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    1.2 CAPSULE CAMERA:

    Capsule camera, endoscopic capsule or video pill is a camera with the size and

    shape of pill. The Imaging Capsule contains a miniature camera, battery, light,

    computer chip and wireless transmitter. The target destination for the device is the small

    bowel, where the miniature camera may help physicians detect sources of bleeding or

    diagnose disease.

    Fig. 1.1. CAPSULE CAMERA

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    2. OBJECTIVE

    At the present time, the capsule camera is primarily used to visualize the small

    intestine. Whereas the upper gastrointestinal tract (esophagus, stomach, and duodenum)

    and the colon (large intestine) can be very adequately visualized with scopes (cameras

    placed at the ends of thin flexible tubes), the small intestine is very long (average 20-25

    feet) and very convoluted. No available scope is able to traverse the entire length of the

    small intestine. The capsule camera travels through the length of the small intestine in

    about 4 hours, and wirelessly transmits two images every second to a receiver carried

    by the patient. The images are of very good quality, comparable to those from scopes.

    The test carries a high sensitivity and specificity for detecting lesions. The main uses

    today are for detecting the cause of gastrointestinal bleeding, and for inflammatory

    bowel disease, such as Cohns disease

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    Fig.2.1. A CAPSULE TO SAVE STOMACHS

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    3. LITERATURE SURVEY

    A 2002 TEC Assessment (1) concluded that wireless capsule endoscopy met the TEC

    criteria as a technique to investigate obscure gastrointestinal (GI) bleeding suspected of

    being of small bowel origin. (2) Specifically, the TEC Assessment reviewed 2 articles

    that focused on the clinical applications of wireless capsule endoscopy in patients with

    obscure GI bleeding. Obscure GI bleeding is defined as recurrent or persistent iron-

    deficiency anemia, positive fecal occult blood test, or visible bleeding with no bleeding

    source found at original endoscopy.

    The first comparative study included 20 patients with obscure digestive tract

    bleeding. Capsule images were reported as good or excellent by the 2 physician

    reviewers, 1 of whom was blinded to clinical information and results of push

    enteroscopy. Overall, wireless capsule endoscopy found a bleeding site in 11 of 20

    (55%) patients studied and provided additional information not detected by push

    enteroscopy in 5 of 20 (25%) cases.

    An updated literature search performed for the period of 2005 through January

    2006 did not identify any additional articles that would prompt reconsideration of the

    relevant policy statement, which remains unchanged. Published studies continue to

    support the role of the capsule camera in the evaluation of obscure GI bleeding.The policy was updated with a literature search through February 2007. Eliakim

    evaluated 106 patients (93 with GER and 13 with Barrett esophagus) with wireless

    endoscopy followed by standard endoscopy as the gold standard. (18) A blinded

    adjudication committee reviewed all discrepant findings. The authors reported a

    sensitivity of 92% (61 of 66) and specificity of 95%. Lin and colleagues reported results

    of a prospective blinded (without adjudication) study of capsule endoscopy compared to

    conventional endoscopy for Barretts esophagus in 66 screening and 24 surveillance

    patients. (19) This study reported a sensitivity of 67% (14 of 21) and specificity of 84%.

    The policy was updated with a literature review in June 2008 using MEDLINE.

    Delvaux studied both esophagogastroduodenoscopy (EGD) and capsule endoscopy

    (CE) in a European study of 98 patients, enriched to include abnormal esophageal

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    findings in two-thirds of patients. (21) EGD was normal in 34 patients and showed

    esophageal findings in 62 (esophagitis 28, hiatus hernia 21, varices 21, Barrett's

    esophagus 11, others 7). Average esophageal transit time of the capsule was 361

    seconds. Capsule endoscopy (CE) was normal in 36 patients but detected esophagitis in

    23, hiatus hernia in 0, varices in 23, Barrett's esophagus in 18, and others in 4. Overall

    agreement per patient was moderate between EGD and capsule endoscopy for the per-

    patient (kappa = 0.42) and per-findings (kappa = 0.40) analyses.

    The policy was updated with a literature search through mid-July 2009.

    Literature was reviewed for several indications for capsule endoscopy and for the

    patency capsule. A recent meta-analysis summarized available studies comparing

    capsule endoscopy to a reference standard of duodenal biopsy. (33) The pooled analysisof 3 studies showed a sensitivity of 83% and a specificity of 98%. The sensitivity of the

    test does not seem to be sufficient to replace duodenal biopsy for the diagnosis of celiac

    disease. The policy statement is unchanged; the use of capsule endoscopy remains

    investigational for the evaluation of celiac disease.

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    4. PROBLEM DESCRIPTION

    Wireless capsule endoscopy is performed using the PillCam, which is a disposable

    imaging capsule manufactured by Given Imaging, Ltd (Norcross, GA). The capsule

    measures 11 by 30 mm and contains video imaging, self-illumination, and image

    transmission modules as well as a battery supply that lasts up to 8 hours. The indwelling

    camera takes images at a rate of 2 frames per second as peristalsis carries the capsule

    through the gastrointestinal tract. The average transit time from ingestion to evacuation

    is 24 hours. The device uses wireless radio transmission to send the images to a

    receiving recorder device that the patient wears around the waist. This receiving device

    also contains some localizing antennae sensors that can roughly gauge where the image

    was taken over the abdomen. Images are then downloaded onto a workstation for

    viewing and processing.

    Evaluation of the esophagus requires limited transit time, and it is estimated that

    the test takes 20 minutes to perform. Alternative techniques include upper endoscopy.

    In 2006, the FDA also provided clearance for the Given AGILE patency system. This

    system is an accessory to the PIllCam video capsule is intended to verify adequate

    patency of the GI tract prior to administration of the PillCam in patients with known or

    suspected strictures. This capsule is of similar size to the endoscopy capsule, but ismade of lactose and barium and dissolves within 30-100 hours of entering the GI tract.

    It carries a tracer material that can be detected by a scanning device. Excretion of the

    intact capsule without symptoms (abdominal pain or obstruction) is reported to predict

    the uncomplicated passage of the wireless capsule.

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    5.TECHNICAL DETAILS

    The procedure involves the patient taking a small capsule, or endoscope with a

    tiny camera, light and radio transmitter inside it. The patient also wears small sensors

    attached to the abdomen with adhesive sleeves. A mini-lens on the tip of the capsule

    would be connected to a tiny "engine" running off electrical signals. An antenna would

    take in the electric signals and send out the data collected and the "brain" behind the

    whole system would be a microchip operating with hi-tech fluids. As the capsule moves

    through the digestive system it records images and sends them by radio signal to a

    receiver/recorder worn by the patient on a waist

    Belt as the patient goes about his or her regular day. The procedure takes about 12 hours

    and the final recording is about 8 hours long. Afterward, a doctor takes the disk from

    the recorder and views the video on a high-resolution monitor. The device takes two

    frames every second, providing about 58,000 images in eight hours as it makes it way

    through the patients entire digestive tract.

    Fig. 5.1.PILL CAMERA OF THE FUTURE

    The camera transmits digital images to a recording device the patient wears on a

    belt. Later, the recorders data is downloaded to a physicians computer. As the video

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    To the body and the strength of the signal was used to calculate the position of

    the capsule in the body. These promote greater efficiency in medical Institutions and

    help improve quality of life for the patients. Gastrointestinal endoscopes are now

    recognized as the only medical devices that can simultaneously perform observations,

    diagnoses (tissue extraction), and treatment. As tiny as a pill measuring just 9

    millimeters in diameter and 23 mm in length, the Norika3 capsule endoscope developed

    by RF is uniquely painless. "Though it hasn't been in practical use yet. Although the

    company says it is still preparing to conduct clinical studies with other medical

    institutions, it expects to market the Norika3 by the end of the year both in Japan and

    overseas. It will accommodate a CCD camera of 0.41 mega pixels and is likely be

    initially marketed at $100. The capsule moves painlessly through the gastrointestinaltract while transmitting color images on a real-time basis. The device accommodates a

    plastic CCD camera with a 0.6-millimeter lens as well as four Light-Emitting Diode

    (LED) flashing devices to supply light in the dark intestines. The camera can transmit

    up to 30 images per minute, as long as the patient is wearing the vest that transmits

    microwaves to the capsule.

    Fig. 5.3.INTERNAL STRUCTURE OF CAPSULE CAMERA

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    5.2. CAPSULE ENDOSCOPE TECHNOLOGY

    (1) Technology of capsule endoscope:

    Compact, low power-consumption imaging technology, wireless transmission

    technology.

    (2) Wireless power supply system:

    Eliminates constraints on operating time and energy levels.

    (3) Drug delivery system:

    Administer drugs directly to the affected area.

    (4) Body fluid sampling technology:

    Extracts body fluid for diagnosis and analysis.

    (5) Self-propelled capsule:

    Propels (capsule) freely within the gastrointestinal tract.

    5.2.1. BENEFITS OVER TRADITIONAL ENDOSCOPY:

    1. Little discomfort

    2. Does not require sedation

    3. Eliminates potential sedation related cardiopulmonary complications.

    4. Offers a simple, safe and less invasive alternative.

    5. Patient satisfaction

    6. Comfort during procedure

    7. Convenience

    8. Immediate recovery

    9. Preferred by patient over traditional endoscopy

    5.2.2. LIMITATIONS OF CAPSULE CAMERA:

    1. A physician cannot stop the cameras progress to change the angle or take a

    prolonged look when it nears suspicious areas.

    2. There is no air insufflations pumping in air to open up intestinal folds for

    Examination.

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    6. CONCLUSION

    Modern endoscopic techniques have revolutionized the diagnosis and treatment of

    diseases of the upper gastrointestinal tract (esophagus, stomach, and duodenum) and the

    colon.

    It is Very effective to use. And by using this can obtain best results.

    Capsule endoscope technology is developed by using capsule camera.

    It is to be in great use in near future.

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    7. BIBLIOGRAPHY

    www.msdn.microsoft.com

    www.wikipedia.org

    www.asptoday.com

    www.capsule-endoscopy.info

    www.google.com

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