awards, education, centers and institutes, and organizations

Awards, Education, Centers and Institutes, and Organizations

The 3A protein of coxsackievirus B3 disrupts the Golgi complex to

inhibit protein trafficking. HeLa cells were transfected with a

reporter construct expressing both the 3A protein and a marker

membrane-trafficking protein, eGFP(mem). Bottom, Untransfected

cell showing intact Golgi (GM130 marker, red). Middle, Early

transfection shows some trafficking of eGFP(mem), with some of the

protein being retained in the Golgi, which is beginning to disperse.

Top, Late in transfection, there is virtual disappearance of the Golgi,

and scattered distribution of eGFP(mem). Nuclei are shown in

blue. Images represent isosurface renderings of a confocal z series,

created with the Imaris software package (Bitplane Scientific

Solutions). Work done by J. Lindsay Whitton, M.D., Ph.D.,

Christopher T. Cornell, Ph.D., and Stephanie Harkins, M.S., in

Dr. Whitton’s laboratory; and William B. Kiosses, Ph.D., Core

Microscopy Facility, Scripps Research.

Class of 2006

Kellogg School of Science and Technology

Staff Awards and Activities

Baran, P.S.—Beckman Young Investigator Award, Arnoldand Mabel Beckman Foundation; Career Award, NationalScience Foundation; Young Investigator Award, Eli Lillyand Company; Excellence in Chemistry Award, Astra-Zeneca; Young Professor Award, E.I. du Pont de Nemoursand Company; Excellence in Chemistry Award, Hoff-mann-La Roche; Young Investigator Award, Amgen,Inc.; Searle Scholar Award, Kinship Foundation;Chemistry Scholar Award, GlaxoSmithKline; Fellow,Alfred P. Sloan Foundation.

Barbas, C.F. III—Fellow, American Association for the Advancement of Science; In-Cites Highly CitedResearcher, Thomson Scientific, Philadelphia, Pennsyl-vania; Member, Faculty in Chemical Biology, Faculty1000, Biology Reports, Ltd.; Editorial Boards, Bioor-ganic and Medicinal Chemistry Letters, Bioorganicand Medicinal Chemistry.

Bartfai, T.—Fellow, American Academy of Arts and Sciences.

Boger, D.L.—Editor-in-Chief, Bioorganic and MedicinalChemistry Letters; Editorial Boards, Tetrahedron Pub-lications, Organic Reactions, Current Opinion in DrugDiscovery and Development, Current Drugs.

Bokoch, G.M.—Editorial Boards, Journal of LeukocyteBiology, Journal of Biological Chemistry, MolecularPharmacology.

Buchmeier, M.J.—Fellow, American Association for theAdvancement of Science; Fellow, American Academyof Microbiology; Codirector, Pacific Southwest Centerfor Biodefense and Emerging Infectious Disease; Member,Scientific Advisory Boards, PathoSystems ResourceIntegration Center (Virginia BioInformatics Institute),Predictive Biology Initiative, Pacific Northwest NationalLaboratories; Member, National Multiple SclerosisSociety Study Section; Editorial Boards, Journal ofVirology, Virology, Viral Immunology, BMC Microbiol-ogy, The Virology Journal, Journal of Neurovirology,Microbiology and Molecular Biology Reviews.

Case, D.A.—Associate Editor, Biopolymers; EditorialBoard, Journal of Biomolecular NMR.

Chisari, F.V.—Member, National Academy of Sciences;Member, Institute of Medicine, National Academy ofSciences; Member, Board of Scientific Councillors,National Institute of Allergy and Infectious Diseases;

Chairman, Hepatitis B Virus Symposium, InternationalCongress of Virology, San Francisco, California; EditorialBoards, Journal of Virology, Viral Immunology, Virology,Microbial Pathogenesis, Journal of Clinical Investigation.

Conkwright, M.D.—Ruth L. Kirschstein National ResearchService Award, National Institutes of Health.

Curtiss, L.K.—Member, Atherosclerosis and InflammationCardiovascular Sciences Study Section, National Institutesof Health; Associate Editor, Journal of Lipid Research;Editorial Board, Arteriosclerosis, Thrombosis, andVascular Biology.

Danuser, G.—Associate Editor, IEEE Transactions onImage Processing; Editorial Board, Biophysical Journal.

Dawson, P.E.—Member, Faculty in Chemical Biology,Faculty 1000, Biology Reports, Ltd.; Editorial Boards,International Journal of Peptide Research and Thera-peutics, Letters in Peptide Science.

Dyson, H.J.—Editorial Boards, Journal of MagneticResonance, Biophysical Journal.

Elder, J.H.—Editorial Boards, Journal of Virology, Virology.

Fokin, V.V.—William. H. Nichols Medal Award Distin-guished Speaker, American Chemical Society New YorkSection, White Plains, New York.

Friedlander, M.—Alcon Research Award, Alcon, Inc.;Chairman, Special Emphasis Panel, National Eye Insti-tute; Member, Neurosciences Blueprint Advisory Panel,National Institutes of Health; Member, NanomedicineInitiative Advisory and Review Panel, National Institutesof Health Roadmap Program; Member, Trans-InstituteAngiogenesis Research Program Portfolio Review, NationalInstitutes of Health.

Gale, A.J.—Early Career Investigator Award, BayerHemophilia Awards Program, Bayer HealthCare L.L.C.,Research Triangle Park, North Carolina; Career Devel-opment Award, National Hemophilia Foundation.

Gascoigne, N.R.J.—Member, Cellular and MolecularImmunology A Study Section, National Institutes ofHealth; Section Editor, Journal of Immunology.

Gerace, L.—Editorial Boards, Journal of Cell Biology,BMC Cell Biology.

Gottesfeld, J.M.—Associate Editor, Journal of BiologicalChemistry.

Gottlieb, R.A.—Member, Research Committee, AmericanHeart Association, Western Regional Affiliate; Member,

T H E S C R I P P S R E S E A R C H I N S T I T U T E 2 0 0 6 3 7 3

Myocardial Ischemia and Metabolism Study Section,National Institutes of Health; Editorial Boards, AmericanJournal of Physiology: Heart and Circulatory Physiol-ogy, Biochemical Journal.

Griffin, J.H.—Distinguished Career Award, InternationalSociety for Thrombosis and Hemostasis.

Havran, W.L.—Editorial Board, Immunological Reviews.

Horwich, A.L.—Corecipient, Stein and Moore Award, theProtein Society.

Janda, K.D.—Section Head, Faculty in Chemical Biology,Faculty 1000, Biology Reports, Ltd.; Editorial Boards,Chemical Reviews, Combinatorial Chemistry Researchand Applications, Bioorganic and Medicinal Chem-istry Letters, Bioorganic and Medicinal Chemistry,Combinatorial Chemistry High-Throughput Screening.

Johnson, E.F.—Editor-in-Chief, Drug Metabolism andDisposition; Editorial Boards, Journal of BiologicalChemistry, Molecular Pharmacology, Archives of Bio-chemistry and Biophysics.

Joyce, G.F.—Member, National Academy of Sciences;Member, Committee on International Security and ArmsControl, National Academy of Sciences; Member, ExternalAdvisory Board, Beckman Institute, California Instituteof Technology, Pasadena, California; Head of Faculty inChemical Biology, Faculty 1000, Biology Reports Ltd.;Associate Editor, BioSystems, Evolutionary Computa-tion, Origins of Life and Evolution of the Biosphere.

Lerner, R.A.—Fellow, American Association for theAdvancement of Science; Robert A. Good Lecture inImmunochemistry, Robert A. Good Immunology Society,St. Petersburg, Florida; Editorial Boards, Bioorganicand Medicinal Chemistry, Bioorganic and MedicinalChemistry Letters, Catalysis Technology, Drug Target-ing and Delivery, Journal of Virology, Molecular Biol-ogy and Medicine, Molecular Medicine, Journal ofPeptide Research, Vaccine, Angewandte Chemie.

Lotz, M.—President, Osteoarthritis Research SocietyInternational; Member, Skeletal Biology and SkeletalRegeneration Study Section, National Institutes of Health;Member, Faculty in Medicine, Faculty 1000, BiologyReports, Ltd.; Associate Editor, Arthritis Research andTherapy, Journal of Immunology; Editorial Boards,Biotherapy, Osteoarthritis and Cartilage, Journal ofOrthopedic Research, Modern Rheumatology.

Markou, A.—Chair, Animal Models and Their Validity tothe Disease Disorder Subcommittee, Task Force on

Medication Development, American College of Neuropsy-chopharmacology; Member, Neurobiology of MotivatedBehavior Study Section, National Institutes of Health;Field Editor, Neuropharmacology; Editorial Boards,American Journal on Addictions, Biological Psychiatry.

Mason, B.J.—Field Editor, Neuropsychopharmacology.

Miles, L.A.—Thrombosis Special Recognition Award,Council on Ateriosclerosis, Thrombosis, and VascularBiology, American Heart Association; President, XVIIthInternational Congress on Fibrinolysis and Proteolysis;Chair, Women’s Leadership Committee, Council on Arte-riosclerosis, Thrombosis and Vascular Biology, AmericanHeart Association and Review Committee 4B, AmericanHeart Association Western States Affiliate ResearchCommittee; Member, American Heart AssociationWestern Consortium; Council Member, InternationalSociety for Fibrinolysis and Proteolysis; Member, Sci-entific Advisory Board Member, International Society ofThrombosis and Haemostasis; Editorial Boards, Frontiersin Bioscience, Thrombosis and Haemostasis.

Mowen, K.A.—Hulda Irene Duggan Arthritis InvestigatorAward, Arthritis Foundation.

Nicolaou, K.C.—G.M. Kosolapoff Award, Auburn Section,American Chemical Society; Burkhardt-Helferich Prize,Institute of Organic Chemistry, University of Leipzig,Leipzig, Germany; Co-Editor-in-Chief, Chemistry & Biol-ogy; Editorial Boards, Tetrahedron Publications, Syn-thesis, Carbohydrate Letters, Chemistry—A EuropeanJournal, Perspectives in Drug Discovery and Design,Indian Journal of Chemistry, Section B, CombinatorialChemistry High-Throughput Screening, Current Opin-ion in Bioorganic Chemistry, Current Organic Chem-istry, Organic Letters, ChemBioChem, Chemistry andBiodiversity, Bulletin for the Chemical Society of Japan,Chemistry—An Asian Journal.

Oldstone, M.B.A.—Fellow, American Academy of Micro-biology; Member, Institute of Medicine, National Acad-emy of Sciences; Elected Member, Scandinavian Societyof Immunology, American Association of Physicians,American Society for Clinical Investigation; Member,Scientific Advisory Committee, Pew Scholars Programin the Biomedical Sciences; Editor, Virology, CurrentTopics in Microbiology and Immunology; EditorialBoards, Immunity, Journal of Clinical Investigation.

Polich, J.—Member, Cognitive Neuroscience Study Sec-tion, National Institutes of Health; Editorial Boards,Brain Topography, Brain and Cognition, Clinical Neu-rophysiology, Journal of Psychophysiology.

3 7 4 T H E S C R I P P S R E S E A R C H I N S T I T U T E 2 0 0 6

Pollard, K.M.—Member, External Advisory Committee,Center for Environmental Health Sciences, Universityof Montana, Missoula, Montana.

Rebek, J., Jr.—Medal of the Academy of Sciences,Prague, Czech Republic; Medal of the National Acad-emy of Sciences, Letters and Arts, Modena, Italy;Member, Academia Europaea; Editorial Boards, Tetra-hedron Publications, Bioorganic and Medicinal Chem-istry Letters, Bioorganic and Medicinal Chemistry,Chemistry and Biology, Current Opinion in ChemicalBiology, Journal of Supramolecular Chemistry.

Reed, S.I.—Editorial Board, Molecular and CellularBiology.

Reisfeld, R.A.—Honorary Degree in Medicine, Universityof Genova, Italy; Coeditor, Journal of Clinical LaboratoryAnalysis; Editorial Boards, Bioconjugate Chemistry,Cancer Biotherapy and Radiopharmaceuticals, CancerImmunology and Immunotherapy, Cancer Research,Clinical Cancer Research, Hybridoma, InternationalJournal of Oncology, Journal of Immunology, TumorTargeting.

Ruf, W.—Thrombosis Special Recognition Award,Council on Arteriosclerosis, Thrombosis, and VascularBiology, American Heart Association; Editorial Board,Journal of Thrombosis and Haemostasis.

Salomon, D.R.—Chair, National Islet Center ResourcesProgram, National Institutes of Health; Member, Trans-plantation, Tolerance, and Tumor Immunology StudySection, National Institutes of Health; Associate Edi-tor, American Journal of Transplantation; EditorialBoard, Transplantation.

Schlaepfer, D.D.—Established Investigator, AmericanHeart Association.

Schmid, S.L.—MERIT Award, National Institutes ofHealth; Alex Novikoff Plenary Lecture, Lysosomes andEndocytosis Gordon Conference, Andover, New Hamp-shire; Fellow, American Association for the Advancementof Science; Board Member and Treasurer, Athena, Uni-versity of California, San Diego; Member, ActivitiesReview Panel, American Heart Association WesternDivision; Member, Review Panel, Howard Hughes Med-ical Institute International Research Scholar Program;Member, Advisory Committee, Burroughs WellcomeCareer Awards in Biomedical Research; Editor-in-Chief,Molecular Biology of the Cell.

Sharpless, K.B.—William H. Nichols Medal, AmericanChemical Society New York Section, White Plains, New

York; Novartis Lecturer in Central Europe, Budapest,Hungary, Bratislava, Slovakia, and Prague, CzechRepublic; Sessler Lecture, Stanford University, Stanford,California; J.P. Freeman Lectureship, University of NotreDame, Notre Dame, Indiana; Backer Lecture, Universityof Groningen, Groningen, the Netherlands; WheelerLecture, University College Dublin, Dublin, Ireland;Closs Lecture, University of Chicago, Chicago, Illinois;Masamune Memorial Lecture, Massachusetts Instituteof Technology, Cambridge, Massachusetts. EditorialBoards, Advanced Synthesis and Catalysis, BeilsteinJournal of Organic Chemistry, Bulletin of the ChemicalSociety of Japan, Chirality, Current Opinion in DrugDiscovery and Development, Current Drug DiscoveryTechnologies, Enantiomer, Organic Letters. Synlett.

Stevens, R.C.—Editorial Boards, Protein Expression andPurification, Biodrugs, Drug Discovery Today, TheProtein Journal.

Stuhlmann, H.—Member, Cardiovascular Differentiationand Development Study Section, National Heart, Lung,and Blood Institute; Editorial Board, Stem Cells.

Sutcliffe, J.G.—Member, International Advisory Board,International Institute of Molecular and Cell Biology,Warsaw, Poland; Member Program Committee, Inter-national Society for Neurochemistry; Editorial Boards,DNA and Cell Biology, Molecular Neurobiology Reviews,Journal of Neuroscience Research, Journal of Molec-ular Neuroscience, Advances in Neuroscience, Jour-nal of Neurochemistry.

Tellinghuisen, T.L.—Career Development Award, NationalInstitute of Allergy and Infectious Disease.

Theofilopoulos, A.N.—18th Annual Paul KlempererAward, New York Academy of Science; Honorary Doc-toral Degree, Medical School, Aristotle University,Thessaloniki, Greece; Honorary Doctoral Degree, Dem-ocritos Medical School, University of Thrace, Alexan-droupolis, Greece; Corresponding Member, Academy ofAthens; Editor, Current Directions in AutoimmuneDiseases (book series); Editorial Boards, Survey ofImmunologic Research, Journal of Clinical Immunol-ogy, Journal of Experimental and Clinical Research,Journal of Clinical Immunology and Immunopathol-ogy, Journal of Immunopharmacology and Immuno-toxicology, Journal of Autoimmunity, InternationalJournal of Oncology, Scandinavian Journal of Immu-nology, Human Immunology, Japanese Journal ofRheumatology.


Torbett, B.E.—Consultant, Center for Biologics Evalua-tion and Research Response, Food and Drug Adminis-tration, States as Certifiers; Member, AIDS Molecularand Cellular Biology Study Section, National Instituteof Allergy and Infectious Diseases; Reviewer, SpecialEmphasis Panel, Program Project in Myeloid Biology,National Heart, Lung, and Blood Institute.

Vogt, P.K.—Medal of Distinction, Institute of OrganicChemistry and Biochemistry, Academy of Sciences ofthe Czech Republic; Fellow, American Academy of Artsand Sciences; Chairman, Scientific Advisory Board,Oncogene Research Institute, University of Singapore;Member, Selection Committee, Robert Koch Foundation;Member, Board of Directors, Foundation for AdvancedCancer Studies; Editorial Boards, Virology, Journal ofVirology, Current Topics in Microbiology and Immunol-ogy, Cancer Research, Proceedings of the NationalAcademy of Sciences, Blood Cells, Molecules andDiseases, Cell Cycle.

Waterman-Storer, C.M.—Who’s Who in Science andEngineering, Marquis Publishing; Keith R. Porter Fellow,Keith R. Porter Endowment for Cell Biology; Director’sPioneer Award, National Institutes of Health; R.R. Bens-ley Award in Cell Biology, American Association ofAnatomists; Established Investigator, American HeartAssociation; Chair, Summer Meeting Series, AmericanSociety for Cell Biology; Member, Cell Structure andFunction Study Section, National Institute of GeneralMedical Sciences; Faculty Member, Annual SummerCourse, Marine Biological Laboratory, Woods Hole,Massachusetts.

Weissmann, C.—Distinguished Research Professor,Department of Biological Sciences, Florida AtlanticUniversity, Jupiter, Florida; Warren Alpert FoundationPrize, Harvard Medical School, Boston, Massachusetts;DART/NYU Biotechnology Achievement Award for BasicBiotechnology, Biotechnology Study Center, NYU Schoolof Medicine, New York, New York; Bernard Fields Lec-ture, Scripps Research Institute, La Jolla, California;Henry Kunkel Lecture, Cambridge, England; GeoffreyH. Bourne Memorial Lecture, St. George’s University,Grenada, West Indies; Editorial Board, Journal ofNeuroVirology.

Whitton, J.L.—Chair, Special Study Section on VaccineDevelopment, National Institutes of Health; Ad HocMember, Experimental Virology and Virology study sec-tions, National Institutes of Health; Editor, Virology;

Acting Editor-in-Chief, Viral Immunology; EditorialBoards, Journal of Virology, FEMS Medical Microbiol-ogy and Immunology.

Wilson, I.A.—Fellow, Royal Society of London; Fellow,American Academy of Arts and Sciences; Member, Sci-entific Advisory Board, Keystone Symposia; AssociateEditor, Journal of Molecular Biology, Immunity; Editor-ial Boards, Science, Journal of Experimental Medicine.

Wong, C.-H.—Georges Smets Chair Award for Organic orPolymer Chemistry, University of Leuven, Belgium; Sci-entific Advisor, Max-Planck-Institut, Dortmund, Germany;Editor-in-Chief, Bioorganic and Medicinal Chemistry;Editorial Boards, Tetrahedron Publications, CurrentOpinion in Chemical Biology, Biocatalysis, AdvancedSynthesis and Catalysis, Journal of the AmericanChemical Society, Chemistry—An Asian Journal.

Wright, P.E.—Honorary Doctor of Science, University ofSydney, Sidney, Australia; Editor-in-Chief, Journal ofMolecular Biology; Editorial Boards, Biochemistry,Current Opinion in Structural Biology, Journal of Bio-molecular NMR.

Wüthrich, K.—Doctor of Science honoris causa, KingGeorge’s Medical University, Lucknow, India; Doctorhonoris causa, University of Pécs, Pécs Hungary; Hon-orary Member, Indian Biophysical Society; CorrespondingMember, Nordrhein-Westfälische Akademie der Wissen-schaften; Foreign Member, Korean Academy of Scienceand Technology; Honorary Member, Korean MagneticResonance Society; Sarojini Damodoran Lecture, TataInstitute of Fundamental Research, Mumbai, India;G.N. Ramachandran Memorial Lecture, Indian Biophysi-cal Society, Pune, India; Editor-in-Chief, Journal ofBiomolecular NMR; Editorial Boards, Biochimie, Bio-polymers, ChemBioChem, Current Opinion in StructuralBiology, IUBMB Life, Journal of Magnetic Resonance,Journal of Membrane Biology, Journal of Structuraland Functional Genomics, Proteins, Structure.

Yagi, T.—Special Reviewer, Neurodegeneration, Neuroin-flammation, Oxidative Stress, and Mitochondria StudySection, National Institutes of Health; Editorial Board,Journal of Bioenergetics and Biomembranes.

Yates, J.R. III—Herbert A. Sober Lectureship Award,American Society for Biochemistry and Molecular Biol-ogy; Christian B. Anfinsen Award, Protein Society.


Kellogg School of Science andTechnology

Vitality, innovation, interdisciplinary scientificexchange—these are some of the cornerstonesof the Kellogg School of Science and Technology

at Scripps Research.This year was a significant one for graduate studies

at the Florida campus with the enrollment of the firstrecruited graduate student, John Whitaker. He joinseight other Ph.D. candidates who transferred to ScrippsFlorida from the University of Michigan with Professorand Associate Dean William Roush. The introduction of2-way, web-based conferencing technology now enablesthe Florida students to participate in California lecturesin real time, as well as opening future Florida chem-istry classes on asymmetric synthesis and related top-ics to interested California students. The technologyalso facilitates the meeting of thesis committees withfaculty on both Scripps Research campuses.

In 2006, we welcomed a total of 42 new studentsto our Ph.D. program from undergraduate institutionsincluding Dartmouth, Brown, Stanford, Cornell, Duke,Pennsylvania State, Tufts, University of Chicago, Uni-

versity of Hamburg, National Taiwan University, and theUniversity of California system. Members of this year’sentering class originally come from countries as far awayas Australia, Slovenia, and China. The entering biologyclass of 27 is the largest in the history of the program.

Shortly after the first-year students arrived at ScrippsResearch, they began a 12-week class called CriticalThinking and Communication in Science to sharpentheir skills in assessment and communication of scientificinformation and ideas. For the first time in 2006, thecourse included an introduction to the Scripps ResearchKresge Library, with an overview of the library’s resourcesand services, a hands-on orientation, and in-depth sem-inars on topics such as databases and citation man-agement software. One of the course requirements is aresearch proposal suitable for submission to a varietyof predoctoral fellowship competitions.

Another opportunity to learn about the institute’sresources and to meet student and faculty colleagueswas provided by the 2006 Faculty Student Retreat.Held at the Bahia Resort on Mission Bay, the retreatwas similar to a professional scientific conference, withstudents from both Florida and California campusespresenting their research through 17 oral presentationsand 150 posters that explored topics such as Micro-Capillary Crystallization and Adventures in Total Synthe-sis: The Stephacidin Family. Mike Burkart (Class of ‘99),now a faculty member in the chemistry and biochemistrydepartment of the University of California, San Diego,also gave a talk, passing on his experiences in scienceand offering career advice to the Ph.D. candidates.

In 2006, numerous honors and awards werebestowed on Kellogg School students highlightingtheir accomplishments:

• An unprecedented number of students (5) wereselected for National Science Foundation Fellow-ships: Daniel Bachovchin, Christine Fang, Gra-ham Johnson, Costas Lyssiotis, and Adrian Ortiz.

• David Horning, a member of the entering class,won a highly competitive Hertz FoundationFellowship, which aims to support the graduateeducation of “America’s most promising tech-nical talent.”

• Lindsey Macpherson received a National Insti-tutes of Health Ruth L. Kirschstein NationalResearch Service Award.

• Stuart Webb won a 3-year fellowship from theNational Institute on Deafness and Other Com-


Jeffery W. Kelly, Ph.D.

munication Disorders of the National Institutesof Health.

• Sherry Niessen won a 2-year Career Develop-ment Award from the California Breast CancerResearch Program.

• Katherine Marcucci won an American HeartAssociation fellowship.

• Noah Z. Burns and Scott T. Harrison werehonored for their research accomplishmentsat Roche’s 3rd annual graduate researchsymposium, Excellence in Chemistry.

In 2006, Kellogg School student stipends and tuitionwere supported by generous donations from individuals,foundations, and corporations—including the Gustavusand Louise Pfeiffer Research Foundation, the Williamand Sharon Bauce Family Foundation, the Fletcher JonesFoundation, the ARCS Foundation, the Hertz Foundation,the Donald E. and Delia B. Baxter Foundation, theKoshland Foundation, the American Chemical Society,Novartis, the Gilula Memorial Fund, the Andrea Eliza-beth Vogt Memorial Fund, David and Ursula Fairchild,and Lesly Starr Shelton.

The Skaggs Oxford Scholarship Program, a joint5-year program of study at Scripps Research and OxfordUniversity, continued in 2006 thanks to generous sup-port by supermarket and drugstore leader L.S. Skaggsand his wife, Aline. The program’s first student has nowcompleted training at Scripps Research and is in theprocess of moving to Oxford University, where she willcomplete work for a joint Ph.D./D.Phil. degree.

In other program news, the Kellogg School has begunthe 3-year process of obtaining reaccreditation. Accredi-tation is a continuous process of improvement and isdivided into 3 stages: an institutional proposal, a capac-ity and preparatory review, and an educational effective-ness review. Six committees are providing input for the3-year self-study process. (See http://www.scripps.edu/library/Accreditation/i_index.html for news and updates.)

In May, we celebrated the many accomplishmentsof our students and the Kellogg School program at theinstitute’s 14th commencement ceremony, which hon-ored 31 graduating students and two honorary degreerecipients. Hon. Alice Sullivan (Ret.), a former Califor-nia Superior Court judge and founder and chief execu-tive officer of Private Judge, was honored for her roleas former chair and current member of the ScrippsResearch Board of Trustees. Alexander Dreyfoos, aresident of West Palm Beach, Florida, who owns and

directs the private capital management firm, The Drey-foos Group, was honored for his numerous scientificand engineering accomplishments and for his serviceas a member of the Board of Trustees. He and his wife,Renate, provided a generous gift of $1 million to theinstitute in 2004.

At the ceremony, Judge Sullivan, whose remarksemphasized the importance of keeping an open mindand welcoming the unexpected, praised this year ’sgraduates. “Today you are to be congratulated on yourtremendous accomplishments in the classroom and thelaboratory,” she said to them. “This is a day to enjoythe promise of success that awaits you because of yourintellect, your dedication, and your hard work. Thetrustees of Scripps Research are immensely proud toknow that you will carry the name and reputation ofThe Scripps Research Institute wherever you go. . .you will honor us as we honor you.”


S T U D E N T S I N C H E M I S T R Y

A N D C H E M I C A L B I O L O G Y

P R O G R A M S

Adrian AccursoDartmouth College, B.A.

Robert AversaCornell University, B.A.

Daniel BachovchinHarvard College, A.B.

Catherine BarglowStanford University, B.S.

Robert BatesMassachusetts Institute of

Technology, B.S.

John BeierleBoston College, B.S.

Jacqueline BlankmanNorthwestern University, B.A.

Grant BoldtSan Diego State University,

M.A.

Diana BowleyUniversity of Northern Iowa,

B.S.

William BrenzovichCollege of William & Mary,

B.S.

Steven BrownUniversity of Wisconsin,

Madison, B.S.

Noah BurnsColumbia University, B.A.

Jason ChenHarvard University, A.B.

Shuibing ChenTsinghua University, M.S.

Johnathan ChittuluruCornell University, B.A.

Chung-Han ChuNational Taiwan University,

B.S.

Ryan ClarkUniversity of California,

San Diego, B.S.

Elizabeth CulybaCollege of William & Mary,

B.S.

Trevor DaleSimon Fraser University, B.S.

Stephen DeanVanderbilt University, B.S.

Jessica DeMartinoUniversity of Delaware, B.S.

Michael DeMartinoUniversity of Delaware, B.S.

Damian EkiertUniversity of Chicago, B.A.

Shelby ElleryCedar Crest College, B.S.

Michael EvansSt. Mary’s College of

Maryland, B.A.

Christine FangUniversity of California, Los

Angeles, B.S.

Doug FowlerNorthwestern University, B.A.

Michael FrederickUniversity of Minnesota, B.S.

Brian FrezzaCarnegie Mellon University,

B.S.

Joie GarfunkleBoston College, B.S.

Jovana GrbicNorthwestern University, B.A.

Yevgeniy GrigoryevCity University of New York,

B.A.

Carlos GuerreroHarvard University, B.A.

Benjamin HafensteinerUniversity of Rochester, B.A.

Geoff HalvorsenUniversity of Illinois, B.S.

Sarah HansonUniversity of California,

Berkeley, B.S.

Nadia HaqCalifornia Institute of

Technology, B.S.

David HarrisCornell University, B.A.

Jennifer HazenFranklin & Marshall College,

B.A.

Simon HilcoveArizona State University, B.S.

Vu HongUniversity of California,

Berkeley, B.S.

Chan-Woo HuhYonsei University, M.S.

Wooyoung HurPohang University, B.S.

Reshma JagasiaUniversity of Alberta, B.S.

Valer JesoMassachusetts Institute of

Technology, B.S.

Robert JonesDuke University, B.S.

Daisuke KatoUniversity of California, Davis,

B.S.

Dong-In KooBrown University, B.S.

Paul KrawczukNew York University, B.S.

Tun-Hsun KuoNational Taiwan University,

M.S.

Sen Wai KwokUniversity of California,

San Diego, B.S.

Jolene LauCalifornia Institute of

Technology, B.S.

Aaron LeconteCarleton College, B.A.

Hyun Soo LeePohang University, M.S.

Sangyeul LeeUniversity of California,

Berkeley, B.S.

Ang LiPeking University, B.S.

Weiwei LiNational University of

Singapore, M.S.

Yee Hwee LimUniversity of Bristol, B.Sc.

David LinStanford University, B.S.

Ricardo LiraUniversity of California,

San Diego, M.S.

Ewa LisCornell University, B.A.

Chang LiuHarvard University, B.A.

Jonathan LocknerUniversity of Illinois at

Urbana-Champaign, B.S.

Andre LoutchnikovUniversity of Toronto, M.S.

Colin LoweryUniversity of Virginia, B.S.

Costas LyssiotisUniversity of Michigan, B.S.

Karen MacMillanUniversity of California, Davis,

B.S.

Thomas MaimoneUniversity of California,

Berkeley, B.S.

Dena MarrinucciUniversity of Vermont, B.S.

Casey MathisonMassachusetts Institute of

Technology, B.S.

Jeremy MillsVanderbilt University, B.S.

Amira Moreno VeraUniversity of Pennsylvania,

B.A.

Timothy NewhouseColby College, B.A.

Andrea NoldIndiana University, B.S.

Christine NguyenBoston College, B.S.


Daniel O’MalleyRice University, B.S.

Adrian OrtizUniversity of Arizona, B.A.

Paresma PatelUniversity of North Carolina

at Chapel Hill, B.S.

Francis PetersUniversity of New South

Wales, B.S.

Anna PolkStevens Institute of

Technology, B.S.

Rajan PraganiGoucher College, B. A.

Duane PrasuhnCarnegie Mellon University,

B.S.

Benjamin PrattDartmouth College, B.A.

Stanislav PresolskiColby College, B.A.

Jessica RaushelTexas A&M University, B.S.

Jeremy RichterButler University, B.S.

Tucker RobertsVanderbilt University, B.S.

William RobertsonUniversity of Colorado, B.A.

Valentin RodionovUniversity of Maryland, M.S.

David SarlahUniversity of Ljubljana, B.S.

Martin SchnermannColby College, B.A.

Ian SeipleUniversity of California,

Berkeley, B.S.

Ryan ShenviPennsylvania State University,

B.S.

Jun ShiWuhan University, B.S

Sarah SiegelUniversity of Virginia, B.S.

Corin SlownYale University, B.S.

Houchao TaoShanghai Institute of Organic

Chemistry, M.S.

Mark TichenorUniversity of California, San

Diego, B.S.

Theresa TiefenbrunnCalifornia Institute of

Technology, B.S.

Jennifer TreweekCalifornia Institute of

Technology, B.S.

George Scott TriaBoston University, B.A.

Porino VaUniversity of Michigan, M.S.

Hillary Van AndaBryn Mawr College, A.B.

Jianhua WangUniversity of Montreal, M.S.

Sheng-Kai WangNational Tsing Hua

University, B.S.

John WhitakerWashington State University,

B.S.

Landon WhitbyUniversity of Utah, B.S.

SusAnn WinbushUniversity of California,

Los Angeles, B.S.

Yang XuUniversity of California, Davis,

B.S.

Yang, Yu-YingNational Chiao Tung

University, M.S.

Isaac YonemotoUniversity of Chicago, B.S.

Travis YoungBoston College, B.S.

Yu, WaynePortland State University, B.S.

Andrea ZuhlNorthwestern University, B.A.

S T U D E N T S I N B I O L O G Y

A N D B I O P H Y S I C S

P R O G R A M S

Parinaz AliahmadMcGill University, B.S.

Phillip AotoUniversity of California, Irvine,

B.S.

Rena AstronomoSimon Fraser University, B.S.

Ann AtwoodBrown University, B.S.

Michael BarnesUniversity of Notre Dame, B.S.

Gira BhabhaUniversity of Chicago, B.A.

Sara BrownellCornell University, B.S.

Eric BrustadPurdue University, B.S.

Anne BunnerIowa State University, B.S.

Russell BurgeArizona State University, B.S.

Stuart CahalanUniversity of California,

San Diego, B.S.

Joshua ChappieBrandeis University, M.S.

Stephen ChenRice University, B.S.

Yee-Ting ChongCornell University, B.A.

Ryan CirzPennsylvania State University,

B.S.

Ronald ColemanCalifornia State University,

Fullerton, B.S.

Corey DambacherSan Diego State University,

M.S.

Neekesh DhariaUniversity of California,

San Diego School of Medicine, B.S.

Melissa DixPennsylvania State University,

B.S.

Jonas DornSwiss Federal Institute of

Technology, M.S.

Bao DuongUniversity of California,

Los Angeles, B.A.

Hunter ElliotColorado College, B.A.

Kelly FlanaganSaint Louis University, B.S.

Amandeep GakhalSimon Fraser University, B.S.

Anna GalkinCornell University, B.S.

Marin GantnerUniversity of Puget Sound,

B.S.

Sulagna GhoshUniversity of Maryland, B.S.

Russell GordleySwarthmore College, B.A.

Daniel GroffAlbertson College, B.S.

Jing GuoPeking University, B.S.

Peter HawkinsBringham Young University,

B.S.

Christine Johanna HeidekerJulius Maximilians Universitaet

Wuerzburg, Diplom

Dawn HillUniversity of Maryland, B.S.

Ronald HillsFlorida State University, B.S.

David HorningHarvard University, A.B.

Amanda HoytUniversity of Washington, B.S.

Julie HsuUniversity of California,

Berkeley, B.A.

Pei-hsin HsuStanford University, M.S.


Jason JensMichigan State University, B.S.

Audra JohnsonSan Francisco State

University, B.S.

Graham JohnsonJohns Hopkins School of

Medicine, M.A.

Jeffrey JohnsonUniversity of Illinois, B.S.

Eiton KaltgradUniversity of California,

San Diego, B.S.

Piotr KazmierczakUniversity of Warsaw, M.Sc.

Donald KerkowUniversity of California,

San Diego, B.S.

Christopher KimberlinUniversity of California,

Santa Barbara, B.S.

Robert KirchdoerferUniversity of Wisconsin,

Madison, B.S.

Heather Kiyomi KomoriAlbertson College, B.S.

Kristopher KoudelkaUniversity of Wisconsin,

River Falls, B.S.

Sherman KuGeorgia Institute of Technology,

B.S.

Jinny KwongUniversity of California,

San Diego, B.S.

Gabriel LanderState University of New York,

Binghamton, B.S.

Pick-Wei LauUniversity of Arizona, M.S.

Daniel LeamanUniversity of Pittsburgh, B.S.

Joon Youb LeeSeoul National University, M.S.

James LimMcGill University, B.S.

Tracey LincolnWilliams College, B.A.

Victor Mitch LunaStanford University, B.S.

Lndsey MacphersonUniversity of California, San

Diego, B.S.

Ranjan MannigeUniversity of Houston, B.S.

Andrea ManuellIowa State University, M.S.

Katherine MarcucciNorthwestern University, B.A.

Christopher MartinTufts University, B.A.

Alexandre MatovTechnical University Varna,

M.Sc.

Mayako MichinoGeorgia Institute of Technology,

M.S.

Takashi MiyamotoUniversity of Tokyo, B.S.

Crystal MoyerUniversity of Pittsburgh, B.S.

Anke MulderPurdue University, B.S.

Amber MurrayMassachusetts Institute of

Technology, B.S.

Sherry NiessenMcGill University, M.S.

Bryan O’NeillUniversity of San Diego, B.A.

Wendelien OswaldCornell University, B.S.

Katherine PetrieUniversity of Pittsburgh, B.S.

John PicuriCornell University, B.S.

William PlaczekWashington University, B.A.

Gunner PoplawskUniversity of Hamburg, Diplom

Randor RadakovitsStockholm University, M.Sc.

Sanjeev RanadeNortheastern University, M.S.

William RidgewayUniversity of California,

Berkeley, B.A.

Christopher RothUniversity of California,

Santa Barbara, B.S.

Sophie RozenzhakWayne State University, M.S.

April SaundersUniversity of California,

Davis, B.S.

Erin SchererUniversity of Arkansas, B.S.

Gabriel SimonUniversity of Pittsburgh, B.S.

Peter SmithPurdue University, B.S.

Sevil SofuevaInternational University

Breman, B.Sc.

Bogdan Tanasa“Gr.T.Popa” University of

Medicine and Pharmacy Iasi, M.D.

Shishi TangUniversity of Toronto, M.S.

Megan ThielgesArizona State University, B.S.

Kathryn ThompsonCentenary College, B.S.

Anne-Marie TurnerWake Forest University, B.S.

Lisa TuttleUniversity of Minnesota, M.S.

José VelaCalifornia State University,

Northridge, B.A.

Sarah VoytekBrown University, B.S.

Andrew WardDuke University, B.S.

Stuart WebbUniversity of California,

Santa Barbara, B.S.

Kathryn WeinellUniversity of Colorado, B.A.

Laura WhiteEmory University, B.S.

Joann WuUniversity of California,

San Diego, B.S.

Fei XuUniversity of Science and

Technology of China, B.S.

Craig YoshiokaUniversity of Florida, B.S.

Jason YoungUniversity of Wisconsin, B.S.


The Center for IntegrativeMolecular Biosciences

The Center for Integrative Molecular Biosciences(CIMBio) was created in 2002 to foster collabo-rative research dedicated to elucidating the high-

resolution structures, mechanisms of action, and in vivodynamic behaviors of the cell’s molecular machines.CIMBio now houses 20 research groups representingdisciplines including chemistry, cell and molecular biol-ogy, electron microscopy, x-ray crystallography, advancedlight microscopy, computational biology, and technol-ogy development. This year Floyd Romesberg, PhilipDawson, and Anette Schneemann relocated their researchgroups here, occupying new laboratories on the secondfloor of the building and adding strengths in chemistryand structural biology.

Our faculty members made a number of noteworthyscientific advances during the past year, a fact that wasreflected in the number of papers published in top-rank-ing scientific journals. The following list highlights someof this groundbreaking science. In the journal Cell,Clare Waterman-Storer and her coworkers describedfundamental dynamic molecular relationships that under-lie rapid cell migration over substrates. Geoffrey Changand members of his laboratory published a paper inScience describing the high-resolution structure of a

membrane protein transporter involved in multidrugresistance. Also in Science, Bridget Carragher, ClintPotter, Jack Johnson and their colleagues reported thestructure of an infectious phage, visualizing the capsid,the tightly spooled, packaged DNA and the tail machin-ery that senses when packaging is complete. In anarticle published in Nature, groups headed by Dr. Car-ragher, Dr. Potter, and William Balch described theunderlying structure of the coat protein complex-IImolecular cage that mediates intracellular transport.Also in Nature, Ron Milligan and colleagues describedthe mechanism of minus-end directed motion by amicrotubule bound kinesin. In Nature Medicine, MariManchester’s group reported the use of a fluorescentlylabeled plant virus as a biosensor for vascular imaging.This novel methodology can effectively image the com-plete embryonic vasculature and highlight the processof angiogenesis in developing tumors.

It was a banner year for Clare Waterman-Storer.She received a number of honors and awards includingthe R.R. Bensley Award in Cell Biology from the AmericanAssociation of Anatomists, the Director’s Pioneer Awardfrom the National Institutes of Health, and an EstablishedInvestigatorship from the American Heart Association.

During November 2005, 41 students from theUnited States, Canada, and Europe attended a 9-daypractical course in molecular microscopy run by theNational Resource for Automated Molecular Microscopy,our Biomedical Technology Resource Center sponsoredby the National Center for Research Resources. Leadingscientists in the field participated in lectures, researchseminars, and practical sessions that covered the theoryand practice of electron microscopy and image analysis.The formal lectures and research seminars attractedmany attendees from the local scientific community. Inall, 27 instructors and 18 assistants were involved inthe course. Financial support for the course was pro-vided by the National Center for Research Resources,The Agouron Institute, FEI Company, Gatan Inc., Pro-tochips Inc., Tietz Video and Image Processing Systems,and Scripps Research.

The fourth in a series of training workshops on soft-ware for automated molecular microscopy was held dur-ing February 2006. Representatives from 5 institutions(Oxford; Purdue; Brandeis; University of California,San Diego; and State University of New York) attendedand received intensive training on installation and useof software developed at the National Resource forAutomated Molecular Microscopy.


Ronald A. Milligan, Ph.D.

In the coming year, Scripps Research will be thefirst research institution worldwide to receive a novelcompact synchrotron light source. This Scripps Cam-pus Synchrotron, to be housed in CIMBio, will signifi-cantly accelerate the pace of determining challengingprotein structures (for example, membrane proteinsand large macromolecular complexes) and structure-based drug design by enabling real-time experimentalevaluation using high intensity, tunable x-rays on cam-pus. This research is part of the new technology devel-opments of the Accelerated Technologies Center for

Gene to 3D Structure in the Kuhn and Stevens Labo-ratories (http://www.atcg3d.org).

These activities and successes during the past yearhighlight the collaborative, interdisciplinary nature ofthe science being carried out at CIMBio. The enthusiasmof our faculty, staff, fellows, and students and their com-mitment to our collaborative mission are also evident atthe standing-room-only biweekly forums—short seminarsdesigned to promote interdisciplinary interactions.


Harold L. Dorris NeurologicalResearch InstituteTamas Bartfai, Ph.D., Director

Major depression and schizophrenia affect millionsof people. Treatment of these conditions requiresan understanding of their underpinnings, and

this need is addressed by The Harold L. Dorris Neurologi-cal Research Institute. Founded in 1999 as the resultof a long-term $10 million commitment by Helen L.Dorris through the Harold L. Dorris Foundation, namedin her brother’s honor, the institute has attracted aninternational cadre of scientists from France, Switzer-

land, Sweden, Mexico, and Italy in such disciplines asneurology, immunology, chemistry, molecular biology,and endocrinology to study neurologic disorders.

The institute also funds the Helen Dorris Fellow inSchizophrenia, a named fellowship position for a post-doctoral researcher to study aspects of schizophreniaand depression from the neurobiological perspectives.The current fellow is Lisa Sharkey. The visiting profes-sors at the institute in 2005 were the noted electro-physiologist and member of the French Academy ofSciences Henri Korn from the Pasteur Institute in Paris,France; noted pharmacologist and member of the RoyalSwedish Academy of Sciences Lars Terenius from theKarolinska Institutet in Stockholm, Sweden; and molec-ular immunologist Hermann Gram and molecular phar-macologist Daniel Hoyer from Basel, Switzerland.

In 2006, the faculty of the institute expandedbeyond the founding faculty members with the electionof 3 talented young faculty members: Dorian McGavern,Eric Zorrilla, and Marisa Roberto.Tamas Bartfai, Ph.D.

The Institute for Childhood andNeglected Diseases

The Institute for Childhood and Neglected Diseases(ICND) was established to apply cutting-edgeresearch to understand the basic mechanisms

underlying diseases of childhood and orphan diseasesthat lack efficacious treatments. Diseases in both thesecategories often affect populations in developing coun-tries, where the health infrastructure may be too poorto support major research efforts on these problems.

Examples of such diseases include malaria, epilepsy,mental retardation, cystic fibrosis, chronic pain, andsleep disorders. The human and economic costs ofthese diseases are staggering. According to the WorldHealth Organization, each year, the microorganism thatcauses malaria infects 300 million persons, and the

Helen L. Dorris Child andAdolescent Neuro-PsychiatricDisorder Institute

The sequencing of the human genome promisesto propel humans into the age of molecular medi-cine, where complex diseases are diagnosed and

treated in a patient- and target-specific manner. For the

nervous system, in particular, the postgenome era holdsthe potential to deliver groundbreaking new medicinesfor previously intractable psychiatric disorders includ-ing anxiety, depression, and schizophrenia.

However, in order to realize this goal, a new breedof research institute is needed that cultivates cross talkamong many experimental disciplines. Indeed, unravel-ing the complexities of the human brain and behaviorcan only be achieved by bringing together scientists fromdiverse backgrounds and expertise, including chemistry,physics, genetics, and behavior.

The Helen L. Dorris Child and Adolescent Neuro-Psychiatric Disorder Institute was established with agenerous gift from mental health advocate and San DiegoState University professor emeritus Helen L. Dorris. Herinterest in mental health advocacy led her to providethe funding to establish this institute, which has a strongemphasis on interdisciplinary approaches to studies ofneurologic and psychiatric disorders.

Specifically, the aim of scientists at the institute isto uncover the pathologic basis of mental disorders andto develop therapies for these disorders. In the past 3years, several talented investigators have been recruitedto join the institute. Together, these investigators areaddressing many of the most challenging problems fac-ing contemporary molecular and behavioral neuroscience.Their research promises to uncover fundamental mecha-nisms for brain function and to reveal novel strategiesand targets for the treatment of nervous system disorders.


Ben Cravatt, Ph.D.

Steve Kay, Ph.D.

disease kills approximately 1 million persons. About90% of the people who have malaria are in Africa,where the annual costs associated with the diseaseare $12 billion. Malaria is the leading cause of child-hood mortality in African countries.

Epilepsy is another widespread and costly disease.It affects about 2.3 million persons in the United Statesand accounts for $12.5 billion in medical costs andreduced productivity each year.

Mental retardation is another condition that affectschildren everywhere; about 1% of American children3–10 years old are mentally retarded. During the1995–1996 school year, about 600,000 6- to 21-year-olds with mental retardation in the United Statesreceived special educational services, at a cost of about$3.3 billion.

Housed in a state-of-the-art, 54,000-square-footbuilding on the east side of the Scripps Research cam-pus, the ICND is a focus group within Scripps Researchfor young scientists who are working in areas relevantto the ICND mission. The concept of the ICND grewout of conversations in 1996 and 1997 among ScrippsResearch president Richard Lerner; John Moores, whowas interested in supporting research on illnesses thataffect people in developing countries; and the brothersBernard and Marc Chase, who were interested in sup-porting research on childhood diseases. John andRebecca Moores, Bill Bauce, and other automobileenthusiasts donated a number of vintage automobiles,which were auctioned to support the ICND. The Mooreswent on to contribute a valuable coin collection, aswell as pledging $5 million to be awarded over 5 years.

The Human Genome Project has led to a deeperunderstanding than ever before of the mechanismsunderlying human disease. The ability to study thedraft mouse and human genomes in parallel is providingan unprecedented opportunity to create a road map forassigning a physiologic function to all of the 35,000-45,000 human genes. This formidable challenge requirescomplex multidisciplinary approaches that allow scien-tists to create and implement the most powerful researchtools available. Investigators at the ICND use genomics,proteomics, and advanced microscopic imaging tech-nologies; develop many novel transgenic animal models;and aggressively apply these technologies in an effortto understand the mechanisms of action of a variety ofdiseases and conditions—malaria, mental retardation,neurodegenerative diseases, neuropathic pain, deafness,sleep disorders, migraines, and epilepsy, for example—

and to devise treatments for these maladies. ICND sci-entists plan to systematically study not only the genesassociated with these abnormalities but also the inter-actions between the genes in living model systems.

ICND researchers have already been recognized bythe international scientific community during the first 5years of the institute’s existence. In December of 2002,3 of the highly prized Top Ten Breakthroughs of the Yearof Science magazine were results produced by ICNDresearchers working on the malarial genome, mecha-nisms of pain perception, and processes important forsleep disorders and seasonal depression. This remark-able level of achievement speaks to the investmentmade in these research areas and bodes well for fur-ther rapid progress in the near future.

Faculty Areas of Research

Steve A. Kay, Ph.D. Molecular mechanisms of circadianrhythms and sleep disorders, genet-ics of anxiety, novel targets in neu-rodegenerative diseases

William E. Balch, Ph.D. Protein trafficking and the molecularbasis for the hereditary childhooddisease cystic fibrosis

Kristin Baldwin, Ph.D. Molecular biology of the sense ofsmell, genetic mechanisms govern-ing neural circuit development inthe olfactory system and cortex

Shelley Halpain, Ph.D. Organization and function of the neu-ronal cytoskeleton, mechanismsunderlying potential treatments forAlzheimer’s disease and repair ofneuronal damage after trauma

Mark Mayford, Ph.D. Molecular basis of cognitive function,including learning and memory dis-abilities and mental retardation

Ulrich Müller, Ph.D. Molecular cell biology of mechanosensoryperception and childhood deafness

Ardem Patapoutian, Ph.D. Ion channels and receptors involved innociception and neuropathic pain

Elizabeth Winzeler, Ph.D. Functional genomic approaches toidentifying targets in Plasmodium,the parasite that causes malaria


Society of Fellows

In its 44th year, the Society of Fellows took pride inmaintaining its mission to serve the scientific com-munity at Scripps Research, with particular emphasis

on enhancing the trainee experience of junior scien-tists. We enjoyed a great year of bringing graduatestudents, postdoctoral fellows, and faculty memberstogether in both professional and social arenas.

Our Distinguished Lecturer Series brought severalprominent scientists to lecture and, more importantly,to interact with junior scientists. The society is thankfulto the speakers for their excellent presentations: ClaireFraser, Paul Nurse, and Stanley Plotkin.

The Society also sponsored a wide range of careerdevelopment workshops and seminars, most notably sev-eral postdoctoral career events including Jorge Cham(The Power of Procrastination), Jean-luc Doumont(Making the Most of Your Presentation), and a grantwrit-ing workshop lead by Luc Teyton. These events weresponsored in partnership with Ryan Wheeler, managerof the newly formed Office of Postdoctoral Services, whichhas greatly expanded our reach by providing help inorganizing events. We acknowledge Ryan’s outstandingassistance and appreciate his commitment to fulfillingthe society’s aims.

The Fall Research Symposium was organized to drawpostdoctoral scholars, graduate students, and facultymembers together in an informal setting. The event, heldin the Beckman Galleria, featured 52 poster presenta-tions covering research projects from all departments.

With a generous contribution from our HumanResources department, we were able to initiate a post-doctoral tuition reimbursement program in the amountof $400 to each fellow. Thus far, the program has funded

15 postdoctoral scholars for professional developmentcoursework. Typical courses included certificate pro-grams like Drug Discovery and Regulatory Affairs heldat the University of California, San Diego, Extension.Such formal coursework provided our postdoctoral can-didates with an important resume booster and gavethem a completive edge in an increasingly competitivejob market.

This year ’s social calendar was again packedwith many entertaining events, including trips to theLA County Museum of Art and Universal Studios, awhale watching excursion, an historical tour of SanDiego, and our annual Big Bear ski trip. Happy hourswere held throughout the year to promote interactionamong scientists at Scripps Research and those atnearby science institutions. This year’s Hawaiian-themedsummer bash was held at Canes Bar and Grill. In addi-tion, a sunset yacht cruise around San Diego Bay wasenjoyed by all who attended. Other notable social eventsthis year included a premier showing of the movie TheDaVinci Code, a day at the Del Mar races, and a WorldCup soccer tipping contest.

Finally, at the annual spring vendor show, the soci-ety played host to approximately 100 scientific vendors,who displayed their latest scientific equipment andtechnology.

The Society of Fellows executive committee expressesits sincere gratitude to the Office of the President andPostdoctoral Services at Scripps Research for enthusi-astic and continued support of the society’s activities.

E x e c u t i v e C o m m i t t e e 2 0 0 5 - 2 0 0 6

O f f i c e r s

Adam Mullick President

Ralph Pantophlet Vice President

Florence Brunel Treasurer

Kelly-Anne Purton Social Chair

Anne Bellon Social Co-Chair

Neil Hime Distinguished Lecturer Series Chair

Reshma Jagasia/ Career Development Committee Chairs

Justin Carlson

Tricia Burdo Vendor Show Chair

Ryan Wheeler Postdoctoral Services Office Liaison

Anne Bunner/ Network for Women in Science Liaisons

Jilla Sabeti

Ron Nepomuceno Website Manager

N o n - O f f i c e r s

Ben Croker Chris Ramsey

Joerg Hinnerwisch BinQing Wei

George Nicola Scott Westenberger

Vandana Ramachandran


S O C I E T Y O F F E L L O W S E X E C U T I V E C O M M I T T E E :

Left to right: back row: Chris Ramsey, George Nicola, Neil Hime,

Anne Bellon, Kelly-Anne Purton, Justin Carlson, Ryan Wheeler;

front row: Ralph Pantophlet, Adam Mullick, Ron Nepomuceno.

A u t h o r I n d e x

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Breton, G. 340Brignole, E. III 24Brik, A. 94Brinson, D.C. 245Brogan, A. 78Brooks, C.L. III 183, 193, 218Brooks, D. 295Brooun, A. 37, 173Brown, J. 24Brown, S. 133Browning, S. 356Bruce, R. 37Brudler, R.M. 160 Bruijnzeel, A. 307Brunel, F. 30Bruning, J. 352Brustad, E. 88Bubeck, A. 34Bu, L. 193Buchmeier, M.J. 56, 291–293Buffkins, K. 308Bulger, P. 83Bunker, K. 70Bunner, A. 202Burge, R. 178Burns, N.Z. 69Burrer, R.J. 291, 292Busby, S.A. 341Buset, E. 295Burtoloso, A. 83Burton, D.R. 108, 109, 135,

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Matsuno-Yagi, A. 250Matsuo, N. 42Matteson, J. 25Mattock, M. 320Maue, M.K.-D. 69Mauro, V.P. 331Mayfield, S.P. 41Mayford, M. 42 McAllister, L. 78McCarty, O.J. 262McClatchy, D. 55McClintock, P.A. 265McCreight, M. 232McDonald, P. 346McElhaney, G. 78McGavern, D.B. 295, 299McGowan, C.H. 227McHeyzer-Williams, L.J. 125McHeyzer-Williams, M.G. 125McKay, D.B. 125 McKeatin, M. 268McKenzie, K. 78McKeown, C. 32McLeod, I. 55Mee, J. 78Meech, R. 332Meehan, T. 117Meijler, M. 78, 146Mejuch, T. 212Mendez-Dias, M. 314Mendoza-Fernandez, V. 314Mercer, B.A. 351Mercurio, P. 28Merriman, E. 203Metanis, N. 30, 212Meyers, A. 201Michino, M. 193 Mico-Alvarez, X. 83Mikolosko, J.R. 160Mikulecky, P. 202Milburn, R. 83Mileni, M. 173Miles, L.A. 43Millar, D.P. 187, 357Miller, B.H. 344Miller, S. 42Milligan, R.A. 44, 291Mills, J. 88Mills, R. 117, 118Milner, R. 257Minond, D. 365Mitchell, J.W. 43Mitra, S.K. 137 Mitsumori, S. 208Mitsutake, A. 193Miyamoto, T. 46Mizutani, M. 149Mizutani, N. 149Moisan, L. 11, 15Molina, J.E. 137 Mols, J. 116Moncalian, G. 167Mondala, T.S. 262Montero, A. 75, 268Montminy, M. 178Moon, S. 189Moore, S. 317Moroi, M. 262Morris, G.M. 195

Morris, K.V. 281Morris, M.A. 351Morita, H. 201Moser, B.A. 225Mosier, D.E. 126Mosnier, L. 259Motiei, L. 75Motta, C. 203Mowen, K.A. 127Moy, K. 173Moyer, J. 32Mu, T. 81Mueller, B.M. 134Mukherji, M. 88Mukhopadhyay, S. 189Müller, U. 45Mullick, A.E. 109Mulligan, S. 44Munafo, D.B. 247Munshi, A. 114Muto, M. 41Myles, A. 11, 15Nahmias, C. 358Nakamura, T.M. 225Nakamaru-Ogiso, E. 250Nalbant, P. 106Nam, J. 70Nagai, K. 89Nangle, L. 203 Narayan, S. 89, 230Nash, S. 308Natarajan, P. 216 Nauli, A. 25Navarro, S. 259Nedellec, R. 126Nelson, J.D. 108, 150Nelson, M. 173Nelson, N. 104Nelson, T.E. 303, 309Nemazee, D. 128Nemerow, G.R. 129, 130, 218Nepomuceno, R. 129Nettles, K.W. 352Neuman, B.W. 291–293Nguyen, C. 345Nguyen, D. 189Nguyen, H.D. 193Nguyen, N. 298Nguyen, S. 69Nicola, G. 199Nicolaou, K.C. 67, 83Nicoletti, D. 75Nie, Z. 317Niessen, F. 134Nieva, J. 3, 927Nishikawa, T. 178Nishimura, C. 180Nold, A. 83Nom, T. 88Nomura, W. 208Noncovich, A. 83Noodleman, L. 191Nordstrom, A. 201Norikane, Y. 75 Norledge, B. 195Northen, T. 201Nowak, R. 32 Nussbaum, A. 301O’Maille, G. 201


O’Malley, D.P. 69O’Neill, B.A. 86O’Reilly, M. 233O’Sullivan, D. 258Oakman, E.L. 86Ober, M. 345Odegard, A. 216Odermatt, S. 11Offord, R. 126Ojakian, R. 294Okamura, A.J. 278Okamura, F. 278Okram, B. 88Oldstone, M.B.A. 295, 296Olson, A.J. 195Olson, B. 222 Olson, E. 276 Omelchenko, A. 195 Orahovats, P. 345Ortiz, A. 83Ortiz, B. 104Osornio, T. 73Ospina, H. 264Oswald, W.B. 109Ota, M. 141Ota, T. 128Otero, F. 203 Otsuka, M. 116Overbaugh, J. 126Owen, R. 345Owens, G.C. 330Ozaki, Y. 262Pache, L. 129Packowski, C. 232Pacquelet, S. 120, 247Paegel, B.M. 207Pagarigan, R. 301Page, L. 25Palida, F.A. 56Palmer, T. 104Palomique, J. 32Pañeda, C. 313Panopoulos, P. 331Pantophlet, R.A. 108Papageorgiou, C. 83Papp, J. 264Pappo. D. 83Para, A. 340Parapera, A. 53Park, J. 78Park, M. 247Park, R. 55Parmer, R.J. 43 Parren, P.W.H.I. 109Parsons, L.H. 310, 312, 317Partridge, J.P. 47Pastore, C. 126Pasunoori, L. 83Patapoutian, A. 46Patel, P. 70Patel, S. 193Paterson, N.E. 307Paulson, J.C. 233Pawlinski, R. 123Payton, S. 308Pebernard, S. 227 Pecheniuk, N. 259Pedrini, B 177Pellequer, J.-L. 261

Pelletier, N. 125Pelmentschikov, V. 189, 191Pendyala, G. 294Peng, H. 270Peram, M.M.R. 92Perego, M. 252, 254Perera, R. 88Perez, M. 299 Perez-Pinera, P. 274Pestonjamasp, K. 106Peters, F. 88Petersen, H. 134Peterson, L.F. 278Peterson, S. 232Petrillo, J.E. 219Petrovan, R.J. 109Petrovic, G. 83Philipson, L.H. 56Phillips, E. 302Picuri, J. 75Pilotte, J. 330, 332Piomelli, D. 315Piper, J. 83Pique, M.E. 160, 167, 195Piran, R. 212Pitram, S. 89Placzek, W.J. 177Pletcher, M.T. 344Pljevaljcic, G. 187Plutner, H. 25Polat, T. 94Polet, D. 83Police, S. 130Polich, J. 311Polis, I. 310Pollard, K.M. 282Pollard, T.D. 56Pollock, S. 108Pond, S. 187Pontow, S. 126Pontremoli, G. 83Popkov, M. 208Pottekat, A. 25Potter, C. 28 Powell, E. 39Powers, E.T. 81Pragani, R. 345Prasad, S. 341Prasuhn, D. 74Pratt, B. 83 Preece, N.E. 183Presolski, S. 74Price, D.J. 193 Prieto, J. 55Prinsen, R.C. 256, 265Prudden, J. 228Pruneda, J. 340Przydzial, M. 346Puckett, J. 186Puga, M. 92Pulokas, J. 28Pulvirenti, L. 304Purcell, R. 267Purdy, R. 304Purse, B. 15Purton, J. 140Purton, K. 267Qi, J. 345Qin, C. 201

Quello, S. 308Quigley, J. 47Quiroz, A.L. 340Quispe, J. 28, 291Radakovits, R. 45Radu, D. 75Rae, C. 39Rahe, N. 75Rahimipour, S. 75Ramachandran, R. 49Ramachandran, V. 54Ramachary, D.B. 208Ramasatry, S.S.V. 208Ramos, A. 126Ramos, C. 45, 50Ramsey, C. 140Rao, S. 308Rasmussen, L.K. 89Ratner, L. 126Ratner, T. 212Raushel, J. 89Rayon, E. 37Razvi, A. 25Razi, N. 233Reader, J. 203Reany, O. 212Rebek, J., Jr. 13, 15Reddy, R. 203Reddy, V. 130, 193Reddy, V.S. 218Reed, S.I. 222Reedy, M. 44Reedy, M.K. 44 Rehen, S.K. 232Reijmers, G.J. 42Rein, A. 56Reisfeld, R.A. 111, 131Reiter, J. 308Reixach, N. 279Reyes, C.R. 169Reynald, R.L. 246Reynolds, A. 45Rice, K. 320Riceberg, J. 261Richards, M.R. 109Richardson, H. 304Richter, J.M. 69Ridgeway, W. 202Riewald, M. 132Riley, E. 304Ritter, M. 33 Rivera, R. 232 Roberto, M. 312, 315, 317Roberts, A.J. 313, 317Roberts, E. 85Roberts, T.C. 86Robertson, M.W. 283Rodionov, V. 74Rodriguez, O. 53Rodriguez-Carreno, M.P. 301Rodriguez-Gabriel, M.A. 225Roeper, S. 89Rogel, J. 92Rojek, J.M. 300Rome, L. 130Romeo, E. 123Romero, A. 70Romesberg, F.E. 86Romijn, E. 55

Rosario, D. 298, 299Rosen, H. 133, 271Rosenstein, R. 195Roth, C. 173Roth, J. 302, 316Roush, W.R. 345Roy, R.S. 172Roychowdhury-Saha, M. 205Rozenshteyn, D. 261Rudyak, S. 222Ruf, W. 33, 111, 134Ruggeri, A.M. 269Ruse, C. 55Ruse, M. 120 Russell, P. 225Rutschmann, S. 104Ryan, K. 365Ryba, T. 345Ryu, Y. 88Saá Prieto, P. 357Saban, S. 130Sabatini, R. 357Sabeti, J. 303Sabino, V. 320Sabouri, M. 29Salazar, R. 306Salès, N. 357Salomon, D.R. 262, 264Sagle, L.B. 86Saikatendu, K. 37, 173Sainz, B. 268Saldana, A. 199Salerno, S. 112Salkowitz-Bokal, J. 126Salvio, R. 11, 15Sanathara, N. 119Sánchez, A.B. 295, 298Sánchez-Alavez, M. 322Sanna, G. 133Sanna, P.P. 314Sanner, M.F. 195Sansen, S. 246Saphire, E.O. 109, 135Saraiva, M.J. 279Sarlah, D. 83Sarvetnick, N. 136Saunders, A.A. 293Savage, J.H. 265Savas, Ü. 246Sawa, M. 94Sawkar, A. 81Sayen, M.R. 271Scaramozzino, F. 252Schaeffer, M.-T. 133Schaffer, L. 230Scampavia, L. 365Scheele, C. 346Scheerer, M. 276Scheppke, L. 33Scheraga, H.A. 193Scherer, E.M. 108Schettini, J. 142Schiefner, A. 160Schiller, S. 88Schimmel, P.R. 11, 203Schlaepfer, D.D. 137Schmid, S.L. 22, 49Schneemann, A 56, 218, 219Schneider, I.C. 53


Schnermann, M. 70Schork, N. 279Schramm, M. 11, 15Schrantz, N. 141Schroeder, R. 304Schuepbach, R.A. 132Schultheisz, H. 202Schultz, P.G. 88Schultz, T.F. 340Schwander, M. 45Schweitzer, P. 312, 315, 317Schwimmer, L.J. 209Scorah, J 227Scott, L.G. 202Sczaniecka, A. 45Secrest, P. 136Segatori, L. 81Seit-Nebi, A. 228Selvarajah, S. 113, 114Semenova, S.G. 231, 307Seo, B.B. 250Seo, J.-Y. 106Serrano, P. 177Sette, A. 292, 293Sever, M. 88Sevilla, N. 295 Sferrazza, G. 357Shabat, D. 208Shadan, F. 308Shafton, A. 92Shaginian, A. 70Sharkey, L. 317, 321Sharpless, K.B. 89Sharpless, W. 89Shaw, D. 83Shekhter, T. 30, 212Shen, Z. 201Shenoy, S. 11Shenvi, R.A. 69Shepard, C. 193Sherman, A. 356Sherman, L.A. 139Shi, J. 276Shi, Y. 72Shigeoka, A. 125Shikhman, A.R. 245Shimada, S. 116Shin, D.S. 167Shin, J. 75Shin, W. 53Shivakumar, D. 189Shore, D.A. 160Shumilak, K. 122Shur, O. 279Sidhpura, N. 319Sidney, J. 292Siefker, D. 41Siegel, S. 81Siggins, G.R. 312, 315, 317,

321Siladi, M.E. 219Silva, F. 208Sim, J. 141Simanski, S. 351Singh, P. 39, 218Sinha, M. 212Sinha, S. 85Sinha, S.C. 214Sipe, J.C. 271

Sitia, G. 269Siuzdak, G. 201Skog, P. 128Slattery, D. 307Slavin, D. 227Slawecki, C.J. 316Slown, C. 70Smith, A. 351Smith, C. 201Smith, J.G. 130Smith, P.A. 86Smith, R. 304Snyder, E.Y. 258Sobel, D.F. 251Sobieszczuk, P. 233Solel, E. 212Solforosi, L. 148Solorio-Alvarado, C. 83Sonderegger, M. 201Song, B.D. 49, 92Soragni, E. 186Soreni, M. 212Sorg, A. 345Soulet, F. 49Sovath, S. 104Speir, J. 216Spencer, K. 36Sperling, E. 202Spicer, T. 365Spiropoulou, C. 295Springsteen, G.G. 207Stagg, S. 25, 28Stanfield, R.L. 108, 160Stathakis, C. 83Steardo, L. 320Stefanko, R.S. 141, 160Steiniger, S. 78Stengel, G. 187Sternik, G. 114Stevens, J. 160Stevens, R.C. 173Stewart, L. 233Stewart, P. 130Stinus, L. 304Stotland, A. 136Stouffer, D. 310Stout, C.D. 170, 220, 221,

265Stowers, L. 50Strosberg, A.D. 358Stroupe, M.E. 160Stuempfig, N.D. 319Stuhlmann, H. 51Sturny, A. 357Subauste, C. 47Subramaniam, P. 357Subramanian, V. 37, 173Sue, S.C. 183Sugase, K. 178Sugawara, A. 89Sugiyama, M. 94Suk, J.Y. 81Sullivan, N.L. 109Summerer, D. 88Sun, C. 111Sun, P. 228Sundaresan, V. 170Sundheim, O. 167Sundstrom, M. 220

Supekova, L 88Surh, C.D. 140Suri, J. 208Surka, M. 49Sutcliffe, J.G. 229–231Suzuki, T. 83Suzuki-Inoue, K. 262Svensson, T. 307Swairjo, M. 203Swan, C.H. 265Szainer, P. 25Szewczyk, P. 169Szurmant, H. 25, 253, 255Szymczyna, B. 202Tabarean, I. 322Tabarin, A 320Taffe, M.A. 318Tagoe, C. 279 Tainer, J.A. 56, 167Takahashi, S. 180Takanashi, S. 72Takao, K. 345Takaoka, L. 70Tam, K. 220Tama, F. 193 Tamura, K. 203Tan, J. 306Tanaka, F. 208Tang, A. 37 Taniguchi, N. 246Tao, H. 70 Tassew, N. 187Tate, S. 27Tateno, H. 233 Taylor, E. 227Taylor, J.A. 56Taylor, K. 118Tedesco, D. 222Tellinghuisen, T.L. 359Tennant, L.L. 178, 180, 183Teyton, L. 141 Thalji, R. 345Thayer, D. 94Theofilopoulos, A.N. 142Thielges, M.C. 86 Thomas, D. 39 Thomas, E.A. 230Thompson, K. 29Thonberg, H. 346Thorpe, I.F. 193Thurbon, D. 314Tian, H. 233Tian, X. 283Tichenor, M. 70Tiefenbrunn, T. 30Tilley, R.E. 123Timmons, J.A. 346Ting, J.P.C. 291–293Tippmann, E. 88Tipton, J.D. 365Tiraby-Nguyen, C. 36Tishon, A. 295Tobias, P.S. 109, 145Tonnu, L. 260Torbett, B.E. 220, 256, 265Torres-Bacete, J. 250Tortosa, M. 345Toulon, A. 117Tran, H.G. 340

Tran, M. 37Trauger, S. 201Treadaway, J.C. 359Trenney, R.L. 139Treweek, J. 78Tria, G. 83Trifilo, M. 295, 296Tripp, J. 89Tripp, M.C. 193, 218Tripurenani, S. 92Trombley, J. 33Troseth, R. 92Truksa, J. 270Truong, P. 299Trzupek, J. 70Tsai, S. 186.Tsao, M.-L. 88Tsatmali, M. 120, 330Tschan, M.P. 265Tschulena, U. 208Tsinoremas, N.F. 368Tsuda, M. 246Tsvetanova, B. 252Tubbs, J.L. 160Turner, C. 83Tuttle, L.M. 183Tzima, E. 203Ulevitch, R.J. 102, 146Umezawa, T. 83Underwood, L. 313Unger, V.M. 56Unwin, N. 52Uritboonthai, W. 201Uryu, S. 137Utsintong, M. 195Utsumi, N. 208Uusitalo, T. 21Uusitalo-Jarvinen, H. 33Uy, H. 104Uzawa, T. 180Uzzell, V. 46Valbracht, J. 245Va, P. 345Valenta, D.T. 109Valente, D. 264Vallee, S. 114Valo, M. 120Van Anda, H. 15Van der Schans, E.J.C. 187van der Stap, L. 314van Drogen, F. 222Van Leeuwen, E.M.M. 140Vanderklish, P.W. 330, 332Vareille, G. 195Vanhnasy, J. 160Varga, J. 111Varughese, K.I. 255Vasilu, D. 233Vela, J. 128Velasquez, J. 173Velcicky, J. 70Venable, J. 55Venkataiah, B. 74Venter, P.A. 219Verdino, P. 160Vereyken, E. 303Versteeg, H. 134Vetter, S. 221Villena, J. 36


Vlkolinsky, R. 317Vogt, P.K. 276Vojkovsky, T. 368Volonterio, A. 151Von Allmen-Zurcher, N. 141Von Huben, S.N. 318von Loehneysen, K. 120Voytek, S.B. 207Waalen, J. 270Waas, W. 203Wada, S. 169Wagner, S. 251Wahlestedt, C. 346Walker, B. 304Walker, R.C. 189Wang, A. 137Wang, C. 141Wang, H. 92Wang, J. 83, 88, 278Wang, L. 173, 270Wang, M. 108Wang, S.-K. 94Wang, X. 89Wang, Z. 283Want, E. 201Ward, A.B. 44, 169Warrington, J. 264Wassenaar, J. 89Watanabe, M. 117Waterman-Storer, C. 53Watry, D. 294Watson, L. 112Watson, S.P. 262Webb, S. 45Webb, W. 201Weber, J.L. 306Weber, K. 32Wee, S. 304Wei, C.H. 139Weide, T. 89Weinkam, P. 86Weiss, F. 319Weissman, C. 355, 356Welsh, D.K. 340 Wennmalm, K. 346Wentworth, A.D. 92Wentworth, P. Jr. 92, 271, 357West, C. 270Whalen, L. 94Wheeler, A. 53Wheeler, R. 193Whiby, L. 70White, R.A. 253Whitefield, B. 69Whitelock, J. 117Whiting, M. 89Whitley, K. 104Whitmire, J.K. 269, 301Whitton, J.L. 293, 301Wieland, S.F. 267Wiethoff, C. 130Wikoff, W. 201Wildman, C. 193Williams, A. 345Williams, J. 225Williams, R.C. 167Williamson, J.R. 202Williamson, R.A. 148Willis, A. 78

Wills, D. 302, 316Wilson, A. 252Wilson, C.A. 264Wilson, I.A. 108, 150, 160Wilson, R.F. 221Wilson-Kubalek, E.M. 44Winbush, S. 345Winzeler, EA. 54Wise, E. 160Wiseman, R.L. 81Witherden, D. 117Witkowski, J.A. 265Wittenberg, C. 224Wohlschlegel, J. 55, 222Wojciak, J. 178Wong, C. 55Wong, C.-H. 94Wong, D. 201Wong, J. 139Wood, T.I. 165, 167Wright, P.E. 158, 178, 180Wu, C.C. 116Wu, C.-Y. 94Wu, D. 94Wu, P. 89 Wu, W. 111, 122Wu, X. 276Wuchrer, M. 94Wüthrich, K. 177Xia, Y. 104Xiang, R. 111, 131, 149Xie, C. 116Xiong, W. 72Xu, C.R. 112 Xu, H. 83 Xu, L. 160Xu, T. 55Xu, X. 160, 259 Xu, Y. 72, 78, 116Yachi, P. 114Yadav, D. 136 Yadav, M. 37, 294Yadav, M.K. 173Yagi, T. 250Yamada, Y. 225Yamagata, A. 167Yamaguchi M. 170 Yamasaki, R. 75Yamashita, T. 250Yan, M. 278 Yang, A.H. 232Yang, G. 29Yang, X. 259Yang, X.-L. 203Yang, Y.-Y. 94Yano, J.K. 246Yao, S. 72Yao, Y. 180, 183Yarar, D. 49Yasuda, M. 42Yasuda, R. 42Yates, J.R. III 55, 258, 264Ye, M. 120Ye, X.Q. 232Ye, Y. 208Yeager, M. 56, 271, 291Yegneswaran, S. 259Yeung, B. 278Yi, J. 280

Yin, X. 278Yin, Y. 169Ying, G. 295, 296Yonemoto, I. 25, 81Yoo, Y.S. 75Yoon, S.-H. 106York-DeFalco, C. 294Yoshida, K. 141, 246Yoshimoto, K. 193Yoshioka, C. 28, 44, 291Yoshizuka, N. 228Young, B.M. 344Young, J. 54Young, T. 88Yu, J. 169Yu, W. 86Yu, Z. 81Yuan, Y. 208Yuem, D. 72Yung, Y. 232Zajonc. D.M. 160Zak, M. 83Zal, M.A. 114Zal, T. 114Zandonatti, M. 294Zastrow, G.M. 344Zeeb, M. 178Zelder, F. 11, 15Zeng, Y. 233Zhang, D.-E. 278Zhang, E. 340Zhang, H. 106, 208Zhang, H.-Y. 346Zhang, Q. 88, 172, 195Zhang, W. 189, 274Zhang, Y. 70 Zhang, Y.Q. 136Zhao, J. 343Zhao, L. 276Zhao, T. 106Zhao, Y. 72, 195, 320Zhong, J. 267Zhou, B. 78Zhou, H. 78, 131, 149Zhou, M. 357Zhu, L. 232Zhu, P. 189Zhu, S. 88Zhu, W.H. 160Zhu, X. 72Ziegler, J. 189Zijlstra, A. 47Zimmerman, J. 86Zlokovic, B.V. 259Zoni, C. 85Zorrilla, E.P. 319, 320Zou, Z. 51Zuniga, E. 295Zwick, M.B. 108, 150


S u b j e c t I n d e x

Acetogenins 215Actin 29, 32, 53Actin filaments 36 Activated protein C 132, 259Acute respiratory distress

syndrome 133Adaptive immunity 125, 131,

134, 141 Adenovirus gene transfer 129Addiction 304, 310, 313, 319Adhesion 262Aging 142, 168, 343AIDS. See HIV infection.Alcohol 305, 313, 316, 318,

320animal models of exposure

during adolescence and adulthood 316

neurobiological mechanisms of consumption 316

Alcohol. See also Ethanol.Alcohol dependence 308Alcoholism 302, 309 Algae 41Allergy 283 Alloantigens 125Allostasis 305Alzheimer’s disease 81, 93, 223,

343Amygdala 317Amyloid diseases 81, 279Amyloidogenesis 81Analytical chemistry 74Anemia 280Angiogenesis 33, 47, 51, 123,

134, 275Anthrax 219Anthrax toxins 106Antibiotics 84Antibodies 161

expression in chloroplasts 41phage display 209to HIV 108, 209 to tumors 209to viruses 109

Antibody genes 112Antibody repertoire 112Antibody-catalyzed water

oxidation pathway 92Anticancer agents 84

(+)-CC-1065 70 chemistry of 70duocarmycins 70

Antidepressants 322Antisense therapy 291Antiviral responses 116Apomyoglobin 180Apoptosis 43, 123, 259, 271Arousal 229 Arthritis 280Asthma 212Asymmetric synthesis 208Ataxia telangiectasia–like

disorder 276Atheronals 93Atherosclerosis 93, 109, 146 Autism 85

Autoimmunity 112, 136, 139,141, 282, 301antitumor 144genetics of 142inhibition of cell cycle in 143role of p21 143

Autophagy 272B cells

antigen recognition by 128immune learning in 128memory 125repertoire 112

Bacteriapilus 168sporulation of 252, 254

Base J DNA 94Biocatalysis 205Biofilms 255Bioinformatics 199, 218Biological chemistry 88Biomarkers 368Biomolecular computing 212Biomolecular sensors 40Bioorganic chemistry 70, 94Biosensors 166Botulinum neurotoxin 78Bovine spongiform

encephalopathy 148Brain-computer interface 311Brain peptides 315Breast cancer 121, 147, 149,

258, 275Calcium channels 303Cancer 38, 47, 122, 131, 134,

142, 187, 223, 227, 228, 266, 274, 276, 278, 368

design of therapeutic antibodies 209

Cannabinoids 273, 315Carbohydrate chemistry 95Carcinogenesis 121Cardiac gap junctions 57Cardiac remodeling 124Cartilage 245Catalysis 74, 90 Catalytic antibodies 88, 161,

208, 215in transgenic plants 212

Cavitands 15Cell cycle

checkpoints 225, 227, 276 control in mammalian cells

223control in yeast cells 222regulation of 224ubiquitin-mediated proteolysis

in 351Cell migration 29, 53, 137Cell morphogenesis 31Cell motility 31, 53Cell recognition molecules 46Cellular differentiation

sporulation 252Chaperones 82, 182Chaperonins 177, 184Charcot-Marie-Tooth disease

205Chemical biology 83Chemical synthesis 83

Cheminformatics 199Chemobodies 210Chemokine receptors 265Chemokines

in the CNS 309Chlamydial infection 122Chloroplasts 41Cholecystokinin 85Chondrocytes 245Chondrogenesis 246Chromosome segregation 30Chronic wasting disease 296Circadian clocks 340Clathrin 49Click chemistry 74, 89CNS development 45Coagulation 111, 123, 132,

134, 259, 260, 261Cocaine 161, 304, 310, 313,

319 Cocaine addiction 79Cocaine antibodies 198Cognition 42Combinatorial chemistry 72, 88Combinatorial libraries 214Complex I defects 250Computer modeling

of proteins and nucleic acids 189

Conformational diseases 25Consortium for Functional

Glycomics 235Copper-catalyzed cycloadditions

90Coreceptor switching 126Creutzfeldt-Jakob disease 148Cyclins 223 Cystic fibrosis 25Cytochrome ba3 171Cytochrome oxidases 170 Cytochrome P450s 170, 246 Cytokines 127, 274

gene expression 116in T-cell homeostasis 140

Cytolysins 45Cytoskeleton 29, 32, 53, 106 Cytotoxic T lymphocytes

in HBV virus infection 266, 267

Deafness 46Dendrimers 91Demyelination 292Dendrites 333Dendritic cells 125, 131 Dendritic spines 36Dengue fever 136Depression 231, 321

genetics of 344Diabetes 37, 118, 136, 139,

141, 256, 341, 343Differentiation 351Directed evolution 207, 209DNA alkylating agents 70DNA damage 87, 225, 227DNA enzymes 188, 207 DNA repair 167, 225, 227DNA replication 276 DNA sensors 76DNA vaccines 131, 149, 301

Docking 196, 200Doublecortin 45Drug abuse 273, 302, 312,

313, 318, 319mechanisms of 317

Drug addiction 273Drug dependence 314Drug discovery 346, 357, 365Dynamin 49Dyslipoproteinemia 260Dystroglycan 257Ecstasy 318Electron cryomicroscopy 56Electrostatics 191Emerging viruses 109Emotion 307Encephalitis 294Endocannabinoids 310Endocytosis

regulation of 49Endoglin 149Endothelial cells 51, 132 Endotoxemia 124Endotoxin 146Energy transduction 171Enzyme inhibitors 95 Enzymes

DNA 207evolution of 87RNA 207structure and dynamics of 183synthetic 212

Epilepsy 85Ethanol 310, 312

CNS action of 317Evolution 86Familial amyloidotic

polyneuropathy 81Familial amyotrophic lateral

sclerosis 167Fatty acid amide hydrolase 174,

273 Fatty acid synthase 25 Feeding 320Feeding behavior 229Feline immunodeficiency virus

as AIDS model 220proteases of 221receptors for 220

Fiber-optic array scanning technology 38

Flavonoids 248Flexibility modeling 196Fluorescence spectroscopy

of nucleic acids 187Fluorescent speckle microscopy

53Focal adhesion kinase 137Forward genetics 104Fragile X syndrome 332Friedrich’s ataxia 187Functional genomics 264Galanin 85, 318, 321Gap junctions 57Gaucher disease 82, 197, 270Gelsolin 82Gene delivery 122, 265 Gene expression profiles 369Gene silencing 281


Genetic alphabet 87Genetic code 203Genetic diseases 270, 279Genomic stability 227Genomics 54, 72, 175, 346Ghrelin 321Glaucoma 248 Glioblastoma multiforme 34Glitazones 341Glucose transporters 245Glutaredoxin 31Glycobiology 95, 233Glycoproteins 135, 263 Griscelli syndrome 248GTPases 25, 120Hair cells 46Heart disease 279, 296α-Helix mimetics 15Hemangiomas 34Hematopoiesis 265, 278Hemochromatosis 270Hemophilia 262Hemorrhagic fever 135Hepcidin 270Hepatitis B virus 58, 266, 267 Hepatitis C virus 267, 268,

358, 359 Hepatocellular carcinoma 359Heroin 310 High-throughput screening 365Hippocampus 303

drug effects on 317Histone deacetylase inhibitors

187HIV infection 113, 114, 126,

170, 220, 265, 281design of therapeutic

antibodies 210human antibodies to 108neutralizing antibodies to 162SIV model of 294

HIV proteases 197HIV vaccines 31, 150HLA-G 256Homeostasis 140

in cartilage 245of T cells 142of T-cell memory cells

Homoserine lactones 147Host resistance 104Human-computer interfaces 195Huntington’s disease 230Hydrogen-deuterium exchange

342Hypocretins 229Image processing 56Immune memory 125Immune privilege 256Immunocytotherapy 299Immunodeficiency 247Immunodominance 301Immunoglobin E 283Immunoglobulins 162Immunologic synapse 115Immunosuppression 133 Inflammation 92, 109, 120,

123, 132, 145, 146, 259Infections 104, 120Influenza virus 160, 217, 235

Innate immunity 106, 114,116, 120, 125, 129, 131,

134, 141, 145, 146, 160Insulin-degrading enzyme 343Insulin resistance 341Insulin signaling 55Integrins 57, 138, 215, 257,

262in breast cancer 258in the CNS 46

Interferons 143, 301Intravasation 48Ion channels 47, 52, 303Iron metabolism 270Iron overload 279Ischemia 123, 257, 271 Joint injury 245Kinesins 44Lassa fever 300Learning 43 Legumain 111, 122Leishmaniasis 357Leukemia 278Leukocytes 106, 120Ligand discovery 199Ligand recognition and

specificity 162Lipid chemistry 172Lipoproteins 260Lung epithelium 120Lymphocyte trafficking 133Lymphocytes

regulation of function 119Lysophospholipids 232α2-Macroglobulin 111Macular degeneration 248 Malaria 54MAP kinases 116, 120 Mass spectrometry 55, 365

of human metabolites 201of peroxisome proliferator-

activated receptors 342of viruses 201on silicon 201

Materials chemistry 74MDMA 318Mechanosensory perception 45Mechanotransduction 245Medicinal chemistry 345Membrane channels

cardiac gap junctions 57Membrane proteins 169, 170,

172topogenesis of 33

Memory 42, 303Metalloenzymes 191, 221Metalloproteins 166Metastasis 38, 47, 123, 258MHC molecules 162MicroRNA 116Microtubules 29, 36 , 44, 53 Microvessels 257Mitochondria 36, 250 Molecular assemblies 194Molecular biophysics 193Molecular dynamics 189Molecular graphics 195Molecular imaging 28Molecular machines 24, 29, 44

Molecular microscopy 28Molecular neurobiology 230Molecular recognition 15Molecular wires 222Monocytes 43Motivation 229, 307Mouse models of behavior 313Multidrug resistance 45, 169Multiple sclerosis 251Muscle repair 332Muscular dystrophies 35Myelin 230Myeloid development 265Myocardial infarction 271Myocarditis 301Myosin 44NADH dehydrogenases 250NADPH oxidase 248Nanodiscs 170NanomedicineNanoparticles 130Nanotechnology 39, 217, 220Nanotubes 76Natural killer cells 131Natural products 69, 70, 83,

215, 345 Necrosis 271Neural aneuploidy 232Neural circuits 27Neuregulins 306NeuroAIDS 294Neuroactive steroids 303Neuroadaptation 304Neurodegeneration 343Neuronal differentiation 330Neuronal plasticity 314Neurons 27, 50, 257, 309

cytoskeletal organization and function of 36

Neuropeptides 305, 312, 316,317, 321

Neurotoxins 174Neurotransmitters 173Neutrophils 247Neurovascular unit 257Nicotine 305, 307

animal models of exposure during adolescence and adulthood 316

dependence 308 Nijmegen breakage syndrome

276Nitric oxide synthases 165,

167, 221 Nitrogenase 191Nociceptin/orphanin FQ 319Nuclear envelope 34, 115Nuclear lamina 34Nuclear magnetic resonance

spectroscopy 177Nuclear magnetic resonance

189of enzyme catalysis 183of IκBα 184of prions 183of protein folding 180of proteins in solution 178

Nuclear pore complexes 34Nucleic acid enzymes 188

Nucleic acids 205 computer modeling of 189function and dynamics of 87structure of 73, 187

Nucleocytoplasmic transport 34Nucleus accumbens 317Obesity 273 Possessive-compulsive disorder

231Olfaction 27, 50Oncogenesis 228, 276Opioids 85, 317Organic chemistry 74Organic synthesis 212, 214 Organocatalysis 209Organometallic chemistry 212Osteoarthritis 245Osteoarthritis. See also arthritis. Oxidative metabolites 82 Oxidative stress 225, 248, 280 Ozone scavengers 212p21-Activated kinases

in cellular regulation 106P450s 222Pain 47, 85Parkinson’s disease 81, 223,

343Phage display 79Pharmacogenomics 346Phenylalanine hydroxylase 173Phenylketonuria 173Pheromones 50Photoactive proteins 165Photoreceptors 340Plasminogen 43Platelets 262, 269Pleiotrophin 274Polyamides 186Prebiotic chemistry 77Prion diseases 148, 357Prions 148, 183, 296, 356, 357Prodrug therapy 111, 215Programmed cell death.

See Apoptosis.Prohormone processing 43Proteases 214Proteasomes 222Protein C 132, 259 Protein design 89, 218 Protein engineering 30, 221Protein folding 81, 180, 184,

189, 193 Protein kinase inhibitors 368Protein kinases 222 Protein misfolding 93Protein misfolding diseases 81,

279Protein modification 278Protein phosphatase 2C

inhibitors 198Protein-protein interactions 38,

358Protein S 260Protein structure 38, 163, 177Protein trafficking 163

and conformational diseases 25

Protein Z-dependent proteaseinhibitor 261


Proteinscarbohydrate binding 233computer modeling of 189 design of 166function and dynamics of 87glycan binding 233predicting interactions of 197structure and function 175 structure of 165, 178, 197,

199 Proteolysis 222Proteomics 37, 55, 365 Purkinje neurons 303Quantum chemistry 191Quorum sensing 182Reactive oxygen species 120,

330Receptors

design of inhibitors 95endothelial cell protein C 132ErbBs in the nervous system

306estrogen-related receptor α 37 for acetylcholine 52for adenoviruses 129for γ-aminobutyric acid 317 for B cells 233for cannabinoids 310, 315 for corticotropin-releasing

factor 305, 316, 318, 321 for FIV 220for galanin 321for HIV 113, 126for IgE 283for IL-2 160 for Lassa virus 300for NMDA 317for nociceptin/orphanin FQ 319for opioids 317for sphingosine 1-phosphate

133G protein–coupled 232, 347 in innate immunity 141in nicotine withdrawal 307metabolic glutamate 319NKG2D 131Nod proteins 146on T cells 162peroxisome proliferator-activated

341protease activated 124, 132,

134 T cell 114, 141Toll-like 105, 109, 116, 120,

129, 145, 146, 160, 292Regenerative medicine 72Reperfusion injury 123, 271Response regulators 254Restriction factors 114Retinoid homeostasis 78Retinopathies 33Reverse genetics 298, 299Reward 307Rho GTPases 106Ribonucleoproteins 188Ribonucleotide reductases 192Ribosomes 41, 189, 331

assembly of 202 Ribozymes 188, 205

Ribozymes. See also RNAenzymes.

RNA enzymes 207RNA interference 116, 189,

281, 346RNA

mechanisms of assembly and catalysis 205

noncoding 112RNA-binding proteins 330Rubinstein-Taybi syndrome 42San Diego Alcohol and

Minorities Project 302Schizophrenia 230, 231Schwann cells 306Scrapie 296Seco-sterols 93Selective serotonin reuptake

inhibitors 344Senescence 229Sensor kinases 252Sensory neurons 46Sepsis 123, 132 Severe acute respiratory

syndrome 177, 291Shock 105Sialosides 234Siglecs 233Signaling 42, 51, 105, 106,

116, 120, 121, 129, 133, 134, 138, 146, 162, 174, 205, 232, 253–255, 274, 303, 306, 310, 351

by proteases 132in coagulation 132in immune tolerance 125in 2-component systems 253response regulators in 254

Single-molecule analysis 76Single-molecule biophysics 189SIV infection

as AIDS model 294Sleep 231Sodium-calcium exchangers 34Stem cells 33, 51, 72, 330

in treatment of brain metastases 258

Stress 36, 304, 320 Stroke 257, 260 Structural biology 24, 167,

173, 177, 195Structural genomics 177Superoxide dismutases 167, 280Synapses 36, 42, 332 Synaptic plasticity 314, 332Synaptic transmission 52Syndecans 113Synthetic chemistry 70, 94 Synthetic methods 345Synthetic systems 75α-Synucleinopathies 82Systemic lupus erythematosus

interferons in 143mouse models of 142role of cell-cycle genes 144role of T cells 144

Systems biology 54Sumoylation 55T cells 139

activation of 114, 117 antiviral function of 301development of 114helper 127homeostasis of 140, 142in autoimmunity 142in regulation of B-cell

immunity 125in SIV infection 294in transplantation 256in tumor immunity 131in viral infections 296 in viral persistence 295, 299in wound healing 118induction of tolerance 125intraepithelial γδ T cells 117,

118memory 140 regulation of development 119regulatory 369selection of 125thymic selection 119

Tangible interfaces 195Tetratricopeptide repeats 254Thermoregulation 322Thermosensation 46ThermoTRPs 47Thrombosis 111, 123, 260 Thymus 119 Tissue factor 111, 123, 134,

197Tissue plasminogen activator

260Tobacco. See Nicotine.Tolerance 125, 131, 139, 144 Toll-like receptors

in coronavirus infection 292Total synthesis 69Toxins 252Transcription 277, 346, 351

and adaptation to environmental stimuli 224

in chondrogenesis 246in vertebrate development 332regulation of 24, 178, 187,

224Transcription factors 178, 277,

332in myeloid development 265

Transcriptional coactivators 37Transformation 229 Transgenic mice

as models for chronic wasting disease 296

Transhydrogenase 170Translation 330–332

in algae 41in chloroplasts 41role of tRNA 203

Translational neurophysiology302

Transmissible spongiformencephalopathies 296, 356,

357Transplantation 125, 256, 264 Transporters 169Transthyretin 81, 279tRNA synthetases 203Tropomodulins 32

Tumor eradication 111, 112Tumor immunity 139Tumor markers 112Tumor targeting 39Tumorigenesis 121, 138, 228 Tyrosine protein kinases 137Urocortins 321Vaccine design 135Vaccines 292

antiviral 301to HIV 108

Vascular imaging 39Vasculogenesis 51Vesicular transport

GTPase regulation of 26Viral clearance 269Viral nanoparticles 40, 51Viral pathogenesis 301Viral persistence 267, 295, 299 Virtual ligand screening 199Viruses

adenoviruses 122, 129, 130 antibodies to 109arenaviruses 293, 298 assembly of 219Borna disease virus 299canine parvovirus 40 coronaviruses 177, 291, 292cowpea mosaic virus 40, 217 coxsackievirus 301Dengue virus 136, 214DNA virus 216Ebola virus 109, 135feline immunodeficiency virus

220 Flock House virus 217, 219for delivery of anthrax

antitoxins 219for treating cocaine addiction

79hepatitis B virus 58, 266, 267 hepatitis C virus 267, 268,

358, 359 HK97 bacteriophage 216icosahedral 219influenza virus 217, 296 Lassa virus 293, 300, 301 lentiviruses 221lymphocytic choriomeningitis

virus 269, 293, 296, 298, 299

measles virus 296mouse cytomegalovirus 105mouse hepatitis virus 291, 292nodaviruses 219 P22 bacteriophage 216retroviruses 220RNA viruses 217severe acute respiratory

syndrome–associated corona-virus 38, 177, 291, 292

simian immunodeficiency virus 294

structure of 177, 218, 291, 293

structure and function of 216sulfolobus turreted icosahedral

virus 216tetraviruses 217


tomato bushy stunt virus 219Visualization 195von Willebrand disease 263Werner syndrome 168Wound healing 118Xenobiotics 282Xenotransplantation 264Xeroderma pigmentosum 227X-ray crystallography 160

of cryptochrome 166of cytochrome oxidases 170of cytochrome P450s 170of fluorescent proteins 166of nitric oxide synthases 165of photoactive yellow protein

165of transhydrogenase 170

Zinc fingers 178, 210


A C K N O W L E D G M E N T S

The scientists who havecontributed sections to thisreport wish to acknowledgethe dedication and hard workof the laboratory technicianswho helped bring theresearch to fruition, theadministrative assistants whohave made it presentable forpublication, and the supportpersonnel who providedcritical specialized servicesand equipment.

EditorBarbara L. Halliburton, Ph.D.

Associate EditorLinda Wood, M.A.

Project ManagerJann CouryOffice of Communications

PhotographyMichael Balderas

Biomedical GraphicsDepartment, Scripps Research

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Printing and duplicationMaryland Composition

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Janette LundgrenThe Skaggs Institute for

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Marcia McRaeMolecular and Integrative

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Vicky Nielsen ArmstrongDepartment of Chemistry

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Department of Neurobiology

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