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TOPIC NAME : CAPUSLE

• Sumitted to: Dr.Khizar HayyatSubmitted By: Zulcaif Ahmad & Saqib Hafeez (696) (719)

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Preparation of Hard Gelatin Capsule

• Developing and preparing the formulation and selecting the capsule size

• Filling the capsule shells• Capsule sealing(optional)• Cleaning and polishing the filled

capsules

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Developing and preparing the formulation and selecting the capsule size

uniform powder

Diluent or filler

Disintegrants

Lubricant or Glidant

Wetting and Solublizing

agent

Coating agent

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Selection of capsule size:-

000 00 o

1 2 3

4 5

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Filling Hard Capsule Shells

Punch

method

.

•When filling a small number of capsules in the pharmacy

•takes the precise number of empty capsules to be filled from the stock container.

Machine

s

•Machines developed for industrial use automatically separate the caps from empty capsules, fill the bodieS

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Filling Hard Capsule Shells

Punched vertically

Hold capsule between the thumb and forefinger

Mix with spatula

Powder place on a clean paper or glass or porcelain plate

Punch method

Empty capsules

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Filling Hard Capsule Shells

Hand-operated capsule filling machines or Feton capsule filling machine

Consist of a couple of plates are capable of producing about 200 to 2000capsules/hr.

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OSAKA MODEL R-180 SEMI AUTOMATIC CAPSULE

FILLING MACHINE

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Capsule Sealing

•that fuses the capsule cap to the body through the double wall thickness at their juncture The process results in a distinctive ring around the capsule where heat welded.

Heat-welding process

•that lowers the melting point in the contact areas of the capsule’s cap and body and then thermally bonds the two parts using low temperatures

Liquid wetting agent

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Capsule Sealing

Heat-welding process

Fuse the cap & body through double wall thickness at their

juncture

distinctive ring around the capsule where heat

welded

Liquid wetting agent

lowers the melting point in contact areas

thermally bonds two parts using low

temperatures (40°C–45°C).

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Cleaning and Polishing Capsules • On a small scale, capsules

may be cleaned individually or in small numbers by rubbing them with a clean gauze or cloth.

On small Scale

• Many capsule-filling machines are affixed with a cleaning vacuum that removes any extraneous material from the capsules as they exit the equipment. industrial cleaning and polishing of filled hard capsules using the Accela-Cota apparatus.

On large scale

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Cleaning and Polishing Capsules

On small scale

Cleaned individually in small numbers

Rubbing with a clean gauze or

cloth.

On large scale

Cleaning vacuum affixed with filling

machine

cleaning and polishing by Accela-Cota

apparatus.

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CAPSULE POLISHING MACHINE

AUTO MATIC CAPSULE

ARRANGEMNT

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Preparation of Soft Gelatin Capsules

Preparation of Soft Gelatin

Capsules

Plate process

Reciprocating die process

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Molds Filling with gelatin and medicament on

bottom plate

Second sheet of gelatin is carefully placed on top of

the medication

Top plate of the mold is put into place

Pressure & heat is applied to seal the capsules

Washing

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References:-

• Pharmaceutical Dosage forms and Drug delivery Systems, Ansel’s, Chapter 7, Page 203-214, Ninth Edition, 2011, 2005 Wolters Kluwer / Lippincott Williams & Wilkins.

• Martin’s physical pharmacy and pharmaceutical sciences, Patrick J. Sinko, Chapter No.22, Page No. 580-581, Sixth Edition 2011, 2006 Lippincott Williams & Wilkins, Wolters Kluwer Business.

• Pharmaceutical preformulation and formulation , Mark Gibson, Page 451-453, 2004, Printed in USA, By Interpharm / CRC.

• Pharmaceutics The design and manufacture of Mediicines, Michael E.Aulton, Third Edition.

• Text book of Pharmaceutics, Bentley’s, Chapter 19 page 310-314, Eight Edition, Edited by: E.A.Rawlins, Published by A.I.T.B.S

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