new protocols to improve

Group Members: ∙ Artem Fayzullin, MD, PhD-student, UiO

∙ Zanina Grieg, MSc, OUH

∙ Kirsten Strømme Kireulf-Vieira, MD, PhD-student, UiO

∙ Birthe Mikkelsen, BSc, OUH

∙ Awais Mughal, MD, PhD-student, OUH

∙ Wayne Murrell, PhD, OUH

∙ Emily Palmero, BSc, OUH

∙ Erlend Skaga, MD, PhD-student, UiO

∙ Håvard Skjellegrind, MD, PhD-student, VIRUUS-OUH

∙ Biljana Stangeland, PhD, Postdoc, CAST, NRC

Asociated Group Members: ∙ Cecilie J Sandberg, MSc, PhD, Lab manager/HR/Daily activities, OUH ∙ Einar O. Vik-Mo, MD, PhD, Deputy Leader, OUH

22

harvesting and cell culturing methods (Westerlund U et al, Exp Cell Res 2003; Moe MC et al, Brain

2005; Westerlund et al, Neurosurgery 2005; Varghese M et al, Stem Cells Dev 2009; Vik-Mo EO et al,

Exp Cell Res 2011 ; Murrell W et al, PlosOne 2013) we have optimized methods to further increase

cellular yield (Behnan and Vik-Mo, in progr). We have continued the work on identifying genes,

pathways and proteins that are differentially regulated in adult human neural stem cells compared to

adult brain tissue (Sandberg et al, PlosOne 2014).

Targeting brain cancer stem cells in glioblastoma

It is thought that stem cells in glioblastoma are critically important in resistance to therapy. Therefore,

there is a strong rationale to target these cells in order to develop new molecular therapies. For more

than a decade an important aim of the lab has been a systematic comparison of adult human neural

stem cells and glioblastoma stem cells (GSC). We have identified differentially expressed cell

properties (Varghese M et al, Neurosurgery 2008, Vik-Mo EO et al, Neuro Oncol 2010 ), and genes

and signaling proteins that may have potential as new and specific targets for treatment of

glioblastoma (Sandberg C et al, Exp Cell Res 2013).

Transcriptional analysis of GSCs identified the Wnt pathway as a promising target in glioblastoma

cancer stem cells (Sandberg C et al, Exp Cell Res 2013). We have found that inhibition of Wnt

signaling with recombinant SFRP1 protein down-regulated nuclear β-catenin and decreased in vitro

proliferation and sphere formation in a dose-dependent manner. Furthermore, expressional and

functional analysis of SFRP1-treated GSCs revealed that SFRP1 halts cell cycling and induces apoptosis.

These observations demonstrate that Wnt signaling is dysregulated in GSCs, and that inhibition of the

Wnt pathway could serve as a therapeutic strategy in the treatment of GBM (Kierulf-Vieira KS et al,

Expr Cell Res 2016).

Based on our micro-array study (Sandberg C et al, Exp Cell Res 2013) we selected 20 genes that were

consistently expressed in GSC cultures and consistently not expressed in NSC cultures. Through

combined analysis of gene and protein expression in GSCs, we identified nine genes for further

investigations as targets for treatment of GBM. The genes were highly co-expressed in all GBM

subtypes and part of the same protein-protein interaction network (Stangeland et al Oncotarget,

2015). Knockdown of one of these genes, the PDZ-binding kinase (PBK), led to decreased viability and

sphere formation in GSCs. Treatment of experimentally induced GBM tumours in mice resulted in a

significant reduction of tumour growth (Joel M et al, Molecular Cancer 2015). We have also

investigated the role of N-acetyltransferase (NAT12) in GSCs. Knockdown studies of the NAT12-gene

resulted in markedly reduced cell viability and sphere-forming ability of GSCs. Intracranial

transplantation of GSCs featuring NAT12 knockdown into severe combined immunodeficient mice

resulted in a significant prolongation of animal survival compared to controls (Mughal A et al,

Molecular Cancer, 2015).

Characterization of invasive glioblastoma stem cells

Glioblastomas are characterized by diffusely infiltrative growth. To investigate the invasive properties

of glioblastoma cells we film cells while they invade into rodent brain slices or 3D-biomatrixes. Our

23

time-lapse microscopy data reveals distinct phenotypic subtypes among invasive cells as well as

specific movement patterns of invasion guided by tumour core signaling.

(Fayzullin A et al, Exp Cell Res, subm). In addition, to get comprehensive data on mechanisms of

invasion we work on transcriptome analysis of invasive glioblastoma cells.

Cancer stem cell differentiation and tolerance to hypoxia

Tolerance to hypoxia may be an important feature in cancer progression. We have previously shown

that GSCs can be differentiated to more mature cell types. We have now investigated how

differentiation influences tolerance to hypoxia. The results suggest that undifferentiated GSCs are

oxygen dependent, and that limited differentiation induces relative hypoxia tolerance. This warrants

a careful approach to differentiation as a glioblastoma treatment strategy (Skjellegrind H et al,

Neurochem Res 2016).

Immunotherapy against cancer stem cells in glioblastoma

We have earlier developed an autologous dendritic cell (DC) based vaccine therapy that specifically

target the cancer stem cells in glioblastoma and conducted a first-in-man study of this therapy (Vik-

Mo EO et al, CII 2013). ). This study gave very promising results: the therapy resulted in the

development of specific immune response, associated with shrinking tumour volume and 2.3 times

increased progression free-survival. Working with our collaborating partners (Gunnar Kvalheim –

partner in the Stem Cell Center, and Professor Dolores Schendel in Munich) we have optimized several

aspects of the vaccine during 2015. This includes improved mRNA amplification, more efficient

production and modifications of the vaccine that has resulted in a stronger immune response. We

have by now been granted money to perform a larger randomized controlled phase II/III clinical study,

evaluating the benefit of adding the new version of the vaccine to current standard care. The study is

planned to enroll 30 patients in each group, and will evaluate both progression-free and overall

survival.

Individualized systems medicine strategy to target cancer stem cells in patients with recurrent

glioblastoma

In a collaboration with our partners at the Finnish Institute for Molecular Medicine, we are combining

the novel technical possibilities of high-throughput screening and deep sequencing with our

established know-how on individualized patients specific tumour stem cell cultures. Exploring a panel

of 450 drugs established in clinical use, as well as targeted therapy drugs in early-phase studies, we

are screening individualized tumour stem cells for drug sensitivity. This approach has recently been

coined Individualized Systems Medicine. The preclinical pipelines have been established in 2015 and

these results will allow the approach to be used to treat patients. Treatment of patients is planned to

start in 2016.

24


‐ Gunnar Kvalheim, OUH

‐ Steinar Aamdal, OUH

‐ Stefan Krauss, OUH

‐ Ola Myklebust, OUH

‐ Petter Brandal, OUH

‐ Elsa Lundanes, UiO

‐ Stewen Wilson, UiO

‐ Markus Perola, Krister Wennerberg,

Finnish Institute for Molecular

Medicine, Finland

‐ Aki Laakso, Emilia Gaa-Paavola, Töölö

Hospital, Helsinki, Finland

‐ Rainer Glass, LMU, München, Germany

‐ Krishna Bhat and Frederick Lang , MD

Anderson Cancer Center, Houston,

USA

‐ Deni Galileo, University of Delaware,

USA

‐ Winston Hide, Harvard University, MA,

USA



Invited lectures at international congresses:

Five invited lectures at international meetings. 30 tons of CO2 emission avoided by denying other

invitations.

Selected publications: Stangeland B, Mughal AA, Grieg Z, Sandberg CJ, Joel M, Nygård S, Meling T, Murrell W, Vik Mo EO, Langmoen IA. Combined expressional analysis, bioinformatics and targeted proteomics identify new potential therapeutic targets in glioblastoma stem cells. Oncotarget. 2015 Sep 22;6(28):26192-215. Mughal AA, Grieg Z, Skjellegrind H, Fayzullin A, Lamkhannat M, Joel M, Ahmed MS, Murrell W, Vik-Mo EO, Langmoen IA, Stangeland B. Knockdown of NAT12/NAA30 reduces tumorigenic features of glioblastoma-initiating cells. Mol Cancer. 2015 Aug 21;14:160. Halvorsen CM, Rønning P, Hald J, Johannesen TB, Kolstad F, Langmoen IA, Lied B, Skaar Holme S, Helseth E. The Long-term Outcome After Resection of Intraspinal Nerve Sheath Tumors: Report of 131 Consecutive Cases. Neurosurgery. 2015 Oct;77(4):585-92; discussion 592-3.

Funding ‐ Norwegian Cancer Society ‐ The Norwegian Research

Council ‐ Norwegian Stemcell Network

and CAST ‐ OUH, Dept of Neurosurgery

25

Movement Disorders Group Leader

Espen Dietrichs, MD/PhD, Professor and Head of Dept of Neurology, UiO


Research profile and aims Our research aims at mapping the clinical expression, natural progression and treatment of these

disorders, as well as their causes (genetic disposition, environmental factors, and pathophysiological

mechanisms).

Clinical research is performed at both sites of Department of Neurology, i.e. at The

National Hospital and at Oslo City Hospital. Laboratory research is performed in the Neuroscience

Research Unit in our new facilities at Domus Medica IV, close to The

National Hospital. Our department is the secondary referral center for all neurology in Oslo (mainly

at Oslo City Hospital), and the tertiary referral center for neurology in the South-East Health Region

Group Members ∙ Victoria Berge, MD, UiO ∙ Silje Bjerknes, MD, OUH ∙ Kari Anne Bjørnarå, MD, PhD, Vestre Viken ∙ Marion Ingeborg Boldingh, MD, PhD, OUH ∙ Ahmed Elsais, MD, PhD, OUH ∙ Erik Eriksen, MD, OUH ∙ Jan Christian Frich, Professor, OUH ∙ Vidar Gundersen, Professor, OUH ∙ Sandra Pilar Henriksen, MSc, OUH ∙ Morten Andreas Horn, MD PhD, UiO/OUH ∙ Zafar Iqbal, PhD, OUH ∙ Emilia Kerty, Professor, UiO/OUH ∙ Jeanette Koht, MD PhD, Vestre Viken ∙ Nadja Anette Myrvik Kvernmo, MD, OUH ∙ Sven Olav Løstegaard, Medical student, OUH ∙ Angelina Hatlø Maniaol, MD, PhD, OUH ∙ Lasse Pihlstrøm, MD, UiO ∙ Trine Haug Popperud, MD, UiO ∙ Aina Rengmark, PhD ∙ Siri Lynne Rydning, MD, OUH ∙ Inger Marie Skogseid, MD, PhD, OUH ∙ Chantal M.E. Tallaksen, Professor, UiO/OUH ∙ Mathias Toft, MD PhD, OUH ∙ Iselin Marie Wedding, MD, PhD, OUH

26

of Norway (which includes one half of the Norwegian population). In addition, we have different

national functions, including deep brain stimulation (DBS) for movement disorders and other

conditions (which is shared with St. Olav’s Hospital).

Ongoing projects Our research group studies movement disorders and neuromuscular disorders. We have projects

with focus on, e.g., Parkinson’s Disease, dystonia, tremors, ataxia and other cerebellar diseases,

hereditary spastic paraparesis, Huntington’s Disease, and myasthenia gravis.


‐ Division of Surgery and Clinical Neuroscience, UiO (Internal collaboration, joint academic and laboratory)

‐ The other university hospitals in Norway

‐ Vestre Viken Hospital Trust

‐ FIGHT-MG, a collaboration of leading neurologist and researchers within Myasthenia Gravis research in Europe. Sponsored by EU. FP7 Grant 242210

‐ LUMC, prof J.J.G.M Verschuuren ‐ P. Bernasconi, Department of Neurology IV,

Neuromuscular Diseases and Neuroimmunology, Fondazione Istituto Neurologico «Carlo Besta», Milan, Italy

‐ COURAGE-PD consortium (consortium studying risk factors for Parkinson's disease, participants from 10 European countries)

‐ Genetic risk factors for Parkinson's disease in Scandinavia (Umeå, Lübeck/Denmark, Göteborg, Linköping, Bergen/Stavanger)

‐ GEO-PD (consortium with participants from 25 countries)

‐ Prof Ole Andreassen UiO, DemGene - Genetics by Dementia

‐ European networks for ataxia and hereditary spastic paraparesis (HSP)




Doctoral thesis Kari Anne Bjørnarå, Clinical and genetic aspects of REM sleep behavior disorder in Parkinson’s disease. Dissertation 13.11.15.

Lasse Pihlstrøm, The genetics of sporadic Parkinson's disease - Refining the insights from genome-wide association studies. Dissertation 27.11.15

Funding Among others:

‐ European Union ‐ The Research Council of

Norway ‐ South-Eastern Norway Regional

Health Authority ‐ Norwegian ExtraFoundation for

Health and Rehabilitation

27

Selected publications: Pihlstrøm L, Berge V, Rengmark A, Toft M. Parkinson's disease correlates with promoter methylation in

the α-synuclein gene. Mov Disord. 2015;30(4):577-80.

Pham U, Solbakk AK, Skogseid IM, Toft M, Pripp AH, Konglund AE, Andersson S, Haraldsen IR, Aarsland D, Dietrichs E, Malt UF. Personality changes after deep brain stimulation in Parkinson's disease. Parkinsons Dis. 2015:490507. Pihlstrøm L, Rengmark A, Bjørnarå KA, Dizdar N, Fardell C, Forsgren L, Holmberg B, Larsen JP, Linder J, Nissbrandt H, Tysnes OB, Dietrichs E, Toft M. Fine mapping and resequencing of the PARK16 locus in Parkinson's disease. J Hum Genet. 2015;60(7):357-62

28

Cerebrovascular Research Group, OUH/UiO Group Leader

David Russell, Professor, Dept. of Neurology, UiO ([email protected]) /

Consultant, OUH ([email protected])

Research profile and aims The main goal is to conduct high-quality cerebrovascular research leading to new knowledge and

hopefully better treatment of the stroke-patient. The research group will promote and facilitate the

use of the European Cerebrovascular Research infrastructure (ECRI) for the completion of large

national and international stroke studies.

Ongoing projects ∙ The Unstable Carotid Artery Plaque Study (UCAPS)

∙ The Norwegian Pediatric stroke Study (NPSS)

∙ The Norwegian Acute Stroke Prehospital Project (NASPP)

∙ The Norwegian Atrial Fibrillation and Stroke Study (NAFS)

∙ The Norwegian Rhematoid Arthritis and Atherosclerosis Study (NRAS)

∙ The Norwegian Vascular Dementia and Atherosclerosis Study (NVDAS)

∙ Ultrasound in Carotid Atherosclerosis and Arthritis Study (UCAAS)


‐ Prof. Lars Thomassen, Haukeland University Hospital

‐ Norwegian Air Ambulance Foundation (NLA)

‐ Prof. L Csiba, University of Debrecen Medical School, Hungary

‐ Prof. N Bornstein, Tel Aviv Souarsky University Medical Centre, Israel

Group Members

∙ Christian Lund, MD,PhD, OUH ∙ Mona Skjelland, MD,PhD, OUH ∙ Anne Hege Aamodt, MD,PhD, OUH ∙ Karolina Ryeng Skagen, MD,PhD fellow, OUH ∙ Azhar Abbas, MD,PhD fellow, OUH ∙ Kristin Evensen, MD/PhD fellow ∙ Sean Wallace, MD/PhD fellow ∙ Kjersti Johnsrud, MD/PhD fellow ∙ Maren Hylen Ranhoff, MD/PhD fellow ∙ Henriette Johansen, MD/PhD fellow ∙ Mahtab Zamani, MD/PhD fellow

29



Doctoral thesis. Azhar Abbas: carotid artery atherosclerosis- The role of inflammation in ischemic stroke. Date for

Dissertation 26.06.15. ISBN 978-82-8264-948-3.

Selected publications: Skagen KR, Johnsrud K, Evensen K, Scott H, Krohg-Sørensen K, Reier-Nilsen F, Revheim ME, Fjeld JG, Skjelland M, Russell D. Carotid plaque inflammation assessed with 18f-fdg PET/CT is higher in symptomatic compared with asymptomatic patients. International Journal of Stroke. 2015;10:730-736 Abbas A, Gregersen I, Holm S, Daissormont I, Bjerkeli V, Krohg-Sørensen K, Skagen KR, Dahl TB, Russell D, Almås T, Bundgaard D, Alteheld LH, Rashidi A, Dahl CP, Michelsen A, Biessen EA, Aukrust P, Halvorsen B, Skjelland M. Interleukin 23 levels are increased in carotid atherosclerosis: Possible role for the interleukin 23/interleukin 17 axis. Stroke. 2015;46:793-799 Wallace S; Dohlen G; Holmstrom H; Lund C; Russell D. Cerebral microemboli detection and differentiation during transcatheter closure of atrial septal defect in a paediatric population.Cardiology in the Young 2015. 25:237-44, 2015


Health Authority ‐ The Research Council of

Norway

30

Epilepsy Research Group ‒ Department of Neurology

Group Leader Erik Taubøll, Professor, Dept. of Neurology, UiO ([email protected]) /

OUH ([email protected])

Research profile and aims The Epilepsy Research Group in the Department of Neurology has been active for more than 20 years. Our research is currently focussed on three main areas: 1) Epilepsy-Translational Research. This focuses on research on temporal lobe epilepsy (TLE) through genetic, basic, and clinical studies. The leader is Kjell Heuser. The main project concerns studying the role of the brain's glial cells in the development and exacerbation of epilepsy (epileptogenesis). The initial studies are basic research using epilepsy models. In addition, larger patient trials are used in which the clinical, radiological (MRI), and neuropsychological development of TLE is monitored over time. 2) “Gender issues”, endocrinology and long-term effects of AEDs. The leader is Sigrid Svalheim. «Gender issues» has been an important area of research for the group over many years, with many PhD theses. The current major focus is studying the long-term side-effects of AEDs on hormones, immunology, haematology and bone health. The group also conducts basic research in collaboration with Jagiellonian University, Krakow, Poland, particularly investigating the effects of AEDs in relation to cancer.

Group Members

∙ Kjell Heuser, Postdoc, OUH ∙ Agnes Balint Bjørke, PhD fellow, OUH and Vestre Viken Hospital Trust ∙ Sigrid Svalheim, MD/Ph.D, OUH ∙ Monika Mokol, PhD fellow, Østfold Hospital Trust ∙ Dag Aurlien, Consultant, Stavanger Univ Hospital ∙ Alba Gonzalez; Ph.D. fellow, OUH ∙ Helle Hermann, PhD fellow, OUH ∙ Line Sveberg, MD/Ph.D., OUH ∙ Ketil Berg Olsen, MD, OUH and Østfold Hospital Trust ∙ Leif Gjerstad, MD/Ph.D. Professor, OUH/UiO, Prof. emeritus

Asociated Group Members

∙ Cecilie Nome, Elective research student, UiO; TLE ∙ Erlend Nagelhus, MD/Ph.D, Professor, UiO and OUH ∙ Rune Enger, Elective research student, OUH/UiO ∙ Bjørnar Hassel, MD/Ph.D, Professor, OUH

31

3) Epilepsy and cardiology / SUDEP (sudden unexpected death in epilepsy patients). The leader is Dag Aurlien who is presently based at Stavanger University Hospital. The project is a collaborative venture between Oslo University Hospital (OUH) and Stavanger University Hospital. Funding has recently been granted from the South-Eastern Norway Regional Health Authority for a PhD fellow in the project, starting in 2015. In addition to these three main areas of research, the group has also interests in deep brain stimulation (DBS) in epilepsy, ketogenic diets for adults, and status epilepticus.

Ongoing projects ∙ Can the brain's glial cells be a point of attack for novel AED treatments? This is a major project in

which, among other approaches, a mouse model is being used to investigate how epilepsy arises and evolves over time. The main question is how glia cells behave during the development and worsening of epilepsy, and whether these changes can be affected by various drugs such as AEDs, anti-inflammatory drugs, drugs that affect intracellular cell signalling etc. The project was funded by the European Science Foundation until 2014, and we have applied for further national and international funding.

∙ Is epilepsy a progressive disease? This is a long-term study that focuses on changes in the clinical, radiological and neuropsychological picture in patients with temporal lobe epilepsy. Comprehensive investigations are conducted on patients with newly diagnosed temporal lobe epilepsy at various time points over a 10-year period. The project has been supported by Health and Rehab with PhD candidates until 2017.

∙ Deep brain stimulation (DBS) in epilepsy. In this study patients with hard-to-treat epilepsy are treated with DBS using a blinded study design. This project is being supported by Health and Rehab until 2016.

∙ Long-term effects of AEDs. Patients starting treatment with the AEDs levetiracetam and lamotrigine will be followed prospectively for two years in terms of immunological, hormonal, and haematological adverse reactions, and possible changes in bone health. The data will be collected through interviews, questionnaires, blood tests, and bone density measurements. This project is supported with a 50 % PhD student from Østfold Hospital.

∙ Investigation of the possible effects of AEDs, primarily valproate, on cell growth and factors of importance in the development of cancer development. This is a collaborative project together with Jagiellonian University in Krakow, Poland. Epilepsy and cardiology. It has become increasingly clear that several epilepsies are channelopathies, as are many cardiac arrhythmias, and are associated with many of the same channels and ions. The relationship between particular generalized epilepsies and cardiac arrhythmias as long QT syndrome (LQTS) will be studied. This is also of central importance for understanding sudden unexpected death in epilepsy (SUDEP). We will also study the impact of several years of epilepsy on cardiac function. This project is supported by The South-Eastern Norway Regional Health Authority with a PhD student from 2015.

32

∙ National registration of refractory status epilepticus. We are collating national experiences on how patients with this condition are treated in Norway and how this can be improved. As there are only a few such patients at each centre, joint exchange of experiences is essential. Approval for an internal quality study was obtained in December 2014 and work on the collection of data commenced in 2015.


‐ Dept. of cardiology, OUH

‐ Special hospital for epilepsy

‐ Stavanger University Hospital

‐ Institute of Cellular Neurosciences, Medical

Faculty, University of Bonn, Germany (Prof. C.

Steinhäuser)

‐ Østfold Hospital

‐ Institute of Basic Medical Science,

Glia cells research group

(GLIALAB), UiO

‐ University of Innsbruck, Austria (Prof. G. Luef)

‐ Jagiellonian University, Krakow, Poland (Prof.

E. Gregoraszczuk)


Peer-reviewed original research articles: 10



Kjell Heuser, invited speaker, the 12th Göttingen meeting of the German Neuroscience society

Erik Taubøll, invited speaker, European Academy of Neurology (EAN), Berlin, June 2015

Selected publications: Szokol K, Heuser K, Rang W, Jensen V, Enger R, Bedner P, Steinhäuser C, Taubøll E, Ottersen OP, Nagelhus EA. Augmentation of Ca2+ signaling in astrocytic endfeet in the latent phase of temporal lobe epilepsy. Front Cell Neurosci. 2015 Feb 25;9:49. doi: 10.3389/fncel.2015.00049. Taubøll E, Heuser K, Sveberg L, Svalheim S. Experimental models for the study of hormonal changes

in epilepsy. Zeitschrift für Epileptologie: Volume 28, Issue 4 (2015), Page 246-253.

Taubøll E, Sveberg L, Svalheim S. Interactions between hormones and epilepsy. Seizure 2015; 28: 3-

11.

Hassel B, Elsais, A, Frøland AS, Taubøll E, Gjerstad L, Quan Y, Dingledine R, Rise F. Uptake and

metabolism of fructose by rat neocortical cells in vivo and by isolated nerve terminals in vitro. J

Neurochem. 2015 May;133(4):572-81.

Funding ‐ Health and rehab, 2 PhD

students ‐ The South-Eastern Norway

Regional Health Authority

33

Multiple Sclerosis (MS) Group Leader

Hanne Flinstad Harbo, MD/PhD/MHA, Professor, and consultant of Neurology,

Department of Neurology. Institute of Clinical Medicine, University of Oslo (UiO) and Oslo

University Hospital (OUH) ([email protected]/ [email protected]).

Research profile and aims Multiple Sclerosis (MS) research group at the Department of Neurology, OUH and UiO, aims to

identify characteristics and susceptibility factors of MS, and to contribute to a better understanding

of the disease and development of better treatments. We perform genetic, immunological, clinical,

epidemiological, environmental, MRI and translational studies of MS in collaboration with national

and international research partners and networks.

Group Members

∙ Hanne Flinstad Harbo, MD/PhD/MHA Professor, OUH/UiO ∙ Elisabeth Gulowsen Celius, MD/PhD, ass. Professor, OUH/UiO ∙ Tone Berge, MSc/PhD, OUH ∙ Steffan D. Bos-Haugen, MSc/PhD, UiO ∙ Stine Marit Moen, MD/PhD, OUH/UiO ∙ Pål Berg-Hansen, MD/PhD fellow, OUH ∙ Gro Owren Nygaard, MD/PhD fellow, OUH ∙ Sigrid Aune de Rodez Benavent, MD/PhD fellow, OUH ∙ Piotr Sowa, MD/PhD fellow, OUH ∙ Christian Page, MSci/PhD fellow, UiO ∙ Ingvild Sørum Leikfoss, MSci/PhD fellow, OUH ∙ Marte Wendel Gustavsen, MD/PhD fellow, UiO ∙ Pankaj K. Keshari, MSci/PhD fellow, OUH ∙ Anna M. Eriksson, MSci/PhD fellow, UiO ∙ Ina S. Brorson, MSci/PhD fellow, UiO ∙ Einar August Høgestøl, MD/PhD fellow, UiO ∙ Anja Bjølgerud, Msci, UiO ∙ Cecilia Smith Simonsen, MD/PhD fellow, Drammen Hospital/OUH ∙ Heidi Øyen Flemmen, MD/PhD fellow, Skien Hospital/OUH

Associated Group Members We had 4 medical students connected to our group, writing student theses, supervised by

Harbo (2) and Celius (2).

mailto:[email protected]/


34

Ongoing projects ∙ Gro Owren Nygaard, PhD fellow: A longitudinal cohort study of disability, cognition and MRI in

early MS patients in Oslo (Health South East grant). Supervisor: Hanne F. Harbo, Co-supervisors: Elisabeth G. Celius and Kristine Beate Walhovd.

∙ Christian Page, PhD fellow: Rare Varient Genotyping in Complex Diseases and Identification of Differentially methylated regions (UiO grant). Supervisor: Bettina K. Andreassen, Co-supervisors: Hanne F. Harbo and Benedicte A. Lie.

∙ Ingvild Sørum Leikfoss, PhD fellow: Molecular characterization of multiple sclerosis associated genes (Health South East grant). Supervisor: Tone Berge, Co-supervisors: Hanne F. Harbo and Anne Spurkland.

∙ Pål Berg-Hansen, PhD fellow: Clinical and epidemiological studies of immigrants with multiple sclerosis in Norway (OUH grant). Supervisor: Elisabeth G. Celius, Co-supervisors: Hanne F. Harbo and Stine Marit Moen.

∙ Sigrid Aune de Rodez Benavent, PhD fellow: A longitudinal cohort study of ophthalmologic biomarkers correlated with neurodegeneration in early MS. (OUH grant). Supervisor: Elisabeth G. Celius, Co-supervisors: Emilia Kerty, Bruno Laeng and Liv Droslum.

∙ Tone Berge, researcher: Vitamin D responsive and other MS susceptibility genes. (Health South East grant).

∙ Steffan Daniel Bos, researcher: Identification of molecular mechanisms and biomarkers of Multiple Sclerosis (MS-biomarkers) – RNA sequencing of CD4+ and CD8+ T cells as potential biomarkers of MS phenotypes. (NFR researcher project grant).

∙ Piotr Sowa, PhD fellow: MRI biomarkers of disease activity and progression in multiple sclerosis (Health South East grant). Supervisor: Mona Beyer, Co-supervisor: Hanne F. Harbo.

∙ Pankaj K. Keshari, PhD fellow: Immunogenetic loci characterization of multiple sclerosis. (South-Eastern Norway Regional Health Authority grant). Supervisor: Tone Berge, Co-supervisors: Hanne F. Harbo and Steffan Daniel Bos.

∙ Marte Wendel Gustavsen, PhD fellow: Clinical and molecular characterization of multiple sclerosis. (NFR researcher project grant). Supervisor: Hanne F. Harbo, Co-supervisors: Tone Berge and Benedicte A. Lie.

∙ Anna M. Eriksson, PhD fellow: Identification of molecular mechanisms and biomarkers of Multiple Sclerosis (MS-biomarkers) – molecular characterization of DEXI and other MS susceptibility genes (NFR researcher project grant). Supervisor: Tone Berge, Co-supervisors: Hanne F. Harbo and Steffan Bos.

∙ Ina S. Brorson, master student until 15.1.15: Vitamin D responsiveness of multiple sclerosis associated genes in CD4+ T cells. Supervisor: Tone Berge.

∙ Ina S. Brorson, PhD fellow from 1.12.15 (UiO grant): Defining and characterizing molecular pathways in multiple sclerosis. Supervisor: Steffan Bos, Co-supervisors: Hanne F Harbo and Tone Berge.

∙ Einar August Høgestøl, PhD fellow fra 1.12.15: MRI- and other biomarkers in multiple sclerosis. (NFR researcher project grant). Supervisor: Hanne F Harbo, Co supervisor: Lars T Westlye and Gro O Nygaard.

∙ Cecilia Smith Simonsen, PhD fellow (OUH-Drammen grant): Predictors for disease susceptibility and disease progression in Multiple sclerosis, Supervisor: Elisabeth Gulowsen Celius, Co supervisors: Stine Marit Moen and Kari Anne Bjørnerå.

∙ Heidi Øyen Flemmen, PhD fellow (Skien grant): Socioeconomic factors as predictors for disease susceptibility and disease progression in Multiple sclerosis, Supervisor: Elisabeth Gulowsen Celius, Co supervisor: Pål Berg-Hansen.

35

∙ Hanne F Harbo, Steffan Bos, Elisabeth G Celius. MS chip study, collaboration with IMSGC. ∙ Hanne F Harbo and MS group Oslo in collaboration with IMSGC. Genetic markers for CSF

phenotypes in MS. ∙ Hanne F Harbo, Steffan Bos, Mona Beyer: BorrSci study, lead from Kristiansand (South-Eastern

Norway Multi- Regional Health Authority grant).

From the front left: Hanne F. Harbo (Professor, consultant of neurology and group leader, MD, PhD), Pankaj Kumar Keshari (PhD student, MSc), Ina Skaara Brorson (senior engineer and PhD student, MSc), Christian Page (PhD student, MSc), Gro Owren Nygaard (PhD student, MD, consultant in neurology), Tone Berge (researcher, MSc, PhD), Piotr Sowa (PhD student, consultant of radiology, MD), Anna M. Eriksson (PhD student, MSc), Ingvild Sørum Leikfoss (PhD student, MSc), Stine Marit Moen (consultant of neurology, MD, PhD), Marte Gustavsen (PhD student, MD), Elisabeth Gulowsen Celius (consultant of neurology and project leader, MD, PhD), Cecilia Simonsen (PhD student, MD), Heidi Øyen Flemmen (PhD student, consultant in neurology, MD), Sigrid A. de Rodez Benavent (PhD student, consultant in ophthalmology, MD), Steffan Daniel Bos (post doc, PhD, MSc) and Pål Berg-Hansen (consultant of neurology and PhD student, MD). (Photo: Kristin Ellefsen, UiO).

Funding ‐ South-Eastern Norway Regional Health Authority ‐ The Research Council of Norway ‐ UiO ‐ Norwegian Extra Foundation for Health and Rehabilitation ‐ South-Eastern Norway Multi- Regional Health Authority grant ‐ Other external: Unrestricted research grant from Novartis, Genzyme and Odd

Fellow

36


National ‐ Mona Beyer, Dept. of Radiology, OUH ‐ Benedicta A. Lie, Dept. of Medical

Genetics, OUH /UiO ‐ Kristine Walhovd and Anders Fjell, Dept.

of Psychology, UiO ‐ Anne Spurkland, Institute of Basic

Medical Sciences, UiO ‐ Bettina Kulle Andreassen, Dept. of

Biostatistics, UiO ‐ Emilia Kerty, Dept. of Neurology,

OUH/UiO ‐ Liv Drolsum, Dept. of Ophthalmology,

OUH/UiO ‐ Ole A. Andreassen, Dept. of Psychiatry,

OUH/UiO ‐ Camilla Stoltenberg, Norwegian Institute

of Public Health ‐ Inger Johanne Bakken, Norwegian

Institute of Public Health ‐ Odd Stokke Gabrielsen, Section for

Biochemistry and Molecular Biology, UiO ‐ Greger Abrahamsen, Division of

Anatomy, Molecular Immunology (MOLIMMUN), UiO

‐ Vibeke Sundvold Gjerstad, Division of Anatomy, Molecular Immunology (MOLIMMUN), UiO

‐ Trygve Holmøy, Dept. of Neurology, Akershus University Hospital

‐ Torbjørn Rognes, Section for Biomedical Informatics, Dept. of Informatics, UiO

‐ Nils Inge Landrø and Bruno Laeng, Dept. of Psychology, UiO

‐ Ole Landsverk, Dept of Pathology, Division of Diagnostics and Intervention, OUH

‐ K.B Nilsen and L. Etholm, OUH, Dept. of Neurophysiology

‐ Kjell-Morten Myhr and Jan Aarseth, Haukeland University Hospital

‐ Atle Bjørnerud, Dept. of Physics, Intervention Centre, UiO/OUH

‐ Frode Berven, Dept. of Biomedicine, University of Bergen

International ‐ Lisa Barcellos, University of California,

Berkeley, US ‐ Jorge Oksenberg, University of

California, San Francisco, US ‐ Sergio E. Baranzini, University of

California, San Francisco, US ‐ Steve Francis, University of California,

San Francisco, US ‐ Anders Dahle, University of California

San Diego, US ‐ Soheil Damangir and Gabriela Spulber,

Karolinska Institute, Stockholm, Sweden

‐ Jan Damoiseaux, Dept. of Neurology, Canisius Wilhelmina Hospital, Nijmegen, the Netherlands

‐ Joost Smolders, Dept. of Neurology, Canisius Wilhelmina Hospital, Nijmegen, the Netherlands

‐ B. Wilhelm, Steinbeis Transfer-Centre for Biomedical Optics and Function Testing, Tübingen, Germany

‐ Nordic MS genetics consortium (Hillert, Olsson, Kockum, Oturai, Sørensen, Saareala)

‐ International MS Genetics Consortium (Adrian Ivinson, Stephen Sawcer, Stephen Hauser, An Goris)

‐ Pablo Villoslada (Hospital Clinic of Barcelona, Spain)

37




Invited lectures at international congresses: Hanne F Harbo at seminar for Prof. Solberg Sorensen, Copenhagen, February 2015: MS genetics


Pål Berg-Hansen: Clinical and epidemiological studies of immigrants with multiple sclerosis in Norway (OUS grant). Dissertation 4.5.2015 ISBN 978-82-8333-004-5/Nr. 1954 Main supervisor: Elisabeth G. Celius, Co-supervisors: Hanne F. Harbo and Stine Marit Moen Ingvild Sørum Leikfoss: Characterization of multiple sclerosis susceptibility genes (Health South East

grant). Dissertation 30.10.15 ISBN 978-82-8333-099-1/Nr. 2085

Main supervisor: Tone Berge, Co-supervisors: Hanne F. Harbo and Anne Spurkland

Marte Wendel Gustavsen: Genetic, clinical and environmental aspects of multiple sclerosis (NFR

researcher project grant). Dissertation 11.12.2015. ISBN 978-82-8333-141-7/Nr. 2113

Main supervisor: Hanne F. Harbo, Co-supervisors: Tone Berge and Benedicte A. Lie


Bos SD, Page CM, Andreassen BK, Elboudwarej E, Gustavsen MW, Briggs F, Quach H, Leikfoss IS,

Bjølgerud A, Berge T, Harbo HF, Barcellos LF (2015) Genome-wide DNA methylation profiles indicate

CD8+ T cell hypermethylation in multiple sclerosis PLoS One, 10 (3), e0117403. PubMed 25734800

Goris A, Pauwels I, Gustavsen MW, van Son B, Hilven K, Bos SD, Celius EG, Berg-Hansen P, Aarseth J,

Myhr KM, D'Alfonso S, Barizzone N, Leone MA, Martinelli Boneschi F, Sorosina M, Liberatore G,

Kockum I, Olsson T, Hillert J, Alfredsson L, Bedri SK, Hemmer B, Buck D, Berthele A, Knier B et al.

(2015) Genetic variants are major determinants of CSF antibody levels in multiple sclerosis Brain,

138 (Pt 3), 632-43. PubMed 25616667

Nygaard GO, Celius EG, de Rodez Benavent SA, Sowa P, Gustavsen MW, Fjell AM, Landrø NI, Walhovd KB, Harbo HF (2015) A Longitudinal Study of Disability, Cognition and Gray Matter Atrophy in Early Multiple Sclerosis Patients According to Evidence of Disease Activity. PLoS One, 10 (8), e0135974

38

Pain Conditions Group Leader

John-Anker Zwart, Professor, Dept. of Neurology, Head of Division of Surgery and

Clinical Neuroscience, UiO ([email protected]) / OUH ([email protected])

Research profile and aims The main focus of the research group is to generate research based knowledge on mechanisms,

prevention and treatment of pain in the musculoskeletal- and nervous system.

Ongoing projects ∙ The Acute Low-Back Pain Study. Clinical, neurophysiological and genetic risc factors ∙ Genetic risk variants in migraine and cardiovascular disease. The Gene HUNT study.

Group Members

∙ Ellen Jørum, Professor, UiO/OUH ∙ Britt Andenes, MD/PhD fellow, UiO ∙ Evy Berntsen, administrative, OUH ∙ Olaf Fjeld, MD/PhD fellow, UiO/OUH ∙ Håvard Furunes, MD/PhD fellow, UiO ∙ Margreth Grotle, Professor, OUH/HioA ∙ Maren Hjelle Guddal, Msc/PhD fellow, UiO ∙ Alf Inge Hellevik, MD/PhD fellow, OUH/NTNU ∙ Ingrid Heuch, MD/senior researcher, OUH ∙ Synne Øien Stensland, MD/ Postdoctoral fellow, OUH ∙ Marianne Bakke Johnsen, Msc/PhD fellow,UiO ∙ Kristin Ørstavik, MD, PhD, senior consultant, OUS ∙ Inge Petter Kleggetveit, MD/Postdoctoral fellow, OUH ∙ Synnøve Kvalheim, MD/PhD fellow, UiO ∙ Ida Løchting, Msc/PhD fellow, UiO ∙ Kristian Bernhard Nilsen, MD/associate Professor, OUH ∙ Linda M. Pedersen, Msc/Postoctoral fellow, OUH ∙ Vibeke Siewers, research coordinator, OUS ∙ Kjersti Storheim, PhD/Associate Professor, UiO/OUH ∙ Jarle Sundseth, MD/PhD fellow, UiO/OUS ∙ Markus Wiedmann, MD/PhD fellow, UiO/OUH ∙ Monica Wigemyr, Msc/research coordinator, OUH ∙ Bendik Winsvold, MD/Postdoctoral fellow, OUH ∙ Lars Christian Haugli Bråten, MD/PhD fellow, UiO/OUS ∙ Maria Dehli Vigeland, Msc/PhD fellow, UiO/OUH ∙ Sigrid Børte, MD/PhD fellow, UiO/OUH ∙ Ingrid Fjeldheim Bånerud, Msc/research coordinator, OUH ∙ Amy Mitchell, Msc/research coordinator, OUH

∙ Marie Udnesseter Lie, Msc/research ccordiantor, OUH

39

∙ Vitamin D and risk factors for chronic back pain – a prospective epidemiological survey. ∙ Risk factors for anterior cruciate ligament injuries in Norwegian adolescents and young

adults: (the ACL/HUNT studies) ∙ Genetic and environmental causes of migraine, a large-scale family-based analysis ∙ Early risk factors for migraine. The young-HUNT study. ∙ Familiar hemiplegic migraine in Norway ∙ The AIM-study (Antibiotics In Modic changes) ∙ The HUNT OsteoArthritis study (the HOA-study) ∙ Lumbar disc prosthesis versus multidisciplinary rehabilitation in chronic back pain and

localized degenerative disc. Long term follow-up of a randomized multicentre trial. ∙ The NORwegian Degenerative spinal STENosis-trial (the NORDSTEN-study) ∙ Physical activity and sport participation during adolescence and musculoskeletal complaints

in adulthood. A population based cohort study ∙ The COPE-study (Cognitive patient education in primary care ) ∙ Spinal surgery in Norway. Trends, costs and regional differences ∙ The Norwegian Cervical Arthroplasty Trial. The NORCAT study. A prospective, single blinded,

randomized, controlled multicenter study. ∙ Risk factors for development of chronic pain after hospitalization for acute low back pain

and/or sciatica. (RUKSAR) ∙ Clinical and genetic aspects of neuropathic pain (CliNGNeuP) ∙ Conditioned pain modulation with respect to different test pain stimuli (CPM2TS) ∙ Physical activity, chronic low back pain and other musculoskeletal complaints, is there a

causual relationship? The HUNT study ∙ Childbirths, hormonal factors and low back pain - a prospective epidemiological survey ∙ A Comparison of Anthropometric Measures for Assessing the Association between Body Size

and Risk of Chronic Low Back Pain: The HUNT Study. ∙ Back Pain in Elederly (BACE). A prospective cohort study of older people visiting primary care

with a new episode of back pain ∙ Genetic risk factors for development of Pain – The Tromsø Study ∙ All-In-HUNT, genetic assessment of neurological and psychiatric disorders


‐ University Hospital of North Norway (UNN)

‐ Drammen Hospital ‐ St.Olavs Hospital/Trondheim

University Hospital ‐ Østfold Hospital ‐ Haukeland University Hospital ‐ The National Institute of

Occupational Health (STAMI) ‐ Norwegian University of

Science and Technology (NTNU)

‐ Oslo and Akershus University College (HiOA)

‐ Leiden University Medical Centre (LUMC), the Netherlands

‐ Broad Institute of MIT and Harvard, Boston, US

‐ Institute for Molecular Medicine (FIMM), Finland

‐ University of Helsinki, Finland ‐ Keele University, UK ‐ University of Odense, Denmark ‐ The low-back pain consortium ‐ The headache genetics consortium

40




Selected publications: Matre D, Hu L, Viken LA1, Hjelle IB, Wigemyr M, Knardahl S, Sand T, Nilsen KB. "Experimental Sleep Restriction Facilitates Pain and Electrically Induced Cortical Responses." Sleep. 2015 Oct 1;38(10):1607-17 Heuch I, Heuch I, Hagen K, Zwart JA (2015) A Comparison of Anthropometric Measures for Assessing the Association between Body Size and Risk of Chronic Low Back Pain: The HUNT Study PLoS One, 10 (10), e0141268

Winsvold BS, Nelson CP, Malik R, Gormley P, Anttila V, Vander Heiden J, Elliott KS, Jacobsen LM, Palta P, Amin N, de Vries B, Hämäläinen E, Freilinger T, Ikram MA, Kessler T, Koiranen M, Ligthart L, McMahon G, Pedersen LM, Willenborg C, Won HH, Olesen J, Artto V, Assimes TL, Blankenberg S et al. (2015) Genetic analysis for a shared biological basis between migraine and coronary artery disease Neurol Genet, 1 (1), e10 2015; 1(1)


Health Authority ‐ The Research Council of

Norway ‐ The Norwegian Fund for Post-

Graduate Training in Physiotherapy

‐ UiO ‐ OUH

41

Neuropsychiatric research group

Group Leader

Ulrik Fredrik Malt, Professor, UiO ([email protected]) / OUH ([email protected])

Research profile and aims The main aim of our research group is to expand our knowledge about the neurobiology of non-psychotic mental disorders with emphasis on bipolar spectrum disorders and associated problems such as sleep. Thanks to an unrestricted grant from Throne-Holst, we have established an EEG-laboratory for measuring neuroplasticity in vivo in collaboration with NORMENT. Our overriding goal is to contribute to better diagnostic accuracy and more focused treatment of the disorders targeted in our research.

Group Members

Senior researchers:

∙ Stein Andersson, Prof. dr.philos, Inst of Psychology, UiO ∙ Birgitte Boye, Prof. dr.med., Inst of Basic medicine, UiO ∙ Erlend Bøen, cand.med., Ph.D. ∙ Torbjørn Elvsåshagen, cand.med. Ph.D., post-doc, UiO ∙ Eva A. Malt, assoc. Prof dr.med., Inst of Clinical Psychiatry, UiO ∙ Karl Ludvig Reichelt, dr.med., Inst of Clinical Psychiatry, UiO

PhD fellows:

∙ Britta Bürker, cand.med., PhD fellow (Throne Holst grant) ∙ Guro Dunvoll, Master of Science; Social educator (Throne-Holst grant) ∙ Torfinn Hynnekleiv, cand.med., PhD fellow ∙ Hans Lövdahl, cand.med., PhD fellow ∙ Nathalia Zak, cand.med. PhD fellow (Ebbe Frøland foundation)

Other researchers:

∙ Torunn Søyseth, Master of Science, Physiotherapist, OUH

Associated research group members:

NORMOOD (NORwegian network on MOOD disorders):

∙ Ulrik Fredrik Malt ∙ Johan Dahl, cand.med. ∙ Siv Grethe Johansen, cand.psychol. ∙ Asja Zvizdic, cand.med.

NORBRAIN (Norwegian Bipolar Research and Innovation Network):

∙ Ulrik Fredrik Malt ∙ Ole A. Andreassen, Prof dr.med. ∙ Per I. Finseth, cand.med., PhD fellow ∙ Gunnar Morken, Prof dr.med.

42

Associated projects are neuropsychiatric and cognitive aspects of heart- and lung transplantation, with the goal to reduce psychological distress and offer the patients better psychosocial follow-up.

Ongoing projects Genes and synapses in mental disorders • Neuropsychobiology in bipolar 2 and borderline personality disorders • Oxidative stress in bipolar 2 disorders • Neurogenesis in bipolar 2 disorders • Neuroplasticity in bipolar 2 disorders • Treatment with second generation epileptic drugs in patients with epilpesy plus • Three G-protein genotypes (G825T, A1166C, C1114G) and association with symptoms of

anxiety and depression in a sample from the general Norwegian population • Studies of genotype-phenotype interactions in patients with 3q29 microdeletion syndrome • Exorphines and anti-bodies in cerebro spinal fluid • Neuropsychiatry in heart transplanted patients • Psychiatric disorders and coping in patients evaluated for lung transplantation


‐ Prof. Ole A. Andreassen group, OUH /UiO: NORMENT (Psychiatry)

‐ Prof dr.med. Dietrichs group, Dept of Neurology, OUH/UiO: Movement disorders

‐ Prof. dr.med. Haugen’s group; OUH/UiO Obstetrics and Gynecology research

‐ Prof. dr.med. Emblem’s group, OUH/UiO: Child surgery research

‐ Prof. dr.med. Gullestads group: Clinical cardiology at Rikshospitalet

‐ Prof. Karteruds research group, OUH/UiO: Personality disorder research

‐ NORBRAIN research group (Gunnar Morken Arne Vaaler and others)

‐ Ana Andreazza, Pharm, PhD, Assistant prof, Dept. of Psychiatry, University of Toronto, Canada /Scientist, Centre for Addiction and Mental Health, Toronto, ON and L. Trevor Young, MD/PhD, prof and Chair, Dept of Psychiatry, University of Toronto (oxidativt stress)

‐ Z. Jeff Daskalakis, MD/PhD, Prof., Head of Temerty Center for Therapeutic Brain Intervention, Dept. of psychiatry, University of Toronto, Canada (electrophysiology, neuroplasticity)

‐ Maria A. Blasco, PhD, Vice-Director of Basic Research, Director of Molecular Oncology Program, Head of Telomeres and Telomerase Group; Spanish National Cancer Center (CNIO), Madrid, Spain (stress and telomere)

‐ Mirjana Maletic-Savatic, MD/PhD, Assistant Prof., Baylor College of Medicine, Houston, TX, US (nevrogenese)

‐ ENIGMA group (Enhancing NeuroImaging Genetics through Meta-Analysis)

‐ Mary Amanda Dew, PhD. Professor of Psychiatry, Psychology, Epidemiology, Biostatistics and Cllinical and Translational Science, Univ of Pittsburgh, PEN, USA

Funding -South-Eastern Norway Regional Health

Authority

-Throne Holst foundation

-Ebbe Frøland foundation

43




∙ Malt EA. Reaching out- communicating with people with autism and learning disabilities. «Masterclass» course in Psychiatry, Luleå, Sweden 19.2.2015

∙ Malt EA. Integrating care - Mental and physical health in people with learning disabilities. «Masterclass» course in Psychiatry, Luleå, Sweden 20.2.2015

∙ Malt UF. Understanding neurodevelopmental disorders in a clinical context. «Masterclass» course in Psychiatry, Luleå, Sweden 19.2.2015

∙ Malt UF. Psychopharmacological treatment of patients with neurological disorders. European Association of Psychiatry annual meeting, Wien 29.3.2015

∙ Malt UF. Depression in patients with chronic obstructive lung disease. Scandinavian Society for Lung Disease meeting, Oslo 11.6.2015.

∙ Elvsåshagen T, Malt UF. Masterclass course in neuroplasticity and psychosomatic disorders. European Association of Psychosomatic Medicine’s Annual Meeting, Nürnberg, 2.7.2015.

∙ Malt UF. Psychopharmakologie: Spezielle Aspekte bei körperlichen Kranken. «Berliner Konsultation-Liaison Kurs», Berlin 23.10.2015 (Deutscher Track)

∙ Malt UF. What the psychiatrist should know about psychopharmacology. «Berliner

Konsultation-Liaison Kurs», Berlin 24.10.2015 (English track)

∙ Malt UF. What can psychiatry contribute to the understanding of extreme violence? 51st Annual Meeting of the Turkish Psychiatric Association, Antalya, Turkey 26.11.2015

∙ Malt UF. Use of psychotropic drugs in neurological disorders. 51st Annual Meeting of the Turkish Psychiatric Association, Antalya, Turkey 28.11.2015

∙ Malt UF. Research on depression during the last two years. New findings with clinical implications. 51st Annual Meeting of the Turkish Psychiatric Association, Antalya, Turkey 28.11.2015

∙ Malt UF. Psychopharmacology in consultation-liaison psychiatry. Half day course for Swedish

residents of psychiatry, Gothenburg, Sweden 1.12.2015


Bøen E. Clinical and brain structural aspects of borderline personality disorders. Dissertation for the

Degree of PhD. Oslo: Faculty of Medicine, University of Oslo 2015. ISBN 978-82-8333-044-1/ Nr. 2041

Lövdahl H. Phenomenological and cognitive aspects of Recurrent Brief Depression. Dissertation for

the Degree of Dr.philos. Oslo: Faculty of Medicine, University of Oslo 2015. ISBN 978-82-8264-939-

Selected publications: Schoeyen HK, Kessler U, Andreassen OA, Auestad BH, Bergsholm P, Malt UF, Morken G, Oedegaard

KJ, Vaaler A. Treatment-resistant bipolar depression: a randomized controlled trial of

electroconvulsive therapy versus algorithm-based pharmacological treatment. Am J Psychiatry. 2015

Jan;172(1):41-51.

44

Dahl J, Andreassen OA, Verkerk R, Malt UF, Sandvik L, Brundin L, Ormstad H. Ongoing episode of

major depressive disorder is not associated with elevated plasma levels of kynurenine pathway

markers. Psychoneuroendocrinology. 2015 Jun;56:12-22. doi: 10.1016/j.psyneuen.2015.02.011.

Elvsåshagen T, Norbom LB, Pedersen PØ, Quraishi SH, Bjørnerud A, Malt UF, Groote IR, Westlye LT. Widespread Changes in White Matter Microstructure after a Day of Waking and Sleep Deprivation. PLoS One. 2015 May 28;10(5):e0127351. doi: 10.1371/journal.pone.0127351. eCollection 2015.

45

Psycho-neuro-endocrinology. Sex on Brain European

Research (SOBER)

Group Leader

Ira Ronit Hebold Haraldsen, MD/PhD, Psychiatrist, OUH ([email protected])

Research profile and aims

The OPTImist-SOBER (Sex on Brain European Research group) is an established research group in neuroendocrinology, focusing on the time correlated phenomenons of pruning and increasing GnRHR expression in sex specific neural network development during sensitive periods, like pre-postnatal, during puberty and ageing. Because of our direct hands on experiences in basic science, from microbiological, immunohistochemistry methods to PET/radiochemistry, we wish to bridge the gap from classical molecular biology to cognitive science.

Furthermore, we are focusing on sex-specific receptor visualization for PET diagnostics and sex-specific ageing processes in Alzheimer Disease models.

Ongoing projects ∙ Development of a Novel F18-PET tracer for early diagnosis of Alzheimer Dementia

∙ Mood and Cognitive Outcome after Heart Transplantation (the MOODHEART study)

∙ Novel risk factor assay for Alzheimer’s disease-Multi-parametric quantification of HPG/HPT-

axis dysfunction

∙ Effect of puberty delaying treatment on the child's cognitive style

∙ Hormones and brain development. Impact of Gonadotropin Releasing Hormone blockade and steroid hormones on brain development through puberty and adolescence

Group Members ∙ Ana Perez, Psycologist, OUH ∙ Anne-Line Sommerdalen, MD, OUH ∙ Syed Nurrudin, VetMD, OUH ∙ Slawomir Wojniusz, Physiotherapist, OUH ∙ Uyen Pham, MD, OUH ∙ Britta Bürker, MD, OUH ∙ Aksel Erichsen, MD, OUH ∙ Patrick Riss Chemist OUH/UiO ∙ Stefan Sütterlin, Psychologist, OUH

46


‐ Mahmood Reza Amiry Moghaddam, UiO

‐ Tor Endestad, UiO ‐ Jo Klaveness, UiO ‐ Dag Erlend Olberg, NMS-Pet

Centre ‐ Erik Ropstad, Norwegian

School of Veterinary Science (NVH)

‐ Anne-Kristin Solbakk, OUH ‐ Reidun Torp, UiO ‐ Thomas Schreiner, OUH

‐ Neil Evans, Glasgow, Scotland ‐ Jane Robinson, Glasgow, Scotland ‐ Els Elaut, Belgium ‐ Griet De Cuypere, Belgium ‐ Guy T’Sjoen, Belgium ‐ Susanne Cerwenka, Germany ‐ Timo O. Nieder, Germany ‐ Hertha Richter-Appelt, The Netherlands ‐ Peggy Cohen-Kettenis, The Netherlands




Koval P, Sütterlin S, Kuppens P. Emotional Inertia is Associated

with Lower Well-Being when Controlling for Differences in

Emotional Context. Front Psychol. 2016 Jan 8;6:1997. doi:

10.3389/fpsyg.2015.01997. eCollection 2015. PMID: 26779099

Sütterlin S, Egner LE, Lugo RG, Wojniusz S. Beyond expectation: a case for nonpersonal contextual

factors in a more comprehensive approach to the placebo effect and the contribution of

environmental psychology. Psychol Res Behav Manag. 2015 Oct 30;8:259-62. doi:

10.2147/PRBM.S91774. eCollection 2015. PMID: 26586970

van de Grift TC, Cohen-Kettenis PT, Steensma TD, De Cuypere G, Richter-Appelt H, Haraldsen IR,

Dikmans RE, Cerwenka SC, Kreukels BP. Body Satisfaction and Physical Appearance in Gender

Dysphoria. Arch Sex Behav. 2016 Apr;45(3):575-85. doi: 10.1007/s10508-015-0614-1. Epub 2015 Oct

16. PMID: 26474976.

Funding ‐ The Research Council of

Norway – The Research Programme on Biotechnology for Innovation (BIOTEK 2021)

‐ South-Eastern Norway Regional Health Authority

‐ Throne Holst foundation

47

Osteoarthritis Research Group Group Leader

Lars Nordsletten, Professor, Dept. of Orthopaedics, UiO ([email protected])

/ Oslo Sports Trauma Research Center, Dept of Sports Medicine, Norwegian School of

Sports Sciences / Chair of the Orthopaedic Centre, OUH / Head of the Experimental

Orthopaedic group, Institute for Surgical Research, OUH ([email protected])

Research profile and aims To study the etiologi, treatment, and prevention of osteoarthritis (OA). We are primarily studying

knee, hip and hand OA.

Ongoing projects ∙ Training in knee OA: RCT between different training forms ∙ Risk factors for OA in hip, knee and hand: HUNT-NLR-OUS study and Ullensaker study ∙ Development of hand OA: New cohort starting 2015 ∙ AktivA: implementation of treatment and prevention and registry of OA in primary care in

Norway ∙ MRI changes with hand OA: Trapezium MRI findings compared to histology

∙ OMEX: RCT between traing and operation in meniscal injury

Group Members ∙ May Arna Risberg, Professor ∙ Tore K. Kvien, Professor ∙ Till Uhlig, Professor ∙ Kåre Birger Hagen, Professor ∙ Ida K. Haugen, Post doc ∙ Ida Svege, Post doc ∙ Ingrid Eitzen, Post doc ∙ Hilde Apold, PhD fellow ∙ Gunnar Flugsrud, Senior Consultant ∙ Alf Inge Hellevik, PhD fellow ∙ Kristin Bølstad, Research Coordinator ∙ Nina Østerås, Post doc ∙ Karin Magnusson Post doc ∙ Alexander Mathiessen, PhD fellow ∙ Britt Elin Øyestad, Post doc ∙ Nina Kise, PhD fellow

48


Scientific production of the research group in 2015 Peer reviewed original research articles: 30

Invited lectures at international congresses: Numerous

Selected publications: Mathiessen, A., B. Slatkowsky-Christensen, T. K. Kvien, H. B. Hammer and I. K. Haugen (2016). "Ultrasound-detected inflammation predicts radiographic progression in hand osteoarthritis after 5 years." Ann Rheum Dis 75(5): 825-830.

Haugen, I. K., B. Slatkowsky Christensen, P. Boyesen, S. Sesseng, D. van der Heijde and T. K. Kvien (2016). "Increasing synovitis and bone marrow lesions are associated with incident joint tenderness in hand osteoarthritis." Ann Rheum Dis 75(4): 702-708. Svege, I., L. Nordsletten, L. Fernandes and M. A. Risberg (2015). "Exercise therapy may postpone total

hip replacement surgery in patients with hip osteoarthritis: a long-term follow-up of a randomised

trial." Ann Rheum Dis 74(1): 164-169.


‐ The Norwegian Arthroplasty Register

‐ The Nord-Trøndelag Health Study (HUNT)

‐ Felson in Boston, US ‐ Sokolowski in Stanford, US

Funding ‐ South-Eastern Norway

Regional Health Authority ‐ Norwegian

ExtraFoundation for Health and Rehabilitation

‐ The Research Council of Norway

‐ Foundation of Sophies Minde

49

Pediatric Ortopaedics Group Leader

Ivan Hvid, Professor, Dept. of Pediatric Orthopaedics, UiO


Research profile and aims The main intention of the group is to promote clinical and experimental children orthopedic

research.

Ongoing projects ∙ Muscle response to bone lengthening ∙ Fixator-Bone load share in limb lengthening ∙ Bone Age evaluation by partial volume carpal MRI ∙ Evaluation of operative treatment of torticollis ∙ Epidemiology of MO (multiple osteochondroma) ∙ Studies on Legg-Calve-Perthes disease ∙ National Pediatric Hip Register


‐ The Norwegian School of Sport Science (bone, muscle research)

‐ University of Graz, Austria (MR Bone Age) ‐ Children’s Hosp, Wilmington, USA (Bone

lengthening studies)

Group Members

∙ Harald Steen, MD/PhD, OUH ∙ Terje Terjesen, Professor emeritus, UiO ∙ Joachim Horn, MD, OUH ∙ Ola Wiig, MD, OUH ∙ Per Reider Høiness, MD, OUH ∙ Andreas Knaus, MD, OUH ∙ Stefan Huhnstock, AS

50



Selected publications: Horn J, Grimsrud Ø, Dagsgard A, Huhnstock S, Steen H. Femoral lengthening with a

motorized intramedullary nail – a matched-pair comparison with external fixator lengthening

in 30 cases. Acta Orthop. 2015 Apr;86(2):248-56

Terjesen T, Lofterød, B, Skaaret, I. Gait improvement surgery in ambulatory children with diplegic

cerebral palsy. Acta Orthop 2015; 86: 511-17.

Terjesen T, Horn J. Have changes in treatment of late-detected developmental dysplasia of the hip

during the last decades led to better radiographic outcome? Clin Orthop Rel Research 2016; 7(2):

157-66.

51

Biomechanics Laboratory Group Leader

Harald Steen, MD/DMSci, Head of Biomechanics Laboratory/Orthopaedic Consultant,

OUH ([email protected])/ Professor, Oslo and Akershus University College of Applied

Sciences ([email protected])

Research profile and aims Biomechanics lab functions as a serviceunit within Oslo University Hospital’s Orthopaedic Clinic, and

contributes as a facilitator/catalysator for accomplishment of various research projects within the

orthopaedic community in the Oslo region. The lab organizes the meetings of the ‘Biomechanics

Forum’ 2-4 times a year, which is a multidisciplinary discussion group of professionals and students.

The laboratory is furnished with technological equipment for mechanical and functional testing, and

participates in planning, execution, result analyses, and publishing of clinical and experimental

studies.

In daily clinical activity the Biomech lab is part of the Paediatric Orthopaedics and Reconstructive

Surgery Department, mainly contributing with preoperative assessment of patients with limb length

discrepancy and other deformities and measurements of forces and load-share in patients operated

with distraction osteogenesis by use of external fixators.

Ongoing projects ∙ Biomechanical Studies of the Effect of Different Fixations upon Stability of Hip Fractures (PhD

Thesis in progress)

Group members ∙ Sanyalak Niratisairak, PhD, UiO ∙ Jan Rune Nilssen, Eng, FFI ∙ Knut Strømsøe, MD/DMSci, Prof. Em. UiO/Alumni ∙ Jan Egil Brattgjerd, MD/PhD-cand, OUH ∙ Bryan Wright, MD, Martina Hansen Hospital (MaHaHo)

Associate group members

∙ Jens Ivar Brox, MD/DMSci, OUH, Professor UiO ∙ Ivan Hvid, MD/DMSci, prof, OUH, Professor UiO ∙ Ragnhild Gunderson, MD, OUH ∙ Joachim Horn, MD/PhD, OUH ∙ Ingrid Skaaret, CPO/MSc/PhD-cand, Sophies Minde Ortopedisk Verksted ∙ Jette Schack, PT/MSc/PhD-cand, OUH, Sophies Minde Ortopedisk Verksted ∙ Geir Hjorthaug, MD/PhD-cand, Martina Hansen Hospital (MaHaHo) ∙ Alexandra Hankin, MD, OUS

52

∙ Cerebral Activity in Lower Extremity Amputees during Normal and Challenging Gait Situations

(PhD Thesis in progress)

∙ Effect of Ankle-Foot Orthoses on Gait in Children with Cerebral Paresis (PhD Thesis in progress)

∙ The Influence of a Non-Osteotomized Fibula on Load-Share Measurements in Tibial Lengthening

Osteotomies - A Cadaver Study

∙ Forces and Strain in Ankle Arthrodiatasis

∙ Health-Related Quality of Life and Physical Fitness in Young Adults with Congenital Lower-Limb

Deficiencies Treated with Prosthetic or Surgical Lengthening

∙ Predictive Factors of Quality of Life and Major Curve Progression in Patients Treated with Boston

Brace for Adolescent Idiopathic Scoliosis (AIS)

∙ Radiostereometric Monitoring in Orthopaedic Reconstructive Surgery

∙ Radiostereometric (RSA) Growth-Analyses after (Hemi-)Epiphysiodeses

∙ Forces and Load-Share during the Callotasis Process

∙ Contribution of Soft and Hard Tissue Resistance during Limb Lengthening Procedures

∙ Bone Age Assessment by use of MRI and Ultrasound


‐ Jan Rune Nilsen, Eng: Mechanical testing projects Norwegian Defence Research Establishment, Kjeller, Norway

‐ William MacKenzie (MD) and Tariq Rahman, PhD: Experimental limb lengthening project Neumors, Alfred I. duPont Hospital for Children, Wilmington, Delaware, US

‐ Martin Urschler, PhD and Darko Stern MSc Radiationless Bone Age assessment by MRI Ludwig Boltzmann Gesellschaft GmbH Medical University of Graz, Austria




Funding External funding 2015 from Stiftelsen Sophies Minde: NOK 2.425.000,- PhD project: Cerebral Activity in Lower Extremity Amputees during Normal and Challenging Gait Situations

53

Doctoral Thesis: Raphael Dziwornu Adobor MD: Screening and Methodological Studies on Adolescent Idiopathic

Scoliosis. Defended under the Medical Faculty, University of Oslo, ISBN 978-82-8333-025-0, No. 2091,

October 29, 2015

Invited lectures at international congresses: Gunderson R, Steen H: Can RSA be used to estimate flexibility in remodeled permanent bone? 4th

International RSA Meeting “A step into the future”, Bologna, Italy, May 13-15, 2015

Slåstad J, Steen H: Higher Consentration Of Vancomycin And Gentamycin In Joint Fluid From In Theatre-Made Hipspacers Compared To Commercially Available Ready-Made Hipspacers 34th Annual Meeting of the European Bone and Joint Infection Society (EBJIS), Estoril/Lisbon, Portugal, September 10–12, 2015 Brattgjerd JE, Niratisairak S, Steen H, Strømsøe K: Biomechanical evaluation of the Hansson Pinloc

Swemac Innovation AB Conference, Fiskebäckskil, Sweden, September 17, 2015

Brattgjerd JE, Niratisairak S, Steen H, Strømsøe K: Biomekanisk studie av fiksasjon for lårhalsbrudd:

Betydning av implantatets design i en human benmodell [Biomechanical study on fixation of collum

femoris fractures: Influence of the implant’s design in a human bone model] Norwegian Orthopaedic

Association, Annual Scientific Meeting, Oslo, October 21-23, 2015, Høstmøteboken, abstract 319, p.

161

Brattgjerd JE, Niratisairak S, Steen H, Strømsøe K: Ulike prekliniske studier av samme

fiksasjonsmetode for lårhalsbrudd: Konsistens mellom implantatets design, FEA og biomekaniske

studier [Different preclinical studies using the same fixation method for the treatment of collum

femoris fractures: Consistency between the implant’s design, finite element analysis and

biomechanical studies] Norwegian Orthopaedic Association, Annual Scientific Meeting, Oslo, October

21-23, 2015, Høstmøteboken, abstract 320, p. 162

Horn J, Steen H, Gunderson RB: Radiostereometric analysis of growth after interventions at or

around the growth plate. Norwegian Orthopaedic Association, Annual Scientific Meeting, Oslo,

October 21-23, 2015, Høstmøteboken, abstract 411, p. 180

Steen H, Lange JE, Brox JI: Early weaning in idiopathic scoliosis. Norwegian Orthopaedic Association, Annual

Scientific Meeting, Oslo, October 21-23, 2015, Høstmøteboken, abstract 704, p. 217

Horn J, Steen H, Gunderson RB: Radiostereometric analysis of growth after interventions at or

around the growth-plate. International Limb Lengthening and Reconstruction Society (ILLRS)

Congress, Combined Meeting of ILLRS, LLRS and ASAMI-BR, Miami, November 4-7, 2015, Abstract

#279.

54

Selected publications: Hjorthaug, Geir Aasmund; Madsen, Jan Erik; Nordsletten, Lars; Reinholt, Finn P.; Steen, Harald; Dimmen,Sigbjørn. Tendon to Bone Tunnel Healing. A Study on the Time-Dependent Changes in Biomechanics, Bone Remodeling,and Histology in a Rat Model. Journal of Orthopaedic Research, 2015; 33(2):216-223 Vårbakken K, Steen H, Samuelsen G, Dahl HA, Leergaard T, Stuge B. Primary functions of

thequadratus femoris and obturator externus muscles indicated from lengths and moment arms

measured in mobilized cadavers. Clin Biomech (Bristol Avon), 2015; 30(3):231-237 (doi:

10.1016/j.clinbiomech.2015.02.004)

Horn, Joachim; Grimsrud, Øyvind; Dagsgard, Anita Hoddevik; Huhnstock, Stefan; Steen, Harald.

Femoral lengthening with a motorized intramedullary nail: A matched-pair comparison with external

ring fixator lengthening in 30 cases. Acta Orthopaedica, 2015; 86(2):248-256

55

CIRRO Group Leaders

Stephan M. Röhrl, ass. Prof., ([email protected]) / orthopaedic consultant,

Division of Orthopaedic Surgery, OUH, Head of the Norwegian Society for Hip and

Kneesurgery

Lars Nordsletten, Prof., Dept of Orthopaedics, UiO

([email protected]) / Oslo Sports Trauma Research Center, Dept of

Sports Medicine, Norwegian School of Sports Sciences / Chair of the Orthopaedic

Centre, OUH / Head of the Experimental Orthopaedic group, Institute for Surgical

Research, OUH ([email protected])

Group Members

Senior members: ∙ Finnur Snorrason, MD/PhD, OUH ∙ Vera Halvorsen, MD, OUH ∙ Britt Stuge, PT/PhD, OUH ∙ Harald Steen, Professor, OUH ∙ Ragnhild Gundersen, MD radiolog, OUH ∙ Eirik Aunan, MD, Lillehammer Hospital

Alumni (PhD): ∙ Wender Figwed, MD/PhD Bærum Hospital ∙ Berte Bøe, MD/PhD, OUH ∙ Einar Lindalen, MD/PhD Lovisenberg Hospital ∙ Jon Dahl, MD/PhD, OUH ∙ Thomas Kibsgård, MD/PhD, OUH

PhD candidates: ∙ Justin van Leeuwen, MD, Betanien Hospital ∙ Bernhard Flatøy, MD, OUH, LIS ∙ Gunnar Petursson, MD, Lovisenberg Hospital ∙ Stian Svenøy, MD, OUH, LIS ∙ Trygve Glad, MD, OUH, LIS ∙ Alexander Fraser, MD, OUH, LIS ∙ Are Stødle, MD,OUH, LIS ∙ Jan Egil Brattgjerd, MD, OUH, LIS ∙ Frank David Ørn, MD, Kristiansund Hospital


56

Research profile and aims The overall aim of CIRRO is to perform sophisticated basic and clinical research in the field of implant surgery and bone turnover, establish a team of dedicated researchers and collaborate nationally and internationally. Our intention is:

∙ To use and develop precise measurement methods (RSA, dynamic RSA and DXA in

musculoskeletal research).

∙ To supervise and help PhD fellows in all connected hospitals/institutions.

∙ To study new treatment options (implants, surgical techniques, biotechnology, rehabilitation

interventions and pharmacological treatment) with precise methods to ensure benefit to

patients in a short time.

∙ To study disease development (cartilage wear, bone loss, changes in body composition)

together with other methods in order to gain insight into mechanisms for disease and

eventual treatment.

∙ To further develop CIRRO as a main research centre that delivers sophisticated services to researchers in South-Eastern Norway Regional Health Authority and adjoint hopitals nationally.

In 2015 we have focused to enlarge our repertoire of possible joints to analyse with RSA technique.

We have started with phantom studies and new implants in the knee and shoulder. We have

accomplished including more patients in ongoing studies in the hand, foot and hip, and finally

established a PhD collaboration with Helse Møre Romsdal. Our team was strengthened by our full

time fellow Masako Tsukanaka from Kyoto University, Japan.

Group Members (continued)

Radiografers:

∙ Alexis Hinohosa, CT og MRI fagradiograf, OUH ∙ Mona Risdal, CT fagradiograph, Application specialist CT, OUH ∙ Silje Klausen, BSC radiography, PgCert Reporting Radiography, OUH ∙ Kathrine Lamark, BSC radiography, MSC Diagnostic imaging, OUH ∙ Siri Engelstad Helmsett, Lovisenberg hospital

Research coordinators:

∙ Marte Traae Magnusson, PT, Master, OUH ∙ Anne Christine Brekke, head nurse, Master, OUH

CIRRO PhD fellows:

∙ Masako Tsukanaka, MD/PhD, Postdoc, Kyoto University Hospital, Japan ∙ Ye Li, MD, Peking University Medical hospital, China ∙ Yang Zhengming, MD, Zhejiang University, China

Students:

∙ Yili Qiu, Cand Med, Turnus Gjøvik Hospital ∙ Andreas Øslebye, Cand Med, Turnus

57

Ongoing projects Hip projects

∙ Unipolar or bipolar hemiarthroplasty for the treatment of displaced femoral neck fractures. A prospective randomised controlled trial of RSA (Radiostereometric Analyses) measurements of acetabular wear. (Collaboration with Bærum Hospital)

∙ Bone remodeling and migration after insertion of femoral stems with different surface coatings. Clinical and experimental studies (PhD project OUH, Ullevål)

∙ Wear and different materials in hip arthroplasty (PhD project OUH, Ullevål) ∙ Reverse hybrid total hip replacement: Wear, fixation and bone remodelling (PhD project

OUH, Ullevål) ∙ THR in patients under 20 years (Collaboration with Hipr registry in Bergen) ∙ Randomized study between operation with pins with or without plate for undisplaced

dislocated femoral neck fracture. Radio stereogrammetric analysis (RSA) of stability and fracture healing and clinical endpoints. (The Pinloc Study)

∙ RCT on the function of the Trochanteric Support Plate(TSP) in combination with the Dynamic Hip Screw(DHS)

Knee projects

∙ A new method to measure ligament balancing. How balanced are total knee arthroplasties? (Collaboration with Lillehammer Hospital)

∙ Patellar eversion in total knee arthroplasty. ∙ Custom positioning guides technique versus conventional technique in total and unikondyler

knee arthroplasty (PhD project OUH, Ullevål + Betanien Hospital) ∙ Computer navigation and conventional technique in total knee replacement (PhD project,

Collaboration with Lovisenberg and Bergen) ∙ In vivo kinematics and performance of contemporary knee arthroplasty (PhD project OUH,

Ullevål in collaboration with HF Møre Romsdal) ∙ Precision of RSA with different RSA systems ∙ Phantom study of the hip and the knee during motion

Pelvis projects

∙ Kinematic analysis of the pelvic girdle during straight leg rise (Continuation of former PhD project)

Ankle and foot projects

∙ Callotasis of the deformed lower leg (Collaboration with Rikshospital) ∙ Investigating acute Lisfranc injuries in the foot and a new surgical procedure (PhD project

OUH, Ullevål) ∙ Kinematics of the midfoot after Lisfranc injury

Shoulder projects

∙ Stability of the glenoid implant in reversed shoulder arthroplasty ∙ Precision and accuracy of model shaped vs large marker model RSA of shoulder prosthesis

58

Hand projects

∙ A prospective randomized trial comparing two different wrist arthroplasties (PhD project OUH, Rikshospital and Ullevål)

∙ Precision and accuracy of 2 different wrist implants (Phantom study)

Most important national and international

collaborators National International

‐ Norwegian Arthroplasty register (NAR)

‐ Norwegian society for hip and knee surgery (NFHKK)

‐ Betanien Hospital Skien ‐ Diakonhjemmet Hospital ‐ Drammen Hospital ‐ Elverum Hospital ‐ Lillehammer Hospital ‐ Lovisenberg Diakonale Hospital ‐ Ringerike Hospital ‐ Oslo Sports Trauma Research

Center (OSTRC) ‐ Fürst Medical Laboratory ‐ Helseforetaket Møre Romsdal

‐ Umeå University Hospital, Arthroplasty unit, Sweden

‐ UmRSA Biomedical, Sweden ‐ Leiden University, The Netherlands ‐ University of Western Australia, Perth

orthopaedic center, Australia ‐ Innovationsmanufaktur, München, Germany ‐ Harvard and Massachusetts General Hospital,

US ‐ Kyoto University Orthopedic Association, Japan ‐ Helsinki bone and joint research group; Finland




Otten VT, Crnalic S, Röhrl SM, Nivbrant B, Nilsson KG (2015). Stability of Uncemented Cups - Long-

Term Effect of Screws, Pegs and HA Coating: A 14-Year RSA Follow-Up of Total Hip Arthroplasty. J

Arthroplasty, 31 (1), 156-61. PubMed 26260783

Tsukanaka M, Röhrl SM, von Schewelov T, Nordsletten L (2015). Identification of femoral head center

of bipolar hemiarthroplasy in radiostereometric analysis with elementary geometrical shape models.

J Biomech, 49 (3), 469-73. PubMed 26705109


Health Authority ‐ Sophies Minde Ortopedi AS ‐ Zimmer

http://dx.doi.org/10.1016/j.arth.2015.07.012


http://pubmed.gov/26260783


59

Flatøy B, Röhrl SM, Bøe B, Nordsletten L (2015). No medium-term advantage of electrochemical

deposition of hydroxyapatite in cementless femoral stems. Acta Orthop, 87 (1), 42-7. PubMed

26364953

Lindalen E, Nordsletten L, Høvik Ø, Röhrl SM (2015). E-vitamin infused highly cross-linked

polyethylene: RSA results from a randomised controlled trial using 32 mm and 36 mm ceramic heads.

Hip Int, 25 (1), 50-5. PubMed 25633755



60

Hand Group Leader

Magne Røkkum, Dept. of Haematology, UiO ([email protected])/OUS

([email protected])

Research profile and aims Clinical and experimental research related to hand, microsurgery and peripheral nerves.

Ongoing projects ∙ Bratberg H: Prospective randomized comparison between percutaneous aponeurotomy

and open aponeurectomy for Dupuytren’s disease.

∙ Williksen JH et al.: Complications and secondary surgeries after volar plating of distal

radius fractures.

∙ Williksen JH et al: Radiological results and clinical outcomes after operative treatment of

distal radius fractures.

∙ Vatne M: Monitoring of the vascularisation in replantated fingers.

∙ Hestmo MT: Replantation in children.

PhD:

∙ Sondre Hassellund: The DROC study (Randomized controlled study on plating versus

conservative treatment of distal radius fractures in the elderly).

∙ Rasmus Thorkildsen: Total joint replacement or interpositional arthroplasty for the

treatment of carpometacarpal thumb arthritis.

Group Members ∙ Torstein Husby, OUH ∙ Hallgeir Brattberg, OUH ∙ John H. Williksen, OUH ∙ Sondre Hassellund ∙ Tone Vaksvik, student, Faculty of Medicine, UiO ∙ Lars-Eldar Myrseth, OUH ∙ Ida Neergård Sletten, OUH ∙ Christian Grimsgaard, OUH ∙ Istvan Rigo, student, Faculty of Medicine, UiO ∙ Ole Reigstad, OUH ∙ Mona Winge, student, Faculty of Medicine, UiO ∙ Rasmus Thorkildsen, student, Faculty of Medicine, UiO ∙ Trygve Holm Glad, student, Fac of Medicine, UiO ∙ Frode Thu, student, Faculty of Medicine, UiO ∙ Maria Vatne, OUH ∙ May Tove Hestmo, OUH ∙ Ragnhild Molland, OUH

mailto:[email protected])/OUS

61

∙ Mona Winge: Is calcium phosphate bone cement an alternative to bone graft?

∙ Istvan Z. Rigo: Flexor tendon injuries in the hand.

∙ Tone Vaksvik: Cold hypersensitivity in hand-injured patients: Function, self management

strategies and prognosis for improvements.

∙ Trygve Holm Glad: Randomized controlled trial between two total wrist arthroplasties. A

clinical, radiostereometric and DEXA study.

∙ Frode Thu: Injuries of the plexus brachialis.


‐ Prof. Jan Erik Madsen, MD, PhD ‐ Dept. of Otorhinolaryngology,

Head and Neck Surgery, OUH

‐ Dept. of Biomaterials, University of Gothenburg, Sweden




Selected publications: Reigstad O, Thorkildsen R, Grimsgaard C, Melhuus K, Røkkum M (2015). Examination and treatment

of scaphoid fractures and pseudarthrosis

Tidsskr Nor Laegeforen, 135 (12-13), 1138-42. PubMed 26130547 SFX Cristin 1282124 (Details)

Reikeras O, Winge MI, Røkkum M (2015). Effect of soft-tissue attachment on tibial fracture healing in

rats. J Orthop Surg (Hong Kong), 23 (1), 47-51. PubMed 25920643 SFX WOS 000353773600011 Cristin

1326653 (Details)

Vaksvik T, Ruijs A, Røkkum M, Holm I (2015). Evaluation of a home treatment program for cold

hypersensitivity using a classical conditioning procedure in patients with hand and arm injuries. J

Hand Ther, 29 (1), 14-22. PubMed 26498337 SFX (Details)

Funding - Sophies Minde Ortopedi AS

62

Norwegian research center for Active Rehabilitation – NAR Group Leader

May Arna Risberg, Professor, The Norwegian School of Sport Sciences

([email protected]) / Dept. of Orthopaedic Surgery, OUH ([email protected])

Research profile and aims The vision of the group is to be an internationally leading research center within the field of active

rehabilitation of musculoskeletal injuries and disorders.

Main Goals

Active rehabilitation of patients with musculoskeletal injuries and disorders

∙ Clinical research ∙ Translational research ∙ Implementation of the research to evidence based practice

Our current research areas include active rehabilitation of (1) knee injuries and osteoarthritis, (2) hip

osteoarthritis, and (3) osteoporosis. Each research area consists of a research team with senior

researchers, PhD fellows, clinicians and a research coordinator.

Ongoing projects Knee

∙ Prospective cohort study of ACL injured children under the age of 13 years. ∙ Knee osteoarthritis after ACL injury – A 20 year follow-up after ACL reconstruction. ∙ Dynamic stability of the ACL-deficient knee (Delaware Oslo ACL Cohort) – A research

collaboration with the University of Delaware, USA. ∙ The Oslo Care study – the effects of a three months rehabilitation program on articular

cartilage femoral defects in the knee.

Group Members

∙ Hege Grindem, PhD, Nimi/The Norwegian School of Sport Sciences ∙ Ida Svege, PhD, OUH ∙ Kari Anne Hakestad, student, Fac of Medicine, UiO ∙ Nina Kise, Faculty of Medicine, UiO ∙ Barbara Wondrasch, PhD, University of Vienna/ The Norwegian School of Sport

Sciences ∙ Ingrid Eitzen, PhD, Cappelen Damm ∙ Britt Elin Øiestad, Phd, Høgskolen i Oslo og Akershus ∙ Kristin Bølstad, MSc, Nimi ∙ Marte Lund, MSc, Nimi

63

∙ The OMEX Study: The effect of arthroscopic partial meniscectomy or exercise therapy as treatment of degenerative meniscus tears in middle-aged patients – A Randomized controlled trial.

∙ Efficacy of strength training and cycling on physical function and cartilage health in patients with knee osteoarthritis – A randomized controlled trial.

∙ Efficacy of strength and aerobic exercise on patient-reported outcomes and structural changes in patients with knee osteoarthritis – A randomized controlled trial.

Hip

∙ A Randomized Trial of Time to Total Hip Replacement after Exercise Therapy for Hip Osteoarthritis.

∙ Exercise therapy and patient education for individuals with hip osteoarthritis. Long-term follow-up of a prospective, randomized controlled intervention study.

∙ Biomechanical characteristics of patients with hip osteoarthritis with mild to moderate pain: A prospective, randomized clinical trial.

∙ HIPARTI: Arthroscopic surgical procedures versus sham surgery for patients with femoroacetabular impingement and/or labral tears. A multicentre, international, double-blinded randomized, controlled trial, and longitudinal cohort study.

Osteoporosis

∙ Effect of active rehabilitation on risk factors for fall, bone mineral density, and the quality of life in osteoporotic patients. A randomized, controlled intervention study.

Most important national and international collaborators National

‐ Martina Hansens Hospital ‐ Akershus University Hospital ‐ Diakonhjemmet hospital ‐ Norwegian School of Sport Sciences

International

‐ University of Delaware, US ‐ University of Southern Denmark (SDU),

Denmark ‐ University of Queensland, Australia


Health Authority ‐ National Institutes of Health (NIH) ‐ Prime Award # R01HD037985 ‐ The Norwegian Research Council ‐ OUH ‐ Norwegian School of Sport

Sciences

64



Invited lectures at international congresses: 13 1. Risberg MA. Exercise therapy/nonsurgical interventions for patients with hip OA.

Hip workshop talk on hip OA management "Exercise therapy/nonsurgical interventions for patients with hip OA". Pre- APA congress. Gold Coast, Queensland, Australia, October 2nd, 2015

2. Risberg MA. Non-Operative Management of Knee Osteoarthritis. 10th ISAKOS Congress

2015. Lyon, France, June 7th–11th, 2015.

3. Risberg MA. State of the art ACL rehabilitation. 25th Anniversary Meeting of the Dutch

Arthroscopy Society. Huis ter Duin, Noordwijk, the Netherlands, May 21st, 2015.

4. Risberg MA. Early OA cohorts. Early Pre-radiographic OA Discussion meeting, 2015 OARSI

World Congress, Seattle, Washington, April 30th – May 03th, 2015.

5. Risberg MA. Non-Operative Management of Knee Osteoarthritis. Sports Rehabilitation

Concurrent Course, 10th ISAKOS Congress 2015. Lyon, France, June 7th–11th, 2015.

6. Risberg MA. Knowledge translation in physical therapy – from clinic to research and back to

the clinic. APA congress. Gold Coast, Queensland, Australia, October 3-6th, 2015.

7. Risberg MA. Evidence for ACL rehabilitation – where are we and where are we going? APA

congress. Gold Coast, Queensland, Australia, October 3-6th, 2015.

8. Risberg MA. Evidence for exercise therapy for patients with hip OA. APA congress. Gold

Coast, Queensland, Australia, October 3-6th, 2015.

9. Risberg MA. Evidence for exercises for knee OA patients – implementation of guidelines. APA

congress. Gold Coast, Queensland, Australia, October 3-6th, 2015.

10. Risberg MA. Knowledge translation in physical therapy – from clinic to research and back to the clinic. Griffith University, Gold Coast, Australia, October 7th, 2015.

11. Risberg MA. Evidence for ACL rehabilitation – where are we and where are we going? ACRISP, Federation University. Ballarat, Australia, October 12th, 2015

12. Risberg MA. Evidence for exercises for knee OA patients – implementation of guidelines.

ACRISP, Federation University. Ballarat, Australia, October 12th, 2015

13. Risberg MA. The effect if arthropscopic surgery for patients with FAI and/or labral tear – a

randomized controlled trial. LaTrobe University. Melbourne, Australia, October 13th, 2015

Doctoral thesis:

Wondrasch B. PhD dissertation. Rehabilitation for patients with focal articular cartilage lesions in the knee. The Norwegian School of Sport Sciences, Oslo, Norway, May 19th, 2015. ISBN 978-82-502-0516-1 Selected publications: Eitzen I, Fernandes L, Kallerud H, Nordsletten L, Knarr B, Risberg MA. Gait Characteristics, Symptoms,

and Function in Persons With Hip Osteoarthritis: A Longitudinal Study With 6 to 7 Years of Follow-up.

J Orthop Sports Phys Ther. 2015 Jul;45(7):539-49. doi: 10.2519/jospt.2015.5441. Epub 2015 May 21.

65

Eitzen I, Fernandes L, Nordsletten L, Risberg MA. No effects of a 12-week supervised exercise therapy

program on gait in patients with mild to moderate osteoarthritis: a secondary analysis of a

randomized trial. J Negat Results Biomed. 2015 Mar 5;14:5. doi: 10.1186/s12952-015-0023-y.

Fitzgerald GK, Hinman RS, Zeni J Jr, Risberg MA, Snyder-Mackler L, Bennell KL. OARSI Clinical Trials Recommendations: Design and conduct of clinical trials of rehabilitation interventions for osteoarthritis. Osteoarthritis Cartilage. 2015 May;23(5):803-14. doi: 10.1016/j.joca.2015.03.013. Review.

66

Oncological Orthopedics

Group Leader Olga Zaikova, Dept. of Orthopaedics, OUH ([email protected])

Research profile and aims The treatment of sarcoma is multidisciplinary, and this is reflected in the need of extensive cooperation among several research groups. The aim is to stimulate multidisciplinary research on sarcoma. The strategy is to build up research networks, both nationally and internationally, and to participate in wide spectrum of research projects from basic research, translational research to clinical studies and retrospective quality studies.

Ongoing projects - Photochemical internalisation as a treatment for leiomyosarcoma , PhD project (Simen

Sellevold) - A study of epidemiology and outcome in chondrosarcoma, PhD prosjekt (Joachim Thorkildsen) - MRI in diagnosis, follow-up and evaluation of treatment results in patients with symptomatic

spinal metastases, PhD prosjekt (Marta Switlyk) - Giant cell tumor in the immature skeleton (Thale Marie Asp Strøm)

- Epidemiology, treatment and outcome of high-grade malignant bone sarcoma in Scandinavia (Olga Zaikova)

- NoSarC - national study of gene mutations in sarcomas. Multidisciplinary national collaboration


- Norwegian National Advisory Unit for Sarcomas

- Department of Oncology, OUH - Department of Tumor Biology,

Institute for Cancer Research, OUH

- Scandinavian Sarcoma Group (SSG) - European Muscolo-Skeletal Oncology Society

(E.M.S.O.S)

Group Members Ole-Jacob Norum, MD, PhD, OUH

Simen Sellevold, MD, OUH

Joachim Thorkildsen, MD, OUH

Thale Marie Asp Strøm, MD, OUH


67




Doctoral thesis: (Navn, tittel på avhandling, samt dato for Dissertation, evt. ISBN)

Marta Switlyk, “MRI and clinical assessment of patients with symptomatic spinal metastases”,

Dissertationdato 17.11.2015 , ISBN 978-82-8333-063-2

Selected publications: Switlyk MD, Kongsgaard U, Skjeldal S, Hald JK, Hole KH, Knutstad K, Zaikova O. Prognostic factors in

patients with symptomatic spinal metastases and normal neurological function. Clin Oncol (R Coll

Radiol). 2015 Apr;27(4):213-21. doi: 10.1016/j.clon.2015.01.002. Epub 2015 Jan 23. PubMed PMID:

25624156.

Zaikova O, Sundby Hall K, Styring E, Eriksson M, Trovik CS, Bergh P, Bjerkehagen B, Skorpil M,

Weedon-Fekjaer H, Bauer HC. Referral patterns, treatment and outcome of high-grade malignant

bone sarcoma in Scandinavia—SSG Central Register 25 years' experience. J Surg Oncol. 2015

Dec;112(8):853-60. doi: 10.1002/jso.24074. Epub 2015 Oct 19. PubMed PMID: 26482729.

Lorenz S, Barøy T, Sun J, Nome T, Vodák D, Bryne JC, Håkelien AM, Fernandez-Cuesta L, Möhlendick

B, Rieder H, Szuhai K, Zaikova O, Ahlquist TC, Thomassen GO, Skotheim RI, Lothe RA, Tarpey PS,

Campbell P, Flanagan A, Myklebost O, Meza-Zepeda LA (2015). Unscrambling the genomic chaos of

osteosarcoma reveals extensive transcript fusion, recurrent rearrangements and frequent novel TP53

aberrations. Oncotarget (in press)

68

Orthopaedic Trauma Research Group Group Leader

Jan Erik Madsen, Professor, Dept. of Orthopaedics ([email protected])/

Consultant, Orthopaedic Trauma, OUH ([email protected])

Research profile and aims The Orthopaedic Trauma Research Group aims to initiate and conduct clinical and experimental trials

at a high international level related to Orthopaedic Trauma. 15–25 continuously ongoing PhD

projects, mainly externally financed, provide the main scientific production.

Ongoing projects ∙ On the classification and treatment of acetabular fractures, John Clarke-Jensen.

∙ Effects of bone resorption inhibition and bone formation stimulation on bone and tendon- to-bone healing: Experimental studies in the rat, Geir Hjorthaug.

∙ Surgical treatment of the distal radius fracture, Ola-Lars Hammer.

∙ Biomechanical studies of the effect of different fixations upon stability of hip fractures, Jan Egil Brattgjerd.

∙ Hip fractures: Incidence and treatment, Ragnhild Øydna Støen.

∙ Treatment of Syndesmotic Injuries of the Ankle, Mette Andersen.

∙ Reversed arthroplasty in the treatment of proximal humerus fractures. Randomized controlled trial and evaluation of glenoid component migration by RSA, Alexander Fraser.

∙ Acute injuries to the Lisfranc joint complex, Are Stødle.

Group Members ∙ Frede Frihagen, PhD, Consultant ∙ Lars Nordsletten, Professor UiO / Consultant OUH ∙ Gunnar Flugsrud, Consultant, PhD ∙ Olav Røise, Professor UiO / Consultant OUH ∙ Stein Øvre, Consultant, PhD ∙ Torstein Husby, Consultant, PhD ∙ Tore Fjalestad, Consultant, PhD ∙ Sigbjørn Dimmen, Consultant, PhD ∙ Johan Hellund, Consultant, PhD ∙ Wender Figved, Consultant, PhD ∙ Knut Strømsøe, Professor, Dept. of Nursing Science, UiO ∙ Kjetil Hvaal, Consultant, PhD ∙ Elisabeth Ellingsen Husebye, Consultant, PhD ∙ Geir Andreassen, Consultant ∙ Tone Bere, Research Coordinator, PhD

69

∙ Conservative versus operative treatment of distal radius fractures, Sondre Hassellund.

∙ Treatment of Charcot neuropathy of the foot, Fredrik Nilsen.

∙ Gastrocnemius recession in foot disorder, Marius Molund.

∙ Mechanical stability in trochanteric hip fractures, Anders Karlsteen.

∙ Arthroscopic rotator cuff repair. Postoperative rehabilitation, clinical outcome and

radiological results, Kjersti Kaul Jenssen.

∙ Time course of patient- relevant functional outcome following surgery for medial

osteoarthritis of the knee, Kjetil Nerhus.

∙ Effects of NSAIDs and corticosteroids on tendon healing in an experimental model, Endre

Søreide.

∙ Function and complications in hip fractures, Stian Svenøy.

∙ Surgical treatment and complications in fractures of the distal radius, John Williksen.

∙ Does the trochanteric stabilizing plate increase stability in trochanteric hip fractures?, Carl

Erik Alm.

∙ In vitro development of a ligament and in vivo analysis of the bone-soft tissue interface, Endre Søreide.

Most important national and international collaborators National

‐ Akershus University Hospital (AHUS)

‐ Asker & Bærum Hospital

‐ Institute for Surgical Research, OUH

‐ Sunnaas Rehabilitation Hospital

‐ Norwegian School of Sport Sciences

‐ Østfold Hospital Health Authority

‐ Martina Hansens Hospital

‐ Lovisenberg Diakonal Hospital




Health Authority ‐ UiO ‐ OUH ‐ Endowment and funds

70


Invited lectures at international congresses: Numerous

Doctoral thesis:

Aron Adelved: Long- term functional and radiological outcome after displaced sacral fractures. Ahus, Lørenskog, 15.4.2015.

Selected publications: Fuglesang HF, Flugsrud GB, Randsborg PH, Stavem K, Utvåg SE (2015). Radiological and functional

outcomes 2.7 years following conservatively treated completely displaced midshaft clavicle fractures

Arch Orthop Trauma Surg, 136 (1), 17-25. PubMed 26538266 SFX WOS 000367752400003 Cristin

1287223 (Details)

Clarke-Jenssen J, Øvre SA, Røise O, Madsen JE (2015). Acetabular fracture assessment in four different pelvic trauma centers: have the Judet views become superfluous? Arch Orthop Trauma Surg, 135 (7), 913-8. PubMed 25931251 SFX WOS 000356246800003 Cristin 1251295 (Details)

Westberg M, Frihagen F, Brun OC, Figved W, Grøgaard B, Valland H, Wangen H, Snorrason F (2015).

Effectiveness of gentamicin-containing collagen sponges for prevention of surgical site infection after

hip arthroplasty: a multicenter randomized trial. Clin Infect Dis, 60 (12), 1752-9. PubMed 25737375

SFX WOS 000358075800005 Cristin 1337174 (Details)

http://x-port-sfx.uio.no/sfx_ubo?sid=Entrez:PubMed&id=pmid:26538266

http://www.publika.no/publika?page=publication&pmid=26538266





71

Oslo Sports Trauma Research Center

Group Leaders

Lars Engebretsen, Professor, UiO ([email protected]), MD/PhD

Roald Bahr (Co-chair) Professor, MD/PhD

Research profile and aims

Group Members

∙ Lars Nordsletten, MD/ PhD, Professor, OUS/OSTRC ∙ Ingar Holme, Professor, OSTRC/NIH ∙ Grethe Myklebust, PhD/PT A/Professor, OSTRC/NIH ∙ Tron Krosshaug, MSc/PhD, A/Professor, OSTRC/NIH ∙ Thor Einar Andersen, MD/PhD, A/Professor, OSTRC ∙ Kathrin Steffen, MSc/PhDResearch Scientist, OSTRC ∙ Lars-Petter Granan, MD/PhD, OUH/OSTRC ∙ Asbjørn Årøen, MD/PhD, Professor, Ahus ∙ Tone T Bere, PT/PhD Research Scientist, OSTRC/OUS ∙ Håvard Moksnes, PT/PhD, Research Scientist, OSTRC/Olympiatoppen ∙ Agnethe Nilstad, PT/PhD, Research Scientist, OSTRC/OUS ∙ Ben Clarsen, PT/PhD, Research Scientist, OSTRC/Olympiatoppen ∙ Håvard Visnes, MD/PT/PhD, Haugland university Hospital ∙ Sverre Løken, MD/PhD, OUH ∙ Robert LaPrade, MD/PhD, Steadman Institute, Vail Colorado ∙ Eirik Kristianslund, MD/PhD, Diakonhjemmet ∙ Stig Heir, MD/PhD, Martina Hansens Hospital ∙ Truls Straume-Næsheim, MD/PhD, Ahus ∙ Rune B Jakobsen, MD/PhD, OUS/Ahus ∙ Hilde Moseby Berge, MD/PhD, Olympiatoppen ∙ John Bjørneboe, MD/PhD, OSTRC ∙ Jan Harald Røtterud, MD/PhD, Ahus ∙ Marianne Martinsen, MSc/PhD, OSTRC ∙ Cathrine N Engen, MD/PhD fellow, Ahus/OSTRC ∙ Steinar Sulheim, MD/PhD fellow, Sykehuset innlandet, Gjøvik ∙ Cathrine Aga, MD/PhD fellow, Martina Hansens Hospital ∙ Christine Holm Moseid, MD/PhD fellow, OSTRC ∙ Gilbert Moatsh, MD/PhD fellow, OUH ∙ MD Guri R Ekås, MD/PhD fellow, OSTRC/OUH ∙ Christian Owesen MD/PhD fellow, Ahus ∙ Svend Ulstein MD/PhD fellow, Ahus ∙ Sophie Steenstrup PhD fellow/PT, OSTRC

72

The Oslo Sports Trauma Research Center is established at the Norwegian School of Sport Sciences as a joint research venture between the Department of Orthopaedic Surgery (Oslo University Hospital), and the Department of Sports Medicine (Norwegian School of Sport Sciences). The aim is to prevent injuries and other health problems in sports through research on risk factors, injury mechanisms, and prevention methods, with a particular emphasis on football, team handball, and alpine skiing/snowboarding. In addition to primary injury prevention research, our cartilage and ligament research group is focused on secondary prevention, i.e. surgical and nonsurgical treatment options to prevent future osteoarthritis. The goal of the center is to strengthen Norwegian health research by providing a catalyst for innovation among highly-ranked researchers and delivering superior research training and mentorship. The emphasis is not only on the production of new knowledge but also the translation of research findings into improvements in the health of Norwegians and the Norwegian health care system.

Ongoing projects In 2015 the Oslo Sports Trauma Research Center has published 45 articles in international journals

with peer review. Seven master’s students have defended their master’s degrees and three PhD

students have defended their dissertations. By the end of 2015 the Center had 96 ongoing projects, 3

accepted and 17 submitted articles, and 6 electronic publications. In addition, 28 projects were in the

planning stage and 22 projects were temporarily on hold. You can find a complete list of projects in

the Center’s annual rapport for 2015.


∙ Stig Andersson, PhD fellow/PT, OSTRC ∙ Arnhild Bakken, PhD fellow/PT, Aspetar ∙ Arnlaug Wangensteen, PhD fellow/PT, Aspetar ∙ Joar Harøy, PhD fellow/PT, OSTRC ∙ Kam Ming Mok, PhD Fellow/MSc, OSTRC ∙ Marc Jacob Strauss, MD, OUH ∙ Christopher LaPrade, PhD fellow, Steadman Institute, Vail Colorado

Associated group members

∙ Oliver Faul, MSc, OSTRC ∙ Inge Andersen, Database developer, MSc, OSTRC ∙ Tone Øritsland, MSc/Research coordinator, OSTRC

73


‐ The Norwegian Olympic and paralympic committee and confederation of sports

‐ Steadman Philippon Research Institute, Vail, US

‐ International Olympic Committee (IOC)

‐ International Ski Federation

‐ Federation Internationale de Football Association

‐ Federation Internationale de Volleyball





Doctoral thesis:

Clarsen, Benjamin. Overuse injuries in sport:

development, validation and application of a new

surveillance method. Norwegian School of Sport

Sciences 2015 (ISBN 978-82-502-0507-9).

Martinsen, Marianne. Preventing eating disorders among young male and female elite athletes.

Norwegian School of Sport Sciences 2015 (ISBN 978-82-502-0508-6).

Røtterud, Jan H. Focal cartilage lesions in anterior cruciate ligament-injured knees. UiO 2015 (ISBN

978-82-8264-946-9).

Selected publications: Clarsen, Benjamin; Bahr, Roald; Heymans, Martijn W.; Engedahl, Martin; Midtsundstad, Guri Elisabeth; Rosenlund, Linn; Thorsen, Gro; Myklebust, Grethe. The prevalence and impact of overuse injuries in five Norwegian sports: Application of a new surveillance method. Scandinavian Journal of Medicine & Science in Sports 2015; 25(3), 323-330.

LaPrade, Christopher M.; Dornan, Grant; Granan, Lars-Petter; LaPrade, Robert F.; Engebretsen, Lars. Outcomes after anterior cruciate ligament reconstruction using the Norwegian Knee Ligament Registry of 4691 Patients: How does meniscal repair or resection affect short-term outcomes? American Journal of Sports Medicine 2015; 43(7), 1591-1597.


Health Authority ‐ Norwegian Ministry of Culture ‐ International Olympic Committee ‐ Norwegian Olympic and

Paralympic Committee and Confederation of Sports

‐ International Ski Federation ‐ Norwegian School of Sport

Sciences ‐ Smith & Nephew ‐ Various grants from other sources

74

Lynch, Andrew D.; Logerstedt, David; Grindem, Hege; Eitzen, Ingrid; Hicks, Gregory E.; Axe, Michael

J.; Engebretsen, Lars; Risberg, May Arna; Snyder-Mackler, Lynn. Consensus criteria for defining

‘successful outcome’ after ACL injury and reconstruction: A Delaware-Oslo ACL cohort

investigation. British Journal of Sports Medicine 2015; 49(5), 335-342.

75

Research in plastic and reconstructive surgery Group Leader

Kim A. Tønseth, Ass. Prof., Dept. of Plastic and Reconstructive Surgery, UiO

([email protected]) / Head of Dept. of Plastic and Reconstructive Surgery,

OUH ([email protected])

Research profile and aims Plastic and reconstructive surgery is performed to restore normal anatomy and function in patients

with congenital and acquired disorders, and in patients with tissue defects after trauma or cancer

surgery. During the last decades research in plastic and reconstructive surgery has led to

development of a large number of treatment options for patients with different kinds of disorders

and defects. These methods are often based on experimental research which has been refined

through clinical procedures. The main outcome is improved quality of life and patient satisfaction,

based on restoration of anomalies and dysfunction.

Ongoing projects ∙ Nina Lindberg. Mothers’ experiences of feeding infants with cleft lip and palate and the effects

of a follow-up program on parental information needs, parental stress and infant growth. Supervisor: KA Tønseth

∙ Mitra Rashidi. Surgical complications in the cardiac heart transplantation patient. Supervisor: A Fiane (thorax, OUH)/ KA Tønseth

∙ Haris Mesic. Microcirculation in perforator flaps. Hovedveileder: KA Kirkebøen ∙ Torjus Wester. Studies on skin tounge microcirculation during shock. Supervisor: K Kvernebo ∙ Kjell Vidar. Metabolic and circulatory effects of fasting and sepsis Supervisor: Øyvind Irtun

(gastrokir, UNN)

Planned PhD-projects:

∙ Christoffer Ingvaldsen: Bloodperfusion of the abdominal skin related to the DIEP-flap procedure. Supervisor: KA Tønseth

Group Members ∙ Hans Erik Høgevold, MD/PhD, OUH ∙ Thomas Moe Berg, MD/PhD, OUH ∙ Charles Filip, MD/PhD, OUH ∙ Tyge Tindholdt, MD/PhD, OUH ∙ Torjus Wester, MD/PhD Fellow, OUH ∙ Haris Mesic, MD/PhD Fellow, OUH ∙ Michael Schneider, MD, OUH ∙ Therese Halvorsen Bjark, MD, OUH ∙ Christoffer Aam Ingvaldsen, MD-student, OUH ∙ Other physicians in the department are involved in isolated projects

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∙ Berit Skraastad. QoL, patient satisfaction and cosmetic outcome after breast reconstruction. Supervisor: KA Tønseth

Planned projects:

∙ Treatment with cultured epidermal cells ∙ Lymphatic malformations ∙ Surgical treatment in transsexuals ∙ Surgical treatment in patients with facial palsy ∙ Breast reconstruction using ADM


‐ Plast. surg. dep., Haukeland

‐ Plast. surg. dep., Linköping, Sweden ‐ Plast. surg. dep., Ghent, Belgium ‐ Plast. surg. dep., Vienna, Austria





Selected publications: 1. Filip C, Feragen KB, Lemvik JS, Lindberg N, Andersson EM, Rashidi M, Matzen M, Høgevold HE

(2015). Multidisciplinary Aspects of 104 Patients With Pierre Robin Sequence Cleft Palate Craniofac J, 52 (6), 732-42. PubMed 25554857 SFX WOS 000367718300017

2. Tønseth KA, Filip C, Hermann R, Vindenes H, Høgevold HE (2015). Extraordinary Large Giant Congenital Melanocytic Nevus Treated with Integra Dermal Regeneration Template. Plast Reconstr Surg Glob Open, 3 (7), e469 PubMed 26301158 SFX Cristin 1290841

3. Jackson C, Eidet JR, Reppe S, Aass HC, Tønseth KA, Roald B, Lyberg T, Utheim TP (2015). Effect of Storage Temperature on the Phenotype of Cultured Epidermal Cells Stored in Xenobiotic-Free Medium. Curr Eye Res, 1-12. PubMed 26398483 SFX Cristin 1259357, 1276907

Funding ‐ OUH



http://dx.doi.org/10.1597/14-161

http://pubmed.gov/25554857?otool=inouolib


http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS&DestLinkType=FullRecord&KeyUT=WOS:000367718300017




http://www.cristin.no/as/WebObjects/cristin.woa/wa/fres?action=sok&nr=1290841








77

Specialized medical rehabilitation – Sunnaas Rehabilitation

Hospital Group Leader Johan K. Stanghelle, MD/PhD, Director of Research ([email protected])/

Professor, Dept. of Physical Medicine and Rehabilitation, UiO

([email protected])

Group Members

∙ Johan K. Stanghelle, MD/PhD, Professor, Sunnaas Rehabilitation Hospital/UiO ∙ Frank Becker, MD/PhD, ass Professor, Sunnaas Rehabilitation Hospital/UiO ∙ Grethe Månum, MD/PhD, ass Professor, Sunnaas Rehabilitation Hospital/UiO ∙ Emil Kostovski, MD/PhD, postdoc fellow, Sunnaas Rehabilitation Hospital/UiO ∙ Svend Rand-Hendriksen, MD/PhD, postdoc fellow, Sunnaas Rehabilitation Hospital/UiO ∙ Anne-Kristine Schanke, PSYCH/PhD, Professor, Sunnaas Rehabilitation Hospital/UiO ∙ Marianne Løvstad, PSYCH/PhD, ass Professor, Sunnaas Rehabilitation Hospital/UiO ∙ Solrun Sigurdardottir, PSYCH/PhD, postdoc fellow, Sunnaas Rehabilitation Hospital ∙ Jan Egil Nordvik, PSYCH/PhD, Sunnaas Rehabilitation Hospital ∙ Arve I. Opheim, PT/PhD, Sunnaas Rehabilitation Hospital ∙ Anne Lannem, PT/PhD, ass Professor, Sunnaas Rehabilitation Hospital/Norwegian school of

Sport Sciences ∙ Reidun Jahnsen, PT/PhD, ass Professor, Sunnaas Rehabilitation Hospital/Oslo and Akershus

University College of Applied Sciences ∙ Birgitta Langhammer, PT/PhD, Professor, Sunnaas Rehabilitation Hospital/Oslo and Akershus

University College of Applied Sciences ∙ Kirsti Skavberg Roaldsen, PT/PhD, ass Professor, Sunnaas Rehabilitation Hospital/Karolinska

Institute ∙ Grace I. Romsland, RN/PhD, Professor, Sunnaas Rehabilitation Hospital/Oslo and Akershus

University College of Applied Sciences ∙ Melanie Kirmess, ST/PhD, ass Professor, Sunnaas Rehabilitation Hospital/UiO ∙ Vegard Strøm, Cand Scient/PhD, Sunnaas Rehabilitation Hospital

Associated group members:

∙ Fin Biering-Sørensen, MD/PhD, Professor, Copenhagen University ∙ Katharina Sunnerhagen, MD/PhD, Professor, Gothenburg University ∙ Lena Hartelius, ST/PhD, Professor, Gothenburg University ∙ Kerstin Fugl-Meyer, SW/PhD, Professor, Karolinska Institute ∙ Anna Olsson, SW/PhD, Professor, Karolinska Institute ∙ Agneta Ståhle, PT/PhD, Professor, Karolinska Institute ∙ Helle Ploug Hansen, RN/PhD, Professor, University of Southern Denmark, Odense ∙ Jennie Ponsford, PSYCH/PhD, Professor, Monash University, Melbourne

78

Research profile and aims Clinical and some basic research within specialized rehabilitation of patients with brain injuries,

spinal cord injuries and multitrauma, and research within selected groups of seldom diagnosis.

Ongoing projects ∙ Follow-up of the most serious injured patients after the July 22nd attack ∙ Multinational studies on specialized rehabilitation for stroke patients and spinal cord injuries ∙ Several studies on neuropsychological consequences after brain injury ∙ Several studies on movement disorders and gait analysis ∙ Basic physiological mechanisms after spinal cord injuries ∙ Basic mechanisms after brain injuries (fMRI, electrophysiological functions etc) ∙ Several studies on patients with seldom diagnosis



‐ Oslo University Hospital ‐ Institute of Psychology, UiO

‐ Oslo and Akershus University College ‐ Norwegian Sport High School ‐ Haukeland University Hospital ‐ St. Olav Hospital / Trondheim University

Hospital ‐ University Hospital of North Norway

‐ Beitostølen Health Sport Center

‐ Karolinska Institute, Stockholm, Sweden ‐ Gothenburg University, Sweden ‐ Copenhagen University, Denmark

‐ University of Southern Denmark, Odense; Denmark

‐ Monash University, Melbourne, Australia

‐ China Rehabilitation and Research Center (CRRC), China

Associated group members (continued)

PhD Fellows/MD: Dag Brekke, Thy Thy Vanem, Ingebjørg Irgens, Erlend Solberg Dørum, Hege

Prag Øra, Claudia Nyberg, Vesna Miloshevska Jakimovska, Mladen Savikj

PhD Fellows/PSYCH: Per Ola Rike, Kjersti Mæhlum Walle, Sveinung Tornås, Solveig Hauger,

Geneviève Ricard, Knut Kolskår

PhD Fellows/RN: Line Nortvedt, Anne-Stine Røberg, Anne Geard

PhD Fellows/PT: Vivien Jørgensen, Emelie Butler Forslund, Matthijs Wouda, Linda Rennie,

Anu Piira

PhD Fellows/SW: Gry Velvin, Jannike K. Vikan

PhD Fellows/ST: Maribeth C. Rivelsrud

PhD Fellows/OT: Anne-Marthe Sanders

Administration:

Annette M. Juelsen

79

‐ Hospitals in Health Region South-East ‐ Rusk Institute of Rehabilitation , NY, USA ‐ Policlinic no2, Petrozavodsk, Karelia,

Russian Federation ‐ Sheba Medical Center, Tel Aviv, Israel ‐ Betlehem Arab Society for

Rehabilitation, Palestine (BASR)

‐ El Wafa Hospital, Gaza, Palestine ‐ Sahlgrenska University Hospital, Högsbo,

Sweden ‐ Bayi 81 Rehabilitation Center, Sichuan,

China

‐ Schweizer Paraplegiker-Forschung AG, Switzerland



Other Publications: 40

Doctoral thesis:

Annica E.M. Johansson: Changes in occupational patterns after disability.

PhD 2015, Institute of Clinical Medicine, Faculty of Medicine, UiO. ISBN 978-82-8264-991-9/Nr.

2125 (Dissertation 21. January 2016).

Selected publications: Velvin G, Bathen T, Rand-Hendriksen S, Østertun Geirdal A. Work participation in adults with Marfan syndrome: Demographic characteristics, MFS related health symptoms, chronic pain, and fatigue. Am J Med Genet A. 2015 Sep 30. doi: 10.1002/ajmg.a.37370. [Epub ahead of print]. PMID: 26420568 Langhammer B, Becker F, Stibrant-Sunnerhagen K, Zhong T, Du X, Bushnik T, Panchenko M, Keren O, Banura S, Elessi K, Luzon F, Lundgren-Nilsson Å, Li X, Sällström S, Stanghelle JK. Specialized stroke rehabilitation services in seven countries: Preliminary results from nine rehabilitation centers. Int J Stroke. 2015 Aug 18. doi: 10.1111/ijs.12599. [Epub ahead of print]. PMID:26282956

Hauger SL, Schnakers C, Andersson S, Becker F, Moberget T, Giacino JT, Schanke AK, Løvstad

M.Neurophysiological Indicators of Residual Cognitive Capacity in the Minimally Conscious State.

Behav Neurol. 2015;2015:145913. doi: 10.1155/2015/145913. Epub 2015 Oct 4. PMID:26504351

80

Ear and hearing research group Group Leader Juha Silvola, Senior Consultant, Dr.Med, OUS ([email protected]), Associate Professor

Research profile and aims Carry out research related to ear and hearing, to investigate how patients benefit from intervention,

treatment, rehabilitation and ear surgery including cochlear implantation. A major part of the

research is through PhD projects, the remaining part is carried out on top of clinical practice with no

specific funding in place.

Ongoing projects ∙ A survey of hearing, language and quality of life in persons who received cochlear implants as

children, Ona Bø Wie, 2012–2018.

∙ Speech perception in noise, measured with HINT (Hearing In Noise Test),

Marte Myhrum, 2010–2016 (PhD project).

∙ Objective Measurements and Cochlear Implants Imaging,

Ralf Greisiger, 2010–2014 (PhD project).

∙ Vestibular function and residual hearing after cochlear implantation,

Karl Fredrik Nordfalk, 2010–2016 (PhD project).

Group members

∙ Juha Tapio Silvola MD/PhD, Ass Professor, OUS/Tampere, Finland ∙ Ona Bø Wie, Cand.Paed.Spec/PhD, Professor, UiO/ISP/OUH ∙ Marie Bunne, MD/PhD, OUH ∙ Greg Jablonski, MD/ PhD, Ass Professor, UiO/OUH ∙ Mariann Gjervik Heldahl, MSc/PhD, OUH ∙ Jens Jørgen Dammerud, MSc/PhD, OUH ∙ Marte Myhrum, MSc/PhD fellow, Senior Engineer, UiO ∙ Ralf Greisiger, MSc/PhD fellow, OUH ∙ Arne Kirkhorn Rødvik, MSc/PhD fellow, UiO/ISP ∙ Karl Fredrik Nordfalk, MD/PhD fellow, OUH ∙ Torstein Grønseth, MD/PhD fellow, OUH ∙ Jacob Skalleberg, MD/PhD fellow, OUH ∙ Marit Enny Gismarvik, M.Health Psychology, Research assistant, OUH ∙ Åsrunn Isaksen, Cand.Paed.Spec, Research assistant, OUH


81

∙ Overview of speech sound confusions for adults and children with cochlear implants,

Arne Rødvik, 2013–2017 (PhD project).

∙ Otitis media chronica and cholesteatoma: bacteriology and antibacterial treatment,

Torstein Grønseth, 2014–2018 (PhD project).

∙ Cochlear implant in minority group children,

Marie Bunne and Viktoria Vedeler Amundsen, 2013–2015.

∙ Visual statistical learning in typically developing children, children with specific language

impairment and children with hearing impairment,

Janne von Koss Torkildsen (University of Oslo), Joanne Arciuli (University of Sydney),

Christiane Lingås Haukedal, Marit Gismarvik and Ona Bø Wie, 2014–2015

∙ Collaboration PhD project with the Department of Radiology, Benedicte Falkenberg-Jensen,

Greg Jablonski, Juha Silvola (PhD project).


Department of Special Needs Education, University of Oslo

‐ Cochlear Corporation

‐ University of Wisconsin, US (Ruth Litovsky)

The Norwegian Directorate of Health

‐ University of Sydney, Australia

‐ University of Tampere, Finland

‐ Harvard University, Boston, US (Dennis Poe)

Central Norway Regional Health Authority

Northern Norway Regional Health Authority

University of Oslo




Health Authority ‐ University of Oslo ‐ The Norwegian Directorate of

Health ‐ Cochlear Corporation

82

Selected publications: 1. Greisiger, R., Shallop, J. K., Hol, P. K, Elle, O. J., & Jablonski, G. (2015). Cochlear implantees: Analysis of behavioural and objective measure for a clinical population of various age groups. Cochlear Implants International, 16(S4), 1–19. doi: 10.1080/14670100.2015.1110372 2. Klein, K. E., & Wie, O. B. (2015). Long-term predictors of narrative skill in children with early

bilateral cochlear implants. Eur. J. Spec. Needs Educ., 30(2), 202–219

3. Nordfalk, K. F., Rasmussen, K., Hopp, E., Bunne, M., Silvola, J. T., & Jablonski, G. (2015). Insertion Depth in Cochlear Implantation and Outcome in Residual Hearing and Vestibular Function. Ear and Hearing, 37(2), 129–137.

83

HPV in Head and Neck Group Leader

Harriet Akre, MD/PhD, Consultant, dept of Otorhinolaryngology & Head and Neck Surgery, OUH /

Associate prof, dept of Otorhinolaryngology & Head and Neck Surgery, UiO

([email protected])

Ongoing projects ∙ Look into the association between Human Papilloma Virus ( HPV) infections and Head and

neck cancers and recurrent respiratory papillomatosis. ∙ Treatment and quality of life in patient with hereditary hemorrhagic teleaniectasia-

associated epistaxis. ∙ Tracheal resections outcomes, a retrospective study in all patients treated with surgery. ∙ Thyroidea Surgery within the rhinolaryngology section OUH 2002–2013, a retrospective

study of outcome. ∙ Larynx cancer, Clinical and epidemiological aspects ( PhD). ∙ Head and Neck Paraganglioma: 2004–2015.

∙ High grade skull base malignancies, a multidisciplinary approach (PhD). ∙ Serial Serum Antibodies to HPV16 in Oropharyngeal Squamous Cell Carcinoma Among Cases

and Controls Participating in the Janus Serum Bank. ∙ Prevalence of human papillomavirus in oropharyngeale carcinomer in patients treated at

OUH in 2010–2011. ∙ Cisplatinum induced ototoxicitet and tinnitus (PhD). ∙ Laser diverticulotomy for Zenker's diverticulum – does it improve quality of life? ∙ Sleep apnea syndrome in patients with paroxysmal atrial fibrillation.

Group Members ∙ Terje Andreas Osnes, MD/PhD, Prof., Head of dept. of Otorhinolaryngology &

Head and Neck Surgery, OUH, UiO ∙ Kjell Brøndbo, MD/PhD, Prof., dept. of Otorhinolaryngology & Head and Neck

Surgery, OUH, UiO ∙ Jesper Bradstorp Boesen, MD/PhD student, UiO ∙ Sinan Dheyauldeen MD/PhD, Consultant, OUH ∙ Guro Haugen Fossum, MD/PhD fellow, OUH ∙ Bianca Lorntzsen, MD, senior registrar, OUH ∙ Jon Mork, MD/PhD, Consultant, OUH ∙ Turid Omland, MD/PhD, Consultant, OUH

84


‐ Dept of Biostatistics OUH ‐ Dept of Genetics OUH ‐ Dept of Neurosurgery OUH ‐ Craniofacial team OUH ‐ Unit of Sleep medisin, Lovisenberg

Diakonal Hospital ‐ Dept of Pathology, OUH ‐ Dep og Medicine, OUH

‐ Several departments, Karolinska Institutet, Stockholm




Doctoral thesis:

Turid Brokke Omland, Recurrent respiratory Papillomatosis, Incidence, HPV genotype profile and risk

for aggressive disease and high-grade laryngeal neoplasia. May 2015 ISBN 978-82-8333-000-7

Tobias Erik Herrscher, Sleep-Disordered Breathing in Heart failure Patients and its Impact on

Cardiovascular Risk, June 2015 ISBN 978-82-8264-819-6

Selected publications: Attramadal CG, Kumar S, Boysen ME, Dhakal HP, Nesland JM, Bryne M (2015). Tumor Budding, EMT

and Cancer Stem Cells in T1-2/N0 Oral Squamous Cell Carcinomas. Anticancer Res, 35 (11), 6111-20

PubMed 26504037 SFX WOS 000363794900045 Cristin 1298694

Heimdal K, Dalhus B, Rødningen OK, Kroken M, Eiklid K, Dheyauldeen S, Røysland T, Andersen R,

Kulseth MA (2015). Mutation analysis in Norwegian families with hereditary hemorrhagic

telangiectasia: founder mutations in ACVRL1. Clin Genet, 89 (2), 182-6. PubMed 25970827 SFX WOS

000368806900006 Cristin 1333597

Opheim LR, Hellman U, Engström-Laurent A, Laurent C (2015). Hyaluronan in Human Vocal Folds in

Smokers and Nonsmokers-A Histochemical Study. J Voice (in press). PubMed 26471808 SFX

Funding ‐ UiO














http://dx.doi.org/10.1016/j.jvoice.2015.05.007




85

Center for Eye Research Group Leader

Bjørn Nicolaissen; Professor, [email protected]

Dept. of Ophthalmology, Oslo University Hospital and University of Oslo

Professor Bjørn Nicolaissen retired from his position at 1.September 2015.

Goran Petrovski; Professor, [email protected] will take over as new

research group leader from June 1 2016.

Group Members

∙ Symira Cholidis, MDm, OUH ∙ Yolanda Lorenzo Corrales, PhD, UiO ∙ Liv K. Drolsum, MD/PhD, Professor, UiO ∙ Brit Engebretsen, Technician, OUH ∙ Helene Zell Thime, Technician, OUH ∙ Gunnhild Fallet Sandvik, MSc, OUH ∙ Camilla Gram, MD, PhD student, UiO ∙ Eli Gulliksen, 1. Engineer, OUH ∙ Anne M. Hagem, MD/PhD student, OUH ∙ James Macpherson, MD/PhD student, OUH ∙ Kristiane Haug Berg, MSc/PhD, UiO ∙ Erling Haaskjold, MD/PhD, UiO ∙ Dag Krohn-Hansen, MD/PhD student, OUH ∙ Linn Lillevold, Registered Nurse, OUH ∙ Morten C. Moe, MD/PhD, Professor, UiO ∙ Jesintha Navaratnam, MD/PhD student, OUH ∙ Charlotte Ness, MD/PhD student, OUH ∙ Agate Noer, PhD/Senior Scientist, UiO ∙ Øyvind Osnes-Ringen, MD/PhD student, OUH ∙ Meeta Pathak, MD/PhD student, UiO ∙ Geir A. Qvale, 1. Consultant, UiO ∙ Amund Ringvold, MD/PhD, UiO ∙ Marianne Råen, MSc, OUH ∙ Aboulghassem Shahdadfar, PhD/ Senior scientist, UiO ∙ Jon K. Slettedal, MD/PhD, Associate Professor, UiO ∙ Marit Sæthre, MD/PhD, OUH ∙ Andreas Thorsrud, MD/PhD student, OUH ∙ Kristine Ustgaard-Andersen, MSc, OUH ∙ Atle Østern, MD/PhD, OUH ∙ Olav Kristianslund, MD/PhD student, OUH



86

Research profile and aims The Department of Ophthalmology, with The Norwegian Eye Bank and Center for Eye Research, is

one of the largest eye clinics in Scandinavia. The main objective of our research is to improve medical

and surgical treatment of eye disorders.

Clinical research

Improving treatment of eye diseases, especially of the cornea, conjunctiva and cataract and

advancing methods for transplantation of tissues. In projects, main focus is on outcome after corneal

transplant surgery and cataract surgery. Results when using traditional and new procedures for

surgical treatment of blindness due to corneal- and ocular surface are being compared. Such new

procedures include transplantation of layers of corneal tissue stored in an eye bank and of tissue

engineered in laboratory facilities. Our clinic has the first program in Scandinavia for transplantation

of ex vivo generated ocular tissue for treatment of corneal and conjunctival disorders

(http://sciencenordic.com/eye-eye-saves-sight).

Interdisciplinary research

Identify how different factors affect cells, tissues and molecules including DNA in healthy tissue and in various eye disorders. Such information may allow for improvements in the treatment of eye diseases. Tissues for transplantation may be cultured or produced in laboratories. We examine how various conditions influence the cells and their molecules including DNA in order to modify and improve the current methods and ultimately the quality of tissues destined for transplantation.

Basic research

Stem cells are central in tissue repair. In projects, characteristics of stem cells derived from normal and from diseased tissues are examined, and factors that regulate their ability for production of differentiated cells and for tissue repair are mapped. In the laboratory, differentiated cells may be stimulated to develop into stem cells, and this opens for entirely new treatment options. In projects, mechanisms that regulate such a development and the potential use of the cells in treatment of eye diseases are being explored.


Associated group members ∙ Magnus T. Røger, MD/PhD, OUH ∙ Andrew R. Collins, PhD, Professor, UiO ∙ Leiv Sandvik, PhD, Professor, OUH ∙ Hans Christian Dalsbotten Aass, MSc, UiO ∙ Ole Kristoffer Olstad, PhD, UiO

http://sciencenordic.com/eye-eye-saves-sight

87

New Funding

In collaboration with University of Praha, CER received funding from the Norway grants for a collaborative project regarding development of new procedures for cultivation and generation of corneal tissue for transplant purposes (http://www.oslo-universitetssykehus.no/aktuelt_/nyheter_/Sider/Stotte-til-norsk-tsjekkisk-hornhinneprosjekt.aspx). In 2015, we also received funding from Helse Sør-Øst for a PhD-student, from Kreftforeningen for a Post doc position, in addition to funding to different projects from Norges Blindeforbund, Norsk Oftalmologisk forening and Blindemissionen IL.

Ongoing projects

Dag Krohn-Hansen. Surgical treatment of congenital eyelid ptosis.

Meeta Pathak. Graft of limbalt epithelium cultivated in medium with human serum.

James Eide Macpherson.Cultivation of corneas for graft: changes in the concentration of

amino acids in culture medium.

Charlotte Larsen Ness. Melanoma in the choroid - could growth of stemcells in melanoma be

hampered by patient-specific immunotherapy?

Jesintha Navaratnam. Development of a new method in the treatment of corneal endothelial

failure, graft of human, cultivated corneal endothelial layer.

Andreas Thorsrud. Corneal collagen cross linking for kerato ectasia: studies on new

treatment method with emphasize on effect and security.

Øyvind Osnes-Ringen. Pathogenesis and treatment of cataracts.

Camilla Gram. Reconstruction of the surface of the eye with mucosa epithelium.

Anne M. Hagem. Keratoconus – normal variations in the corneal surface in the Norwegian

population.

Olav Kristianslund. Outcome of cataract surgery in patients with pseudoexfoliation syndrome.

http://www.oslo-universitetssykehus.no/aktuelt_/nyheter_/Sider/Stotte-til-norsk-tsjekkisk-hornhinneprosjekt.aspx

http://www.oslo-universitetssykehus.no/aktuelt_/nyheter_/Sider/Stotte-til-norsk-tsjekkisk-hornhinneprosjekt.aspx

88


- Groups of National Center for Stem Cell Research, www.stemcellnorway.org

- Prof. Francisco Javier Romero, Fundacion Ofthalmologica del Mediterraneo, Valencia, Spain

- Prof. Katerina Jirsova, Charles University, Praha, Czech Republic

- Prof. Vinagolu Rajasekhar, Senior researcher, Memorial Sloan Kettering Institute, New York, USA.

- Prof. Jesper Hjortdal, Inst. For Klinisk Medicin, Aarhus, Denmark

- Prof. Martine Jaeger, Leiden University medical center, Netherlands

- Charlotta Zetterström, M.D., Ph.D., Professor [email protected]

- Prof. Sarah Coupland, Liverpool Ocular Oncology, Department of Molecular & Clinical Cancer Medicine, University of Liverpool, UK

- Prof. Einar Stefánsson, Department of Ophthalmology, University of Iceland, Iceland

- Assoc. Prof. Heli Skottman/Prof. Hannu Uusitaalo, BioMediTech/Department of Ophthalmology, University of Tampere, Finland

- Assist. Prof. Mehrdad Rafat, Department of Biomedical Engineering, Linköping University, Sweden

- Prof. Kai Kaarniranta, Department of Ophthalmology, University of Eastern Finland, Finland




1. Long-Term Cultures of Human Cornea Limbal Explants Form 3D Structures Ex Vivo - Implications for Tissue Engineering and Clinical Applications. Szabó DJ, Noer A, Nagymihály R, Josifovska N, Andjelic S, Veréb Z, Facskó A, Moe MC, Petrovski G.PLoS One. 2015 Nov 18;10(11):e0143053. doi: 10.1371/journal.pone.0143053. eCollection 2015.

Funding/ Funding sources - Blindemissionen IL - Norges Blindeforbund - The Research Council of Norway - South-Eastern Norway Regional

Health Authority

- The Norwegian Cancer Society - Oslo University Hosptial

http://www.stemcellnorway.org/


89

2. Recovery of plasma vascular endothelial growth factor concentrations during aflibercept

loading phase and after the transition to bimonthly treatment for neovascular age-related macular degeneration. Roald AB, Aass HC, Moe MC. Br J Ophthalmol. 2015 Dec;99(12):1610-3. doi: 10.1136/bjophthalmol-2015-306781. Epub 2015 May 12.

3. Suspension surgery with autogenous fascia lata via a less invasive modification of the

Crawford method on 85 patients with congenital severe eyelid ptosis. Krohn-Hansen D, Haaskjold E, Nicolaissen B. J Plast Surg Hand Surg. 2015;49(4):214-9. doi: 10.3109/2000656X.2014.1001853. Epub 2015 Jan 26.

http://www.ncbi.nlm.nih.gov/pubmed/25966740



90

Clinical Retina Research Group Leader

Ragnheiður Bragadóttir, MD/PhD, Head of Vitreoretinal Division, dept. of

Ophthalmology, OUH / UiO ([email protected])

Research profile and aims Clinical implementation and evaluation of new treatment – and diagnostic modalities for

vitreoretinal disorders.

Ongoing projects ∙ PASS-study. Epiretinal strontium-90 brachytherapy combined with intravitreal injection of

bevacizumab (Avastin) for treatment of patients with exudative AMD resistant to anti-VEGF

Group Members Karina Berg, MD/PhD fellow

Agnieszka Bober, MD

Thomas Bærland, MD

Nils Andreas Eide, MD

Rowan Faber, MD

Dag Fosmark, MD/PhD

Erke Maja Gran, MD/PhD

Øystein Kalsnes Jørstad, MD

Marta Haugstad, MD

Katrine Holen, opthalmic nurse, master student

Josephine Prener Holtan, MD/PhD fellow

Elma Jelin, PhD student

Sonja Lerdal, research assistant and technician

Morten C. Moe, MD/PhD

Anca Roald, MD/PhD

Panagiotis Salvanos, MD, phD student

Marianne Strøm MD

Monica Sneve MD, PhD

Magne Sand Sivertsen MD, PhD

Ana Carla Schippert surgery nurse, mastergrade student


91

∙ treatment. Ragnheidur Bragadottir, Agnieszka Monika Bober and Thomas Bærland. Dept. of Ophthalmology, OUH, Torfinn Nilssen, head of Dept. and Bernt Louni Rekstad consultant engineer, Cancer and Surgery Division, Dept. of Medical Physics, OUH.

∙ Lucentis compared to Avastin study. Randomised, double-blind, prospective multicentre study of the effect of intravitreal injection of bevacizumab (Avastin®) compared to ranibizumab (Lucentis®) in patients with exudative Age Related Macular degeneration (AMD) in Norway. Karina Berg, Terje Pedersen, Leiv Sandvik, Ragnheidur Bragadóttir. PhD project.

∙ Mapping of patients with hereditary retinal disease in Norway. Josephine Prener Holtan, Kaja Selmer, Dept of Medical Genetics, OUH, Ketil Heimdal, Dept. of Medical Genetics, OUH, Ragnheidur Bragadottir. PhD project

∙ Ultra-Widefield Fundus Autofluorescence in the Diagnosis and Evaluation of Retinal Detachment and Intraocular tumors. Panagiotis Salvanos, Morten Carstens Moe, Thor Paaske Utheim, Ragnheidur Bragadottir. PhD project

∙ INJECT: Investigation of JETREA® in Patients with Confirmed Vitreomacular Traction. Rowan Faber and Ragnheidur Bragadottir investigators in Oslo, Norway

∙ Converting eyes with treatment-resistant exudative AMD to aflibercept – two year follow up. Øystein Kalsnes Jørstad, Rowan Thomas Faber and Morten Carstens Moe.

∙ Uveal melanoma – clinical follow-up and cellular characterization. Eide N et al. Clinical follow-up and cellular characterization in bone marrow and primary tumours.

∙ AMD PROM- patients reported outcome measures in treatment of wet age related macula degeneration. Jelin E et al. Patient derived tool to measure most important dimensions for patients being treated for neovascular AMD.

∙ Eylea-2014 study. Plasma concentrations of vascular endothelial growth factor before and after repeated intravitreal aflibercept injections in patients with exudative age-related macular degeneration. Anca B. Roald, Dept. of Ophthalmology, OUH, Hans C.D. Aass, Dept of Biochemistry, OUH, Morten C. Moe, Dept. of Ophthalmology, OUH

∙ Age related macular degeneration; incidence, progression and predictors for disease 2007-2016: The Tromsø study7 &Tromsø Eye Study 2. Maja Gran Erke and Marianne Strøm. PhD project

∙ The vitreomacular interface: Prevalence and associated risk factors of vitreomacular traction,

epiretinal membrane, lamellar macular hole and macular hole. Progression and predictors of

diseases on the vitreomacular interface 2007-2016. Monica Sneve.

∙ Correlation between visual function and demographic variables in patients with wet age

related macula degeneration. Ana Carla Schippert, surgery nurse and mastergrade student


‐ Dr.med. Vet. Ernst O. Ropstad, Norwegian School of Veternary Science

‐ Geir Bertelsen, MD, PhD, Dept. of Ophthalmology, University of Tromsø, Universitetssykehuset Nord Norge.

‐ Prof dr. Med. Vet. Kristina Narfström, University of Missoury, Columbia, US

‐ Prof MD/PhD Barbara Wilhelm, University of Tübingen, Germany

92




Berg K, Hadzalic E, Gjertsen I, Forsaa V, Berger LH, Kinge B, Henschien H, Fossen K, Markovic S,

Pedersen TR, Sandvik L, Bragadóttir R (2015):Ranibizumab or Bevacizumab for Neovascular Age-

Related Macular Degeneration According to the Lucentis Compared to Avastin Study Treat-and-

Extend Protocol: Two-Year Results. Ophthalmology, 123 (1), 51-9PubMed 26477842 SFX WOS

000367060700025 Cristin 1283653

Carling U, Dorenberg EJ, Haugvik SP, Eide NA, Berntzen DT, Edwin B, Dueland S, Røsok B

(2015):Transarterial Chemoembolization of Liver Metastases from Uveal Melanoma Using Irinotecan-

Loaded Beads: Treatment Response and Complications. Cardiovasc Intervent Radiol, 38 (6), 1532-

41.PubMed 25832764 SFX WOS 000365219100017 Cristin 1264424

Eide N, Garred Ø, Beiske K, Fodstad Ø (2015):Bilateral uveal melanomas with different gene

expression detected with 7 years interval. Acta Ophthalmol, 94 (1), 99-102. PubMed 26496992 SFX

WOS 000368732300036


Health Authority ‐ OUH ‐ The Norwegian Association of

the Blind and Partially Sighted (NABP)

93

Retinal Vessel Diameters Research Group Group Leader

Nina C.B.B.Veiby, MD/PhD, specialist, Dept. of Ophthalmology, OUH

([email protected])

Research profile and aims The project is based on a 980 fundus photographs from epidemiological, cross-sectional study

(Inter99), which enables a detailed survey of the relationship between retinal vascular diameter and

general health. The project objective is to measure the caliber, length and tortuosity of arteries and

veins in the retina at fundus photos from these people, who are characterized with disorders in

glucose metabolism, cardiovascular disease and general health.

These morphometric characteristics are compared with known targets for morbidity and risk of

mortality, to clarify whether fundus photography can supplement or replace established risk and,

thus, be applied to screening for disease and prevention of disease. The aim is, thus, to examine

whether digital fundus photography can be used as a

simple method to diagnose and / or monitor

systemic disease, which is normally not available for

non-invasive and non-destructive examination.

Ongoing projects ∙ Data analysis from Inter99 Eye Study

Group Members

∙ Dragana Drobnjak, MD/PhD Fellow, OUH ∙ Michael Larsen, Professor, University of Copenhage/Glostrup Hospital, Denmark ∙ Line Kessel, MD/PhD, University of Copenhagen/Glostrup Hospital, Denmark ∙ Bjørn Nicolaissen, MD/PhD, Professor, OUH ∙ Leiv Sandvik, Professor, OUH

Funding ‐ The Danish Medical Research

Council ‐ Øjenfonden ‐ Øjenforeningen Værn om Synet ‐ Center for Biomedical Optics

and New Laser Systems Graduate School

‐ The Danish Diabetes Association

‐ The Norwegian Association of the Blind and Partially Sighted

‐ The Norwegian Blind Mission ‐ IL, South-Eastern Norway

Regional Health Authority

94

Most important national and international collaborators International

‐ Dept. of Ophthalmology, Glostrup Hospital, Denmark

‐ Dept. of Ophthalmology, Westmead Hospital, Sydney, Australia



Selected publications: Retinal vessel diameters and cardiovascular risk factors in the Inter99 Eye Study: an epidemiologic

study , BMC Ophthalmology

95

Publication list KKN research groups 2015

Abbas A, Gregersen I, Holm S, Daissormont I, Bjerkeli V, Krohg-Sørensen K, Skagen KR, Dahl TB, Russell D, Almås T, Bundgaard D, Alteheld LH, Rashidi A, Dahl CP, Michelsen AE, Biessen EA, Aukrust P, Halvorsen B, Skjelland M (2015) Interleukin 23 levels are increased in carotid atherosclerosis: possible role for the interleukin 23/interleukin 17 axis Stroke, 46 (3), 793-9

Albanese A, Abbruzzese G, Dressler D, Duzynski W, Khatkova S, Marti MJ, Mir P, Montecucco C, Moro E, Pinter M, Relja M, Roze E, Skogseid IM, Timerbaeva S, Tzoulis C (2015) Practical guidance for CD management involving treatment of botulinum toxin: a consensus statement J Neurol, 262 (10), 2201-13

Almaas R, Jensen U, Loennecken MC, Tveter AT, Sanengen T, Scholz T, Holm I (2015) Impaired motor competence in children with transplanted liver J Pediatr Gastroenterol Nutr, 60 (6), 723-8

Alnæs MS, Mardal KA, Bakke S, Sorteberg A (2015) Computational fluid dynamics evaluation of flow reversal treatment of giant basilar tip aneurysm Interv Neuroradiol, 21 (5), 586-91

Andelic N, Arango-Lasprilla JC, Perrin PB, Sigurdardottir S, Lu J, Landa LO, Forslund MV, Roe C (2015) Modeling of Community Integration Trajectories in the First Five Years after Traumatic Brain Injury J Neurotrauma, 33 (1), 95-100

Andersen MR, Frihagen F, Madsen JE, Figved W (2015) High complication rate after syndesmotic screw removal Injury, 46 (11), 2283-7

Andersson H, Sem M, Lund MB, Aaløkken TM, Günther A, Walle-Hansen R, Garen T, Molberg Ø (2015) Long-term experience with rituximab in anti-synthetase syndrome-related interstitial lung disease Rheumatology (Oxford), 54 (8), 1420-8













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http://dx.doi.org/10.1007/s00415-015-7703-x





http://dx.doi.org/10.1097/MPG.0000000000000757


http://dx.doi.org/10.1177/1591019915597415



http://dx.doi.org/10.1089/neu.2014.3844



http://dx.doi.org/10.1016/j.injury.2015.08.021






http://dx.doi.org/10.1093/rheumatology/kev004

96

Anke A, Andelic N, Skandsen T, Knoph R, Ader T, Manskow U, Sigurdardottir S, Røe C (2015) Functional Recovery and Life Satisfaction in the First Year After Severe Traumatic Brain Injury: A Prospective Multicenter Study of a Norwegian National Cohort J Head Trauma Rehabil, 30 (4), E38-49

Attramadal CG, Kumar S, Boysen ME, Dhakal HP, Nesland JM, Bryne M (2015) Tumor Budding, EMT and Cancer Stem Cells in T1-2/N0 Oral Squamous Cell Carcinomas Anticancer Res, 35 (11), 6111-20

Aunan E, Næss G, Clarke-Jenssen J, Sandvik L, Kibsgård TJ (2015) Patellar resurfacing in total knee arthroplasty: functional outcome differs with different outcome scores Acta Orthop, 87 (2), 158-64

Baftiu A, Johannessen Landmark C, Nikaj V, Neslein IL, Johannessen SI, Perucca E (2015) Availability of antiepileptic drugs across Europe Epilepsia, 56 (12), e191-7

Bakken IJ, Aaberg KM, Ghaderi S, Gunnes N, Trogstad L, Magnus P, Håberg SE (2015) Febrile seizures after 2009 influenza A (H1N1) vaccination and infection: a nationwide registry-based study BMC Infect Dis, 15, 506

Becker I, Nieder TO, Cerwenka S, Briken P, Kreukels BP, Cohen-Kettenis PT, Cuypere G, Haraldsen IR, Richter-Appelt H (2015) Body Image in Young Gender Dysphoric Adults: A European Multi-Center Study Arch Sex Behav, 45 (3), 559-74

Beiske GA, Holmøy T, Beiske AG, Johannessen SI, Johannessen Landmark C (2015) Antiepileptic and Antidepressive Polypharmacy in Patients with Multiple Sclerosis Mult Scler Int, 2015, 317859

Berg-Hansen P, Celius EG (2015) Socio-economic factors and immigrant population studies of multiple sclerosis Acta Neurol Scand, 132 (199), 37-41



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Berg-Hansen P, Moen SM, Harbo HF, Celius EG (2015) Comments on the review article 'Time trends in the incidence and prevalence of multiple sclerosis in Norway during eight decades' Acta Neurol Scand, 132 (5), 364-7

Berg K, Hadzalic E, Gjertsen I, Forsaa V, Berger LH, Kinge B, Henschien H, Fossen K, Markovic S, Pedersen TR, Sandvik L, Bragadóttir R (2015) Ranibizumab or Bevacizumab for Neovascular Age-Related Macular Degeneration According to the Lucentis Compared to Avastin Study Treat-and-Extend Protocol: Two-Year Results Ophthalmology, 123 (1), 51-9

Berge E, Cohen G, Lindley RI, Sandercock P, Wardlaw JM, Sandset EC, Whiteley W (2015) Effects of Blood Pressure and Blood Pressure-Lowering Treatment During the First 24 Hours Among Patients in the Third International Stroke Trial of Thrombolytic Treatment for Acute Ischemic Stroke Stroke, 46 (12), 3362-9

Bergeron MF, Mountjoy M, Armstrong N, Chia M, Côté J, Emery CA, Faigenbaum A, Hall G, Kriemler S, Léglise M, Malina RM, Pensgaard AM, Sanchez A, Soligard T, Sundgot-Borgen J, van Mechelen W, Weissensteiner JR, Engebretsen L (2015) International Olympic Committee consensus statement on youth athletic development Br J Sports Med, 49 (13), 843-51

Berner K, Hall KS, Monge OR, Weedon-Fekjær H, Zaikova O, Bruland ØS (2015) Prognostic factors and treatment results of high-grade osteosarcoma in norway: a scope beyond the "classical" patient Sarcoma, 2015, 516843

Berzina G, Sveen U, Paanalahti M, Sunnerhagen KS (2015) Analysing the modified rankin scale using concepts of the international classification of functioning, disability and health Eur J Phys Rehabil Med (in press)

Bhandari M, Devereaux PJ, Einhorn TA, Thabane L, Schemitsch EH, Koval KJ, Frihagen F, Poolman RW, Tetsworth K, Guerra-Farfán E, Madden K, Sprague S, Guyatt G, HEALTH Investigators (2015) Hip fracture evaluation with alternatives of total hip arthroplasty versus hemiarthroplasty (HEALTH): protocol for a multicentre randomised trial BMJ Open, 5 (2), e006263









http://dx.doi.org/10.1016/j.ophtha.2015.09.018







http://dx.doi.org/10.1136/bjsports-2015-094962





http://dx.doi.org/10.1155/2015/516843

http://dx.doi.org/10.1155/2015/516843



http://dx.doi.org/10.1136/bmjopen-2014-006263


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Bialer M, Johannessen SI, Levy RH, Perucca E, Tomson T, White HS (2015) Progress report on new antiepileptic drugs: A summary of the Twelfth Eilat Conference (EILAT XII) Epilepsy Res, 111, 85-141

Bjarnason JA, Pripp AH, Reikeras O (2015) Reliability of measures used in radiographic evaluation of the adult hip Skeletal Radiol, 44 (7), 935-9

Bjørnarå KA, Dietrichs E, Toft M (2015) Longitudinal assessment of probable rapid eye movement sleep behaviour disorder in Parkinson's disease Eur J Neurol, 22 (8), 1242-4

Blaauw BA, Dyb G, Hagen K, Holmen TL, Linde M, Wentzel-Larsen T, Zwart JA (2015) The relationship of anxiety, depression and behavioral problems with recurrent headache in late adolescence – a Young-HUNT follow-up study J Headache Pain, 16, 10

Boldingh MI, Dekker L, Maniaol AH, Brunborg C, Lipka AF, Niks EH, Verschuuren JJ, Tallaksen CM (2015) An up-date on health-related quality of life in myasthenia gravis -results from population based cohorts Health Qual Life Outcomes, 13, 115

Boldingh MI, Maniaol AH, Brunborg C, Dekker L, Heldal AT, Lipka AF, Popperud TH, Niks EH, Verschuuren JJ, Tallaksen CM (2015) Geographical Distribution of Myasthenia Gravis in Northern Europe--Results from a Population-Based Study from Two Countries Neuroepidemiology, 44 (4), 221-31

Boon P, Vonck K, van Rijckevorsel K, El Tahry R, Elger CE, Mullatti N, Schulze-Bonhage A, Wagner L, Diehl B, Hamer H, Reuber M, Kostov H, Legros B, Noachtar S, Weber YG, Coenen VA, Rooijakkers H, Schijns OE, Selway R, Van Roost D, Eggleston KS, Van Grunderbeek W, Jayewardene AK, McGuire RM (2015) A prospective, multicenter study of cardiac-based seizure detection to activate vagus nerve stimulation Seizure, 32, 52-61


http://dx.doi.org/10.1016/j.eplepsyres.2015.01.001



http://dx.doi.org/10.1007/s00256-015-2101-0


http://dx.doi.org/10.1111/ene.12723

http://dx.doi.org/10.1111/ene.12723



http://dx.doi.org/10.1186/1129-2377-16-10

http://dx.doi.org/10.1186/1129-2377-16-10





http://dx.doi.org/10.1186/s12955-015-0298-1

http://dx.doi.org/10.1186/s12955-015-0298-1






http://dx.doi.org/10.1159/000431036

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http://dx.doi.org/10.1016/j.seizure.2015.08.011


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Bos SD, Page CM, Andreassen BK, Elboudwarej E, Gustavsen MW, Briggs F, Quach H, Leikfoss IS, Bjølgerud A, Berge T, Harbo HF, Barcellos LF (2015) Genome-wide DNA methylation profiles indicate CD8+ T cell hypermethylation in multiple sclerosis PLoS One, 10 (3), e0117403

Bredesen IM, Bjøro K, Gunningberg L, Hofoss D (2015) Patient and organisational variables associated with pressure ulcer prevalence in hospital settings: a multilevel analysis BMJ Open, 5 (8), e007584

Brodtkorb E, Nakken KO (2015) The relationship between epilepsy and religiosity illustrated by the story of the visionary mystic Wise-Knut Epilepsy Behav, 46, 99-102

Brommeland T, Rydning PN, Pripp AH, Helseth E (2015) Cranioplasty complications and risk factors associated with bone flap resorption Scand J Trauma Resusc Emerg Med, 23, 75

Carling U, Dorenberg EJ, Haugvik SP, Eide NA, Berntzen DT, Edwin B, Dueland S, Røsok B (2015) Transarterial Chemoembolization of Liver Metastases from Uveal Melanoma Using Irinotecan-Loaded Beads: Treatment Response and Complications Cardiovasc Intervent Radiol, 38 (6), 1532-41

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