by: sydney freedman
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By: Sydney Freedman. General Background. 1895: Germany, smallpox outbreak Led to Jaundice Liver doesn’t destroy blood cells properly 1942: United States, WWII, vaccinated against yellow fever Jaundice Vaccines used to prevent viral diseases caused another - PowerPoint PPT PresentationTRANSCRIPT
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By: Sydney Freedman
+General Background 1895: Germany, smallpox
outbreak Led to Jaundice
Liver doesn’t destroy blood cells properly
1942: United States, WWII, vaccinated against yellow fever Jaundice
Vaccines used to prevent viral diseases caused another
All infect and damage the liver Means “liver inflammation”
Different strains
+What is Hepatitis A?
Serious liver disease caused by HAV Found in stool Causes inflammation of
liver and affects ability to function
Acute virus Recovery=complete
elimination (no damage) Mildest form
1-2 months
+Transmission of Hepatitis A
Spread orally when contaminated food or water is ingested Disease of feces and filth
sewage disposal/unclean conditionsthrive
Come in contact w/ blood or stool of infected individual
Individual doesn’t properly wash hands and then touches objects or food
+Signs, Symptoms and Diagnosis
Show up after 2-6 weeks Signs and Symptoms:
dark urine, fatigue, itching, loss of appetite, low-grade fever, nausea/vomiting, pale or clay colored stools, yellow skin (jaundice)
Diagnosis: Noticed in physical exam
(enlarged/ tender liver) Blood tests show: raised
IgM and IgG antibodies and elevated liver enzymes
+Treatment and Prevention
Rest, avoid alcohol and other substances that are toxic to the liver (Tylenol), avoid fatty foods
Vaccines are available (4 weeks) Booster is necessary
Wash hands thoroughly after using the bathroom
Avoid unclean food and water
+What is Hepatitis B? Serious liver disease caused by
HBV Irritation and swelling of the
liver Infects 5% of the world’s
population with a lifelong chronic infection Destruction of liver
cellscirrhosis Causes 5 million liver cancer
cases a year More common in areas of
Southeast Asia, tropical Africa, gay men and intravenous drug users
+Transmission of Hepatitis B Transmission occurs
through sexual contact and contact with contaminated blood and bodily fluids Blood transfusions Direct contact with blood
in health care settings Tattoo or acupuncture
with unclean needles or instruments
Shared needles during drug use
Shared personal items (such as toothbrushes, razors, and nail clippers) with an infected person
+Signs, Symptoms and Diagnosis May not appear for up to 6
months Signs and Symptoms:
Appetite loss, fatigue, low-grade fever, muscle and joint aches, nausea and vomiting, yellow skin and dark urine due to jaundice
Diagnosis: Tests: antibody to HBsAg,
Hepatitis B core antigen, Hepatitis B surface antigen, Hepatitis E surface antigen Identify/Monitor Liver
Damage: albumin level, liver function tests and prothrombin time
Need ongoing blood tests
+Treatment and Prevention Monitor liver and other
bodily functions Liver failureliver transplant
Rare Antiviral medications
Decrease/remove HBV from blood and reduce risk of cirrhosis and cancer
Vaccines are available Only 1 percent receive
vaccines
Avoid sexual contact with a person who has hepatitis
Avoid sharing personal items, such as razors or toothbrushes
Do not share drug needles or other drug equipment
First dose of the hepatitis B vaccine at birthcomplete the series of three shots by 6 months old
+What is Hepatitis C?
Caused by HCV viral disease that leads to
swelling of the liver Not as globally common as
B, but much higher percentage of individuals become chronically ill More cases of cirrhosis
and liver cancer
+Transmission of Hepatitis CTransmitted through bodily
fluids like B Sexual contact with a person who has
hepatitis C Inject street drugs or share a needle with
someone who has hepatitis C Received a blood transfusion before July
1992 Received a tattoo or acupuncture with
contaminated instruments Blood, blood products, or solid organs
from a donor who has hepatitis C Share personal items such as
toothbrushes and razors with someone who has hepatitis C
Was born to a hepatitis C-infected mother
+Signs, Symptoms and Diagnosis Not as common for symptoms to
develop…may not be noticed until cirrhosis has developed and liver is permanently scarred
Possible Signs and Symptoms: Abdominal pain, abdominal
swelling, clay-colored or pale stools, dark urine, fatigue, fever, itching, jaundice, loss of appetite, nausea and vomiting
Diagnosis: Blood tests Genetic testing for the hepatitis C
genotype Identify and monitor liver damage:
Albumin level, liver function tests, prothrombin time and liver biopsies
+Treatment and Prevention
Given an antiviral medication that is taken 3 times a week for 6 to 12 months Effective if started within
2 to 3 months of infection No vaccine
Avoid contact with blood Do not share needles with
anyone Tattoos and piercings
+There is more? Strands go all the way up to
G D, delta virus, is only found
with B Symptoms become more
severe E is different strand than A,
but is also spread through fecal contamination Large outbreaks in Asia
and South America Later two new strands were
isolatedF&G
+Works Cited
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001323/
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001324/
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001329/
http://www.cdc.gov/vaccines/pubs/vis/downloads/vis-hep-a.pdf
Killer Germs By: Barry and David Zimmerman Google Images