Axon targeting in the Drosophila visual system

Adult compound eye Eye imaginal disc

Recruitment of photoreceptors

Repo: glia

24B10

gigamesh mutant

Requirement of gish in eye epithelium, but not glial cells or differentiated R cells

Regulation of retinal basal glial cell migration

Hh and Spitz are transported in R axon to lamina for proliferation (Hh) and differentiaiton (Spitz)

Brakeless is required for R1-6 axon targeting

Brakeless is a nuclear Zn finger protein

Glia cells are required for R1-6 axon targeting

Nonstop controls glial cell migration

Nonstop: Ub protease, required in glial cellsJab1/CSN5: COP9 subunit, required in R cells for glial cell migration

LAR in R7 target selection

GEF

S/T kinase

AdaptorN-CAM