JRP-h21 BioReMIRJRP-h21 BioReMIR

Biologically Relevant Metrology of Ionising RadiationWhy the project is needed What the project will change How the project will make this possible

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d • 2.5 million radiotherapy treatments of cancer in EU per year• Combining different radiation types could give better results

• A metrologically sound methodology for determining radiobiological weighting factors will become available

• Developing micro- and nanodosimeters for multi-scale measurement of particle track structure in clinics

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• Combining different radiation types could give better results

• Different biological effectiveness must be taken into account

• Up to 20% variance in prescribed dosage depending on

• Combining different radiation types will become possible where dosage is prescribed in a standardised way

• Treatments at different centres will be comparable (�costs)

• Calibration of nanodosimetry with biological end points

• Developing a prototype treatment planning tool based on multi-scale model for prediction of treatment outcome

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• Up to 20% variance in prescribed dosage depending on methodology for determining biological weighting factors

� Lack of comparability between centres

• Treatments at different centres will be comparable (�costs)

• Novel treatment modalities will become faster available

• Potential of radiotherapy will be fully exploitable

multi-scale model for prediction of treatment outcome

• Establishing uncertainty budget for microdosimetric and nanodosimetric quantities

� Development of full potential of radiotherapy is hampered• Potential of radiotherapy will be fully exploitable

(� cure rates, � quality of life of patients) � Quantitative comparison of treatment plans

WP5: Traceability for biologically relevant metrology of ionising radiation

WP1: Practical easy-to-use detectors for multi-scale characterisation of particle track structure of ionising radiation

WP 1 WP5

characterisation of particle track structure

• Calibration of • Developing portablegas-based

WP 1

WP2WP4

WP5nanodosimetry based on CHOcell line survival

gas-based microdosimeters

WP3WP3• Reference multi-scale

measurement set-up

RADIO-BIOLOGY

NANO-DOSIMETRY

MICRO-DOSIMETRY

1-2 nm1 µm

• Investigate nano-scale technologies for advanced detectors

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set-upadvanced detectors

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WP2: Extending the multi-scale simulation tool to WP4: Uncertainty budget of track structure quantities WP3: Integrating the multi-scale approach into

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WP2: Extending the multi-scale simulation tool to cell killing and functional changes in cells

Track structure characteristics

WP4: Uncertainty budget of track structure quantities obtained from measurement and simulation

• Uncertainties of micro-/nanodosimetric distributions

WP3: Integrating the multi-scale approach into radiotherapy treatment planning

• Prototype treatment planning tool based on nanodosimetry

∑∞

=

=1

1ν

νν PMChromatin structure− measurement: operating parameters

− simulation: interaction cross section models

• Benchmarking by comparing correlated distributions

• Simulate treatment outcome using radiobiological models

� Evaluated radiotherapy plans for review by clinicians

∑∞

=

=i

i PFν

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• Benchmarking by comparing correlated distributions � Evaluated radiotherapy plans for review by clinicians

1.21.3 protons

α-particles

Integration of all cellular damage

Correct repair

Incorrect repair

Apoptosis & Necrosis

0.9

1.0

1.1

Tsi

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Integration all over the exposed cellsCellular outcome

Tissue outcome

0.1 1 100.75

0.8

0.9

Projectile energy in MeVTissue outcome

Projectile energy in MeV

Knowledge Transfer and Training:

�Stakeholder Committee

Uptake and Exploitation:

� Interaction with companies developing treatment planning tools

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�Stakeholder Committee

�Consumer group (healthcare professionals, patients)

�Web page including video on micro-/nanodosimetry suited for general public

� Interaction with companies developing treatment planning tools

�Demonstration of the tools to the clinical community

�Patenting novel detectors and furthering commercialisation

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�Web page including video on micro-/nanodosimetry suited for general public

�Conference contributions, papers

�Open source distribution of codes through Geant4 platform

�Patenting novel detectors and furthering commercialisation

�Propose designed reference facility as metrology-based radiobiology end station at accelerators

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�Open source distribution of codes through Geant4 platform

� 2 Stakeholder Workshops, 3 training courses

� International School on micro- and nanodosimetry� International School on micro- and nanodosimetry

�Cooperation with standardisation bodies (IAEA, ICRU, ESTRO, EURADOS, ...)

Consortium:

• Multidisciplinary team combining expertise in cutting edge research on metrology

Collaborators:

• Stakeholders from radiotherapy and industry aiding with establishing a pipeline of

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• Multidisciplinary team combining expertise in cutting edge research on metrology of radiation effects at the microscopic scale, radiobiology, and radiotherapy.

• 14 world leading European institutions including 7 NMIs/DIs, 4 research institutes bringing in special skills and 3 clinical partners providing a route to exploitation.

• Stakeholders from radiotherapy and industry aiding with establishing a pipeline of innovation from fundamental metrological research into the clinical environment.

• Clinical and pre-clinical collaborators represent the global elite of cutting edge research for improved radiotherapy.

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bringing in special skills and 3 clinical partners providing a route to exploitation. research for improved radiotherapy.

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