MARS Imaging:

Biomedical 3Dspectroscopic X-ray imaging

Anthony Butler

Goal

To bring spectroscopic X-ray imaging

into medical use

X-ray Detector

Technology

Clinical

Application

Our team is bridging this gap

Overview

X-raysource

Object PatternRecognition

System

Detector

The Team Technical team

University of Canterbury

Clinical team University of Otago

International Partners Incl. CERN, Cambridge Uni and

Erlangen Uni

The company MARS Bioimaging Ltd

Benefits of Spectral X-rays

Better image quality Less artefacts

eg. Around coronary artery stents

K-edge imaging Better use of contrast agents

eg. Less scanning

Intrinsic tissue contrast eg. Breast cancer from normal tissue

Polychromatic Bone

Soft tissueGadolinium

Modelled using the 8 energy thresholds

Potential of full body imaging

The MARS ScannerMedipix All Resolution System

Energy resolution

Spatial resolution

Temporal resolution

Desktop microCT (x-ray)-Small animal studies-Pathology studies

MedipixSpectroscopic Photon Processing Detector

17 Institutes, 12 years

Hosted by CERN

We provide Test-bed for technology Application development First clinical experiments

First MARS medical scan

Iodine contrast12 keV 17 keV 33 keV 42 keV

Looks like a “traditional CT”

MARS has higher resolution

Results: Grey Scale Imaging

12keV 17keV

33keV 42keV

Results: Spectral Imaging

Iodine Non-iodine

Useful for heart and cancer imaging

Results: Spectral Imaging

Anthony Butler

Nick Cook (CDHB) Nanette Schleich (UC)Juergen Meyer (Physics UC)Peter Renau (UC Maths)Fred Ross (Electrical UC)Phil Bones (Electrical UC)Stephen Hemmingson (Physics UC)Ross Ritchie (Physics UC)Nigel Anderson (Radiology UO)Richard Heinz (Physics UC)Jonathan Selkirk (Physics UC)

MARS

Medipix All Resolution System

Phil Butler (Physics UC)Jochen Butzer (Physics UC)Markus Firsching (Erlangen)Henry Liu (UO Radiology)Richard Watts (Physics UC)Nicola Scott (Cardiology, UO)Raphael Grasset (HITLab UC)Dave van Leeuwen (Electrical UC)Tim Buckenham (Radiology UO)Rachel Cullens (CPIT / UO)Medipix Collaboration (CERN)