bch 6206-2011 syllabus
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BCH 6206-2011 SyllabusTRANSCRIPT
2010 Lecture Topics for BCH 6206
BCH 6206: METABOLIC CONTROL ANALYSISTENTATIVE SCHEDULE: FALL 2011
M, W, F - Period 2 (8:30 AM - 9:20 AM), Room R3-265
In this course, we will discuss metabolism at a more advanced level than in the introductory courses, with a focus on how we know, what we know. Students are expected to have performed with a B or better in an introductory course in Biochemistry. Courses such as BCH 4204, CHM 4207, CHM 3218, BCH 3025 or GMS 6001 are considered appropriate introductory courses for BCH 6206.The text, Biochemistry by Voet and Voet (3rd Edition), will serve as a general reference. This is available in the Health Science Center Bookstore. Older versions are also acceptable, although the pages of interest may be somewhat different from the 3rd edition. Outside reading in primary journals, reviews, and special monographs will be assigned when appropriate. There will be a heavy reliance on class notes throughout the course.Each lecture title (see syllabus e-learning in Sakai) represents the general area to be covered. The first five weeks or so are devoted to discussing the tools that we use to study metabolism. The second five weeks or so are devoted to signaling as applied primarily to carbohydrate metabolism. The final five weeks are devoted to selected topics in lipid/steroid synthesis, and amino acid, and nucleic acid metabolism.
EXAMINATION SCHEDULE
There will be three (3) - three hour examinations. All three will be composed of essay, short answer, and other question types. RoomTuesday9/276:00 - 9:00 PM(Lectures 8/22 - 9/21)(C1-4)Tuesday11/16:00 - 9:00 PM(Lectures 9/23 - 10/26)(C1-4)Monday12/139:00 - 12:00 AM(Lectures 10/28 - 12/6)(C1-4)
CORE INSTRUCTORS
Dr. Susan Frost, Professor (Course Coordinator) R3-216A [email protected]
Dr. Daniel Purich, Professor (Biochemistry)R3-126 [email protected]
Dr. Arthur Edison, Professor (Biochemistry)R3-226B [email protected]
Dr. Nicholas Simpson, Research Associate Professor (Medicine)P1-31 [email protected]
Dr. Joanna Long, Associate Professor (Biochemistry)LG-187 [email protected]
Dr. Brian Cain, Professor (Biochemistry)R3-254 [email protected] 392-6473
Dr. Michelle Gumz, Assistant Professor (Medicine)CG-92B [email protected] 273-6887
E-learning: http://lss.at.ufl.edu
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2010 Tentative Lecture Topics for BCH 6206
DateTopicInstructor
WEEK 1M 8/22Introduction to metabolic controlFrost
W 8/24Tools of metabolismFrost
F 8/26General Introduction to NMRSimpson
WEEK 2M 8/29 Isotopomer analysis: part 1Simpson
W 8/31 Isotopomer analysis: part 2Simpson
F9/2Introduction to MetabolomicsEdison
WEEK 3M 9/5Labor Day (No Class)
W 9/7Metabolomics: statistical analysis Edisonand data mining
F 9/9Metabolomics: published examplesEdison
WEEK 4M 9/12Enzyme cooperativity and allostericPurichtransitions
W 9/14Radioisotopic tracers:Purich protein turnover and pathway kinetics
F 9/16Metabolic control analysisPurich
WEEK 5M 9/19Using metabolic inhibitors to Purichunderstand pathways
W 9/21Dan..last year you omitted a lecture in this series for lack of time.you can have it back this year if you feel like you could expand something.as I am eliminating the in-class review????
9/23 would begin the material for second testing cycle
F 9/23Membrane structure: lipidsFrost
WEEK 6M 9/26Membrane structure: proteins Frost
Tu 9/27*First Exam (6-9 PM) (normally Th, but Rosh Hashanah starts on W)(includes 13 lectures of material)
W 9/28Facilitated nutrient transportFrost
F 9/30Active nutrient transportFrost
WEEK 7M 10/3Signaling: G-protein receptorsFrostDateTopicInstructor
W 10/5Signaling: tyrosine kinase receptorsFrost
F 10/7Signaling: steroids and lipidsFrost
WEEK 8M 10/10Lipid rafts as signaling platformsFrostW 10/12Role of lipid in macromolecular synthesisFrostand targeting: part 1
F 10/14Role of lipid in macromolecular synthesisFrostand targeting: part 2WEEK 9M 10/17Nutrients as signaling molecules: part 1Frost
W 10/19Nutrients as signaling molecules: part 2Frost
F 10/21Counter-regulation of glycolysis and Frostgluconeogenesis
WEEK 10M 10/24Counter-regulation of glycogen turnoverFrost
W 10/26Circadian rythyms and central pathwayGumzRegulation
10/28 would begin the material for the third testing cycleF 10/28Fatty acid oxidationFrost
WEEK 11M 10/31Regulation of the TCA cycleFrostTu 11/1Second Exam (6-9 PM)(includes 15 lectures of material)
W 11/2Energy conservation (or not)Frost
F 11/4Homecoming (No Class)
WEEK 12M 11/7F1FO ATP synthaseCain
W 11/9Fatty acid biosynthesisGumz
F 11/11Veterans Day (No Class)WEEK 13M 11/14Prostaglandin metabolismGumz
W 11/16Cholesterol metabolismGumz
F 11/18Lipoprotein metabolismGumz
WEEK 14M 11/21Nitrogen homeostasisPurich
DateTopicInstructor
W 11/23Amino acid metabolism: part 1Purich
F 11/25Thanksgiving Break (No Class)
WEEK 15 M 11/28Amino acid metabolism: part 2Purich
W 11/30Nucleotide metabolism part 1: Purichsynthesis, turnover, and salvage
F 12/2Nucleotide metabolism part 2:Purichsynthesis, turnover, and salvage
WEEK 16M 12/5Folate coenzyme synthesis:Purichone-carbon metabolism
W 12/7Heme biosynthesisPurich
WEEK 17M 12/12Third Exam (9AM-12PM)(includes 15 lectures of material)