big data visualization and spatial computing in precision...
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Alexandros Sigaras | @AlexSigarasSenior Research Associate in Computational BiomedicineWeill Cornell Medicine
Biomedical Big Data Summer Bootcamp 2019
Weill Cornell Medicine06.19.2019
Big Data Visualization and Spatial Computing in Precision Medicine
PrecisionMedicine
“The right treatment, for the right person,
at the right time”
The New style of tailored treatment
http://meyercancer.weill.cornell.edu/news/2015-01-22/new-style-tailored-treatment
Irene Price | 76y Female
• 2009 | Diagnosed with Bladder Cancer; initially followed traditional treatment showing signs of success
• Relapse | High-grade urothelial carcinoma in bladder and several lymph nodes
• Cystectomy (Bladder removal), sample sent for Genetic Analysis (WES)
• Underwent Radiation Therapy, Genetic Analysis Results showed HER2 Amplification (mutation common in breast cancer)
• Relapse | Signs of metastasis to the liver• Chemotherapy targeted treatment | 8 cycles with
Taxol and Herceptin• Disease free since Nov 2014
Medical History
Precision MedicineImpact
Dr. Kevin Holcomb and Ronda Kotelchuck
https://healthmatters.nyp.org/amazing-things-ronda-kotelchuck/
“I love Dr. Holcomb… He’s very reasonable, and he respects the patient. We really do make decisions jointly.”
Ronda Kotelchuck
Artificial Intelligencein Healthcare
PMKB
Huang et al “The cancer precision medicine knowledge base for structured clinical-grade mutations and interpretations” JAMIA 2017
CNN Smoothie
P Khosravi et al. “Deep Convolutional Neural Networks Enable Discrimination of Heterogeneous Digital Pathology Images” EBioMedicine 2018
CNN Smoothie
P Khosravi et al. “Deep Convolutional Neural Networks Enable Discrimination of Heterogeneous Digital Pathology Images” EBioMedicine 2018
Spatial Computing in Medicine
Reality-VirtualityContinuum
Milgram, Paul, et al. "Augmented reality: A class of displays on the reality-virtualitycontinuum." Telemanipulator and telepresence technologies. International Society for Optics and Photonics, 1995.
PhysicalReality (PR)
VirtualReality (VR)
AugmentedReality (AR)
AugmentedVirtuality (AV)
Mixed Reality (MR)
AugmentedReality
MixedReality
Visualizing Cancer Drug Networks
Gayvert, Kaitlyn M., et al. "A computational drug repositioning approach for targeting oncogenic transcription factors." Cell reports 15.11 (2016): 2348-2356.
Tumor BoardUsing Mixed Reality across the world
https://twitter.com/AlexSigaras/status/897242543276138496
Realtime collaborationin Mixed Reality
Realtime collaborationin Mixed Reality
https://twitter.com/AlexSigaras/status/835210917746966529
Physicsin Mixed Reality
Caryl and Israel Englander Institute for Precision Medicine
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eipm.weill.cornell.edu