CancerResearchVOLUME 50 •NUMBER 17 •CNREA8 •PP 5211-5605

CONTENTS§

Asterisks * preceding page numbers refer to studies using human-derived material.

Editorial

5211 Advances in Brief. Carlo M. Croce. Editor-in-Chief.

*5212 Activity of the Thymidylate Synthase Inhibitor 2-Desamino-Ari°-

propargyl-5,8-dideazafolic Acid and Related Compounds in Murine (L1210) and Human (W1L2) Systems in Vitro and in L1210in Vivo. Ann L. Jackman. Gordon A. Taylor, Brigid M.O'Connor, Joel A. Bishop. Richard G. Moran, and A. Hilary

Calvert.

5219 Induction of Cytochrome P-450 and 5-Aminolevulinate SynthaseActivities in Cultured Rat Hepatocytes. Peter R. Sinclair. WilliamJ. Bernent. Sally A. Haugen, Jacqueline F. Sinclair, and Philip S.Guzelian.

* 5225 Tumor Localization by Combinations of Monoclonal Antibodiesin a New Human Colon Carcinoma Cell Line (LIM1899). SarahM. Andrew, Jin Ghee Teh. Ricky W. Johnstone. Sarah M.Russell, Robert H. Whitehead, Ian F. C. McKenzie, and Geoffrey A.Pietersz.

*5231 Smoking and Renal Cell Carcinoma. Carlo La Vecchia, EvaNegri, Barbara D'Avanzo, and Silvia Franceschi.

*5234 Augmentation of Antibody Dependent Cell Mediated Cytotoxicityfollowing in Vivo Therapy with Recombinant Interleukin 2.Jacquelyn A. Hank, Randy R. Robinson, Jean Surfus, BarbaraM. Mueller, Ralph A. Reisfeld, Nai-Kong Cheung, and Paul M.Sondel.

* 52-10 Detection of Minimal Residual Disease in Leukemic Patientswith the t(10;14)(q24;qll) Chromosomal Translocation. JacobKagan, Lawrence R. Finger, Emanuel Besa, and Carlo M. Croce.

5245 DNA Fingerprinting of 7,12-Dimethylbenz(a|anthracene-inducedand Spontaneous CD-I Mouse Liver Tumors. Brian J. Ledwith,Richard D. Storer. Srinivasa Prahalada, Sujata Manam, Karen R.Leander, Matthew J. van Zwieten, Warren W. Nichols, andMatthews O. Bradley.

5250 Effect of Tunicamycin on Sialomucin and Natural Killer Susceptibility of Rat Mammary Tumor Ascites Cells. Seema Bharathan,John Moriarty, Charles E. Moody, and Anne P. Sherblom.

* 5257 Effect of Guanine and Adenine Nucleotides on Bombesin-stimu-

lated Phospholipase C Activity in Membranes from Swiss 3T3and Small Cell Lung Carcinoma Cells. Yoav Sharoni. JeanViallet, Jane B. Trepel. and Edward A. Sausville.

*5263 Clonal Analysis of Lymphocytes from Tumor, Peripheral Blood,and Nontumorous Kidney in Primary Renal Cell Carcinoma.Tae-Yoon Kim, Andrew C. von Eschenbach. MaryLynne D.Filaccio. Kazuhiro Hayakawa, David R. Parkinson. Charles M.Balch, and Kyogo Itoh.

5269 Tiazofurin Is Phosphorylated by Three Enzymes from ChineseHamster Ovary Cells. Priscilla P. Saunders, Christy D. Spindler,Mei-Tao Tan. Esperanza Alvarez, and Roland K. Robins.

5275 Intracellular DNA Strand Scission and Growth Inhibition ofEhrlich Ascites Tumor Cells by Bleomycins. Robert W. Byrnes,Jeffrey Templin. Daniel Sem, Suzanne Lyman, and David H.Petering.

* 5287 Augmentation of Cytotoxic Effect of Tumor Necrosis Factor onHuman Immunodeficiency Virus-infected Cells by Staurosporine,a Potent Protein Kinase C Inhibitor. Yoshiaki Hamamoto,Toshifumi Matsuyama, Naoki Yamamoto, and NobuyukiKobayashi.

*52'M Regulation of Progesterone Receptor Gene Expression.

E. Vegeto, M. G. Cocciolo, F. Raspagliesi, A. Piffanelli,R. Fontanelli, and A. Maggi.

5296 Failure of Chronic Glutathione Elevation to Reduce CytotoxicityProduced by Exposure to ci's-Diamminedichloroplatinum(II),

Ionizing Radiation, or Hyperthermia. Michael L. Freeman,Michael J. Meredith, and Donald R. Eisert.

5301 2-Acetylaminofluorene-mediated Alteration in the Level of LiverArylsulfotransferaseIV duringRat Hepatocarcinogenesis. David P.Ringer, Tom R. Norton, and Boyd A. Howell.

5308 Attenuating Effect of Bromocriptine on Cysteamine Anticar-cinogenesis of Stomach Cancers Induced by /V-Methyl-jV'-nitro-TV-nitrosoguanidine.Masaharu Tatsuta, Hiroyasu lishi,Miyako Baba, Makoto Ichii, Akihiko Nakaizumi, HiroyukiUehara. and Haruo Taniguchi.

* 5312 Abnormalities in Structure and Expression of the RetinoblastomaGene in Small Cell Lung Cancer Cell Lines and Xenografts inNude Mice. Káre Rygaard, George D. Sorenson, Olive S.Pettengill. Charles C. Cate, and Mogens Spang-Thomsen.

5318 Application of a New Approach for the Quantitation of Drug Syn-ergism to the Combination of c/s-Diamminedichloroplatinum andl-i8-D-Arabinofuranosylcytosine. William R. Greco, HyoungSook Park, and Youcef M. Rustum.

* 5328 a-Interferon Structure and Natural Killer Cell Stimulatory Activity. Bo-Liang Li, Xiao-Xia Zhao. Xin-Yuan Liu, Hyon Suk Kim,Karel Raska, Jr., John R. Ortaldo, Barbara Schwartz, and SidneyPestka.

5333 Role of P450IIE1 in the Metabolism of 3-Hydroxypyridine, aConstituent of Tobacco Smoke: Redox Cycling and DNA StrandScission by the Metabolite 2,5-Dihydroxypyridine. Sang GeonKim and Raymond F. Novak.

5340 Substrate Specificity of the Exonuclease Associated with CalfDNA Polymerase i. Ralph D. Sabatino, Thomas W. Myers, andRobert A. Bambara.

*5345 Carbohydrate Analysis of Immunoglobulin G Myeloma Proteinsby Lectin and High Performance LiquidChromatography:Role ofGlycosyltransferases in the Structures. Tetsuo Nishiura, ShigeruFujii, Yoshio Kanayama, Atsushi Nishikawa, YoshiakiTomiyama, Masato lida, Takahiro Karasuno, Hirohisa Nakao,Takeshi Yonezawa, Naoyuki Taniguchi, and Seiichiro Tarui.

5351 Role of Growth Factor Synthesis in the Acquisition of Insulin/Insulin-like Growth Factor I Independence in Rat Mammary CarcinomaCells. Stephen P. Ethier.CaterinaChiodino, and RichardF.Jones.

§The CONTENTS arranged by Subject Category can be found immediately following these CONTENTS.

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5365

* 5369

5374

*5382

!':5387

*5392

!'Õ5399

:*:5406

*5414

5421

5426

*5438

5446

Suppressor Cell Activity in a Randomized Trial of Patients Receiving Active Specific Immunotherapywith Melanoma Cell Vaccine and Low Dosages of Cyclophosphamide. Dave S. B. Hoon.Leland J. Foshag, Anne S. Nizze, Roger Bohman, and Donald L.Morton.

PorphyrinPhotosensitivity in Cell Lines Expressing a Heat-resistant Phenotype. Charles J. Gomer, Natalie Rucker, and SamWong.

PhotosensitizingDyes for the Selection of NontumorigenicRevert-ants from Human Lung Cancer Cell Lines. Josh W. McDonald,Douglas E. Brash, Allan R. OserofF, and Curtis C. Harris.

Identification of Ultraviolet-inducible Proteins That Bind to aTGACAACA Sequence in the Polyoma Virus Regulatory Region.Zeev A. Ronai and I. Bernard Weinstein.

Androgen Receptor Gene Expression in Human Prostate Carcinoma Cell Lines. W. D. Tilley. C. M. Wilson, M. Marcelli. andM. J. McPhaul.

Effect of a-Interferon, 17/3-Estradiol,and Tamoxifen on EstrogenReceptor Concentrationand Cell Cycle Kinetics of MCF 7 Cells.W. R. Bezwoda and K. Meyer.

Non-P-Glycoprotein Mediated Multidrug Resistance PrecedesP-Glycoprotein Expression during in Vitro Selection for Dox-orubicin Resistance in a Human Lung Cancer Cell Line. F. Baas.A. P. M. Jongsma, H. J. Broxterman, R. J. Arceci, D. Housman,G. L. Scheffer. A. Riethorst, M. van Groenigen, A. W. M.Nieuwint. and H. Joenje.

Inhibition of Human Breast Cancer Cell Proliferation in TissueCulture by the Neuroleptic Agents Pimozide and Thioridazine.Jeannine S. Strobl, Keith L. Kirkwood, Tracy K. Lantz. MichaelA. Lewine. Virginia A. Peterson, and Jennings F. Worley III.

A Deletion Linked to a Poly(ADP-ribose) Polymerase Gene onChromosome 13q33-qter Occurs Frequently in the Normal BlackPopulation as Well as in Multiple Tumor DNA. Kishor G.Bhatia, Barry W. Cherney, Konrad Huppi, Ian T. Magrath,Jeffrey Cossman, Edward Sausville. Francisco Barriga, BruceJohnson, Barry Gause, George Bonney, Janet Neequayi, MariaDeBernardi, and Mark Smulson.

Antitumor Effects of a-Interferon and -y-Interferonon a MurineRenal Cancer (Renca) in Vitro and in Vivo. T. J. Sayers, T. A.Wiltrout. K. McCormick, C. Husted, and R. H. Wiltrout.

Monoclonal Antibody Therapy of Murine Lymphoma: EnhancedEfficacy by Concurrent Administration of Interleukin 2 or Lym-phokine-activated Killer Cells. Kirk R. Schultz. Jay P. Klarnet.David J. Peace. Martin A. Cheever. Christopher C. Badger. IrwinD. Bernstein, and Philip D. Greenberg.

Modulation of 06-Methylguanine-DNA Methyltransferase in Ratand Hamster Liver after Treatment with Dimethylnitrosamine.Janet Hall. Henriette Brésil,Mireille Serres, Ghyslaine Martel-Planche, Christopher P. Wild, and Ruggero Montesano.

Cloning and Characterization of Human Tumor Cell InterstitialCollagenase. Nancy Smyth Templeton. Peter D. Brown. Anna T.Levy, Inger M. K. Margulies. Lance A. Liotta, and William G.Stetler-Stevenson.

Mass Spectrometric Analysis of Tobacco-specific NitrosamineHemoglobin Adducts in Snuff Dippers, Smokers, and Non-smokers. Steven G. Cannella, Shashi S. Kagan, Mark Kagan,Peter G. Foiles, George Palladino, Arthur M. Quart, ElaineQuart, and Stephen S. Hecht.

Dose-Response Study of DNA and Hemoglobin Adduct Formation by 4-(Methylnitrosamino)-l-(3-pyridyl)-l-butanone in F344Rats. Sharon E. Murphy. Adrienne Palomino. Stephen S. Hecht,and Dietrich Hoffmann.

5453 Evaluation of Cysteine Adduct Formation in Rat Hemoglobin by4-(Methylnitrosamino)-l-(3-pyridyl)-l-butanone and RelatedCompounds. Steven G. Cannella, Shashi S. Kagan, Thomas E.Spratt, and Stephen S. Hecht.

5460 Potentiation of Natural Killer Cell Activity and Tumor Immunityby Diacetylputrescine. Terry L. Bowlin, Andrea Rosenberger,David Stemerick, and Michael L. Edwards.

5464 Aristolochic Acid Activates ras Genes in Rat Tumors at Deoxy-adenosine Residues. Heinz H. Schmeiser, Johannes W. G.Janssen, John Lyons, Hans R. Scherf, Wolfgang Pfau, AlbrechtBuchmann, Claus R. Bartram, and Manfred Wiessler.

* 5470 Ecological Correlation between Arsenic Level in Well Water andAge-adjusted Mortality from Malignant Neoplasms. Chien-JenChen and Chin-Jen Wang.

5475 Prevention of Central Nervous System Toxicity of the AntitumorAntibiotic Acivicin by Concomitant Infusion of an Amino Mixture. Marta G. Williams, Robert H. Earhart, Howard Bailey, andJ. Patrick McGovren.

*5481 Peripheral Airway Cell Differentiation in Human Lung CancerCell Lines. Adi F. Gazdar, R. Ilona Linnoila, Yukio Kurita,Herbert K. Oie, James L. Mulshine, Jean C. Clark, and Jeffrey A.Whitsett.

* 5488 Establishment and Characterization of a Human AdrenocorticalCarcinoma Cell Line That Expresses Multiple Pathways of Steroid Biosynthesis. Adi F. Gazdar, Herbert K. Oie, Cedric H.Shackleton, T. R. Chen, Timothy J. Triche, Charles E. Myers,George P. Chrousos. Murray F. Brennan, C. A. Stein, and RenatoV. La Rocca.

ÃŽ"C5497Gangliosides and Sialoglycoproteins Carrying a Rare Blood

Group Antigen Deeerminant, Cad, Associated with Human Cancers as Detected by Specific Monoclonal Antibodies. NozomuHiraiwa. Kiyotaka Tsuyuoka. Yu-Teh Li, Mitunobu Tanaka,Taiko Seno. Yasuto Okubo, Yoshihiro Fukuda, Hiroo Imura,and Reiji Kannagi.

5504 Cytotoxicity Phase of Diethylnitrosamine-induced Hepatic Neoplasia in Medaka. Darrel J. Lauren, Swee J. Teh, and David E.Hinton.

5515 Assessment of Protein Kinase C Isozymes by Enzyme Iinmu-noassay and Overexpression of Type II in Thyroid Adenocar-cinoma. Masatoshi Hagiwara, Takahisa Hachiya, MasatoWatanabe, Nobuteru Usuda, Futoshi lida, Katsuyuki Tamai, andHiroyoshi Hidaka.

* 5520 Differentiation and Growth Modulation of Chronic MyelogenousLeukemia Cells by Bryostatin. Michael Lilly. Chris Tompkins,Chris Brown, George Pettit, and Andrew Kraft.

5526 Establishment and Characterization of a Tumorigenic MurineVascular Endothelial Cell Line (F-2). Ken-Ichi Toda. KaoniTsujioka, Yukiya Maruguchi. Kazuhiro Ishii, Yoshiki Miyachi,Kagemasa Kuribayashi, and Sadao Imamura.

* 5531 Establishment and Characterization of Human Renal Cancer andNormal Kidney Cell Lines. T. Ebert, N. H. Bander, C. L. Finstad,R. D. Ramsawak, and L. J. Old.

5537 Role of Tumor Necrosis Factor in Flavone Acetic Acid-inducedTumor Vasculature Shutdown. Viswanath Mahadevan, Saleem T.A. Malik, Anthony Meager, Walter Fiers, Graham P. Lewis, andIan R. Hart.

5543 In Vivo Administration of Interferon a and Interleukin 2 InducesProliferation of Lymphoid Cells in the Organs of Mice. Raj K.Puri. William D. Travis, and Steven A. Rosenberg.

on May 24, 2020. © 1990 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from

*5551 In Vivo Interleukin 2-induced Activation of Lymphokine-acti-

vated Killer Cells and Tumor Cytotoxic T-Cells in Cervical

Lymph Nodes of Patients with Head and Neck Tumors. LiciaRivellini, Carlo Gambacorti-Passerini, Massimo Squadrelli-

Saraceno, Maria Ilaria Grosso, Giulio Cantù, Roberto Molinari,Attilio Orazi. and Giorgio Parmiani.

* 5558 Enhancementof RicinA ChainImmunotoxinActivityby Perhex-iline on Established and Fresh Leukemic Cells. Jean-PierreJaffrézou.Thierry Levade. Emilienne Kuhlein, OlivierThurneyssen, Marielle Chiron, HélèneGrandjean, DominiqueCarrière,and Guy Laurent.

5567 Effect of 12-0-Tetradecanoylphorbol-13-acetate on Colony Formation and Intercellular Communication in a ( '»cultureSystem of

JB6 Clones. Ichiro Yamadori, Ursula I. Heine. Susan Kenney.Charles W. Riggs, and Jerry M. Rice.

5574 Combined Histochemical and Biochemical Analysis of Sex Hormone Dependence of Ferric Nitrilotriacetate-induced Renal Lipid

Peroxidation in ddY Mice. Shinya Toyokuni, Shigeru Okada,Shuji Hamazaki, Yukiko Minamiyama, Yoshihiro Yamada, PingLiang, Yasutomo Fukunaga, and Osamu Midorikawa.

5581 Selection for Spontaneous Metastasis after Calcium Phosphate-

mediated Transfer of DNA. Ruth J. Muschel.

*5587 MalignantTransformationof Human Fibroblastsby a Trans-fectedN-rasOncogene.Daniel M. Wilson,DajunYang,John E.Dillberger. Stephen E. Dietrich, Veronica M. Mäher,andJ. Justin McCormick.

5594 AnnouncementsEighty-secondAnnual Meetingof the AACRCall for Nominations for the ScientificAwards of the AACRAACR SpecialConferences in Cancer ResearchFuture Annual Meetingsof the AACRRecent DeathCalendar of Events

5596 Employment Register of the AACR

5604 Author Index

NOTE: AACR forms available in the back of this issue—•Application for Active and Corresponding Membership•Application for Associate Membership

on May 24, 2020. © 1990 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from

Cancer Research

VOLUME 50 •NUMBER 17

CONTENTS Arranged by Subject Category

Editorial

5211 Advances in Brief. Carlo M. Croce, Editor-in-Chief.

BASIC SCIENCES

Biochemistry and Biophysics5219 Induction of Cytochrome 1' 450 and 5-Aminolevulinate Synthase

Activities in Cultured Rat Hepatocytes. Peter R. Sinclair, WilliamJ. Bernent, Sally A. Haugen, Jacqueline F. Sinclair, and Philip S.Guzelian.

5250 Effect of Tunicamycin on Sialomucin and Natural Killer Susceptibility of Rat Mammary Tumor Ascites Cells. Seema Bharathan.John Moriarty. Charles E. Moody, and Anne P. Sherblom.

*5257 Effect of Guanine and Adenine Nucleotides on Bombesin-stimu-lated Phospholipase C Activity in Membranes from Swiss 3T3and Small Cell Lung Carcinoma Cells. Yoav Sharoni. JeanViallet. Jane B. Trepel. and Edward A. Sausville.

5269 Tiazofurin Is Phosphor) lated by Three Enzymes from ChineseHamster Ovary Cells. Priscilla P. Saunders. Christy D. Spindler.Mei-Tao Tan. Esperanza Alvarez, and Roland K. Robins.

5275 Intracellular DNA Strand Scission and Growth Inhibition ofEhrlich Ascites Tumor Cells by Bleomycins. Robert W. Byrnes,Jeffrey Templin, Daniel Sem, Suzanne Lyman. and David H.Petering.

*5328 cr-InterferonStructure and Natural Killer Cell Stimulatory Activity. Bo-Liang Li. Xiao-Xia Zhao. Xin-Yuan Liu. Hyon Suk Kim,Karel Raska. Jr.. John R. Ortaldo. Barbara Schwartz, and SidneyPestka.

5333 Role of P450IIE1 in the Metabolism of 3-Hydroxypyridine, aConstituent of Tobacco Smoke: Redox Cycling and DNA StrandScission by the Metabolite 2,5-Dihydroxypyridine. Sang GeonKim and Raymond F. Novak.

5340 Substrate Specificity of the Exonuclease Associated with CalfDNA Polymerase <. Ralph D. Sabatino. Thomas W. Myers, andRobert A. Bambara.

Carcinogenesis5301 2-Acetylaminofluorene-mediated Alteration in the Level of Liver

ArylsulfotransferaseIV duringRat Hepatocarcinogenesis.David P.Ringer, Tom R. Norton, and Boyd A. Howell.

5308 Attenuating Effect of Bromocriptine on Cysteamine Anticar-cinogenesis of Stomach Cancers Induced by \-Mciliyl~V-nitro-/V-nitrosoguanidine. Masaharu Tatsuta, Hiroyasu lishi.Miyako Baba, Makoto Ichii. Akihiko Nakaizumi, HiroyukiUehara, and Haruo Taniguchi.

* 5369 Photosensitizing Dyes for the Selection of NontumorigenicRevert-ants from Human Lung Cancer Cell Lines. Josh W. McDonald,Douglas E. Brash, Allan R. Oseroff, and Curtis C. Harris.

5426 Modulation of O6-Methylguanine-DNA Methyltransferase inRat and Hamster Liver after Treatment with Dimeth-ylnitrosamine. Janet Hall, Henriette Brésil,Mireille Serres,Ghyslaine Martel-Planche. Christopher P. Wild, and RuggeroMontesano.

*5438 Mass Spectrometric Analysis of Tobacco-specific Nitrosamine

Hemoglobin Adducts in Snuff Dippers, Smokers, and Non-smokers. Steven G. Cannella, Shashi S. Kagan, Mark Kagan,Peter G. Foiles, George Palladino, Arthur M. Quart, ElaineQuart, and Stephen S. Hecht.

5446 Dose-Response Study of DNA and Hemoglobin Adduct Formation by 4-(Mothylnitrosamini))-l-(3-pyridyl)-I-bulanom> in F344Rats. Sharon E. Murphy, Adrienne Palomino, Stephen S. Hecht,and Dietrich Hoffmann.

5453 Evaluation of Cysteine Adduct Formation in Rat Hemoglobin by4-(Methylnitrosamino)-l-(3-pyridyl)-l-butanone and RelatedCompounds. Steven G. Cannella, Shashi S. Kagan, Thomas E.Spratt. and Stephen S. Hecht.

5464 Aristolochic Acid Activates ras Genes in Rat Tumors at Deoxy-adenosine Residues. Heinz H. Schmeiser, Johannes W. G.Janssen. John Lyons, Hans R. Scherf, Wolfgang Pfau. AlbrechtBuchmann. Claus R. Bartram, and Manfred Wiessler.

5504 Cytotoxicity Phase of Diethylnitrosamine-induced Hepatic Neoplasia in Medaka. Darrel J. Lauren, Swee J. Teh, and David E.Hinton.

5567 Effect of 12-O-Tetradecanoylphorbol-13-acetate on Colony Formation and Intercellular Communicationin a Coculture System ofJB6 Clones. Ichiro Yamadori, Ursula 1. Heine. Susan Kenney,Charles W. Riggs. and Jerry M. Rice.

5574 Combined Histochemical and Biochemical Analysis of Sex Hormone Dependence of Ferric Nitrilotriacetate-induced Renal LipidPeroxidation in ddY Mice. Shinya Toyokuni, Shigeru Okada,Shuji Hamazaki, Yukiko Minamiyama, Yoshihiro Yamada, PingLiang. Yasutomo Fukunaga. and Osamu Midorikawa.

*55S7 Malignant Transformation of Human Fibroblasts by a Intns-fected N-ras Oncogene. Daniel M. Wilson, Dajun Yang, John E.Dillberger, Stephen E. Dietrich, Veronica M. Mäher, andJ. Justin McCormick.

Endocrinology*5291 Regulation of Progesterone Receptor Gene Expression.

E. Vegeto. M. G. Cocciolo. F. Raspagliesi. A. Piffanelli.R. Fontanelli, and A. Maggi.

*5.<X2 Androgen Receptor Gene Expression in Human Prostate Carcinoma Cell Lines. W. D. Tilley, C. M. Wilson. M. Marcelli, andM. J. McPhaul.

* 5488 Establishment and Characterization of a Human AdrenocorticalCarcinomaCell Line That Expresses Multiple Pathways of Steroid Biosynthesis. Adi F. Gazdar. Herbert K. Oie, Cedric H.Shackleton, T. R. Chen, Timothy J. Triche, Charles E. Myers,George P. Chrousos, Murray F. Brennan, C. A. Stein, and RenatoV. La Rocca.

Immunology*5225 Tumor Localization by Combinations of Monoclonal Antibodies

in a New Human Colon Carcinoma Cell Line (LIM1899) SarahM. Andrew, Jin Ghee Teh. Ricky W. Johnstone, Sarah M.Russell, Robert H. Whitehead, Ian F. C. McKenzie, and GeoffreyA. Pietersz.

* Indicates studies using human-derived material.

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* 5234 Augmentation of Antibody Dependent Cell Mediated Cytotoxicityfollowing in Vivo Therapy with Recombinant Interleukin 2.Jacquelyn A. Hank, Randy R. Robinson. Jean Surfus. BarbaraM. Mueller, Ralph A. Reisfeld. Nai-Kong Cheung, and Paul M.Sondel.

* 5263 Clonal Analysis of Lymphocytes from Tumor, Peripheral Blood,and Nontumorous Kidney in Primary Renal Cell Carcinoma.Tae-Yoon Kim. Andrew C. von Eschenbach, MaryLynne D.Filaccio, Kazuhiro Hayakawa. David R. Parkinson, Charles M.Balch. and Kyogo Itoh.

*54I4 Antitumor Effects of a-Interferon and •y-Interferonon a Murine

Renal Cancer (Renca) ¡nVitro and in Vivo. T. J. Savers, T. A.Wiltrout. K. McCormick, C. Husted. and R. H. Wiltrout.

5421 Monoclonal Antibody Therapy of Murine Lymphoma: EnhancedEfficacy by Concurrent Administration of Interleukin 2 or Lym-phokine-activated Killer Cells. Kirk R. Schultz, Jay P. Klarnet,David J. Peace, Martin A. Cheever. Christopher C. Badger, IrwinD. Bernstein, and Philip D. Greenberg.

5460 Potentiation of Natural Killer Cell Activity and Tumor Immunityby Diacetylputrescine. Terry L. Bowlin. Andrea Rosenberger,David Stemerick, and Michael L. Edwards.

*54')7 Gangliosides and Sialoglycoproteins Carrying a Rare Blood

Group Antigen Determinant, Cad, Associated with Human Cancers as Detected by Specific Monoclonal Antibodies. NozomuHiraiwa. Kiyotaka Tsuyuoka. Yu-Teh Li. Mitunobu Tanaka,Taiko Seno, Yasuto Okubo. Yoshihiro Fukuda, Hiroo Imura,and Reiji Kannagi.

5515 Assessment of Protein Kinase C Isozymes by Enzyme Immu-noassay and Overexpression of Type II in Thyroid Adenocar-cinoma. Masatoshi Hagiwara. Takahisa Hachiya. MasatoWatanabe. Nobuteru Usuda, Futoshi lida. Katsuyuki Tamai, andHiroyoshi Hidaka.

5543 In Vivo Administration of Interferon a and Interleukin 2 InducesProliferation of Lymphoid Cells in the Organs of Mice. Raj K.Puri, William D. Travis, and Steven A. Rosenberg.

*555I In Vivo Interleukin 2-induced Activation of Lymphokine-acti-vated Killer Cells and Tumor Cytotoxic T-Cells in CervicalLymph Nodes of Patients with Head and Neck Tumors. LiciaRivoltini. Carlo Gambacorti-Passerini. Massimo Squadrelli-Saraceno, Maria Ilaria Grosso, Giulio Cantù, Roberto Molinari.Attilio Orazi, and Giorgio Parmiani.

Molecular Biology and Genetics* 52-10 Detection of Minimal Residual Disease in Leukemic Patients

with the t(10;14)(q24;qll) Chromosomal Translocation. JacobKagan, Lawrence R. Finger, Emanuel Besa, and Carlo M. Croce.

5245 DNA Fingerprinting of 7,12-Dimethylbenz|a]anthracene-inducedand Spontaneous CD-I Mouse Liver Tumors. Brian J. Ledwith,Richard D. Storer, Srinivasa Prahalada. Sujata Manam, Karen R.Leander. Matthew J. van Zwieten. Warren W. Nichols, andMatthews O. Bradley.

5374 Identification of Ultraviolet-inducible Proteins That Bind to aTGACAACA Sequence in the Polyoma Virus Regulatory Region.Zeev A. Ronai and I. Bernard Weinstein.

*5392 Non-P-Glycoprotein Mediated Multidrug Resistance Precedes

P-Glycoprotein Expression during in Vitro Selection forDoxorubicin Resistance in a Human Lung Cancer Cell Line.F. Baas, A. P. M. Jongsma, H. J. Broxterman, R. J. Arceci,D. Housman, G. L. Scheffer. A. Riethorst. M. van Groenigen,A. W. M. Nieuwint. and H. Joenje.

* 5-106 A Deletion Linked to a Poly(ADP-ribose) Polymerase Gene onChromosome 13q33-qter Occurs Frequently in the Normal BlackPopulation as Well as in Multiple Tumor DNA. Kishor G.Bhatia. Barry W. Cherney. Konrad Huppi, Ian T. Magrath,Jeffrey Cossman. Edward Sausville, Francisco Barriga, BruceJohnson. Barry Gause, George Bonney, Janet Neequayi, MariaDeBernardi, and Mark Smulson.

* 54.11 Cloning and Characterization of Human Tumor Cell InterstitialCollagenase. Nancy Smyth Templeton, Peter D. Brown, Anna T.Levy, Inger M. K. Margulies. Lance A. Liotta. and William G.Stetler-Stevenson.

5581 Selection for Spontaneous Metastasis after Calcium Phosphate-mediated Transfer of DNA. Ruth J. Muschel.

Preclinical Pharmacology and Experimental Therapeutics*5212 Activity of the Thymidylate Synthase Inhibitor 2-Desamino-Arl°-

propargyl-5,8-dideazafolic Acid and Related Compounds in Murine (1.1210) and Human (\V1L2) Systems in Vitro and in I.I 210in Vivo. Ann L. Jackman, Gordon A. Taylor, Brigid M.O'Connor. Joel A. Bishop, Richard G. Moran, and A. Hilary

Calven.

5296 Failure of Chronic Glutathione Elevation to Reduce CytotoxicityProduced by Exposure to ci's-Diamminedichloroplatinum(II),

Ionizing Radiation, or Hyperthermia. Michael L. Freeman.Michael J. Meredith, and Donald R. Eisert.

5318 Application of a New Approach for the Quantitation of Drug Syn-ergism to the Combination of m-Diamminedichloroplatinum andl-/3-D-Arabinofuranosylc)tosine. William R. Greco, HyoungSook Park, and Youcef M. Rustum.

* 5399 Inhibition of Human Breast Cancer Cell Proliferation in TissueCulture by the Neuroleptic Agents Pimozide and Thioridazine.Jeannine S. Strobl. Keith L. Kirkwood. Tracy K. Lantz. Michael A.Lewine. Virginia A. Peterson, and Jennings F. Worley III.

5475 Prevention of Central Nervous System Toxicity of the AntitumorAntibiotic Acivicin by Concomitant Infusion of an Amino AcidMixture. Marta G. Williams. Robert H. Earhart, Howard Bailey,and J. Patrick McGovren.

5537 Role of Tumor Necrosis Factor in Flavone Acetic Acid-inducedTumor Vasculature Shutdown. Viswanath Mahadevan, SaleemT. A. Malik. Anthony Meager, Walter Fiers, Graham P. Lewis,and Ian R. Hart.

"*•5558 Enhancement of Ricin A Chain Immunotoxin Activity by Perhex-iline on Established and Fresh Leukemic Cells. Jean-PierreJaftrezou. Thierry Levade, Emilienne Kuhlein, OlivierThurneyssen. Marielle Chiron, HélèneGrandjean. DominiqueCarrière,and Guy Laurent.

Tumor Biology* 5312 Abnormalities in Structure and Expression of the Retinoblastoma

Gene in Small Cell Lung Cancer Cell Lines and Xenografts inNude Mice. Kare Rygaard. George D. Sorenson, Olive S.Pettengill, Charles C. Cate, and Mogens Spang-Thomsen.

5351 Role of Growth Factor Synthesis in the Acquisition of Insulin/Insulin-like Growth Factor I Independence in Rat MammaryCarcinoma Cells. Stephen P. Ethier, Caterina Chiodino, andRichard F. Jones.

5365 Porphyrin Photosensitivity in Cell Lines Expressing a Heat-resistant Phenotype. Charles J. Corner. Natalie Rucker, and SamWong.

* 5387 Effect of a-Interferon, 17/3-Estradiol, and Tamoxifen on Estrogen

Receptor Concentration and Cell Cycle Kinetics of MCF 7 Cells.W. R. Bezwoda and K. Meyer.

on May 24, 2020. © 1990 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from

*5520

5526

* 55.M

* 5287

5345

Peripheral Airway Cell Differentiation in Human Lung CancerCell Lines. Adi F. Gazdar, R. Ilona Linnoila. Yukio Kurita.Herbert K. Oie, James L. Mulshine. Jean C. Clark, and Jeffrey A.Whitsett.

Differentiation and Growth Modulation of Chronic MyelogenousLeukemia Cells by Bryostatin. Michael Lilly, Chris Tompkins,Chris Brown, George Pettit. and Andrew Kraft.

Establishment and Characterization of a Tumorigenic MurineVascular Endothelial Cell Line (F-2). Ken-Ichi Toda, KaoniTsujioka, Yukiya Maruguchi, Kazuhiro Ishii, Yoshiki Miyachi,Kagemasa Kuribayashi. and Sadao Imamura.

Establishment and Characterization of Human Renal Cancer andNormal kidney Cell Lines. T. Eben. N. H. Bander, C. L. Finstad.R. D. Ramsawak. and L. J. Old.

Virology

Augmentation of Cytotoxic Effect of Tumor Necrosis Factor onHuman Immunodeficiency Virus-infected Cells by Staurosporine,a Potent Protein Kinase C Inhibitor. Yoshiaki Hamamoto.Toshifumi Matsuyama. Naoki Yamamoto, and NobuyukiKobayashi.

CLINICAL AND EPIDEMIOLOGICALINVESTIGATIONS

Clinical

Carbohydrate Analysis of Immunoglobulin G Myeloma Proteinsby Lectin and High Performance LiquidChromatography:Role ofGlycosyltransferases in the Structures. Tetsuo Nishiura, ShigeruFujii. Yoshio Kanayama. Atsushi Nishikawa. YoshiakiTomiyama. Masato lida, Takahiro Karasuno. Hirohisa Nakao,Takeshi Yonezawa. Naoyuki Taniguchi, and Seiichiro Tarui.

5358 Suppressor Cell Activity in a Randomized Trial of Patients Receiving Active Specific Immunotherapywith Melanoma Cell Vaccine and Low Dosages of Cyclophosphamide. Dave S. B. Hoon.Leland J. Foshag, Anne S. Nizze. Roger Bohman. and Donald L.Morton.

Epidemiológica!

5231 Smoking and Renal Cell Carcinoma. Carlo La Vecchia. EvaNegri. Barbara D'Avanzo, and Silvia Franceschi.

5470 Ecological Correlation between Arsenic Level in Well Water andAge-adjusted Mortality from Malignant Neoplasms. Chien-JenChen and Chin-Jen Wang.

5594 AnnouncementsEighty-second Annual Meeting of the AACRCall for Nominations for the Scientific Awards of the AACRAACR Special Conferences in Cancer ResearchFuture Annual Meetings of the AACRRecent DeathCalendar of Events

5596 Employment Register of the AACR

5604 Author Index

NOTE: AACR forms available in the back of this issue—•Application for Active and Corresponding Membership•Application for Associate Membership

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1990;50:5211-5603. Cancer Res     50 (17)

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