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Bio‐Compatible Microsystem Packaging of VCSELaser for Implantable Devices
Dr Alexander Steinecker, CSEM, Alpnach (CH)
EPoSS Annual Forum, Torino (IT), 25.09.2014
Copyright 2014 CSEM | Alexander Steinecker | EPoSS Annual Forum, 25.9.2014, “VCSELs for Bio Implants” | Page 1
Copyright 2014 CSEM | Alexander Steinecker | EPoSS Annual Forum, 25.9.2014, “VCSELs for Bio Implants” | Page 2
The miracle of hearing
Copyright 2014 CSEM | Alexander Steinecker | EPoSS Annual Forum, 25.9.2014, “VCSELs for Bio Implants” | Page 3
Cochlear Implants ‐ a technical masterpiece
Source: www.medel.com
Copyright 2014 CSEM | Alexander Steinecker | EPoSS Annual Forum, 25.9.2014, “VCSELs for Bio Implants” | Page 4
Cochlear Implants – Background
• Areas in cochlear correspond to acoustic frequency
• Degradation of sound transmission in the inner earcan be bridged
low frequencies(< 100 Hz)
high frequencies(> 10 kHz)
Copyright 2014 CSEM | Alexander Steinecker | EPoSS Annual Forum, 25.9.2014, “VCSELs for Bio Implants” | Page 5
Limitations of electrical stimulation
Source: Clark G. The multi-channel cochlear implant: past, present and future perspectives. Cochlear Implants Int. 2009;10 Suppl. 1:2-13
• Very sensitive local frequency responsewithin cochlear, mismatch acoustic vs. Electric hearing
• From one to four electrodes rapid improvement achieved, above 4‐20 nodetectable advantage
• Nerve Cell tissue damage due to directhigh current stimulation density
• Poor spatial resolution with electricstimulation
Copyright 2014 CSEM | Alexander Steinecker | EPoSS Annual Forum, 25.9.2014, “VCSELs for Bio Implants” | Page 6
Advantages of opto‐acoustical stimulation
• Laser pulses in water generate acoustic signals – «Optophony»
• Spectral response enables high temporal and frequency selective stimulation
Telecom VCSEL
Copyright 2014 CSEM | Alexander Steinecker | EPoSS Annual Forum, 25.9.2014, “VCSELs for Bio Implants” | Page 7
EU Project STREP‐ICT FP7 ACTION ‐
Project Reference EU 611230 STREP ICT‐2013.3.3
Enhance hearing experience forseverely impaired patients byeliminating limitations in spatial and temporal excitation of cochlearimplants based on electricalstimulation
ACTive Implant for OptoacousticNatural sound enhancement
Copyright 2014 CSEM | Alexander Steinecker | EPoSS Annual Forum, 25.9.2014, “VCSELs for Bio Implants” | Page 8
Overview of innovation areas in optical cochlear device
Copyright 2014 CSEM | Alexander Steinecker | EPoSS Annual Forum, 25.9.2014, “VCSELs for Bio Implants” | Page 9
Key technology components for optical stimulation
Copyright 2014 CSEM | Alexander Steinecker | EPoSS Annual Forum, 25.9.2014, “VCSELs for Bio Implants” | Page 10
Optical Cochlear Microsystem I – Packaging ‐ Housing
State of the art: Biocompatible housingmaterials Ti, Ta
Drastic size reduction (<800µm dia), hermetic enclosure with low temperature sealingprocess (<250°C for few seconds)
1mm Transparency in IR range
Copyright 2014 CSEM | Alexander Steinecker | EPoSS Annual Forum, 25.9.2014, “VCSELs for Bio Implants” | Page 11
Optical Cochlear Microsystem II – Packaging ‐ Connections
State of the artfeedthrough 4mm width
hermetic low temperature sealing with approved long term biocompatible materials (ceramics and highly biocompatible metals such as Nb, Pt, Ti)
Copyright 2014 CSEM | Alexander Steinecker | EPoSS Annual Forum, 25.9.2014, “VCSELs for Bio Implants” | Page 12
Optical Cochlear Microsystem III – Biocompatible Sapphire Lens
Sapphire lens for high biocompatibility
Plasma reactive ion etching (RIE‐ICP) only manufacturing option for micro‐optics in sapphire on Wafer Level
Copyright 2014 CSEM | Alexander Steinecker | EPoSS Annual Forum, 25.9.2014, “VCSELs for Bio Implants” | Page 13
Optical Cochlear Microsystem IV – VCSEL arrays
Parameter ValueLaser array 10 x 10Wavelength 1400 – 1900 nmPeak output power > 20 mWOperating range 20 – 45 oCDrive current <30 mA
Long wavelength VCSEL with superiorperformance for 1.3 μm < 2.3 μm
optimized for maximum efficiency at human body temperature
Copyright 2014 CSEM | Alexander Steinecker | EPoSS Annual Forum, 25.9.2014, “VCSELs for Bio Implants” | Page 14
Optical Cochlear Microsystem V ‐ Biocompatible flex circuit (ST Microelectronics/CSEM)
• Flex circuit
• Platinum, Niobium, Tantalum, Biocompatible polymers
• Highly flexible
• Chip on wire technology
• Chip integrated directly on wire
• High throughput
Copyright 2014 CSEM | Alexander Steinecker | EPoSS Annual Forum, 25.9.2014, “VCSELs for Bio Implants” | Page 15
Leading edge European Medical device manufacturing
MiniaturizationAdvanced Long WavelenthVCSEL Laser
BiocompatibleFlexprint
Low temperaturebiocompatible
hermeticenclosure
Biocompatiblemicrolens at wafer scale
Semi‐automaticsmall scalepackaging
Copyright 2014 CSEM | Alexander Steinecker | EPoSS Annual Forum, 25.9.2014, “VCSELs for Bio Implants” | Page 16
Thanks to our cooperation partners and funding bodies!
Reference:“James, R.Jose, Low Temperature Hermetic Sealing for Implantable Medical Systems, 2010”R.Jose James, CSEM SA
This project is supported by the EU Commission, the European Research Funding organisation under FP7 STREP ICT‐2013.3.3 Program Grant No. 611230