argeville: the art of senses - mettler toledo · pdf filesegment marketing lab ... moisture in...

Weighing and Analysis in the Laboratory

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Cosmetics, Fragrances, Food Ingredients

Argeville: The Art of Senses

Argeville began business in Mougins (in the Maritim Alps region) in

1932. Initially, a traditional, local manufacturer of natural flower prod-

ucts, the company is now dealing internationally with various clients

in the food-processing and cosmetic industries. Discover how METTLER

TOLEDO helps to ensure daily high quality scent manufacturing.

Quality First Argeville’s development has made signifi-cant progress during the last ten years. In addition to the creation of a European laboratory specializing in extraction, the company has developed its R&D skills and purchased advanced technology equipment including formulation assistance tools. The multi-step quality control system used dur-ing manufacturing includes a precise or-ganoleptic examination, vapour zone chro-matography and several physicochemical analyses. This system creates computerized data sheets for each type of raw material and allows a summary of their use, their conservation and composition quality.

Enhanced Physicochemical AnalysesDensity, refractive index and color ana-

lyses are critical and tedious. These mea-surements were previously carried out by chemistry technicians with a non-auto-mated density meter, a refractometer and a spectrocolorimeter. These procedures were time-consuming, used up a great number of samples and had a high manual error rate during the capture of results on the AS 400 server. The company’s response capacity was clearly reduced whilst client demands became ever more demanding.

METTLER TOLEDO’s Solution: The LiQC SystemArgeville called upon METTLER TOLEDO’s problem solving expertise and a new measuring chain was installed including a DR40 Refractometer linked to a SC30 Sample Delivery Unit, a Power Purge Unit (PPU) and a colorimeter all connected to

Analytical solutions in the laboratory

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METTLER TOLEDO Cosmetics, Fragrances, Food Ingredients 1

Publisher Mettler-Toledo AG Laboratory Division Im Langacher CH-8606 Greifensee, Switzerland

Production Segment Marketing LABGlobal MarCom Switzerland

Subject to technical changes. © Mettler-Toledo AG 02/10Printed in Switzerland.

the server through the LiQC multi-devices software. Bernard Soulier, director of raw material quality control, could quickly measure the benefits of the new measur-ing chain, “Where we needed a 12 ml sample to only measure colour, we can now carry out density, refractive index and colour measurements simultaneously with the same quantity and still re-use the sample", says Mr. Soulier. He adds, “In practice, the measuring chain works from 6 a.m. to 9 p.m. and analyzes about 150 samples. Each sample is analyzed for no more than 5 minutes thanks to the PPU which ensures the fastest drying.”

The newly installed measuring chain includes a DR40 Refractometer linked to a SC30 Sample Delivery Unit, a Power Purge Unit and a Colorimeter.

Bernard Soulier, director of raw material quality control at Argeville.

Argeville is originally from Mougins. Several laboratories can be found on site.

www.mt.com/LIQC

Mr. Soulier was also impressed by the system’s user-friendliness. He adds, “The analyses are now completed by produc-tion staff rather than by laboratory tech-nicians.”

The LiQC system also guarantees data security. The locked keyboard and the restricted access bypass errors resulting from data capture and interpretation of results. Finally, the chain is installed on the production and conditioning site, some distance from the control labora-tory. “This saves us a huge amount of analysis time!”, concludes Mr. Soulier.

3METTLER TOLEDO Cosmetics, Fragrances, Food Ingredients 1

The Instrument of ChoiceOil in water formulas are light liquids or lotions that do not feel heavy on the skin. The majority of the formula is wa-ter which may evaporate on the skin and leave a small amount of oil. Water in oil formulas are heavy, greasy products con-sisting mostly of oil. Generally, water in oil products are developed for skin that has a good water content but requires more oil from a moisturizing product.

Thermogravimetric analysis (TGA) is an excellent tool for analyzing the moisture content of cosmetic skin creams. The results shown in the figure (right) were measured using the METTLER TOLEDO TGA/DSC 1 and evaluated using STARe Excellence software.

Samples of oil in water (o/w) creams with different water contents were heated from 20 °C to 200 °C at a heating rate of 2 K/min in a nitrogen atmosphere. The TGA curves indicate that all creams, with the exception of sample C, show a sig-nificant weight loss between 30 °C and 140 °C. The weight loss is caused by the evaporation of volatile components, espe-cially water.

Moisture in Cream Reliably Measured

Skin moisturizing products are developed and manufactured to target

different areas of the body. They consist of two basic formulas: oil in

water and water in oil. Analyzing the moisture content of skin moistur-

izing creams is a key aspect in end product quality control. It also

helps to ensure that the end product is suitable for its intended and

marketed use.

The TGA/DSC 1 is a valuable instrument for product quality control within the cos-metics industry. It provides excellent and reliable thermogravimetric measurement performance and high temperature accu-racy. With the addition of the sample ro-bot, hermetically sealed crucibles can be pierced immediately prior to measuring. This unique feature prevents the sample taking up or losing moisture between weigh-in and measurement. The TGA/DSC 1 also has the added benefit of simul-taneous calorimetric analysis, which is of great benefit to cosmetics manufacturers.

www.mt.com/ta

Know-how

Learn more about the application of thermal analysis in cosmetics.

The Pharmaceuticals applica-tion handbook is a useful tool as many analyses made in cosmet-ics are similar to those made in the pharmaceutical industry.Information about this handbook can be found at:

www.mt.com/ta-books

TGA/DSC 1

Moisture content of o/w creams by TGA.(Source: METTLER TOLEDO collected applications)

4 METTLER TOLEDO Cosmetics, Fragrances, Food Ingredients 1

Ideal SolutionsFor Perfect Formulations

Formulation is a precise art requiring both high weighing accuracy

and the careful control of a large number of ingredients.

METTLER TOLEDO’s weighing solutions ensure the correct mix every

time.

Let the Balance GuideThe built-in application available on all XP/XS Balances provides step-by-step instructions to guide the users through formulation procedures. The color-coded SmartTrac weighing guide ensures all component substances are weighed to within specified tolerances. Barcode read-ers can be used for sample and ingredi-ent identification eliminating transcrip-tion errors and making the whole process much faster. LabX™ software provides ul-timate flexibility in order to design work-flows that exactly match individual SOPs whilst processing and storing all data – a big plus when dealing with complex mixes of ingredients!

Accessorize and SimplifyA range of accessories are available to help users work more ergonomically with in-creased convenience and safety:

The two SmartSens sensors built in to all XP Balances can be individually pro-grammed to allow hands-free balance operation which is perfect for situations where hands may become easily soiled. The remote ErgoSens sensors offer hands-free functionality for XS Balances and pro-vide up to two further hands-free options for XP Balances.

Mounting the terminal at eye-level on a stand behind the balance makes it much easier to read and frees up valuable bench space. The Bluetooth printer can be locat-ed away from the balance, even in another office, to avoid vibration and contamina-tion issues whilst ensuring recipes are fully documented and traceable.

Magnetic stirrers are often used when the quality of a formulation is dependent on thorough mixing throughout the addition of ingredients. The standard weighing pan can be replaced with the magnetic pro-tection shield weighing pan to eliminate

any magnetic interference from the stirrer.METTLER TOLEDO aims to make working processes as simple as possible in order to ensure the perfect mix is achieved every time!

www.mt.com/xp-analytical www.mt.com/XP-precision

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Save space and avoid soiling the terminal by using the optional stand.

SmartSens allows hands-free operation.


Perfumes made in Italy has been a truly successful story spreading

optimism with an operating commercial network spanning from Italy to

Russia and being amongst the best 100 companies in the province of

Milan. The beginning, however, was not so bright.

GRC Parfum – a Company in Full SwingIn 1998, plans were afoot to close the site with production transferred to other countries; a development not at all to the satisfaction of Silvano Corlazzoli. Coura-geously, he made a management buyout and purchased the factory. Renamed GRC Parfum, the now family owned company tripled its sales from 1998 to 2007 and made huge investments into plant in-frastructure and staff with the latter, ac-cording to Corlazzoli, being one of the main assets of the company. Devoted to continuous innovation, operator safety and progress, the newest production site is highly automated. 33 km of steel tubing transport more than 1600 different raw materials to the mixing machine which fabricates around one million kilograms of final products annually. These produc-tion conditions require a finely tuned

quality control system and equipment that can easily deal with the continuous flow of test samples.

Instruments that Fulfill RequirementsDensity and refractive index determina-tions are the two most commonly used values to monitor the quality of incom-ing and outgoing goods and GRC Parfum relies on the METTLER TOLEDO DR40 combined meter with sample automation for this task. This benchtop instrument successfully fulfills the requirements of modern quality laboratories with ease. Small sample quantities in tightly closed vials are placed onto the sample changer. The analysis is then started, the measure-

Odour QualityMETTLER TOLEDO Takes Charge

ment values retrieved and the whole sys-tem cleaned automatically. Other quality parameters, such as pH, conductivity and color measurements can easily be in-cluded into the sample loop saving pre-cious time and sample substance. In the case of GRC Parfum, the measured values are directly exported to a LIMS system using LIQC software which greatly im-proves data handling security. "’Made in Italy’ is highly estimated in the world of perfume – a recognition of our quality", says Letizia Corlazzoli, responsible logistics and acquisition. Similarly, METTLER TOLEDO is esteemed for its amazing solutions in the analytical world.

www.mt.com/LiQC

Modern building of GRC Parfum.

Dario Volpones, Perfumer of GRC Parfum.


Preparation of standard solutions is a routine task in the cosmetics

or flavor & fragrances industries. This critical procedure is performed

several times each day and must be done with care and precision

as so much further work depends upon the accuracy of the solution.

With the One Click Standard Preparation Package, standard solutions

can now be easily prepared in a fraction of the usual time. Full user

guidance is provided and all calculations and documentation are com-

pleted automatically.

One Click™ Standard PreparationPowered by LabX™

The challenge for accuracyA simple solution can take fifteen minutes or more to prepare due to the time spent on preparation, calculations, weighing and documentation. Error can be easily introduced into the procedure via tran-scription error, incorrect calculations and dosing difficulties.

Performing calculations correctly is es-sential to produce a final concentration within required tolerances. However, the procedure of copying figures from the balance to a calculator or spreadsheet is tiresome and prone to error. Dosing can be tricky when using weighing paper or

Simplicity with One Click WeighingThe standard preparation procedure is started with one touch on the balance touchscreen. The user simply follows the step-by-step instructions on the balance and LabX takes care of all the rest. Steps 1-5 illustrate how easy it is to prepare a standard solution in just over one minute – a dramatic difference to the traditional method.

The user inputs the required concentra-tion and all calculations are performed automatically; transcription error and incorrect formulae are no longer a worry. The balance tells the user how much sub-stance is required. Dosing is made easy by the ErgoClip dedicated flask holder which allows dosing straight into the flask – no more fiddly weighing paper. Any spilled sample falls into the tray below the holder and has no influence on the weighing process. The SmartTrac weighing guide provides help for weighing-in the correct amount; the weighing bars turning from red to green when the weight is within tol-erance. The user confirms when dosing is completed and the final concentration is calculated automatically. A green results screen indicates at a glance that the con-centration is within specified tolerances. A

LabX

™

weighing boats. Any spilled sample will generate errors in the final concentration and it is often difficult to be certain that no sample remains on the paper. Care must be taken to write all the solution details clearly and correctly on the label for the flask. Ensuring that all informa-tion has been recorded is necessary for full traceability not only of the solution but also of all work based upon it. This takes a lot of time and mistakes can be easily made.

One Click Standard Preparation powered by LabX™ eliminates these problems making the whole process significantly faster and worry-free.


www.mt.com/one-click-weighing

label for the flask is printed automatically with all necessary information included. Throughout the procedure, LabX™ auto-matically stores all data securely in a cen-tral database ensuring full traceability. A report can be printed automatically at the end of the process; it can even be sent to a printer outside the laboratory. Results are easily accessed to print further reports as required.

LabX™ contains a built-in method tem-plate for preparing a standard solution and the Method Designer allows the tem-plate to be customized according to users’ precise needs. New methods can also be created from scratch. Some general report templates are also included for ease-of-use and the Report Designer offers users the opportunity to create personalized re-

ports according to their own or corporate style.

One Click Standard Preparation powered by LabX™ – the easy way to prepare stan-dards!

The method is started with the One Click™ shortcut on the balance touchscreen. LabX™ guides the user step-by-step through the process on the balance, performs calculations automatically, and takes care of saving all data. The complete solution can be tailored to match individual process requirements.

One Click™ StartEnter the desired concentration.

Required weight of substance is calcu-lated automatically.

WeighErgoClip for direct dosing into flask.

SmartTrac™ guide helps to weigh the correct amount.

Result Calculation Concentration calcu-lated automatically.

Green screen indicates result is within specified tolerances.

LabelA flask label is printed automatically.

All information is included – even the expiry date.

DocumentationEverything is auto-matically recorded.

Customized reports can be printed auto-matically.

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Traditional Way

15:00 min.

New Way

1:10 min.


Onl

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Tool

s Optimize Your BusinessWith METTLER TOLEDO Online Tools

There are several ways to enhance business workflow in order to increase overall productivity whilst simultaneously decreas-ing costs. Our internet page dedicated to productivity is a great online tool for supporting business optimization.

• Discover product solutions that support productivity (see example), automation, flexibility and mobility.

• Browseourinvestmentcalculatorsandcalculatesavingsdirectly online.

• Useourwebinarstodiscoverhowtoimprovespecific technical knowledge.

Make use of our productivity internet page as a business optimization resource: www.mt.com/lab-productivity

Optimize your business online

Try our online investment calculators

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Innovative and cost saving solutions to increase productivity!QUANTOS – For automated powder dosingErgoClips – For direct manual dosingMelting point systems – For simultaneous measurement

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Solutions to automate sample handling, analysis and datatransfer!Sample changers – For automated sample analysisLabX / LiQC software – For efficient data managementAutoChem – For accelerated chemical synthesis

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Modular instrument concepts increase flexibility!Titrators Excellence line – For tailored titrationpH meters – For multi-parameter measurementsWeighing modules – For endless applications

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Tailored titrimetric analysisThe titration Excellence line’s modular design with its sophisticated plug and play method allows each system to be exactly adapted to highly specific needs.

Calculate savings online: www.mt.com/titration-Excellence-ROI

Enhanced DSC/TGA sample processingImprove analysis accuracy and speed with the automatic processing of 34 samples and simultaneous crucible opening prior to measurement.

Calculate savings online: www.mt.com/ta-value-calculator


Workflows are advanced by applying the latest trends and technologies. Our webinars offer the opportunity to receive specific information on our products and applications whilst reporting on the newest and most advanced methods and standards.

Live webinarsAppreciate the direct exchange with industry experts and get information in real-time with our live webinars. This offers the opportunity of receiving, information directly from one of our specialists. Additionally, experts are able to answer ques-tions immediately after each presentation.

Update knowledge online and always stay one step ahead

On demand webinarsChoose the flexibility of where and when to update knowl-edge with the latest information. Our on demand webinars offer the choice of listening to a selection of pre-prepared interesting topics anytime and anywhere. In addition this offers the possibility of accessing the webcast as many times as required.

Choose between:• Live webinars • On demand webinars

Enhancing safety in the workplace: Automated powder dosing of hazardous compoundsLearn how Quantos’ automated powder dosing reduces the risks involved in handling active and potent drug compounds. www.mt.com/quantos-webinars

One example of our broad webinar offering:

Explore our full Webinar program on www.mt.com/webinar


Analytical Instruments For Creative and Effective Cosmetic Products

Prod

uct N

ews

The new G20 Compact Titrator combines simplicity and dependability for the cosmetics

and flavors & ingredients industry in one instrument. The G20 is especially designed

for basic applications and can be simply operated due to the well established unique

One Click™ user interface and the Plug&Play concept of the accessories. Automate up

to 9 samples with the automated Rondolino titration stand whilst LabX™ light Titration

laboratory PC software offers data reliability and comprehensive documentation.

ShortcutsThe One Click™ user interface offers four shortcuts for an immediate operation start. Every user has personalized screen, shortcuts and operation language.

Plug & PlayThe burette and sensor automatically identify and reduce any errors during installation.

Dependable Operation

One Click Titration™

Compact Sample ChangerAnalyze up to 9 samples automa-tically with the Rondolino SampleChanger.

Easy Automation

www.mt.com/G20-Titrator


In order to ensure the consistent product quality of flavors and fragrances, the refractive

index and density of each individual batch need to be checked. The new LiquiPhysics

Excellence line includes all tools necessary to automate the measurement of both param-

eters simultaneously.

LabX

Modular solutionsUpgrading a RM refractometer with a DX density cell module is a cost- and space-saving solution allowing the deter-mination of both density and refractive index.

Simultaneous dataThe quality control of flavors and fragrances requires the determina-tion of several parameters. Liqui-Physics™ Excellence can perform all measurements in one run.

Data traceabilityLabX™ PC software effortlessly runs and controls each instru-ment and safely transfers data onto a superordinate ERP or LIMS system.

Continuous measurementScanStraight facilitates sample data input when performing measure-ments on a sample changer. Once the vials are placed on the tray, LiquiPhysics™ Excellence auto-matically takes care of the rest.

www.mt.com/LiquiPhysics

Info Spot

Mettler-Toledo AGLaboratory DivisionIm LangacherCH-8606 Greifensee, Switzerland

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Which environmental conditions influence a balance? How often should a balance be tested? Knowing the cor-rect answers to these questions saves time and money.

The Risk Check is an online tool designed to analyze the weighing risks of a balance independent of model, type or manufacturer. It offers a point of reference in the jungle of regulation guidelines and supports quality and laboratory managers along with anyone else in charge of balances.

The Risk Check can:• Provide instant expert advice according to individual weighing risk. • Demonstrate how to optimize the quality and performance of the tested balance.

Balance Risk CheckHow good is your quality system?

www.mt.com/GWP-riskcheckSpend 5 minutes with the Risk Check to test the fitness of your weighing processes:

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