The most prescribing statin in the world Atorvastatin, a lipid lowering agent is ranked as top selling pharmaceutical generic in 2011. Due to its pleotropic effects it is also the most choice able statin to the Bangladeshi doctors for the management of hypercholesterolemia

Brand name :AvatorLipid Lowering AgentTherapeutic Class :AtorvastatinNaming :Generic name :Atorvastatin

Dosage formStrengthPack SizeUnit PriceTablet10mg30S10.00

Mode of action :Inhibits HMG-CoA reductaseAvatorReduces conversion of HMG-CoA to mevalonate, Decreases Cholesterol Synthesis in liver*HMG CoA= Hydroxy Methyl Glutaryl- Coenzyme AIncreases no. of LDL receptor on hepatocyte Decreases LDL in blood

Treatment : HypercholesterolemiaMixed DyslipidemiaHypertriglyceridemia

Indications: Prevention : AtherosclerosisHypertensionAnginaStrokeMyocardial Infarction

Adults: Usually 10mg once daily; if necessary, may be increased at intervals of at least 4 weeks to max. 80mg once daily;

Child 1018 years : Initially 10mg once daily, increased if necessary at intervals of at least 4 weeks to usual max. 20mg once daily. Dosage and Administration:

Major Brands

Brand NameCompanyMRP/TabAtovaBeximco10.00AnzitorSquare10.04DivastinDrug Int.10.00TCL-RAristopharma10.00LipiconSk+F10.00TiginorIncepta10.00

CardiologistDiabetologistMedicine SpecialistNeurologistGeneral Physician

Target Doctors

Unique Selling points :Reduces Total cholesterol, LDL cholesterol and triglyceride but increases HDL cholesterol significantly Total cholesterol : 29-45% (From baseline)LDL cholesterol : 39-60% Triglyceride : 19-37%HDL cholesterol: 5-6%Provides fastest onset of clinical benefitAtorvastatin : Within 2 weeksLovastatin : Within 1 yearSimvastatin : Within 2 year

Unique Selling points :Shows positive dose-response relationship over the range of 10-80 mg

Stops the growth of plaques in artery walls

Unique Selling points :Safe and efficacious in patients aged 65-75 years Safe and efficacious in patients with type 2 diabetes(37% reduction rate in LDL-C)

Unique Selling points :Safe for long term use(4 years)Well tolerated in patients with renal dysfunction(No dose adjustment)

Guidelines :Statin should be initiated to achieve target LDL is 100mg/dL

1. Statin Therapy should be given to achieve target LDL is 100mg/dL

1. Dose should be increased if LDL level 100mg/dL is not achieved