biomedical imaging ii
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Biomedical Imaging II. Class 6 – Optical Tomography II: Instrumentation 03/13/06. Measurement principle. Measure optical intensity migrating from small irradiation spot ( source , S) to detector (D) position “Scan” object to obtain measurements for many S-D pairs - PowerPoint PPT PresentationTRANSCRIPT
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BMI II SS06 – Class 6 “OT Instrum.” Slide 1
Biomedical Imaging IIBiomedical Imaging II
Class 6 – Optical Tomography II: Instrumentation
03/13/06
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BMI II SS06 – Class 6 “OT Instrum.” Slide 2
Measurement principleMeasurement principle
Measure optical intensity migrating from small irradiation spot (source, S) to detector (D) position
“Scan” object to obtain measurements for many S-D pairs
Light propagation is scatter-dominated Signals are obtained under any angle
Signal is strongest near source (backscattered)
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BMI II SS06 – Class 6 “OT Instrum.” Slide 3
DOT characteristics summaryDOT characteristics summary
Functional imaging method
Sensitive to hemoglobin oxygenation states (contrast mechanism)
Low spatial resolution (~mm - ~cm)
Excellent temporal resolution (~ms), capability of studying hemodynamics
DOT assesses tissue function rather than providing an accurate image of anatomical features.
Examples: breast cancer, functional brain imaging
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BMI II SS06 – Class 6 “OT Instrum.” Slide 4
Continuous Wave (C.W.) MeasurementsContinuous Wave (C.W.) Measurements
Simplest form of OT: lowest spatial resolution, “easy” implementation, greatest penetration
Measuring transmission of constant light intensity (DC)
Simple, least expensive technology most S-D pairs
High “frame rates” possible
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BMI II SS06 – Class 6 “OT Instrum.” Slide 5
Example: Optical brain imagingExample: Optical brain imaging
“Partial view” or back reflection geometry
Scalp
Bone
Cortex
CSF
2-3 cm
Source / Detector 1
Detector 2
Detector 3
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BMI II SS06 – Class 6 “OT Instrum.” Slide 6
Time-Resolved MeasurementsTime-Resolved Measurements
Measuring the arrival time/temporal spread of short pulses (<ns) due to scattering & absorption (narrowing the “banana”)
Expensive, delicate hardware (single-photon counters, fast lasers, optical reflections, delays…)
Long acquisition times (low frame rates)
Potentially better spatial resolution than DC measurements
t
I
t0 t
I
t0
Prompt or ballistic Photons (t = d/c)
d
“Snake” Photons
Diffuse Photons
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BMI II SS06 – Class 6 “OT Instrum.” Slide 7
Frequency-Domain MeasurementsFrequency-Domain Measurements
Propagation of photon density waves (PDW): PDW = 9 cm, cPDW = 0.06 c (*
Measure PDW modulation (or amplitude) and phase delay
RF equipment (100MHz-1GHz)
Wave strongly damped, challenging measurement
t
I
t0
t
I
t0
t
I
t0Photon density waves
t
I
t0
Phase
Modulation
(* f = 200 MHz, μa = 0.1 cm-1, μs’ = 10 cm-1 n = 1.37
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BMI II SS06 – Class 6 “OT Instrum.” Slide 8
Principle components of a DOT system Principle components of a DOT system
Target
Lightsource
Delivery
Sourcescan
Detector
Detectorscan
DAQstorage
Timing,control
Collection
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BMI II SS06 – Class 6 “OT Instrum.” Slide 9
Multi-detector implementationMulti-detector implementation
Scanning of single detector (only used in lab setups):
• Safes hardware components, cost
• Long acquisition times
Parallel multi-detector acquisition
• No “time skew”
• Stable setup
• Added hardware
Mixed approach (Scanning limited number of detectors)
• Feasible for “static imaging”
• Used in TR, FD methods because of expensive detection hardware
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BMI II SS06 – Class 6 “OT Instrum.” Slide 10
Multi-source position implementationMulti-source position implementation
Time-division multiplexing : One source position is illuminated at one time for the duration of the detection (~10-100 ms).
Time skew between sources
Switching mechanism necessary:
• Optical switch (challenges: isolation, stability, size)
• Electronic switching of multiple sources (multiple laser sources & drivers – cost, complexity)
Frequency encoding: All sources are on at the same time.
Intensity modulation at different frequencies allows electronic separation of the signals originating from different sources.
No time skew
Reduced dynamic range
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BMI II SS06 – Class 6 “OT Instrum.” Slide 11
Dynamic rangeDynamic range
Ratio of largest to smallest “useable” signal (saturation limit noise limit)
Typically 1:104 (80 dB) for detection electronics
Signal falls of rapidly (~ factor 10 per cm distance on surface)
Determines the maximum tissue volume that can be probed
With second sourceOne source
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BMI II SS06 – Class 6 “OT Instrum.” Slide 12
Solution: Detector gain switchingSolution: Detector gain switching
I1
12 10
II
13 100
II
14 1,000
II
15 10,000
II
S1
1
10
1001,000
10,000
1
10
1001,000
10,000
1
10
1001,000
10,000
1
10
1001,000
10,000
1
10
1001,000
10,000
0 1
0 1
0 1
0 1
0 1
S2
1
10
1001,000
10,000
1
10
1001,000
10,000
1
10
1001,000
10,000
1
10
1001,000
10,000
1
10
1001,000
10,000
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BMI II SS06 – Class 6 “OT Instrum.” Slide 13
Semiconductors ISemiconductors I
Energy levels in solids have band structure :
Thermal excitation creates intrinsic carriers (electron-hole pairs): ni = np 1.51010 cm-1 (Si at room temperature, kT = 0.025 eV)
Photoelectric excitation possible for
g gh E hc E
Valence band
Conduction band
Ele
ctro
n en
erg
y
Bound electrons
Free electrons
Eg < 5 eV for insulatorEg 1 eV for semiconductorEg = 0 eV for metals
+
-
22 3
gE
kTi in p T e
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BMI II SS06 – Class 6 “OT Instrum.” Slide 14
Semiconductors IISemiconductors II
Doping with impurities increases number of free carriers (~ typ. by factor of 107) according to Ea,d 0.045 < kT
Donor: Pentavalent impurity (e.g., P) provides excess e- n-type semiconductor
Acceptor: Trivalent impurity (e.g., B) “captures” e- creates additional holes p -type semiconductor
Internal photoelectric effect:
Donor doped: n-type
Acceptor doped: n-type
, ,a d a dh E hc E
Ed
Ea
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BMI II SS06 – Class 6 “OT Instrum.” Slide 15
Diode junction of p-type and n-type semiconductors:
1. Diffusion of carriers potential across junction (n-type is left positively charged, p-type is left negatively charged)
2. Recombination at junction region of depletion of free carriers high resistance voltage drop
3. Carriers generated within diffusion length of the depletion region are separated by potential slope
4. Photoelectric current Ip produced by
photodiode (proportional to irradiation intensity)
Photodiodes (PD)Photodiodes (PD)
+ --
- - -
- --
- --
-++
+ ++
+ ++
++
+p n
Diffusion lengthNegative
net chargePositive
net charge
Anode CathodeIp
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BMI II SS06 – Class 6 “OT Instrum.” Slide 16
Photodiode OperationPhotodiode Operation
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BMI II SS06 – Class 6 “OT Instrum.” Slide 17
Photodiode (Transimpedance) AmplifierPhotodiode (Transimpedance) Amplifier
Converts photocurrent to voltage according to:
Bandwidth:
Highly linear
“Photovoltaic Mode”
out PD fV I R
3
1
2dbf
fRC
PD
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BMI II SS06 – Class 6 “OT Instrum.” Slide 18
PD characteristicsPD characteristics
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BMI II SS06 – Class 6 “OT Instrum.” Slide 19
Photomultiplier tubes (PMT)Photomultiplier tubes (PMT)
External photoelectric effect converts light intensity into current of free electron
Cascade of secondary electron emission / multiplication
Signal amplification G = N typ. ~106 (N: no. of dynodes, : gain per dynode ~4)
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BMI II SS06 – Class 6 “OT Instrum.” Slide 20
PMT spectral sensitivityPMT spectral sensitivity
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BMI II SS06 – Class 6 “OT Instrum.” Slide 21
Avalanche PhotodiodesAvalanche Photodiodes
Reverse biased with high voltage (~100V)
Internal 10-1000× amplification through avalanche effect
Gain temperature sensitive -> requires cooling/regulation
Available in ready-to-use modules
Pricey
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BMI II SS06 – Class 6 “OT Instrum.” Slide 22
Comparison PD vs. PMTComparison PD vs. PMT
Property PD PMT
Sensitivity 10-12 W 10-15 - 10-16 W
Active area ~ mm2 ~ cm2
Speed MHz - GHz (small area) ~ GHz
Dynamic range >109 <105
Size Small (mm) Medium to large (~cm)
Power supply Low voltage High voltage (~0.1-1 kV)
Ruggedness Very good Limited
Cost Cheap – moderate (~$10) Expensive (~$100)
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BMI II SS06 – Class 6 “OT Instrum.” Slide 23
Light sources ILight sources I
Near infrared range (600-900 nm)
Power ~1-100 mW: Signal quality vs. exposure limit (~ mW/mm2)
Laser diodes (semiconductor lasers): Most widely used
+ Small
+ Inexpensive (o.k…. ~$10 - $1000)
+ High efficiency, easy-to-operate
+ RF modulation possible
+ ps-pulsed systems available
(Poor beam quality)
Discrete wavelengths (760, 785, 800, 810, 830,.. nm)
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BMI II SS06 – Class 6 “OT Instrum.” Slide 24
Semiconductor-based light sourcesSemiconductor-based light sources
“Forward bias” causes reduction of potential wall diode in conducting mode
Electrons and holes recombine in depletion layer, carriers are replenished by current source
Emitting of recombination radiation light emitting diode
For special diode geometries and reflecting end faces, laser action can be achieved laser diode
+ --
- - -
- --
- --
-+ +
+ ++
+ ++
++
+p n
+
-- - -- ---
--
--
+ ++ +
++ ++ ++ + + + +
-
+ +
LED
LD
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BMI II SS06 – Class 6 “OT Instrum.” Slide 25
Types of laser diodesTypes of laser diodes
“Butterfly”
“HHL”
“TO3”
“C-mount”
“5-mm can /9-mm can:”Low / mid-power (mW-100 mW)
Hi-power (~W)
Hi-power (~W)
“Fiber pigtail”
Telco app.
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BMI II SS06 – Class 6 “OT Instrum.” Slide 26
Laser diode driversLaser diode drivers
Laser diodes require a controlled current source
LD are highly sensitive to ESD, short pulses, and all kinds of electromagnetic interference
Line filters
Power on ramping
Off shorting
LD require cooling and often temperature control to stabilize the output power Thermoelectric cooling (TEC) elements
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BMI II SS06 – Class 6 “OT Instrum.” Slide 27
Light sources IILight sources II
Solid state lasers: Optically active crystals (TiSa)
+ Short pulses (< ps, time-resolved systems)
+ Good beam profile
Bulky (requires pump laser)
Expensive
Difficult to operate
Non-laser sources: light emitting diodes (LED)
Broad wavelength range
Diffuse emitter
Power ~ 10mW
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BMI II SS06 – Class 6 “OT Instrum.” Slide 28
Snells’ law:
Total internal reflection for > c when going from n1 to n2 < n1:
Fiber components:
Core (n1)
Cladding (n2)Coating (mechanical stab.)
n1 > n2 “guided modes”
Light propagation in optical fibers ILight propagation in optical fibers I
01
0 1
sin
sin
n
n
0
1
2
1
sin c
na
n
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BMI II SS06 – Class 6 “OT Instrum.” Slide 29
Light propagation in optical fibers IILight propagation in optical fibers II
Acceptance angle a: Maximum incoupling angle ai resulting in guided transmission:
“Numerical Aperture” NA = sin a
Divergence angle: Maximum exiting angle ad (ai ad aa)
2 21 2
0
1sin a n n
n
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BMI II SS06 – Class 6 “OT Instrum.” Slide 30
Properties of some optical materialsProperties of some optical materials
Important interfaces
Various fiber materials
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BMI II SS06 – Class 6 “OT Instrum.” Slide 31
Fiber modesFiber modes
Different modes of optical propagation = different spatial intensity patterns
Number of possible modes depending on core radius, refractive indices
Multimode (MM) fibers
large core > 50 m
Higher efficiency
Higher power
(Cheaper)
Single-mode (SM) fibers
small core < 10 m
Better beam quality
No pulse shape
distortion (Telecom apps)
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BMI II SS06 – Class 6 “OT Instrum.” Slide 32
Intensity profile for MM fibersIntensity profile for MM fibers
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BMI II SS06 – Class 6 “OT Instrum.” Slide 33
Fiber transmission lossesFiber transmission losses
Absorption losses
Bending losses
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BMI II SS06 – Class 6 “OT Instrum.” Slide 34
Coupling light into optical fibersCoupling light into optical fibers
Focusing optics must provide:
Focus spot size s core diameter
Beam convergence angle acceptance angle
Mechanical alignment:
Focus on fiber core front face (x-y-z)
Beam perpendicular to front face (-)
Fiber face cut, polished
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BMI II SS06 – Class 6 “OT Instrum.” Slide 35
DYNOT system (best DOT imager around!!!)DYNOT system (best DOT imager around!!!)
referencesignals
Target
LD 1
Incouplingoptics
MDU
Source fiber bundles
Collecting fiberbundles
Laser current
DPS 1
Laserdiodes
Fiberpigtails
Motor controller
Beamsplitter
LD 2
Laser controller
Mirror
DPS 2
PCI busData acquisition
board
Measuringhead
OTDM
LDD + TECD
LDD + TECD
f 1 f 1
f 2 f 2
Personalcomputer
Bifurcatedfibers
Referencesignals
1
2
3
4
5
6
7
8
910
11
12
13
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BMI II SS06 – Class 6 “OT Instrum.” Slide 36
Fiber OpticsFiber Optics
Deliver light to/from tissue
Bifurcated design ( co-located S/D pairs)
Source fiber bundle
Detector fiber bundle
Probing end
Reinforced jacketing
Soft jacket
Bifurcation
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BMI II SS06 – Class 6 “OT Instrum.” Slide 37
Laser DiodesLaser Diodes
Laser Diodes
780 nm
830 nm
“Fiber pigtails” = opt. output
Electrical connectors
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BMI II SS06 – Class 6 “OT Instrum.” Slide 38
Laser ControllerLaser Controller
Commercial Newport 8000 Laser diode and temperature controller
Thorlabs Inc. OEM laser driver
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BMI II SS06 – Class 6 “OT Instrum.” Slide 39
Fast Multi-Channel Optical SwitchFast Multi-Channel Optical Switch
Multi-wavelength
32 fibers
~70 Hz switch speed = 2Hz frame rate @ 30 sources
fiber pigtails
incoupling unit
circular fiber array
DC servomotor
beam-splitter cube
focusing optics
rotating mirror
source fiber bundles
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BMI II SS06 – Class 6 “OT Instrum.” Slide 40
Commercial fiber-optic switchCommercial fiber-optic switch
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BMI II SS06 – Class 6 “OT Instrum.” Slide 41
Multi-Channel Detector Multi-Channel Detector
Gain switching
32 Parallel detection channels
Electronic wavelength separation
Gain Setting of detector determines its sensitivity
Gain (TTL) S/H
Out @
Out @
Ref. f2
PTIA
PTIA
PGA
PGA
Lock-in@ f2
Lock-in@ f2
S/HS/HLock-in@ f1
Lock-in @ f1
SiPD
1 1000
S/HS/H
1 1000
Ref. f1
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BMI II SS06 – Class 6 “OT Instrum.” Slide 42
The DYNOT (DYnamic Near-infrared OT) InstrumentThe DYNOT (DYnamic Near-infrared OT) Instrument
7
3
4
5
1
2
9
8
1
2
3
4
5
5
6
6
1 – power supply, 2 – motor controller, 3 – detector, 4 – laser controller, 5 – host PC w/ monitor, 6 – fiber optics, 7 – optical switch, 8 – optics shielding cover, 9 – laser diodes
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BMI II SS06 – Class 6 “OT Instrum.” Slide 43
HelmetHelmetHelmet kit can be configured depending on application
Probes individually spring loaded
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BMI II SS06 – Class 6 “OT Instrum.” Slide 44
Measurement GeometriesMeasurement Geometries
1. Unilateral temporal arrangement (motor cortex)
2. Distributed Arrangement (frontal, temporal, parietal)
3. Installing / adjusting the optical probes
4. Complete 56 arrangement 30 sources 30 detectors = 900 data channels
1
2
3 4
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BMI II SS06 – Class 6 “OT Instrum.” Slide 45
Baby HelmetBaby Helmet
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BMI II SS06 – Class 6 “OT Instrum.” Slide 46
Dual Breast Measurement HeadDual Breast Measurement Head
Patient in prone position
Simultaneous dynamic bilateral breast imaging
Fiber protrusion individually adjusted (manually; pneumatic possible)
Measuring cup positions individually adjusted
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BMI II SS06 – Class 6 “OT Instrum.” Slide 47
Highly Flexible 2×-Breast SetupHighly Flexible 2×-Breast Setup
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BMI II SS06 – Class 6 “OT Instrum.” Slide 48
Adjusting MechanismAdjusting Mechanism
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BMI II SS06 – Class 6 “OT Instrum.” Slide 49
Probe PlacementProbe Placement
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BMI II SS06 – Class 6 “OT Instrum.” Slide 50
Optical Fibers
Animal Imaging StudiesAnimal Imaging Studies