™™

ADAPT™SprayUS 6,667,308, US 7,507,731, US 7,521,467, US 7,521,468, US7,524,877, US 7,541,356, US 7,541,356 PATENTED APPLICATIONS

• May Improve Sleep* • May Experience Weight Loss* • May Heighten Libido* • May Reduce Stress and Anxiety*

ADAPT™ Spray provides 30 days of a

convenient, non-invasive supply of a patented

adaptogen that works epigenetically based on

your body’s needs. ADAPT™ Spray may be

used for a number of reasons, such as delaying

the effects of aging.

PatentedAdaptogen� UnlimitedShelfLife� UniqueDelivery Overthecounter�WorksEpigenetically

* These statements have not been evaluated by the Food and Drug Administration.

This product is not intended to diagnose, treat, cure, or prevent any disease. © 2018-2019 Dr. Dori Naerbo, Ph.D. All Rights Reserved

TableofContents

AGING,MANYFACTORS........................................................................................................................3WHATISADAPT™X.1?..........................................................................................................................3HOWDOESITWORK?...........................................................................................................................3WHATARETHEBENEFITS?.................................................................................................................4ISITSAFE?.................................................................................................................................................4CLINICALTRIALSANDPATENTSDOUBLE-BLINDRANDOMIZEDYALEPROTOCOLSLEEPSTUDY............................................................................................................................................5US7,794,761,US7,541,356&US7524877...................................................................................6COMPOUNDSOFTHEINVENTIONASANANTIDEPRESSANTANDAPHRODISIACINHUMANMALES...........6

US7,541,356&US7524877...............................................................................................................6EXAMPLE3...............................................................................................................................................................6COMPOUNDSOFTHEINVENTIONASANANTIDEPRESSANT...............................................................................6EXAMPLE6...............................................................................................................................................................7COMPOUNDSOFTHEINVENTIONFORWEIGHTLOSS..........................................................................................7WEIGHTLOSSASANANTIDEPRESSANTINHUMANFEMALES..........................................................................7US6,667,308............................................................................................................................................................8COMPOUNDSFORUSEASANTIDEPRESSANTS,APHRODISIACSANDADJUNCTIVETHERAPIESINHUMANS.....................................................................................................................................8

PATENTABSTRACTS.............................................................................................................................9

Aging,ManyFactors

We begin to age the day we are born. New evidence shows that serotoninlevels decline aswe age and age-related disorders such as depressedmood,sleepdifficultiesoccur.Wethinkofserotoninasacompoundinthebrainthatpromotes feelingsofpersonal security, relaxation, andconfidence. But90%-95% of our serotonin resides in the intestinal track, hence the gut-brainconnection.

Researchershavefoundthatasweagesubtlechangesinserotoninlevelsmayalsoplayalargeroleincardiovascular,depressionandmooddisorders.Iffact,it is hard to find a system in the body that is not regulated by serotonin. Aserotonin deficiency can result in sleep disturbance, anxiety, depression,carbohydratesbinging,saggingorwrinkledskin,andpain,justtonameafew.

Basedonnewtechnologyanddiscoveries,wemaynowbeabletoimproveourhealthbybalancingserotoninandmelatonintorestoreyouthfullevels.

WhatisAdapt™X.1?

Adapt™X.1asimple,yetpowerful-patentedadaptogenthatcreatesanuntoldmelodytoyourcells.Infact,nootheradaptogencandowhatAdapt™X.1can,andwehavethepatentstoproveit. Adapt™X.1exclusiveformulationhasaninnate intelligence that defies all other adaptogens on the market availabletoday!

The active ingredients of Adapt™ X.1 are extracted from monocot naturalgrasses that contain themost potent type of certain polyphenols during theearlygrowthstage.Theformulationismicronizedmeaningitisproducedusingstateofthearttechnologysothatthemoleculesaremadesmallenoughtopassthrough the cellmembrane. Oncemicronized themolecules are attached toclustersofwaterasthecarrierdeliverysystem.

HowDoesItWork?

Adapt™X.1adjuststoyourbody’sneedsepigenetically.WhenourcellsareinastateofdisharmonyAdapt™X.1worksastheconductortohelpourorchestraof cells to sing in perfect pitch and harmony. It opens your serotonin andmelatoninpathwaysandmayupregulateordownregulateaccordingtoyourphysiology.Thisincredibleadaptogenbringyourbodybackintobalanceorastate of homeostasis literallymaking you feel like a teenager, again! Whentakentheproductbeginstoworkimmediatelytobalancethebody.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. © 2018-2019 Dr. Dori Naerbo, Ph.D. All Rights Reserved

WhatAretheBenefits?

The patents in Adapt ™ X.1 Spray relates to compositions and methods toinduce weight loss, appetite suppression and as adjunctive therapies forfibromyalgia, sleep apnea, diabetes, hyperglycemia and arthritis and moreparticularly, to novel compositions of phenolic and indoleamine-likecompoundswhich areobtainable in concentrations and amounts suitable forhumanuse.Backed by 20 years of research, multiple use patents and double blind YaleProtocolstudysays theAdapt™X.1active ingredientsbalancesyourbody toalleviatethefollowingconditions:

• SleepDisorder• Fibromyalgia/Pain• AppetiteSuppression• SexualFunctionBothDesireandPerformance• CognitiveFunction• StressandAnxiety• Anti-aging• MoodDisorder

• Wrinkles/SaggingSkin• WeightLoss• FatMetabolism• HappyMood• AdjunctiveTherapyforSubstanceAbuse• Gut&Digestion• ImmuneFunction• Andmuchmore...

IsitSafe?

Yes, it is safeand thebeautyof this technology is thatyourbodydetermineshowitisgoingtobeused.• NoSideEffects• NoAllergicReactions• NoDrugInteractions• YouCannotOverdoseOnIt• ItHasUnlimitedShelfLife• There'sNothingLikeItInTheMarketItdefiesanythingelsethat'sbeingdevelopedorhasbeendeveloped.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. © 2018-2019 Dr. Dori Naerbo, Ph.D. All Rights Reserved

ClinicalTrialsandPatentsDouble-BlindRandomizedYaleProtocolSleepStudyApproximately 75 study candidateswere screened ofwhich 60 appropriatesubjects enrolled into the study (thosewith “moderate” levels of perceivedstress). Subjects scoring 6 or greater during the screening survey wereeligible for enrollment into the supplementation study (a score of 6-10indicatesmoderatestress).Subjects were randomized to receive the Adapt dietary supplement, (SleepAid;30 subjects)ora look-alikePlacebo (30 subjects) for4weeks. SubjectswereinstructedtoconsumeoftheSleepAidsupplementbeforebedtime.The 4-week duration was selected as more representative of persistentchanges in mood state that may result from superior hormone andneurotransmitter balance (as opposed to short- term changes in emotionsthatmaybemorecloselylinkedwithstressorsofdailyliving).TheResults:30%fellasleepfaster,30%fewerwakefulevents,25%moretime in REM sleep. Sleep-deprivation lowersyourmetabolismandappetitecontrol.

InternationalSocietyforSportsNutrition(ISSN)AnnualScientificConference

Overtrainingsyndrome(OTS) isastress-relatedphenomenonexperiencedbyelite level and recreational athletes alike. Athletes are subjected to stressorsfromphysical,psychological,andbiochemicalsourcesthatmayleadtoOTSandsignificant decrements in mental and physical performance. OTS may becharacterized by elevated perceived stress, reducedmood quality, increasedtension/anxiety, and disrupted sleep quality/quantity; each of which caninfluence and compound the other, leading to a vicious cycle of increasinglypoorperformance,increasedstress,anddisruptedsleeppatterns.ResultsComparedtothePlacebogroup,theMGEgroup(allp<0.05):-Had8%lessTension(7.9+5.9v.8.6+5.5)-Had15%lessDepression(6.8+6.9v.8.0+7.9)-Had25%lessIrritability(6.4+5.0v.8.0+7.9)-Fellasleep33%faster(0.63+0.79v.0.84+0.90)-Had50%bettersleep"efficiency"(0.26+0.59v.0.52+0.71)-Had40%bettersleep"quality"(0.67+0.48v.1.12+0.97)-Wokeup30%fewertimeseachnight(2.1+2.5v.3.0+1.5)-Experienced24%moretimeindeepREMsleep(1.85+0.46hv.1.41+0.30h)

US7,794,761,US7,541,356&US7524877

CompoundsoftheInventionasanAntidepressantandAphrodisiacinHumanMales

Sexualdysfunctionisanotherpervasivedisorder.Intheoverallpopulation,itisbelieved that forty-three percent (43%) of women and thirty-one percent(31%) ofmen between the ages of 18 and 59 experience sexual dysfunctionandsomerepeatedly. Sexualdysfunctionmay include, forexample, a lackofinterestinsex,problemswitharousal,notenjoyingsex,andanxietyassociatedwith sexual performance. Indeed, feeling good in general has been found tohaveasignificant impactonsexual function. Inthisregard,thosepeoplewhoare unhappy or depressed may be more likely to experience difficultiesassociatedwithsexualdysfunction.

Arousal problems affect over 20million Americanmales (i.e., about 2 in 10adult men), similar statistics have been reported worldwide, with suchdifficultiesoftenassociatedwithoraccompaniedbysomesortofdepressionormood disorder.Meanwhile, prescription antidepressants have been found toactually exacerbate the situation, since a frequent side effect of their use issexual dysfunction. In fact, sexual response may actually diminish in up toseventy-fivepercent(75%)ofprescriptionantidepressantusersforusingthesame. To this end, there is a need for forms of treatment that reducedepressionorotherwisebettermoodwithanaccompanyingenhancementofsexualresponse,arousalordesireor,inthealternative,donothaveanegativeimpactonaperson'ssexualfunction.

Adouble-blindcrossoverstudywasdoneonhumanmalestotestcompoundsof the invention as a therapeutic agent for treating depression or otherwiseelevatingmoodaswellasbetteringsexualfunction.

Amajority ofmales reported increased vim and vigor, both in duration andfrequency thanusually experiencedwhennot taking the compound.Manyofthe male subjects studied stated they experienced feelings “like a teenager”regardingenergy,sexualfunctionandotherwise.

US7,541,356&US7524877

EXAMPLE3

CompoundsoftheInventionAsanAntidepressantThis example further relates to a method for lessening depression andotherwisebetteringmoodorfeelingsofwell-being.

EXAMPLE6

CompoundsoftheInventionforWeightLoss

WeightLossAsanAntidepressantinHumanFemales

Obesitylevelsareontheriseandinsomecountriesitisestimatedthatnearlyhalfthepopulationwillbeobeseby2030.Wearelivingisasocietywheretheparentswillmost likelyout livetheirchildrenasobesity inchildrenbetweentheagesof5-19continuetorise.Thehigh-riskcountriesinparticulararetheUnited States, Mexico and England, where 47%, 39% and 35% of thepopulationrespectivelyareprojectedtobeobesein2030.

Stress,emotionalfactors,lackofexercise,foodcraving,andpoorsleepqualityare just a few of the factors that contribute to obesity. In fact, studies havefoundthatwhenyousleeplessyouaremore likelytobeoverweight. This isduetothehormonessuchastheriseofghrelinandreductionofleptinduringsleep.

Thenovelcompoundsoftheinventionactasappetitesuppressantssometimesreferred to as appetite depressants. As known in the art, study illustratessignificant activity of the compounds of the present invention in reducing adesire to consume Sugars, simple carbohydrates (e.g., Snack foods) andunhealthy Saturated fats (e.g., Snack foods andmeats). Given that the novelcompoundsofthepresentinventionhavebothweightlossandmoodbetteringproperties,suchpropertiesmayprovetobeabeneficialtherapyforarthritis.Itiswellknownintheart,thatosteoarthritisisadegenerativejointdiseaseandthemostcommonformofarthritis.Unlikejointproblemscausedbyswellingorinflammation, osteoarthritis stems primarily from a breakdown of theconnectivetissuesthatbindmusclesandbonestogether.

Giventhatthenovelcompoundsofthepresentinventionhavebothweightlossandmoodbetteringproperties, suchpropertiesmayprove tobe abeneficialtherapy for arthritis. It is well known in the art, that osteoarthritis is adegenerativejointdiseaseandthemostcommonformofarthritis.Unlikejointproblems causedby Swelling or inflammation, osteoarthritis stemsprimarilyfrom a breakdown of the connective tissues that bind muscles and bonestogether. The ensuingdamage includesdeteriorationof joint Surfaces,whichnolongermeshSmoothlyandinsteadcauseconsiderablepain.Jointproblemsareusuallyworsenedbyexcessiveweight.For example, the knees bear a considerable load even during such simpleactivities as walking, whereas any decrease in overall body weight canpositively affect the performance or quality of life in arthritic individuals.Meanwhile, preparations that improvemood have been found to amelioratethedebilitatingpainassociatedwitharthritisorotherwisebettertoleranceofarthriticconditions.Likewise,thenovelcompoundsofthepresentinventionmaybeadvantageousto diabetic and hyperglycemic people, for whom weight loss and moodenhancingmedications can improve glycemic control. The compounds of the

presentinventionalsoprovideapplicabletherapyforotherdisorders.For example, weight loss may improve physical functioning in fibromyalgiapatients, while mood-enhancing medications may alleviate other adversesymptomsofthiscondition.Weightlossmayalsohelpeliminateorotherwisediminish sleep apnea,making the novel compounds of the present inventionvaluablefortreatmentofthiscondition.

US6,667,308

COMPOUNDSFORUSEASANTIDEPRESSANTS,APHRODISIACSANDADJUNCTIVETHERAPIESINHUMANS

Phenoliccompoundswithaphenolicmolecule towhicharecovalently linkedan oxygen-containing group, a nitrogen or another oxygen containing group,and a C-C alkoxy group, obtainable from monocotyledonous plants, animalsthat eat Such plants, or chemical Synthesis, have been found to act as anantidepressant or otherwise a treatment for bettering mood, a therapy forimproving Sexualdesireorperformance, an adjunctive therapy for achievingweightloss,andanadjunctivetherapyforSubstanceabuseandaddiction.

The invention is in the field of treating depression, Sexual dysfunction,Substanceabuseoraddiction,andininducingweightloss,compoundsusedinsuchtreatments,andthemakingofsuchcompounds.

Ithasbeenfoundthatcompoundsoftheinvention,wheningestedorotherwiseintroduced into the body of a human or animal, are effective as: (1) anantidepressantinthatitbettersmoodandreducesorrelievessymptomsofdepression;(2)insextherapiesinthesensethatitimprovessexualdesireand performance (e.g., desire, arousal, and performance); (3) an effectiveadjunctive therapy for weight loss; (4) as an adjunctive treatment forsubstanceabuseandaddiction;(5)forpreservingandaugmentinginnateimmunedefensesinhumansandanimals;and(6)forreducingsymptomsandcomorbidbehaviorsrelatingtoanxiety.

PatentAbstracts

No.6,667,308–IssuedDecember23,2003

ABSTRACT: Phenolic compounds with a phenolic molecule to which arecovalently linked an oxygen-containing group, a nitrogen or another oxygencontaining group, and a C.sub.1 -C.sub.4 alkoxy group, obtainable frommonocotyledonousplants,animalsthateatsuchplants,orchemicalsynthesis,have been found to act as an antidepressant or otherwise a treatment forbettering mood, a therapy for improving sexual desire or performance, anadjunctive therapy forachievingweight loss, andanadjunctive therapyfor substance abuse and addiction. These compounds, at concentrationssuitableforhumantherapeuticuse,maybeobtainedfromplantssuchascornintheirearlygrowthstagesandfrompartsofanimalssuchasthevelvetantlertipsofdeerandelk.

No.7,507,731–IssuedMarch24,2009

ABSTRACT: Phenolic compounds with a phenolic molecule to which arecovalently linked an oxygen-containing group, a nitrogen or another oxygencontaining group, and a C.sub.1-C.sub.4 alkoxy group, obtainable frommonocotyledonousplants,orbychemicalsynthesis,havebeenfoundtoactasweight loss agents, appetite suppressants, mood enhancers andadjunctive therapy forarthritis, sleepapnea, fibromyalgia,diabetesandhyperglycemia.Additionalchemicalcompoundsofthepresentinventionmayincludebenzoxazinoids-cyclichydroxyamicacids, lactams, andcorrespondingglucosides, which may serve as precursors to phenolic compounds. Thephenolic compounds and precursors of phenolic compounds of the presentinvention, at concentrations suitable for human therapeutic use, may beobtained from monocotyledonous plants such as corn in their early growthstateswhicharetimelyharvestedforoptimumyield.

No.7,521,467–April21,2009

ABSTRACT: Phenolic compounds with a phenolic molecule to which arecovalently linked an oxygen-containing group, a nitrogen or another oxygencontaining group, and a C.sub.1-C.sub.4 alkoxy group, obtainable frommonocotyledonousplants,orbychemicalssynthesis,havebeenfoundtoactasweight loss agents, appetite suppressants, mood enhancers andadjunctive therapy forarthritis, sleepapnea, fibromyalgia,diabetesandhyperglycemia.Additionalchemicalcompoundsofthepresentinventionmayincludebenzoxazinoids-cyclichydroxyamicacids, lactams, andcorrespondingglucosides, which may serve as precursors to phenolic compounds. Thephenolic compounds and precursors of phenolic compounds of the presentinvention, at concentrations suitable for human therapeutic use, may beobtained from monocotyledonous plants such as corn in their early growthstateswhicharetimelyharvestedforoptimumyield.(SeeClaimsinthepatentsfordistinctionsbetweenthispatentandPatentsNo.7.521,468and7,524,877.)

No.7,521,468–IssuedApril21,2009

ABSTRACT: Phenolic compounds with a phenolic molecule to which arecovalently linked an oxygen-containing group, a nitrogen or another oxygencontaining group, and a C.sub.1-C.sub.4 alkoxy group, obtainable frommonocotyledonousplants,orbychemicalsynthesis,havebeenfoundtoactasweight loss agents, appetite suppressants, mood enhancers andadjunctive therapy forarthritis, sleepapnea, fibromyalgia,diabetesandhyperglycemia.Additionalchemicalcompoundsofthepresentinventionmayincludebenzoxazinoids-cyclichydroxyamicacids, lactams, andcorrespondingglucosides, which may serve as precursors to phenolic compounds. Thephenolic compounds and precursors of phenolic compounds of the presentinvention, at concentrations suitable for human therapeutic use, may beobtainedfrommonocotyledonousplantssuchascornintheirearlygrowthstates which are timely harvested for optimum yield. (See Claims in thepatents for distinctions between this patent and Patents No. 7.521,467 and7,524,877.)

No.7,524,877–IssuedApril28,2009

ABSTRACT: Phenolic compounds with a phenolic molecule to which arecovalently linked an oxygen-containing group, a nitrogen or another oxygencontaining group, and a C.sub.1-C.sub.4 alkoxy group, obtainable frommonocotyledonousplants,orbychemicalsynthesis,havebeenfoundtoactasweight loss agents, appetite suppressants mood enhancers andadjunctive therapy forarthritis, sleepapnea, fibromyalgia,diabetesandhyperglycemia.Additionalchemicalcompoundsofthepresentinventionmayincludebenzoxazinoids-cyclichydroxyamicacids, lactams, andcorrespondinggluxosides, which may serve as precursors to phenolic compounds. Thephenolic compounds and precursors of phenolic compounds of the presentinvention, at concentrations suitable for human therapeutic use, may beobtainedfrommonocotyledonousplantssuchascornintheirearlygrowthstates which are timely harvested for optimum yield. (See Claims in thepatents for distinctions between this patent and Patents No. 7.521,467and7,521,468.)

No.7,541,356–IssuedJune2,2009

ABSTRACT: Phenolic compounds with a phenolic molecule to which arecovalently linked an oxygen-containing group, a nitrogen or another oxygencontaining group, and a C.sub.1-C.sub.4 alkoxy group, obtainable frommonocotyledonousplants,orbychemicalsynthesis,havebeenfoundtoactasweight loss agents, appetite suppressants, mood enhancers andadjunctive therapy forarthritis, sleepapnea, fibromyalgia,diabetesandhyperglycemia.Additionalchemicalcompoundsofthepresentinventionmayincludebenzoxazinoids-cyclichydroxyamicacids, lactams, andcorrespondingglucosides, which may serve as precursors to phenolic compounds. Thephenolic compounds and precursors of phenolic compounds of the presentinvention, at concentrations suitable for human therapeutic use, may be

obtained from monocotyledonous plants such as corn in their earlygrowthstateswhicharetimelyharvestedforoptimumyield.

No.7,794,761–IssuedSeptember14,2010

ABSTRACT: Phenolic compounds with a phenolic molecule to which arecovalently linked an oxygen-containing group, a nitrogen or another oxygencontaining group, and a C.sub.1-C.sub.4 alkoxy group, or their precursorcompounds, obtainable from monocotyledonous plants, or by chemicalsynthesis, have been found to calm and/or reduce anxiety and relatedbehaviors and states in humans and animals. Additional chemicalcompounds of the present invention may include benzoxazinoids-cyclichydroxyamicacids,lactams,andcorrespondingglucosides,whichmayserveasprecursorstophenoliccompounds.Thephenoliccompoundsandprecursorsofphenolic compounds of the present invention, at concentrations suitable forhumanandanimaltherapeuticuse,maybeobtainedfrommonocotyledonousplantssuchascornintheirearlygrowthstateswhicharetimelyharvestedforoptimumyield.

NOTE:Therearenopatentspending.

OTHERPUBLICATIONS

Alibhai,S.K.,"ReproductiveresponseofGerbillusharwoodiito6-MBOAintheKoraNationalReserve,Kenya,"JournalofTropicalEcology,2:377-379,1986.

Anderson et al., "Effects of melatonin and 6-methoxybenzoxazolinone onphotoperiodiccontroloftestissizeinadultmalegoldenhamsters,"JournalofPinealResearch,5:351-65,1988.

Argandona et al., “Effect of content and distribution of hydroxamic acids inwheat on infestation by the aphid, Schizaphis graminum,' Phytochemistry,2004):673-676,1981.

Argandona et al., “Role of hydroxamic acids in the resistance of cereals toaphids.”Phytochemistry,19:1665-1668,1980.

Arient J., “2-Styryl BenzoxazoleDerivatives”. Czechoslav ChemCommun., vol.45,3160-3165,1980.

Arnason et al., "Phototoxins in plant-insect interactions. InHerbivores, Theirinteractionswithsecondaryplantmetabolites,"EditedbyM.Berenbaumetal.,AcademicPress,N.Y.;Ecologicalandevolutionaryprocesses,pp.317-341vol.II.2ndEd.,1992.

Assabgui et al., "Hydroxamic acid content of maize (Zea mays) roots of 18Ontario hybrids and prediction of antibiosis to western corn rootworm,Diabrotica virgfera virgifera Leconte ( Cleoptera: Chrysomelidae)," CanadianJournalofPlantScience,73:359-363,1993.

Barnesetal.,"Isolationandcharacterizationofallelochemicalsinryeherbage,"Phytochemistry,26(5):1385-1390,1987.

Barnesetal.,"Roleofbenzoxazinonesinallelopathybyrye(SecalecerealeL.),"JournalofChemicalEcology,13(4):889-906,1987.

Berger et al., "Chemical triggering of reproduction in Microtus montarus,"Science(WashingtonD.C.),214(4516):69-70,1981.

Berger et al., "Effect of 6-methoxybenzoxazolinoneon sex ratio andbreedingperformance inMicrotusmontanus,"BiologyofReproduction,1987;36:255-260,1987.

Berger et al., “Effect of 6-methoxybenzoxazolinoneon sex ratio andbreedingperformance in Microtus montanus,” Biology of Reproduction, 1987:36:255-260,1987.

Bergvinson et al., "Putative role of photodimerized phenolic acids in maizeresistance to Ostrinia nubilalis (Lepidoptera: Pyralidae)," EnvironmentalEntomology,23(6):1516-1523,1994.

Bjostad, Louis B. and Hibbard, Bruce E., "6-Methoxy-2-Benzoxazolinone: aSemiochemicalforHostLocationbyWesternCornRootwormLarvae,"JournalofChemicalEcology,vol.18,No.7,pp.931-944,1992.

Blumetal.,"Allelopathicactivityinwheat-conventionalandwheat-no-tillsoils:development of soil extract bioassays," Journal of Chemical Ecology, 18(12):2191-2221,1992.

Bostad, Louis B. and Hibbard, Bruce E., "6-Methoxy-2-Benzoxazolinone: aSemiochemicalforHostLocationbyWesternCornRootwormLarvae.”JournalofChemicalEcology,vol.18,No.7,pp.931-944,1992.

Brake et al., “Delay of onset of oviposition in pullets promoted by 6-methoxybenzoxazolinone.”PoultryScience,64(4):774-776,1985.

Breeding Performance in Microtus Montanus, Biol. Repod, 36(2):255-60(1987).

Brice,C., "Theeffectof6-methoxybenzoxazolinoneon laboratorymice,"Ph.D.Thesis,UniversityofLondon,London,England,1987.

Bronson,F.H.,“Mammalianreproduction:anecologicalperspective.”BiologyofReproduction,32(1):1-26,1985.

Butterstein et al., "The plantmetabolite 6-methoxybenzoxazolinone interactswith follicle-stimulating hormone to enhance ovarian growth," Biology ofReproduction,39:465-71,1988.

Butterstein et al., “A naturally occurring plant compound, 6-methoxybenzoxazolinone, stimulates reproductive responses in rats.”BiologyofReproduction,32:1018-1023,1985.

Calder, I.C., “N-Hydroxylation of P-Acetophenetidideas a Factor inNephrotoxicity”,JournalofMedicinalChemistry,vol.16,No.5,499-502,1973.

Campos et al., "Toxicity and toxicokinetics of 6-methoxybenzoxazolinone(MBOA) in the European corn borer Ostrinia nubilalis (Hubner)," Journal ofChemicalEcology,14(3):989-1002,1988.

ChemicalEcology,18(12):2191-2221,1992.

Cooksey,C.,“ASimpleOnePotReactionof4-Alkoxyand4-Alkylthio-CatecholsandO-Benzoquinones.”OrganicPreparationsandProceduresInt.,vol.28,No.4,463-467,1996.

Cooksey,C.;"ASimpleOnePotReactionof4-Alkoxyand4-Alkylthio-CatecholsandO-Benzoquinones";OrganicPreparationsandProceduresInt.,vol.28,No.4,1996,463-467.

Copajaetal.,"HydroxamicacidcontentofperennialTriticeae,"Phytochemistry,30(5):1531-1534,1991a.

Copajaetal.,"HydroxamicacidlevelsinChileanandBritishwheatseedlings,"Ann.AppliedBiology,118:223-227,1991b.

Copajaetal.,“Hydroxamicacidlevels inChileanandBritishwheatseedlings.”Ann.AppliedBiology,118:223-227,1991b.

Cranford et al., “Stimulation of reproduction in Peromyscus leuopus and P.maniculatuswith6-MBOAinthefield.”VirginiaJournalofScience,37:240-247,1986.

Cuevas et al., "Effect of hydroxamic acids from cereals on aphidcholinesterases,"Phytochemistry,34(4):983-985,1993.

Daya et al., "Effect of 6-methoxy-2-benzoxazolinone on the activities of ratpineal N-acetyltransferase and hydroxyindole-O-methyltransferase and onmelatoninproduction,"JournalofPinealResearch,8:57-66,1990.

Dowd et al., "Enzymatic oxidation products of allelochemicals as a basis forresistance against insects: effects on the corn leafhopper Dalbulus maidis,"NaturalToxins,4:85-91,1996.

Epsteinetal.,“Dynamicsof6-methoxybenzoxazolinoneinwinterheat,Effectsofphotoperiodandtemperature,” JournalofChemicalEcology,12(10):2011-2020,1986.

Epstein et al., “Dynamics of 6-Methoxybenzoxazolinone in Winter Wheat,”JournalofChemicalEcologyvol.12,No.10,pp.2011-2021.

Epstein, et al. Dynamics of 6-Methoxybenzoxazolinone inWinterWheat, J. ofChem.Ecol,vol.12,No.10,(1986).

Frandsenetal.,"Maternaltransferofthe6-MBOAchemicalsignal inMicrotusmontanus during gestation and lactation," Canadian Journal of Zoology, 71:1799-1803,1993.

Garcia H.L., “Dermatological complications.”PuBMed Abstr. 12180897;AmericanJournalofClinicalDermatology,3(7):497506,2002.

Gianolietal.,"Characteristicsofhydroxamicacidinductioninwheattriggeredbyaphidinfestation,"JournalofChemicalEcology,23(12):2695-2705,1997.

Givovichet al., "HydroxamicAcidGlucosides inHoneydewofAphidsFeedingonWheat,"JournalofchemicalEcology,vol.18No.6:841-846,1992.

Gomita et al., “Behavioral and EEG effect of coixol (6-methoxybenzoxazolinone), one of the components on Coix Lachryma-Jobi L.var.may-yenStapf.”NipponYakurigakuZasshi,77(3):245-59,1981.

Gower et al., "Reproductive responses of male Microtus montanus tophotoperiod,melatonin,and6-MBOA,"JournalofPinealResearch,8:297-317,1990.

Gower, B.A., "Endocrine effects of the naturally occurring reproductivestimulant,6-methoxybenzoxazoline,"Ph.D.Thesis,UniversityofUtah,SaltLakeCity,Utah,116pp.1990.

Griffenetal., "Selectiveserotoninreuptake inhibitorsdirectlyalteractivityofneurosteroidogenic enzymes," Proceedings of Natural Academy Sciences(WashingtonD.C.),96(23):13512-13517,1999.

Hayashi et al., "6-Methoxy-2-benzoxazolinone in Scoparia dulcis and itsproductionbyculturedtissues,"Phytochemistry,37(6):1611-1614,1994.

Hoshi-Sakoda, M., "Structure Activity Relationships of Enzoxazolinones withRespecttoAuxin-InducedGrowthandAuxinBindingProtein',Phytochemistry,vol.37No.2,297-300,1994.

Kato-Noguchi.,H.Phytochem.1999.vol.52,pp.1023-1027.*

Katzetal.,"Centralobesity,depressionandthehypothalamo-pituitary-adrenalaxis in men and postmenopausal women," International Journal of ObesityRelatedMetabolismDisorders,24:246-51,2000.

Klugeetal.PHytochem.1997.vol.44,No.4,pp.639-641.*

Korn et al., "Initiation of breeding in a population of Microtus townsendii(Rodentia)withthesecondaryplantcompound6-MBOA,"Oecologia(Berl.),71:593-596,1987.

Lee, HS., "Tyrosinase inhibitors of Pulsatilla cernua root-derived materials,"PubMedAbstr.11879010,JournalofAgriculturalFoodChemicals,50(6):140,2002.

Leighton et al., “Substrate specificity of a glucosyltransferase and an N-hydroxylase involved in the biosynthesis of cyclic hydroxamic acids inGramineae.”Phytochemistry,36(4):887-892,1994.

Lerosen,A.L.,“TheMigrationofAcetylandBenzoylGroupsinO-Aminophenol”,JournaloftheAmericanChemicalSociety,vol.70,2705-2709,1948.

Loomisetal.PlantPhysiology.1957.vol.32,No.5,pp.379-385.*

Mayoral et al., "A high performance liquid chromatography method forquantification of DIBOA, DIMBOA, andMBOA from aqueous extracts of cornandwinter cereal plants," Journal of LiquidChromatography, vol. 17,No. 12,pp.2651-2665,1994.

McGahueyetal., “TheArizonaSexualExperienceScale (ASEX): reliabilityandvalidity.”JournalofSex&MaritalTherapy,26:25-40,2000.

Meek et al., "Interaction of maternal photoperiod history and food type ongrowthandreproductivedevelopmentof laboratorymeadowvoles(Microtuspennsylvanicus),"PhysiologyandBehavior,57(5):905-11,1995.Moffattetal.,

“Effects of photoperiod and 6-methoxy-2 benzoxazolinone on male-inducedestrusinprairievoles.”PhysiologyandBehavior,49:27-31,1991.

N. Berenbaum et al., Academic Press, N.Y.; Ecological and evolutionaryprocesses,pp.317-341vol.II,2"Ed.,1992.

Nachman, R.; "Convenient Preparation of 2-Benzoxazolinones with1,1-Carbonyldiimidazole'.J.HeterocyclicChemistry,vol.19,15451547,1982.

Negus et al., "Reproductive strategies of Dicrostonyx groenlandicus andLemmussibiricusinhigh-arctictundra,"CanadianJournalofZoology,76:391-399,1998.

Negusetal., “Experimental triggeringofreproduction inanaturalpopulationof Microtus monatus," Science (Washington D.C.), 196(4295): 1230-1231,1977.

Nelsonetal.,"Photoperiodaffectsreproductiveresponsivenessto6-methoxy-2-benzoxazolinoneinhousemice,"BiologyofReproduction,43:586-91,1990.

Nicoletal., “Ascreenofworldwidewheatcultivars forhydroxamicacid levelsandaphidantixenosis.”AnnotatedAppliedBiology,121:11-18,1992.

Niemeyeretal.,"Changesinhydroxamicacidlevelsofwheatplantsinducedbyaphidfeeding,"Phytochemistry,28(2):447-449,1989.

Niemeyer et al., "Chromosomal location of genes for hydroxamic acidaccumulation in Triticum aestivum L. (wheat) using wheat aneuploids andwheatSubstitutionlines.”Heredity,79:10-14,1997.

Ostrinia nubilalis, as related to geographical origin.” Canadian Journal ofBotany,68:311-316,1990.

Perezetal.Phytochem.1985.vol.24,No.12,pp.2963-2966.*

Perezetal.,"Differenceinhydroxamicacidcontentinrootsandrootexudatesof wheat (Triticum aestivum L.) and rye (Secale cereale L.): possible role inallelopathy,"JournalofChemicalEcology,17(6):1037-1043,1991.

Pischon et al., "Recent developments in the treatment of obesity," PuBMedAbstr.12187313,CurrentOpinionsofNephrologicalHypertension,11(5):497-502,2002.

Chemical Society, vol. 53,996-1001, 1931. PuBMedAbstr. 12187313, CurrentOpinionsofNephrologicalHypertension,11(5):497-502,2002.

Reidetal.,"ResistanceofmaizegermplasmtoEuropeancornborer;Ostrinianubilalis, as related to geographical origin," Canadian Journal of Botany, 68:311-316,1990.

Richardson et al., "Cyclic hydroxamic acid accumulation in corn seedlingsexposed to reduced water potentials before, during, and after germination,"

Journal of Chemical Ecology, 19(8): 1613-1624, 1993;* Assabgui et al.,"Hydroxamicacidcontentofmaizerootsof18Ontariohybridsandpredictionofantibiosis towesterncornrootworm,"CanadaJournalofPlantScience,73:359-363,1993.

Rindone,B., “OxidationofAromaticAnilswithLeadTetra-Acetate', JournaloftheChemicalSocietyPerkinTrans1,2022-2025,1975.

Rosenblatt, D.H.; "An Anomalous Result of an Attempted Dakin Reaction”:JournalofAmericanChemicalSociety,vol.75,46074608.

Rowsemittetal., “Reproductive function inDipodomysordiistimulatedby6-methoxybenzoxazolinone.”JournalofMammology,70(4):805-809,1989.

Rudolfetal.,"Subjectivequalityoflifeinfemalein-patientswithdepression:Alongitudinal study," International Journal of Social Psychiatry, 45(4): 238-46,1999.

Sandersetal., “6-methoxybenzoxazolinone:Aplantderivative thatstimulatesreproduction in Microtis montanus, "Science (Washington D.C.), 214(4516):67-69,1981.

Schadler et al., "The plantmetabolite, 6-methoxybenzoxazolinone, stimulatesan increase in secretion of follicle-stimulating hormone and size ofreproductiveorgansinMicrotuspinetorum,"BiologyofReproduction,38:817-820,1998.

SeroctinResearch&Technologies,Inc.v.UnigenPharmaceuticals,Inc.etal.IntheUnitedStatesDistrictCourt,FortheDistrictofUtah,CentralDivision,CaseNo. 2:07CV582, pleading entitled "Defendants' Preliminary InvalidityContentions".

Smissmanetal.J.Org.Chem.1957.vol.22,p.220.*

Sweatetal., "Uterotropic6-methoxybenzoxazolinone isanadrenergicagonistandmelatoninanalog,"MolecularCellularEndocrinology,57:131-138,1988.

Tangetal.Phytochemistry.1975.vol.14,No.9,pp.2077-2079.*

Urbanski et al., "Influence of photoperiod and 6-methoxybenzoxazolinone onthe reproductive axis of inbred LSH/Ss Lak male hamster," Journal ofReproductionandFertility,90:157-162,1990.

Vaughan et al., "Hormonal consequences of subcutaneous 6-methoxy-2-benzoxazolinone pellets or injections in prepubertal male and female rats,"JournalofReproductionandFertility,83:859-66,1988.

Virtanenetal.Arch.Biochem.Biophys.1957.vol.69,p.486-500.*

Virtanenetal.,“Precursorsofbenzoxazolinoneinryeplants.I.PrecursorII,theAgylcone.”ActaChemicaScandinavica,14(2):499502,1960.

Wang et al., "Hypotensive activity of the pineal indoleamine hormonesmelatonin, 5-methoxytryptophol and 5-méthoxytryptamine,"PubMed Abstr.10752670,PharmacologicalToxicology,86(3):125-8,2000.

Xie et al., "Distribution and variation of hydroxamic acids and relatedcompoundsinmaize(Zeamays)rootsystem,"CanadianJournalofBotany,69:677-681,1991.

Yuwiler et al., “Effects of 6-methoxy-2-benzoxazolinone on the pinealmelatoningeneratingsystem.” JournalofPharmacologicalExp.Ther:,233:45-50,1985.

Zhangetal.J.Med.Chem.1995.vol.38,No.4,pp.735-738.*

Zunigaetal., "Hydroxamicacid content inundifferentiatedanddifferentiatedtissuesofwheat,"Phytochemistry,30(10):3281-3283,1991.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. © 2018-2019 Dr. Dori Naerbo, Ph.D. All Rights Reserved