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Circulation VOLUME 61 January-June, 1980 No. 1 (January) Current Topics: Biostatistics: How to Detect, Correct and Prevent Errors in the Medical Literature ........ Stanton A. Glantz Original Articles: Cryosurgical Ablation of the Atrioventricular Node-His Bundle: Long-term Follow-up and Properties of the Junctional Pacemaker George J. Klein, Will C. Sealy, Edward L. C. Pritchett, Lura Harrison, Donald B. Hackel, Dwight Davis, Jackie Kasell, Andrew G. Wallace, and John J. Gallagher EDITORIAL: Trading Arrhythmia for Atrio- ventricular Block ...................... Kenneth M. Rosen, Ramesh C. Dhingra, and Christopher R. C. Wyndham The Belgian Heart Disease Prevention Project. Modification of the Coronary Risk Profile in an Industrial Population .............. Marcel Kornitzer, Guy De Backer, Michele Dramaix, and Claude Thilly EDITORIAL: Prevention of Cardiovascular Disease and Risk-factor Intervention Trials Lewis H. Kuller In-hospital Prognosis of Patients with First Non- transmural and Transmural Infarctions .... Samer Thanavaro, RonaldJ. Krone, Robert E. Kleiger, Michael A. Province, J. Philip Miller, Vincent R. deMello, and G. Charles Oliver The Dependence of Accumulation of 13NH3 by Myocardium on Metabolic Factors and Its Implications for Quantitative Assessment of Perfusion ............................ Steven R. Bergmann, Stanley Hack, Timothy Tewson, Michael J. Welch, and Burton E. Sobel Detection of Multivessel Coronary Disease After Myocardial Infarction Using Exercise Stress Testing and Multiple ECG Lead Systems Julio F. Tubau, Bernard R. Chaitman, Martial G. Bourassa, and David D. Waters Multiple-lead QRS Changes with Exercise Test- ing. Diagnostic Value and Hemodynamic Implications .......................... Julian L. Berman, Joshua Wynne, and Peter F. Cohn Production of Circulating Platelet Aggregates by Exercise in Coronary Patients ........... Andrew G. Kumpuris, Robert J. Luchi, Caroline C. Waddell, and Richard R. Miller, with the technical assistance of James A. Brown and Yolanda A. Repinecz 1 8 16 18 The Effect of Timolol vs Placebo on Angina Pectoris ............................. Wilbert S. A ronow, Marvin Turbow, Steven Van Camp, Mark Lurie, and Kenneth Whittaker Effect of Coronary Arterial Pressure on Coronary Stenosis Resistance .................... Jeffrey S. Schwartz, Peter F. Carlyle, and Jay N. Cohn Evaluation of Transluminal Angioplasty of Chronic Coronary Artery Stenosis. Value and Limitations Assessed in Fresh Human Cadaver Hearts ....................... Garrett Lee, Richard M. Ikeda, James A. Joye, Hugo G. Bogren, Anthony N. DeMaria, and Dean T. Mason Selective Coronary Arteriography in Children A. Formanek, P. H. Nath, C. Zollikofer, and J. H. Moller Distribution and Anomalies of Coronary Arteries in Tetralogy of Fallot .................. Roberto Piero Dabizzi, Giuseppe Caprioli, Luigi Aiazzi, Carlo Castelli, Giorgio Baldrighi, Lucio Parenzan, and Vincenzo Baldrighi Pulmonary Vascular Disease in Total Anomalous Pulmonary Venous Drainage ............ Edgar A. Newfeld, A llen Wilson, Milton H. Paul, and Joan S. Reisch Pulsatile Aortopulmonary Pressure-Flow Dy- namics of Patent Ductus Arteriosus in Patients with Various Hemodynamic States Madison S. Spach, Gerald A. Serwer, Page A. W. Anderson, Ramon V. Canent, Jr., and Aaron R. Levin Left Atrioventricular Valve Atresia: Clinical Management ......................... John J. Mickell, Robert A. Mathews, Sang C. Park, Cora C. Lenox, F. Jay Fricker, William H. Neches, and James R. Zuberbuhler 26 29 34 44 Observer Variance in the Qualitative Evaluation of Left Ventricular Wall Motion and the 53 Quantitation of Left Ventricular Ejection Fraction Using Rest and Exercise Multi- gated Blood Pool Imaging Robert D. Okada, Howard D. Kirshenbaum, 62 Frederick G. Kushner, H. William Strauss, Robert E. Dinsmore, John B. Newell, Charles A. Boucher, Peter C. Block, and Gerald M. Pohost, with the technical assistance of William H. Shea (Continued) iii 66 70 77 84 95 103 110 123 128 by guest on June 15, 2018 http://circ.ahajournals.org/ Downloaded from

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CirculationVOLUME 61

January-June, 1980

No. 1 (January)

Current Topics:Biostatistics: How to Detect, Correct and Prevent

Errors in the Medical Literature ........Stanton A. Glantz

Original Articles:Cryosurgical Ablation of the Atrioventricular

Node-His Bundle: Long-term Follow-upand Properties of the Junctional Pacemaker

George J. Klein, Will C. Sealy,Edward L. C. Pritchett, Lura Harrison,Donald B. Hackel, Dwight Davis, Jackie Kasell,Andrew G. Wallace, and John J. Gallagher

EDITORIAL: Trading Arrhythmia for Atrio-ventricular Block ......................

Kenneth M. Rosen, Ramesh C. Dhingra, andChristopher R. C. Wyndham

The Belgian Heart Disease Prevention Project.Modification of the Coronary Risk Profilein an Industrial Population ..............

Marcel Kornitzer, Guy De Backer,Michele Dramaix, and Claude Thilly

EDITORIAL: Prevention of CardiovascularDisease and Risk-factor Intervention Trials

Lewis H. KullerIn-hospital Prognosis of Patients with First Non-

transmural and Transmural Infarctions ....

Samer Thanavaro, RonaldJ. Krone,Robert E. Kleiger, Michael A. Province,J. Philip Miller, Vincent R. deMello, andG. Charles Oliver

The Dependence of Accumulation of 13NH3 byMyocardium on Metabolic Factors and ItsImplications for Quantitative Assessment ofPerfusion ............................

Steven R. Bergmann, Stanley Hack,Timothy Tewson, Michael J. Welch, andBurton E. Sobel

Detection of Multivessel Coronary Disease AfterMyocardial Infarction Using Exercise StressTesting and Multiple ECG Lead Systems

Julio F. Tubau, Bernard R. Chaitman,Martial G. Bourassa, and David D. Waters

Multiple-lead QRS Changes with Exercise Test-ing. Diagnostic Value and HemodynamicImplications ..........................

Julian L. Berman, Joshua Wynne, andPeter F. Cohn

Production of Circulating Platelet Aggregates byExercise in Coronary Patients ...........

Andrew G. Kumpuris, Robert J. Luchi,Caroline C. Waddell, and Richard R. Miller,with the technical assistance of James A. Brownand Yolanda A. Repinecz

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The Effect of Timolol vs Placebo on AnginaPectoris .............................

Wilbert S. A ronow, Marvin Turbow,Steven Van Camp, Mark Lurie, andKenneth Whittaker

Effect of Coronary Arterial Pressure on CoronaryStenosis Resistance ....................

Jeffrey S. Schwartz, Peter F. Carlyle, andJay N. Cohn

Evaluation of Transluminal Angioplasty ofChronic Coronary Artery Stenosis. Valueand Limitations Assessed in Fresh HumanCadaver Hearts .......................

Garrett Lee, Richard M. Ikeda, James A. Joye,Hugo G. Bogren, Anthony N. DeMaria, andDean T. Mason

Selective Coronary Arteriography in ChildrenA. Formanek, P. H. Nath, C. Zollikofer,and J. H. Moller

Distribution and Anomalies of Coronary Arteriesin Tetralogy of Fallot ..................

Roberto Piero Dabizzi, Giuseppe Caprioli,Luigi Aiazzi, Carlo Castelli, Giorgio Baldrighi,Lucio Parenzan, and Vincenzo Baldrighi

Pulmonary Vascular Disease in Total AnomalousPulmonary Venous Drainage ............

Edgar A. Newfeld, A llen Wilson, Milton H. Paul,and Joan S. Reisch

Pulsatile Aortopulmonary Pressure-Flow Dy-namics of Patent Ductus Arteriosus inPatients with Various Hemodynamic States

Madison S. Spach, Gerald A. Serwer,Page A. W. Anderson, Ramon V. Canent, Jr.,and Aaron R. Levin

Left Atrioventricular Valve Atresia: ClinicalManagement .........................

John J. Mickell, Robert A. Mathews,Sang C. Park, Cora C. Lenox, F. Jay Fricker,William H. Neches, and James R. Zuberbuhler

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Observer Variance in the Qualitative Evaluationof Left Ventricular Wall Motion and the

53 Quantitation of Left Ventricular EjectionFraction Using Rest and Exercise Multi-gated Blood Pool Imaging

Robert D. Okada, Howard D. Kirshenbaum,62 Frederick G. Kushner, H. William Strauss,

Robert E. Dinsmore, John B. Newell,Charles A. Boucher, Peter C. Block, andGerald M. Pohost, with the technical assistanceof William H. Shea

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CONTENTS OF VOLUME 61

Accuracy and Reproducibility of New M-modeEchocardiographic Recommendations forMeasuring Left Ventricular Dimensions ...

Michael H. Crawford, David Grant,Robert A. O'Rourke, Mark R. Starling, andBertron M. Groves

Detection and Estimation of the Degree of MitralRegurgitation by Range-gated Pulsed Dop-pler Echocardiography .................

A bdul S. A bbasi, Mary W. A llen,Dominic DeCristofaro, and Irvin Ungar

Limitations of Echocardiography in the Assess-ment of Left Ventricular Size and Functionin Aortic Regurgitation .................

Abdulla M. Abdulla, Martin J. Frank,Mario I. Canedo, and Miltiadis A. Stefadouros

Right Ventricular Performance in EssentialHypertension .........................

Jack Ferlinz

Contrasts and Similarities of Acute Hemody-namic Responses to Specific Antagonism ofAngiotensin II ([Sar', Thr8] A II) and toInhibition of Converting Enzyme (Captopril)

F. M. Fouad, J. M. K. Ceimo, R. C. Tarazi,and E. L. Bravo

Thrombosed Bjork-Shiley Mitral Prostheses ...H. Copans, J. B. Lakier, R. H. Kinsley,

P. R. Colsen, V. U. Fritz, and J. B. Barlow

Electrophysiology of Coronary Reperfusion. AMechanism for Reperfusion Arrhythmias . .

David K. Murdock, Jerod M. Loeb,David E. Euler, and Walter C. Randall

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Characteristics of Reflection as a Mechanism ofReentrant Arrhythmias and Its Relationshipto Parasystole ........................

Charles Antzelevitch, Jose Jalife, andGordon K. Moe

Cardiac Arrhythmias After Chronic Embolizationof the Sinus Node Artery: Alterations inParasympathetic Pacemaker Control .....

Jerod M. Loeb, David E. Euler, Walter C. Randall,John F. Moran, and Gissur Brynjolfsson148

Case Report:Recurrent Mycardial Infarction in a Young Man

Due to Coronary Arterial Spasm Demon-strated at Autopsy .....................

Nabil R. H. El-Maraghi and Brian J. Sealev

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Key References:Hypertensive Diseases ......................

compiled by Gerald R. Dreslinski andEdward D. Frohlich

Drug Management of Hypertension ...........compiled by Suzanne Oparil

Letters to the Editor ..... ........ 213

News from the American Heart Association . Ad page 44

No. 2 (February)

Original Articles:The Relationship Between Acute Occlusive Cor-

onary Thrombi and Myocardial InfarctionStudied in 100 Consecutive Patients .......

Malcolm D. Silver, Giorgio Baroldi, andFabio Mariani

Effectiveness of Dipyridamole in Reducing theSize of Experimental Myocardial Infarction

Arthur J. Roberts, Jerome G. Jacobstein,Paul R. Cipriano, Daniel R. Alonso,John R. Combes, and William A. Gay, Jr.

Prognostic Value of a Single Exercise Test 3Weeks after Uncomplicated MyocardialInfarction ............................

Dennis M. Davidson and Robert F. DeBuskRegional Assessment of Myocardial Metabolic

Integrity In Vivo by Positron-emissionTomography with "C-labeled Palmitate ...

Michel M. Ter-Pogossian, Milton S. Klein,Joanne Markham, Robert Roberts, andBurton E. Sobel

Myocardial Lactate Extraction: Multi-determinedMetabolic Function ....................

Edward W. Gertz, Judith A. Wisneski,Richard Neese, Alan Houser, Richard Korte,and J. David Bristow

Effect of Non-nicotine Cigarettes and CarbonMonoxide on Angina ...................

Wilbert S. Aronow

219 Effects of Low and High Glucose in a Glucose-Insulin-Potassium Infusion on Hemody-namics and Exercise Tolerance in Patientswith Angina Pectoris ...................

Udho Thadani, Miguel A. Chiong, andJohn 0. Parker

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Treadmill Score Quantifies ElectrocardiographicResponse to Exercise and Improves TestAccuracy and Reproducibility ...........

Milton Hollenberg, W. Roger Budge,Judith A. Wisneski, and Edward W. Gertz

Clinical and Angiographic Correlates of Exercise-induced ST-segment Elevation. IncreasedDetection with Multiple ECG Leads ......

David D. Waters, Bernard R. Chaitman,Martial G. Bourassa, and Julio F. Tubau

Contribution of Dynamic Vascular Wall Thicken-ing to Luminal Narrowing During CoronaryArterial Constriction ...................

Rex N. MacAlpin

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vCONTENTS OF VOLUME 61

Lipoprotein Cholesterol Distributions in SelectedNorth American Populations: The LipidResearch Clinics Program Prevalence Study

Gerardo Heiss, Israel Tamir, Clarence E. Davis,Herman A. Tyroler, Basil M. Rifkind,Gustav Schonfeld, David Jacobs, andIvan D. Frantz, Jr.

Renal Effects of Nitroprusside and Hydralazinein Patients with Congestive Heart Failure

John J. Cogan, Michael H. Humphreys,C. Jeffrey Carlson, and Elliot Rapaport

Effect of Hydralazine on Renal Failure in Patientswith Congestive Heart Failure ...........

Gordon L. Pierpont, David C. Brown,Joseph A. Franciosa, and Jay N. Cohn

Effects of Nitroprusside on Venous Return andCentral Blood Volume in the Absence andPresence of Acute Heart Failure .........

Hubert Pouleur, James W. Covell,and John Ross, Jr.

Hemodynamics of a New Angiotensin Antagonist[Sar', Thr8] A II, in Hypertensive Man

Robert J. Cody, Jr., Robert C. Tarazi,Fetnat M. Fouad, and Emmanuel L. Bravo

Mechanisms of Blood Flow During Cardiopul-monary Resuscitation ..................

Michael T. Rudikoff, W. Lowell Maughan,Mark Effron, Paul Freund, andMyron L. Weisfeldt

The Effect of the Pericardium on VentricularSystolic Function in Man ...............

Dennis T. Mangano

Effects of Propranolol on Left Ventricular Func-tion in Normal Men ....................

Steven Port, Frederick R. Cobb, andRobert H. Jones

Accuracy of Subxiphoid Echocardiography forAssessing Left Ventricular Size and Per-formance ............................

Mark R. Starling, Michael H. Crawford,Robert A. O'Rourke, Bertron M. Groves,and K. Wray Amon

Echocardiographic Documentation of VegetativeLesions in Infective Endocarditis: ClinicalImplications ..........................

James A. Stewart, Diana Silimperi, Philip Harris,N. Kent Wise, Theodore D. Fraker, Jr.,and Joseph A. Kisslo

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Pulsed Doppler Echocardiographic Study ofMitral Stenosis .......................

Christian Thuillez, Pierre Theroux,Martial G. Bourassa, Didier Blanchard,Pierre Peronneau, Jean-Leon Guermonprez,Benoit Diebold, David D. Waters, andPierre Maurice

Hemodynamic Factors That Affect CalculatedOrifice Areas in the Mitral Hancock Xeno-graft Valve ...........................

Josk L. Ubago, Alvaro Figueroa, Thierry Colman,Alberto Ochoteco, and Carlos G. Duran

Comparison of Endocardial Catheter Mappingwith Intraoperative Mapping of VentricularTachycardia ..........................

Mark E. Josephson, Leonard N. Horowitz,Scott R. Spielman, Allan M. Greenspan,Christine VandePol, and Alden H. Harken

Quantification of Aortic Valvular Regurgitationin Dogs by Nuclear Imaging .............

Ronald H. Baxter, Lewis C. Becker,Philip 0. Alderson, Pierre Rigo,Henry N. Wagner, Jr., and Myron L. Weisfeldt

Valve Replacement in Aortic Insufficiency withLeft Ventricular Dysfunction ............

David G. Clark, John H. McAnulty, andShahbudin H. Rahimtoola

Aortic Valvulotomy in Neonates ..............L. Henry Edmunds, Jr., Henry R. Wagner,and Michael A. Heymann

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Right Ventricular Volume Determinations in 18Patients with Pulmonary Atresia and IntactVentricular Septum. Analysis of Factors In-fluencing Right Ventricular Growth .......

Raman G. Patel, Robert M. Freedom,C.A.F. Moes, Kenneth R. Bloom,Peter M. Olley, W. G. Williams,George A. Trusler, and Richard D. Rowe

Characterization of the Cardiomyopathy in

Infants of Diabetic Mothers .............

Howard P. Gutgesell, Michael E. Speer,and Harvey S. Rosenberg

Ethmozin, A New Antiarrhythmic Drug forSuppressing Ventricular Premature Com-plexes ...............................

Philip J. Podrid, Anatoli Lyakishev,Bernard Lown, and Nicholai Mazur

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Key References:Modification of Infarct Size ..... ............ 458

compiled by Robert Roberts

Letters to the Editor ....... ................ 460

News from the American Heart Association .... Ad page 54

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CONTENTS OF VOLUME 61

No. 3 (March)

Dickinson W. RichardsLecture:

Circulatory Adjustments to Hypoxia ..........Donald D. Heistad and Francois M. Abboud

Original Articles:Observations on the Optimum Time for Operative

Intervention for Aortic Regurgitation. I.Evaluation of the Results of Aortic ValveReplacement in Symptomatic Patients ....

Walter L. Henry, Robert 0. Bonow,Jeffrey S. Borer, James H. Ware,Kenneth M. Kent, David R. Redwood,Charles L. McIntosh, Andrew G. Morrow,and Stephen E. Epstein

Observations on the Optimum Time for OperativeIntervention for Aortic Regurgitation. II.Serial Echocardiographic Evaluation ofAsymptomatic Patients .................

Walter L. Henry, Robert 0. Bonow,Douglas R. Rosing, and Stephen E. Epstein

EDITORIAL: Timing of Valve Replacement inPatients with Chronic Aortic Regurgitation

Robert A. O'Rourke and Michael H. CrawfordSurface Topography of Stenotic Aortic Valves by

Scanning Electron Microscopy ...........Jeanne M. Riddle, DonaldJ. Magilligan, Jr.,

and Paul D. SteinGenetic-Epidemiologic Study of Early-onset

Ischemic Heart Disease ................James J. Nora, Randall H. Lortscher,

Richard D. Spangler, Audrey H. Nora, andWilliam J. Kimberling

Clinical Judgment and Statistics. Lessons from aSimulated Randomized Trial in CoronaryArtery Disease ........................

Kerry L. Lee, J. Frederick McNeer,C. Frank Starmer, Philip J. Harris,and Robert A. Rosati

Spectral Analysis of Arterial Bruits (Phonoangi-ography): Experimental Validation .......

Arnold Miller, Robert S. Lees, J. Philip Kistler,and William M. Abbott

The Effect of Altered Renal Perfusion Pressureon Clearance of Digoxin ................

Teut Risler, John C. Somberg, Robert D. Blute, Jr.,and Thomas W. Smith

Tolerance to the Circulatory Effects of OralIsosorbide Dinitrate. Rate of Developmentand Cross-tolerance to Glyceryl Trinitrate

Udho Thadani, Dante Manyari, John 0. Parker,and Ho-Leung Fung

Radionuclide and Hemodynamic Assessment ofLeft Ventricular Functional Reserve inPatients with Left Ventricular Aneurysm andCongestive Cardiac Failure. Response toExercise Stress and Isosorbide Dinitrate

J. D. Stephens, David S. Dymond, andR. A. J. Spurrell

Metabolic Assessment of Exercise in ChronicHeart Failure Patients Treated with Short-term Vasodilators .....................

Stanley A. Rubin, Kanu Chatterjee, andWilliam W. Parmley

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Effects of Oral Propranolol on Left VentricularSize and Performance During Exercise andAcute Pressure Loading ................

Michael H. Crawford, JoAnn Lindenfeld, andRobert A. O'Rourke, with the technicalassistance of K. Wray Amon

Atenolol: Once-daily Cardioselective Beta Block-ade for Angina Pectoris .................

Graham Jackson, Janice Schwartz,Robert E. Kates, Mark Winchester, andDonald C. Harrison

Angina in Idiopathic . Hypertrophic SubaorticStenosis. A Clinical Correlate of RegionalLeft Ventricular Dysfunction: A Videometricand Echocardiographic Study ............

Martin G. St. John Sutton, A bdul J. Tajik,Hugh C. Smith, and Erik L. Ritman

Intrapericardial Abnormalities in Patients withPericardial Effusion. Findings by Two-dimensional Echocardiography ...........

Randolph P. Martin, Robert Bowden,Katherine Filly, and Richard L. Popp

Abnormal Blood Pressure Response and MarkedIschemic ST-segment Depression as Pre-dictors of Severe Coronary Artery Disease

Miguel E. Sanmarco, Steven Pontius, andRonald H. Selvester

Noninvasive Diagnosis of Coronary ArteryDisease: The Cardiokymographic Stress Test

R. A. Silverberg, G. A. Diamond, R. Vas,D. Tzivoni, H. J. C. Swan, and J. S. Forrester

Inert Gas Measurements of Myocardial Perfusionin the Presence of Heterogenous Flow Docu-mented by Microspheres ................

Peter Schanzenbiicher and Francis J. Klocke

Thallium-201 Myocardial Perfusion Imaging inInfants and Children. Value in DistinguishingAnomalous Left Coronary Artery from Con-gestive Cardiomyopathy ................

Howard P. Gvtgesell, William W. Pinsky,and E. Gordon DePuey

Serial Exercise Radionuclide Angiography. Vali-dation of Count-derived Changes in CardiacOutput and Quantitation ofMaximl ExercieVentricular Volume Change after Nitro-glycerin and Propranolol in Normal Men

Sherman G. Sorensen, James L. Ritchie,James H. Caldwell, Glen W. Hamilton,and J. Ward Kennedy

The Detection of Coronary Artery Disease withRadionuclide Techniques: A Comparison ofRest-Exercise Tlhallum Imagig and EjectionFraction Response .....................

James H. Caldwell, Glen W. Hamilton,Sherman G. Sorensen, James L. Ritchie,David L. Williams, and J. Ward Kennedy

Thallium-201 Myocardial Imaging to EvaluateRight Ventricular Overloading.

Fumitaka Ohsuzu, Shunnosuke Handa,543 Makoto Kondo, Hajime Yamazaki,

Takeshi Tsugu, Atsushi Kubo, Yaeko Takagi,and Yoshiro Nakamura

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CONTENTS OF VOLUME 61

Leftward Septal Displacement During RightVentricular Loading in Man .............

Jeffery A. Brinker, James L. Weiss,Donald L. Lappe, John L. Rabson,Warren R. Summer, Solbert Permutt,and Myron L. Weisfeldt

Body Surface Map Patterns of Altered Depolar-ization and Repolarization in Right BundleBranch Block .........................

Gurbachan S. Sohi and Nancy C. FlowersIntraventricular Reentry with Narrow QRS

Complex ...........................C. Pratap Reddy and Abdolkarim Khorasanchian

Alternate Ventriculoatrial Conduction ........Samuel Levy, Raymond Roudaut, Eric Bouvier,

Israel W. P. Obel, Jacques Clementy,and Henry Bricaud

626Case Report:

Ventricular Function of Single Ventricle AfterVentricular Septation ..................

Yasuhisa Shimazaki, Yasunaru Kawashima,Tohru Mori, Hikaru Matsuda,Soichiro Kitamura, and Kanji Yokota

Key References:Vasodilators in Congestive Heart Failure ......

compiled by Jay N. Cohn

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648 Letters to the Editor .......................

News from the American Heart Association . . Ad page 48A

No. 4 (April)

Editorial:Electrical Safety Standards for Electrocardio-

graphic Apparatus .....................

American Heart Association Committee on

Electrocardiography: David B. Geselowitz,Robert C. Arzbaecher, Roger C. Barr,Stanley A. Briller, Anthony N. Damato,Nancy Flowers, Kay Millar, G. Charles Oliver,Robert Plonsey, and Ralph E. Smith

Original Articles:Clinical Significance of Upsloping ST Segments

in Exercise Electrocardiography .........Rob D. Rijneke, Carl A. Ascoop, andJan L. Talmon

Influence of Left Ventricular Dimensions on

Endocardial and Epicardial QRS Amplitudeand ST-segment Elevations During AcuteMyocardial Ischemia ..................

Jon Lekven, Kanu Chatterjee, John V. Tyberg,and William W. Parmley

Spontaneous Variability of Complex VentricularArrhythmias Detected by Long-term Electro-cardiographic Recording ................

Eric L. Michelson and Joel MorganrothEpicardial Activation in Patients with Left Bundle

Branch Block .........................

Christopher R. C. Wyndham, Thomas Smith,Mooideen K. Meeran, Robert Mammana,Sidney Levitsky, and Kenneth M. Rosen

Development of a Bladder-free Cuff for Measuringthe Blood Pressure of the Fingers and Toes

Masafumi Hirai, Takashi Ohta, andShigehiko Shionoya

Evidence for Additional Blood Pressure Correlatesin Adults 20-56 Years Old ..............

RichardJ. -Havlik, Robert J. Garrison,Manning Feinleib, Stephen Padgett,William P. Castelli, and Patricia M. McNamara

Changes After Quitting Cigarette Smoking ....

Gary D. Friedman and Abraham B. Siegelaub

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Optimal Diagnosis in Acute Myocardial Infarc-tion. A Cost-effectiveness Study ..........

Peer Grande, Claus Christiansen, Asger Pedersen,and Merete Sanvig Christensen

Detection of Residual Jeopardized Myocardium3 Weeks After Myocardial Infarction byExercise Testing with Thallium-201 Myo-cardial Scintigraphy ...................

John D. Turner, Kerry M. Schwartz,Joseph R. Logic, L. Thomas Sheffield,Santosh Kansal, David I. Roitman,John A. Mantle, Richard 0. Russell, Jr.,Charles E. Rackley, and William J. Rogers

Symptom-limited vs Heart-rate-limited ExerciseTesting Soon After Myocardial Infarction

Robert F. DeBusk and William HaskellAre the Clinical and Hemodynamic Events During

Exercise Stress Testing in Invasive Studiesin Patients with Angina Pectoris Repro-ducible9 .............................

Udho Thadani, John R. Lewis, Dante Manyari,Kayoomars Boroomand, James Cohen,Roxroy 0. West, and John 0. Parker

Rest and Exercise Hemodynamic Effects of OralHydralazine in Patients with CoronaryArtery Disease and Left Ventricular Dys-function .............................

Michael C. Hindman, David A. Slosky,Robert H. Peter, Glenn E. Newman,Robert H. Jones, and Andrew G. Wallace

Sequence of Events in Angina at Rest: PrimaryReduction in Coronary Flow .............

S. Chierchia, C. Brunelli, I. Simonetti,M. Lazzari, and A. Maseri

Effect of Acute Coronary Artery Occlusion onLocal Myocardial Extracellular K+ Activityin Swine .............................

Jeffrey L. Hill and Leonard S. Gettes

Transluminal Angioplasty: Correlation of Mor-phologic and Angiographic Findings in anExperimental Model ...................

Peter C. Block, Kenneth L. Baughman,Richard C. Pasternak, and John T. Fallon

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CONTENTS OF VOLUME 61

Quantification of Coronary Arterial Narrowingat Necropsy in Acute Transmural MyocardialInfarction. Analysis and Comparison ofFindings in 27 Patients and 22 Controls ....

William C. Roberts and Ancil A. JonesTime Course of Thallium-201 Redistribution

After Transient Myocardial Ischemia .....George A. Beller, Denny D. Watson,

Peter Ackell, and Gerald M. PohostLinear Relationship Between the Distribution of

Thallium-201 and Blood Flow in Ischemicand Nonischemic Myocardium DuringExercise .............................

A nton P. Nielsen, Kenneth G. Morris,Robert Murdock, Frederick P. Bruno,and Frederick R. Cobb

Technetium-99m Pyrophosphate Uptake in Ex-perimental Viral Perimyocarditis. SequentialStudy of Myocardial Uptake and PathologicCorrelates ...........................

A kira Matsumori, Kazunori Kadota, andChuichi Kawai

Elevated Plasma Fibrinopeptide A and Throm-boxane B2 Levels During CardiopulmonaryBypass ..............................

Gerald C. Davies, Michael Sobel, andEdwin W. Salzman

Evaluation of Aortic Valve Replacement inPatients with Valvular Aortic Stenosis .....

Walter L. Henry, Robert 0. Bonow,Jeffrey S. Borer, Kenneth M. Kent,James H. Ware, David R. Redwood,Samuel B. Itscoitz, Charles L. McIntosh,Andrew G. Morrow, and Stephen E. Epstein

Original Articles:Isolated Left Anterior Descending Coronary

Atherosclerosis: Long-term Comparison ofInternal Mammary Artery and VenousAutografts ...........................

Bruce W. Lytle, Floyd D. Loop, Robert L. Thurer,Laurance K. Groves, Paul C. Taylor, andDelos M. Cosgrove

EDITORIAL: The Role of Bypass Surgery inIsolated Left Anterior Descending ArteryStenosis or Occlusion ..................

Martial G. BourassaSurgical Treatment of Variant Angina: Use of

Plexectomy with Aortocoronary Bypass ...Michel E. Bertrand, Jean M. LaBlanche,

Michel F. Rousseau, Henri H. Warembourg, Jr.,Czeslas Stankowtak, and Georges Soots

Myocardial Perfusion as an Indicator of GraftPatency after Coronary Artery BypassSurgery .............................

A lbert J. Kolibash, Thomas D. Call,Charles A. Bush, Marc R. Tetalman, andRichard P. Lewis

Effect of Atrial Septal Defect Repair on LeftVentricular Geometry and Degree of MitralValve Prolapse ........................

Theodore L. Schreiber, Harvey Feigenbaum,and Arthur E. Weyman, with the technical

786

791

797

802

Detection of Patent Coronary Bypass Grafts byComputed Tomography. A PreliminaryReport ..............................

Bruce H. Brundage, Martin J. Lipton,Robert J. Herjkens, Walter H. Berninger,Roland W. Redington, Kanu Chatterjee, andEric Carlsson

Echocardiographic Evaluation of Long-term Effectsof Exercise on Left Ventricular Hypertrophyand Function in Professional Bicyclists ....

Toshihiro Nishimura, Yoshihisa Yamada,and Chuichi Kawai

Range-gated Pulsed Doppler EchocardiographicDiagnosis of Supracardiac Total AnomalousPulmonary Venous Drainage ............

Jan Skovranek, Stanislav Tuma,Dagmar Urbancova, and Milan Samainek

Congenital Left Ventricular Inflow ObstructionEvaluated by Two-dimensional Echocardi-ography .............................

A. Rebecca Snider, Claude L. Roge,Nelson B. Schiller, and Norman Silverman

Two-dimensional Echocardiographic Findings inRight-sided Infective Endocarditis ........

Marvin Berger, Luis A. Delfin, Mansoor Jelveh,and Emanuel Goldberg

808

814Key References:

Coronary Artery Spasm ....................compiled by C. Richard Conti

Letters to the Editor .......................

826

832

841

848

855

862

865

News from the American Heart Association ....Ad page 54

No. 5 (May)

869

875

Left Ventricular Response to Isometric Exercisein Patients with Denervated and InnervatedHearts ..............................

William M. Savin, Edwin L. Alderman,William L. Haskell, John S. Schroeder,Veil B. Ingels, Jr., George T Daughters II,and Edward B. Stinson, with the assistance ofAnne Schwarzkopf

Responses of Normal Children and Young Adultsto Controlled Bicycle Exercise ...........

Frederick W. James, Samuel Kaplan,Charles J. Glueck, Jai- Yeong Tsay,Mary Jo S. Knight, and Catherine Jessee Sarwar

877Short- and Long-term Efficacy of a Calcium-

antagonistic Agent (Nifedipine) Combinedwith Methyidopa in the Treatment of SevereHypertension .........................

Maurizio D. Guazzi, Cesare Fiorentini,Maria T. Olivari, Antonio Bartorelli,Giovanni Necchi, and Alvise Polese

882

888

assistance of Janie Stewart

Angiotensin II, Plasma Renin and Sodium Deple-tion as Determinants of Blood PressureResponse to Saralasin in Essential Hyper-tension ... ...

Chalemphol Thananopavarn, Michael S. Golub,Peter Eggena, Jack D. Barrett, andMohinder P. Sambhi

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902

913

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(Continued)

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CONTENTS OF VOLUME 61

Central and Peripheral Hemodynamic Effects ofAngiotensin Inhibition in Patients withRefractory Congestive Heart Failure ......

David P. Faxon, Mark A. Creager,Jonathan L. Halperin, Haralambos Gavras,Jay D. Coffman, and Thomas J. Ryan

Immediate and Sustained Hemodynamic andClinical Improvement in Chronic HeartFailure by an Oral Angiotensin-convertingEnzyme Inhibitor ......................

Richard Ader, Kanu Chatterjee, Thomas Ports,Bruce Brundage, Beverely Hiramatsu, andWilliam Parmley

The Effect of Concurrent Oral Administration ofPropranolol and Disopyramide on CardiacFunction in Healthy Men ...............

W. F. Cathcart-Rake, J. E. Coker, F. L. Atkins,D. H. Hoffman, K. M. Hassanein, D. D. Shen,and D. L. Azarnoff

Use of Catheter-tip Velocity-Pressure Transducerto Evaluate Left Ventricular Function inMan: Effects of Intravenous Propranolol ...

WolfP. Klinke, Leonard G. Christie,Wilmer W. Nichols, Michael E. Ray,R. Charles Curry, Carl J. Pepine, andC. Richard Conti

Exercise Capacity in Patients with Severe LeftVentricular Dysfunction ................

William Benge, Robert L. Litchfield, andMelvin L. Marcus

Assessment of Ventricular Wall Thickness inVivo by Computer Transmission Tomog-raphy ...............................

Claes G. Skioldebrand, Carl-OlafOvenfors,Constantine Mavroudis, and Martin J. Lipton

Evaluation of Methods for Quantitating LeftVentricular Segmental Wall Motion in ManUsing Myocardial Markers as a Standard

Neil B. Ingels, Jr., George T. Daughters II,Edward B. Stinson, and Edwin L. Alderman

Value and Limitations of Segmental Analysis ofStress Thallium Myocardial Imaging forLocalization of Coronary Artery Disease

Pierre Rigo, Ian K. Bailey, Lawrence S. C. Griffith,Bertram Pitt, Robert D. Burow,Henry N. Wagner, Jr., and Lewis C. Becker

Scintigraphic Detection of Carotid Atherosclero-sis with Indium-l11-labeled AutologousPlatelets .............................

Harmon H. Davis II, Barry A. Siegel,Laurence A. Sherman, W. Andrew Heaton,Thomas P. Naidich, J. Heinrich Joist,and Michael J. Welch

Exercise-induced ST-segment Elevation. Correla-tion of Thallium-201 Myocardial PerfusionScanning and Coronary Arteriography ....

Richard F. Dunn, Ian K. Bailey, Roger Uren,and David T. Kelly

925

931

938

Value of Early Thallium-201 Scintigraphy forPredicting Mortality in Patients with AcuteMyocardial Infarction ..................

Kenneth J. Silverman, Lewis C. Becker,Bernadine H. Bulkley, Robert D. Burow,E. David Mellits, Clayton H. Kallman,and Myron L. Weisfeldt

The Initial Chest X-ray in Acute MyocardialInfarction. Prediction of Early and LateMortality and Survival .................

Alexander Battler, Joel S. Karliner,Charles B. Higgins, Robert Slutsky,Elizabeth A. Gilpin, Victor F. Froelicher,and John Ross, Jr.

Comprehensive Clinical Electrophysiologic Studiesin the Investigation of Documented or Sus-pected Tachycardias. Time, Staff, Problemsand Costs ............................

David L. Ross.-Jeronimo Farre, Frits W.H.M. Bar,Eddy J. Vanagt, Willem R. M. Dassen,Isaac Wiener, and Hein J. J. Wellens

Origin of the Atrial Electrogram Recorded fromthe Esophagus ........................

Eric N. Prystowsky, Edward L. C. Pritchett,and John J. Gallagher

Methods for Recording Electrograms of theSinoatrial Node During Cardiac Surgery inMan ................................

Robert J. Hariman, Ehud Krongrad,Robert A. Boxer, Frederick 0. Bowman, Jr.,James R. Malm, and Brian F. Hoffman

946

955

960

966

Unmasking of Ventricular Preexcitation by VagalStimulation or Isoproterenol Administration

Julio Przybylski, Pablo A. Chiale,M. Susana Halpern, Gerardo J. Nau,Marcelo V. Elizari, and Mauricio B. Rosenbaum

Echocardiographic Evaluation of Atrial StenosisUsing Diastolic Posterior Left VentricularWall Motion ..........................

Joe R. Wise, Jr.

Echo-phonocardiographic Determination of LeftAtrial and Left Ventricular Filling Pressureswith and Without Mitral Stenosis ........

Andres R. Palomo, Miguel A. Quinones,Alan D. Waggoner, Andrew G. Kumpuris,and Richard R. Miller

973

982

Case Report:Hypoplastic and Fibrotic Sinus Node Associated

with Intractable Tachycardia in a NeonateKim M. Fox, Robert H. Anderson, and

Katherine A. Hallidie-Smith

989

Key References:Clinical Exercise Stress Testing ..............

compiled by L. Thomas Sheffield1053

Letters to the Editor ... ......... 1056

News from the American Heart Association .... Ad page 46

(Continued)

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CONTENTS OF VOLUME 61

No. 6 (June)

Original Articles:Postextrasystolic Potentiation of Regional Me-

chanical Performance During ProlongedMyocardial Ischemia in the Dog .........

William E. Boden, Chang-seng Liang,and William B. Hood, Jr.

EDITORIAL: Evaluation of Inotropic ContractileReserve in Ischemic Heart Disease UsingPostextrasystolic Potentiation ...........

Peter F. Cohn, M.D.Disruption in the Temporal Sequence of Regional

Ventricular Contraction. I. Characteristicsand Incidence in Coronary Artery Disease.

B. Leonard Holman, Joshua Wynne, John Idoine,and Jane Neill

Comparison of Early Systolic and HolosystolicEjection Phase Indexes by Contrast Ven-triculography in Patients with CoronaryArtery Disease ........................

Robert Slutsky, Joel S. Karliner,Alexander Battler, Kirk Peterson, andJohn Ross, Jr.

The Effect of Transient Ischemia with Reperfusionon Thallium Clearance from the Myocardium

Henry Gewirtz, A li K. Maksad, Albert S. Most,Michael J. Sullivan, and Douglas R. Shearer

The Effects of Intracoronary Nitroglycerin onLeft Ventricular Systolic and DiastolicFunction in Man ......................

William P. Hood, Jr., Ivo A mende,Rudiger Simon, and Paul R. Lichtlen

Intraaortic Balloon Counterpulsation with andWithout Reperfusion for Myocardial In-farction Shock ........................

Marcus A. De Wood, Robert N. Notske,Gerald R. Hensley, John Paul Shields,William P. O'Grady, Julie Spores,Michael Golden, and John H. Ganji

Cross-sectional Echocardiographic Analysis ofthe Extent of Left Ventricular Asynergyin Acute Myocardial Infarction ..........

James J. Heger, Arthur E. Weyman,L. Samuel Wann, Edwin W. Rogers,James C. Dillon, and Harvey Feigenbaum

Cross-sectional Echocardiography. II. Analysisof Mathematic Models for QuantifyingVolume of the Formalin-fixed Left Ventricle

H. L. Wyatt, Ming K. Heng, Samuel Meerbaum,Pascal Gueret, John Hestenes, Eugene Dula,and Eliot Corday

Evaluation of Pulmonary Hypertension byM-mode Echocardiography in Childrenwith Ventricular Septal Defect ...........

Norman H. Silverman, A. Rebecca Snider,and Abraham M. Rudolph

Straddling Right Atrioventricular Valves inAtrioventricular Discordance ............

A nton E. Becker, Siew Yen Ho, Gilda Caruso,Simcha Milo, and Robert H. Anderson

The Surgical Anatomy of Common Atrioven-tricular Orifice Associated with Tetralogyof Fallot, Double Outlet Right Ventricleand Complete Regular Transposition ......

Saroja Bharati, John W. Kirklin,Hugh D. McAllister, Jr., and Maurice Lev

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1071

1075

1083

1091

1098

1105

1113

1119

1125

1133

1142

Left Ventricular Function After Repair of Tetral-ogy of Fallot and Its Relationship to Ageat Surgery ...........................

Kenneth M. Borow, Laurence H. Green,Aldo R. Casteneda, and John F. Keane

Previously Undiagnosed Variant Angina as aCause of Chest Pain after Coronary ArteryBypass Surgery .......................

David D. Waters, Pierre Theroux, Jean Crittin,Franz Dauwe, and Henry F. Mizgala

Thromboxane Release During Pacing-inducedAngina Pectoris: Possible VasoconstrictorInfluence on the Coronary Vasculature ....

Robert Ira Lewy, Leslie Wiener, Paul Walinsky,Allan M. Lefer, Melvin J. Silver, andJ. Bryan Smith

Ventricular Premature Complexes in Prognosisof Angina ............................

William Ruberman, Eve Weinblatt,Judith D. Goldberg, Charles W. Frank,Sam Shapiro, and Banvir S. Chaudhary

Perspectives on Systolic Hypertension. TheFramingham Study ....................

W. B. Kannel, T. R. Dawber, and D. L. McGeeLabile Hypertension: A Faulty Concept? The

Framingham Study ....................W. B. Kannel, Paul Sorlie, and Tavia Gordon

Atherosclerosis-related Responses to CigaretteSmoking in the Baboon ........ .........

Walter R. Rogers, Robert L. Bass III,Donald E. Johnson, Arthur W. Kruski,C. Alex McMahan, Milka M. Montiel,Glenn E. Mott, Robert L. Wilbur, andHenry C. McGill, Jr.

The Relationship Between Cerebrospinal FluidCreatine Kinase and Morphologic Changesin the Brain After Transient Cardiac Arrest

Per Vaagenes, John Kjekshus, andAnsgar Torvik

Metabolic Studies in Mitral Valve ProlapseSyndrome. A Neuroendocrine-CardiovascularProcess ..............................

Harisios Boudoulas, James C. Reynolds,Ernest Mazzaferri, and Charles F. Wooley

Clinical Profile of Restrictive CardiomyopathyJoseph R. Benotti, William Grossman,

and Peter F. CohnBeneficial Effects of Afterload Reduction Therapy

in Patients with Congestive Heart Failureand Moderate Aortic Stenosis ...........

Barry H. Greenberg and Barry M. MassieTest of a Model of Antiarrhythmic Drug Action.

Effects of Quinidine and Lidocaine on Myo-cardial Conduction ....................

Luc Hondeghem and Bertram G. KatzungEDITORIAL: Thoughts of a ComputerphobeLeonard S. Gettes

Epicardial and Endocardial Activation DuringSustained Ventricular Tachycardia in Man

Leonard N. Horowitz, Mark E. Josephson,and Alden H. Harken

Site of Conduction Delay During FunctionalBlock in the His-Purkinje System in Man

MasoodA khtar, Carol Gilbert,Mamoun Al-Nouri, and Stephen Denker

(Continued)

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CONTENTS OF VOLUME 61

Case Reports:Anatomic Substrate of Impaired Antegrade Con-

duction Over an Accessory AtrioventricularPathway in the Wolff-Parkinson-WhiteSyndrome ............................ 1249

George J. Klein, Donald B. Hackel, andJohn J. Gallagher

Corrected Transposition with Severe IntracardiacDeformities with Wolff-Parkinson-WhiteSyndrome in a Child. ElectrophysiologicInvestigation and Surgical Correction. 1256

D. Woodrow Benson, Jr., John J. Gallagher,H. Newland Oldham, Will C. Sealy,Richard Sterba, and Madison S. Spach

Key References:Clinical Cardiac Electrophysiology ...........

compiled by Kenneth M. Rosen1262

Letters to the Editor .... .......... 1267

Volume Author Index ..... ......... 1275

Volume Subject Index ..... ......... 1281

News from the American Heart Aciation . . Ad page 40A

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61 (5)

Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 1980 American Heart Association, Inc. All rights reserved.

is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231Circulation 1980;61:869-1061Circulation. 

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