biol 300 firsties
TRANSCRIPT
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BIOL 300
Pathophysiology
Christopher Westerkamp,
Ph.D.
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We are here on earth to fart around.Don't let anyone tell you anydifferent.
Kurt Vonnegut
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2005 leading causes of
Diseases of heart
Malignant neoplasms Cerebrovascular diseases
Chronic lower respiratory diseases
Accidents
Diabetes mellitus
Alzheimers disease
Influenza and pneumonia Kidney disease
Se ticemia
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Obesity Trends* Among U.S. AdultsBRFSS, 1985
(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)
No Data
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Obesity Trends* Among U.S. AdultsBRFSS, 1986
(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)
No Data
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Obesity Trends* Among U.S. AdultsBRFSS, 1987
(*BMI 30, or ~ 30 lbs. overweight for 5 4
person)
No Data
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Obesity Trends* Among U.S. AdultsBRFSS, 1988
(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)
No Data
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Obesity Trends* Among U.S. AdultsBRFSS, 1989
(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)
No Data
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Obesity Trends* Among U.S. AdultsBRFSS, 1990
(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)
No Data
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Obesity Trends* Among U.S. AdultsBRFSS, 1991
(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)
No Data
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Obesity Trends* Among U.S. AdultsBRFSS, 1992
(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)
No Data
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Obesity Trends* Among U.S. AdultsBRFSS, 1993
(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)
No Data
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Obesity Trends* Among U.S. AdultsBRFSS, 1994
(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)
No Data
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Obesity Trends* Among U.S. AdultsBRFSS, 1995
(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)
No Data
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Obesity Trends* Among U.S. AdultsBRFSS, 1997
(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)
No Data
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Obesity Trends* Among U.S. AdultsBRFSS, 1998
(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)
No Data
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Obesity Trends* Among U.S. AdultsBRFSS, 1999
(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)
No Data
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Obesity Trends* Among U.S. AdultsBRFSS, 2000
(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)
No Data
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Obesity Trends* Among U.S. AdultsBRFSS, 2001
(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)
No Data
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(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)
Obesity Trends* Among U.S. AdultsBRFSS, 2002
No Data
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Obesity Trends* Among U.S. AdultsBRFSS, 2003
(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)
No Data
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Obesity Trends* Among U.S. AdultsBRFSS, 2004
(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)
No Data
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Obesity Trends* Among U.S. AdultsBRFSS, 2005
(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)
No Data
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Obesity Trends* Among U.S. AdultsBRFSS, 2006
(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)
No Data
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CV Disease Prevalence
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Pathology
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Pathology
Investigation of structural
alterations in cells, tissues,and organs used to identifydisease
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Pathology
Investigation of structural
alterations in cells, tissues,and organs used to identifydisease
Patho h siolo
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Pathology
Study of the traits, causes,
and effects of disease Pathophysiology
Study of the underlyingchanges in functionresultin from disease or
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Etiology
Study of disease causation
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Etiology
Study of disease causation
Also used to refer to causeof disease
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Etiology
Study of disease causation
Also used to refer to causeof disease
Idiopathic no knowncause
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Etiology
Study of disease causation
Also used to refer to causeof disease
Idiopathic no knowncause
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3 categories of etiology
Genetic
Congenitalacquired
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Pathogenesis
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Pathogenesis
Pattern of development of a
disease
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Pathogenesis
Cell dysfunction > tissuedysfunction > organ
dysfunction
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Pathogenesis
What are the biochemicalchanges in an injured cell?
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Pathogenesis
What distinguishes reversiblefrom irreversible damage?
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Clinical Manifestations
Signs and symptoms of adisease
Signs
Symptoms
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Clinical Manifestations
Signs and symptoms of adisease
Signs: objective alterationsthat can be observed andmeasured
Symptoms: subjectiveexperiences reported by a
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What is a disease?
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What is a disease?
What is normal?
How do we define normal?
How do we define disease?
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Molly is a 75 year old womanwho lives alone. For 2 days,
she had a fever and chills andstayed mostly in bed. Onrising to go to the bathroom,she felt dizzy, fainted and fellto the floor.
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Molly is a 75 year old womanwho lives alone. For 2 days,
she had a fever and chills andstayed mostly in bed. Onrising to go to the bathroom,she felt dizzy, fainted and fellto the floor.
Orthostatic hypotension
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What would be the normalresponse of blood pressure tostanding?
What happened to her heart
rate before fainting? Why didshe faint?
How did fainting and fallinghelp establish homeostasis?