Introduction to Association Mapping Module

Association Mapping: GWAS and Sequencing Data

Instructors: Timothy Thornton and Michael Wu

Summer Institute in Statistical Genetics (SISG)

July 2019

Seattle, Washington

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Introduction to Association Mapping Module

Introduction: Course Aims

This is a course on statistical methods and software for geneticassociation studies of complex traits. We aim to cover:

I Case-Control Association Testing

I Genetic Association Testing with Quantitative Traits

I Gene and Pathway Level Analysis

I Population Structure/Ancestry Inference

I Genetic Association Testing in Samples with Structure

I Interaction Analysis

I Collapsing Tests for Rare Variant Analysis

I Kernel Tests and Omnibus Tests for Rare Variants

I Power and Sample Size, Design Considerations, EmergingIssues

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Introduction to Association Mapping Module

Introduction: Resources

Importantly, the class site is:http://faculty.washington.edu/tathornt/SISG2019.html

Contains (or will contain);

I PDF copies of slides (in color)

I Datasets needed for exercises

I Exercises for you to try

I Our solutions to exercises (later!)

I Links to software packages

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Introduction to Association Mapping Module

Introduction: About Mike

I Associate Member,FHCRC Public Health Sciences Division

I Affiliate Associate Professor,UW Boistatistics

I Research in:High dimensional dataKernel machine methodsVariable selection and regularizationPathway and network based analysisTranslational researchStatistical genomics/genetics

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Introduction to Association Mapping Module

Introduction: About Tim

I Associate Professor,UW Biostatistics

I Affiliate Investigator,Fred HutchinsonCancer Research Center

I Research in:Genetic Association StudiesCorrelated Genetic DataInferring Genetic AncestryRelatedness EstimationPharmacogenomics

... and you?

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Introduction to Association Mapping Module

Introduction: Course Structure

I 10 sessions over 2.5 daysI What to expect in a typical session;

I 45 mins teaching/lectureI 30 mins hands-on exercisesI 15 mins summary, discussion

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