Beyond sutures and staples lies a more innovative solution

Protection and strength

• Provides significantly greater skin-holding strength than skin staples or subcuticular suture1*

• Distributes wound closure tension evenly along the incision and across the entire area of incision

• Provides a flexible microbial barrier with 99% protection in vitro for 72 hours against organisms commonly responsible for surgical site infection (SSI)2†

– Demonstrates in vitro inhibition of Methicillin-resistant Staphylococcus aureus, Methicillin-resistant Staphylococcus epidermidis, and Escherichia coli3‡

Patient satisfaction

• Leads to greater overall patient satisfaction when compared to staples4§

• Leads to better cosmesis when compared to staples4§

• Patient may be able to shower immediately after the procedure if directed by a healthcare professional5

• At the time of removal, DERMABOND PRINEO System is associated with less pain than other wound closure devices6

• No post-surgical dressings may mean easier self-care and greater self-confidence for patients7

DERMABOND® PRINEO® Skin Closure System (42 cm)

DERMABOND PRINEO System provides minimally invasive closure – no holes in the skin

* In an ex vivo study, more load in N was required to create a 3-mm gap between skin edges approximated with DERMABOND PRINEO System (22 cm) than with subcuticular 4-0 MONOCRYL® (poliglecaprone 25) Suture or PROXIMATE® Ethicon Endo-Surgery skin staples (P<.001).

†Staphylococcus epidermidis, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Enterococcus faecium‡Clinical significance unknown§Double-blinded quantitative research study comparing surgeon experience with DERMABOND PRINEO System (22 cm) and skin staples in total knee arthroplasty. N=83 Orthopaedic surgeons. 90% CI. Fielded June/July 2017.

Expanding the portfolio with secure, protected closure of incisions up to 40 cm

Superior strength compared to skin staples or 4-0 suture

References: 1. Kumar A. AST-2014-0246. Study to compare the tissue holding strength of DERMABOND® PRINEO® 22 cm Skin Closure System (DP22) to conventional wound closure techniques. September 25, 2014. Ethicon, Inc. 2. Su 06TR071 Study Report for in vitro evaluation of microbial barrier properties of DERMABOND ProTape. Ethicon, Inc. 3. Bhende In-vitro study to evaluate the ability of PRINEO™ Skin Closure System to kill bacteria on contact. June 26, 2012. Ethicon, Inc. 4. PRINEO Claims Research Quant Detail. August 16, 2017. Ethicon, Inc. 5. DERMABOND® PRINEO® Skin Closure System Instructions for Use. Ethicon, Inc. 6. Parvizi D, Friedl H, Schintler MV, et al. Use of 2-octyl cyanoacrylate together with a self-adhering mesh (Dermabond Prineo) for skin closure following abdominoplasty: an open, prospective, controlled, randomized, clinical study. Aesthetic Plast Surg. 2013;37(3):529-537. 7. De Cock E, F, Mueller K, Tan R. Changing the surgical wound closure management pathway: time and supplies with PRINEO vs. standard of care for abdominoplasy surgery in Germany. Poster presented at: International Society for Pharmaocoeconomics and Outcomes Research, 11th Annual European Congress: November 2008; Athens, Greece. 8. Stratafix & Prineo Study, RWE16-ETH-012. January 18, 2017. Ethicon, Inc. 9. Inflated Costs of Hip and Knee Replacement Index Stays and 30d Readmission.xlsx. Ethicon, Inc. 10. Kumar A. AST-2012- 0290. Completion Report: Study to compare the tissue holding strength of PRINEO Skin Closure System with conventional wound closure techniques. 2012. October 11, 2012. Ethicon, Inc.

For complete indications, contraindications, warnings, precautions, and adverse reactions, please reference full package insert.

©2017 Ethicon US, LLC. All rights reserved. 082927-171024

Potentially improve outcomes and reduce costBased on a retrospective analysis of 1,942 TKA procedures, DERMABOND® PRINEO® Skin Closure System was associated with

reduced readmission rates, reduced length of hospital stay, and reduced probability of discharge to non-home setting

compared to skin staples.8*

COMPARATIVE SKIN-HOLDING STRENGTHSDERMABOND PRINEO System was shown to be1,10†:

stronger than stapleson average

stronger than 4-0 sutureon average

Mea

n m

ax lo

ad (N

) p

rio

r to

3 m

m g

ap (+

/- 1

mm

)

20 0

1 7 5

1 50

1 2 5

1 0 0

7 5

50

2 5

0Skin Staples 4-0 Subcuticular

SutureDERMABOND PRINEO

System (22 cm)

166.53

112.498.69

*Study performed on DERMABOND PRINEO System (22 cm).†In an ex vivo study, more load in N was required to create a 3-mm gap between skin edges approximated with DERMABOND PRINEO System (22 cm) than with subcuticular 4-0 MONOCRYL® (poliglecaprone 25) Suture or PROXIMATE® Ethicon Endo-Surgery skin staples (P<.001).

12% reductionin length of stay8

with DERMABOND PRINEO System

31% reductionin discharge to non-home setting8

with DERMABOND PRINEO System

30-Day 60-Day 90-Day

4.4%

1.8%

5.4%

3.0%

7.4%

5.4%

0

2

4

6

8

30, 60, 90 DAY ALL-CAUSE READMISSION RATES8

by avoiding readmission within 30 days of TKA

Skin Staples DERMABOND PRINEO System

$12,8399

Potential cost savings

33% 40%