Block Day- 3/7/12

Homework:-Design your own protein pathway Project- due Friday-Protein Pathways/Protein Structure QUIZ- FRI- DID YOU MISS MONDAY’S CHECKUP?-

Serotonin Pathway

Homework CheckCircle your answer:• How does a MAO inhibitor treat depression?It decreases or increases the amount of serotonin.

Circle your answer:• If the AAAD enzyme doesn’t work, will there be higher or lower amounts of serotonin?

Serotonin Pathway

Serotonin Homework Answers:1. Less serotonin2. Higher serotonin3. Lower serotonin4. Blocks the enzyme MAO from working which

keeps serotonin available and decreases depression.

Make an entry:

Entry 19: Fruit Fly Eye Color- 3/7/12Tape in picture and take notes

2-amino-4-hydroxypterdine

(BLUE)

tetrahydroiopterin

biopterin(BLUE)

drosopterin(ORANGE)

sepiapterin(YELLOW)

isosepiapterin(YELLOW)

xanthopterin(GREEN-BLUE)

isoxanthopterin(VIOLET-BLUE)

Molecule A(colorless)

PTERIDINE PIGMENTS OMMOCHROMEPIGMENTS

Molecule B(colorless)

ommochrome pigment(BROWN)

31

5

4

6

2 9

7

8 10

In order to see pigments, they must be transported into specific areas of the eye cells. All the ommochrome and pteridine pigments use the same transport proteins (labeled as protein #10 on the network)

Color of fly is result of mixture of all pigments in network

Drosophila Eye Color Pigment Network

Wild Type Brown

Scarlet White

2-amino-4-hydroxypterdine

(BLUE)

tetrahydroiopterin

biopterin(BLUE)

drosopterin(ORANGE)

sepiapterin(YELLOW)

isosepiapterin(YELLOW)

xanthopterin(GREEN-BLUE)

isoxanthopterin(VIOLET-BLUE)

Molecule A(colorless)

PTERIDINE PIGMENTS OMMOCHROMEPIGMENTS

Molecule B(colorless)

ommochrome pigment(BROWN)

31

5

4

6

2 9

7

8 10

In order to see pigments, they must be transported into specific areas of the eye cells. All the ommochrome and pteridine pigments use the same transport proteins (labeled as protein #10 on the network)

Color of fly is result of mixture of all pigments in network

Wild Type (red-brown)= need all 10Brown= 9, 10 needed, must be missing #1

Red= need 1-8, 10- missing #9White= missing #10- no way color transported

Metabolic Network ProjectCheck

box Requirement Score

Name of organism _____/1 Starting protein _____/1 3 proteins that determine trait, with

names _____/3 3 enzymes, with names _____/3

Drawing of organism with each trait_____/3

Explanation of what enzymes are needed for each trait _____/6

Creativity,clarity,neatness _____/3TOTAL _____/20

Make an entry-Entry 20: Protein Quiz Review- 3/7/12

Lactose

Glucose

Lactase

Galactose

Key:

Metabolites

Enzyme reactions

Labrador (dog) pigmentation

Tyrosine Dopaquinone

Brown pigment

Black pigment

Yellow pigmenttyrosinase

TRP-2

TRP-1Boxes = metabolitesArrows = enzymes that change the metabolites

Phenylalanine

Homogentisicacid

Tyrosine

Tyramine

Thyroxine

Hydroxy-phenylpyruvate

Dopa

Dopamine

NoradrenalineAdrenaline

Dopaquinone Melanin

Phenylpyruvate

Maleyl-acetoacetate

Prephenate

1

2 4

35

6