bbs1-hl1-k3 cell junction-intercellular communication print

8/20/2019 BBS1-HL1-K3 Cell Junction-Intercellular Communication Print

1/24

C E L L J U N C T I O N S


2/24


3/24

Intro"uction cont$"

%embraneroteins


4/24

CytoseletonsCytoseleton 'bers: 3dimensional protein structures

found in cytoplasm (3 types microtubule, actinlament/microlament,intermediate lament)


5/24


6/24

Ty#es (ase" on )unction

• Occlu"ing !unctions $ight %unctions• Communicating !unctions &ap %unctions• *nchoring !unctions 'dherens %unctions

(desmosomes/macula adherens ! zonula adherens),

focal adhesions ! hemidesmosomes

Ty#es (ase" on Symmetry

• Symmetrical !unctions tight %unctions,desmosomes/macula adherens, zonula adherens !gap %unctions

• *symmetrical !unctions hemidesmosomes

Ty#es (ase" on Location

• (etween Cells gap %unctions, tight %unctions,desmosomes/macula adherens ! zonula adherens

• (etween Cells & matrix focal adhesions !

Classi'cation


7/24

Cell Junctions %a#


8/24

,Tight Junctions


9/24

!unctions .aries in"i/erent ty#eof e#ithelia,

i"e" pitheliumlining ofintestine *"*** morepermeable to+a than

epithelium liningof urinarybladder

pithelial cellscan transientlyalter tight

!unctions toincreased

permeabilityi"e" -ncreasedpermeability toamino acidsfrom lumen ofintestine

throughepithelial after


10/24


11/24

0, *nchoring Junctions


12/24

,cont$"


13/24

1onula *"herens


14/24

The fol"ing of an e#ithelial sheet to form an e#ithelial tube

$he oriented contraction of the bundles of actin laments running along adhesion belts causes the epithelial cells to narro. at their ape and helps the epithelial sheet to rollup into a tube" 'n eample is the formation of the neural tube in early vertebrate

development" 'lthough not sho.n here, rearrangements of the cells .ithin theepithelial sheet are also thought to have an important role in the process

,cont$"

* J t

http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=mboc4&part=A4754&rendertype=def-item&id=A4766http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=mboc4&part=A4754&rendertype=def-item&id=A4783http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=mboc4&part=A4754&rendertype=def-item&id=A5522http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=mboc4&part=A4754&rendertype=def-item&id=A5071http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=mboc4&part=A4754&rendertype=def-item&id=A5071http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=mboc4&part=A4754&rendertype=def-item&id=A5522http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=mboc4&part=A4754&rendertype=def-item&id=A4783http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=mboc4&part=A4754&rendertype=def-item&id=A4766


15/24

, *nc or ng Junct onscont$"


16/24


17/24

*utoimmune "isease "isru#t "esmosomes

blistering of sin

*nc or ng


18/24

, *nc or ng Junctions cont$"


19/24

, ucont$"


20/24

, Junctions3a# Junctions


21/24

3a# Junctions Cont$"


22/24

Cell JunctionsSummary


23/24

cont$"


24/24

$-#' 0'1-2

bbs1-hl1-k3 cell junction-intercellular communication print

Documents