CARBOHYDRATE OF BRAIN TISSUE

• Triosephosphate• Hexose• Lactic acid• Pyruvic acid

Minerals: Ion, macromolecules and micromolecules.

Na, K, Cu, Fe, Ca, Mg and P

Metabolism of nervous tissue

1. Needs high amount of energy2. Even higher in grey matter 3. Aerobic environment4. Anabolism takes place too5. Main substrate is glucose6. Metabolism of amino acids

NEUROTRANSMITTERS

1- Most are synthesized in presynaptic terminal

2- Once synthesized, they are stored in vesicles

3- Released in response to nerve impulse: 4- Termination: by: Reuptake of the neurotransmitter into presynaptic terminal Or Enzymatic inactivation

Glutamate Glutamine

Glutaminase

Metabolism of Ammonia

Hyperammonia – 1. Stops Kreb’s cycle

2. Depletion of ATP 3. Accumulation of

Glu and Gln

4. Changes in osmosis

5. Influx of water