C-myc

Presented by Tavia Clark

c-Myc: The Quintessential Oncogene

• Transcription factor involved in:– Cell growth – Cell proliferation– Repression of gene transcription– Apoptosis– Angiogenesis

TABLE 1  Growth inhibition and apoptosis following treatment with antisense oligonucleotides to c-myc

  Growth inhibition Apoptosis  

Cell or Tumor in vivo in vitro in vivo in vitro Reference

Human acute lymphoblastic leukemia

  (CEM-C7)   +   + 18

Burkitt's lymphoma lines         30

  Ramos (EBV−)   +   +  

  Daudi (EBV+)   +   −  

Small cell lung cancer lines

  GLC4, GLC4-cDDPa, GLC4-Adr   +   − 46

Human erythroblasts   +   − 47

Human CML blastsb + + ? ? 48

Melanoma linesc + + + +  49, 50

Thyroid cancer lines   +   ? 51

Orbital fibroblasts   +   − 52

Monomyeloid cells (HL-60)   +   + 36

Burkitt's lymphoma (Daudi, ST486)   +   ? 53

Ovarian cancer lines   +   +e 54d

Lymphoma U937       + 55e

Breast Cancer MCF-7       + 55

Ewing's sarcoma CHP-100       + 55

Burkitt's lymphoma ST-486       + 55

Breast cancer (MCF-7, MDA-MB-231)   +   ? 56

Human T lymphocytes

  +IL-2 or PHA   +   − 57

Burkitt lymphomas (ST486, JD38)   +   ? 58

Hematopoietic cells   +   ? 59

Esophageal cancer cells   +   + 44

*Symbols: +, effect tested for and seen; −, effect tested for and not seen; ?, not tested (or not reported)

Links

• http://arjournals.annualreviews.org/doi/full/10.1146/annurev.physiol.60.1.575?cookieSet=1

• http://www.myccancergene.org/index.asp

• http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1550296

• http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T23-44Y0Y3F-1&_user=130907&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000004198&_version=1&_urlVersion=0&_userid=130907&md5=aa23778ee7ca3420a6b4cb277d165126

• http://www.tumor-gene.org/cgi-bin/TGDB/tgdb_fetch_gene.cgi?gene=myc

• http://www.cancerindex.org/geneweb/MYC.htm

• http://news-service.stanford.edu/news/2004/october13/med-felsher-1013.html

Articles• Bruno Amati, Konstantinos Alevizopoulos and Jaromir Vlach, “MYC

and the Cell Cycle,” Frontiers in Bioscience, 3, d250-268 (1998)• Jonas A Nilsson and John L Cleveland, “Myc pathways provoking

cell suicide and cancer,” Oncogene, 22, 9007-9021 (2003)• J Craig Cohen, et. al. “Transient in utero knockout (TIUKO) of C-

MYC affects late lung and intestinal development in the mouse,” BMC Developmental Biology, 4:4 (2004)

• E. Brad Thompson, “The many roles of c-Myc in apoptosis,” Annual Review of Physiology, 60, 575-600 (1998)

• Werner Lutz, Javier Leon and Martin Eilers, “Contributions of Myc to tumorigenesis,” BBA Reviews on Cancer, 1602:1, 61-71 (2002)

• Amy Adams “Switching off cancer gene turns cells healthy in mice,” Sanford Report, October 13, 2004

• Bruna Pucci, Margaret Kasten, and Antonio Giordano, “Cell cycle and apoptosis,” Neoplasia 2:4, 291-299 (2000)