Carefree Skincare

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BY

Our Company

International skincare company based in the US

Focused on developing and commercializing innovative and highly efficacious anti-aging products that enhance the health and appearance of aging skin

Markets and sells cosmeceutical products to aesthetic professionals in order to meet the rapidly growing patient demand for skin rejuvenation products

Boasts an accomplished management team with 35+ years industry experience

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Our Philosophy

To provide our customers with cutting edge products that are sold through aesthetic professionals to meet the needs of the rapidly growing skin rejuvenation market

To produce only high quality products, having partnered with an FDA-approved manufacturer, to ensure excellence in product development and formulations

To be an industry leader in customer service excellence

To be a leading player in the aesthetic skincare marketplace worldwide

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Our Core Team

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Greg Chanitz

Randy Kriech

• Managing Partner• Founder

• Managing Partner• Founder

• VP of Sales/Marketing, PRIORI Skincare• VP of Sales/Marketing, Percos India• Regional Sales Director, Triax Pharma• Sr. Sales/Marketing Mgr, SkinMedica• Regional Sales Director, Elan Dermatology

• National Sales Director , AGI /Remergent• National Sales Director, Pierre Fabre / Avene• Regional Sales Director, Elan Dermatology• Director Business Development, Topiderm

The Skincare Revolution

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DNA repair is at the center of the coming revolution

Molecular biology applied to skin Most important risk to skin DNA is

the sun Sunlight causes DNA damage DNA repair enzymes excise DNA

containing damage Patched by the body’s natural repair

process

Point of Distinction

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UV

DNA Youth Recovery

DNA Damage Free Radicals

DNA Oxidation CellOxidation

ANTIOXIDANTSantioxidants

10x more thanoxidation

DNA Damage is 10 times more prevalent than free radical damage

The Next Wave in the Skincare Revolution

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Potent DNA repair enzymes Powerful antioxidants Unique formulas Next generation ingredients Precise delivery technologies Exceptional Results

Photodamage is Complex

Wrinkles Increased UV spots Loss of elasticity Hypo- and hyperpigmentation Increased skin cancer risk

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What is DNA Damage? The familiar double helix known as DNA is subject to thousands

of daily assaults: from the outside by radiation, pollutants and thermal damage; from the inside by replication errors and the body’s normal processes.

DNA is particularly susceptible to UV damage. While the skin’s own melanin and added sunscreen reflect or absorb a certain amount of light, enough solar radiation invariably gets through to the cell’s nucleus to directly damage DNA.

The skin is not defenseless. There are many DNA repair enzymes that spring into action when the cell is alerted to damage. The damaged strand is recognized and snipped out, and polymerases takes over, using the opposite strand as a template to guide the correction.

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In a 24 hour period, your body can only repair 50% of photodamage

DNA Damage (cont.) Everyone Needs DNA Repair Enzymes Some enzymes known as endonucleases assist in repairing the DNA by

seeking out the damaged DNA and sending a rallying call for the body’s own repair enzymes to remove lesions. Micrococcus luteus is one of the most UV-resistant microbes known to science.

Liposome delivery of this marine microbe recognizes cellular UV damage and accelerates the skin’s repair and recovery process.

Arabidopsis thaliana, also known as OGG1, is a second endonuclease repair enzyme found in the mustard plant. It targets both the nucleus and the energy-making mitochondria of the cell. OGG1 seeks out a common type of free radical damage to DNA and helps the body’s natural process by initiating the cellular repair process.

Anacystis nidulans is a light sensitive enzyme, sourced by plankton and algae, that adheres directly to the damaged DNA and channels energy it absorbs from the sunlight to separate and then restore the fused rungs. About 20 minutes of sunshine or an hour of indoor light are sufficient to activate this photolyase enzyme and help clear the DNA of UV damage.

The key to the effectiveness of these topically applied enzymes is their liposome delivery system, which transports them directly to the cells.

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DNA Repair Enzymes

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Anacystis nidulans Micrococcus luteus Arabidopsis thaliana

Enzyme Photolyase Endonuclease OGG1

Source Plankton Marine Micorbe Mustard Plant

Human Repair Photoreactivation Base Excision Repair

Base Excision Repair

Light Dependent Independent Independent

Speed Instant with Light 4-6 hours 4-6 hours

Immune System Protection Protection Not Known

Skin Protection Erythema Peeling Not Known

DNA Repair Enzyme - Micrococcus luteus

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Untreated

Treated with Micrococcus luteus Micrococcus luteus: liposome

delivery of this enzyme, sourced from marine microbes, recognizes cellular UV damage and accelerates the skin repair and recovery process

DNA Damage

DNA Repair Enzyme - Anacystis nidulans

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UV causes DNA damageLiposomes deliver photolyase into skinPhotolyase activity recognizes DNA

damageAbsorbs visible light and UVAReverses DNA damage

T T

DNA Repair Enzyme - Anacystis nidulans

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Anacystis nidulans is a light sensitive enzyme, sourced by plankton and algae, that adheres directly to the damaged DNA and channels energy it absorbs from the sunlight to separate and then restore the fused rungs.

About 20 minutes of sunshine or an hour of indoor light are sufficient to activate this photolyase enzyme and help clear the DNA of UV damage.

UV

UV+Photosomes

Human skin UVBDNA damage (green)

Anacystis nidulans light activation

DNA Repair Enzyme – Anacystis nidulans

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Anacystis nidulans is a light sensitive enzyme, sourced by plankton and algae, that adheres directly to the damaged DNA and channels energy it absorbs from the sunlight to separate and then restore the fused rungs.

About 20 minutes of sunshine or an hour of indoor light are sufficient to activate this photolyase enzyme and help clear the DNA of UV damage.

It takes 45+ minutes to reach sunburn with Anacystis nidulans vs. 15 minutes without

Micrococcus luteus and Anacystis nidulans

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Untreated

Treated with M. luteus & A. nidulans Micrococcus luteus + Anacystis

nidulans + visible light 6 hour results

DNA Damage

DNA Repair Enzyme – Arabidopsis thaliana

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Arabidopsis thaliana, also known as OGG1, is a second endonuclease repair enzyme found in the mustard plant.

It targets both the nucleus and the energy-making mitochondria of the cell.

OGG1 seeks out a common type of free radical damage to DNA and helps the body’s natural process by initiating the cellular repair process.

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Repairs oxidative damage to DNA• 90% elimination in 2 hrs

Liposome Delivery Most useful for being able to transfer and deliver active ingredients to the

application site of topical products

The liposome wall is very similar, physiologically, to the material of cell membranes

When a product containing liposomes is applied to the skin, the liposomes are deposited on the skin and begin to merge with the cellular membranes

In the process, the liposomes release their payload of active materials into the cells

As a consequence, not only is delivery of the actives very specific--directly into the intended cells--but the delivery takes place over a longer period of time

Liposomes are manufactured from various fatty substances that are used to encapsulate, or to create a sphere around, active materials, acting as a delivery system

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Restore & Defend with DNA Focused Skincare

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CELFIX CosmeceuticalsDNA Youth Recovery

Facial Serum

DNA Youth Recovery CELFIX Cosmeceuticals: DNA Youth Recovery

Facial Serum50 ml / 1.7 oz.

Benefits: DNA technology for daily skincare 3 DNA Repair Enzymes Repair of UV and free radical damage Calms skin while speeding recovery Indicated for photo-damaged skin, lines, wrinkles,

& uneven skin tones

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DNA Youth Recovery cont. Makes use of targeted repair enzymes that are derived from

natural sources such as marine plankton and other plants Utilizes an encapsulated, liposomal delivery system to drive

the enzymes into the nucleus of the skin cell Employs a Chinese Evodia plant derivative which has been

proven through clinical studies to help calm and soothe irritated skin

Uses hyaluronic acid, which has the ability to retain 1000 times its weight in water, to help the skin maintain its youthful appearance

Has a non-comedogenic, paraben-free formula

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DNA Youth Recovery (cont.) Speeds up the DNA repair process, therefore, assisting in the

recovery from non-invasive procedures

Provides faster DNA recovery, which offers added protection to the UV damage suffered from sun exposure

Holds off collagen degradation in the lower layers of the skin, therefore helping to reduce the appearance of fine lines and wrinkles

Is a must if you are concerned about overall skin health

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Key Ingredients Micrococcus luteus: liposome delivery of this enzyme, sourced from

marine microbes, recognizes cellular UV damage and accelerates the skin repair and recovery process

Arabidopsis thaliana: liposome delivery of the repair enzyme known as OGG1, sourced from mustard seed, recognizes DNA damage and helps the body’s natural process by initiating the cellular repair process

Anacystis nidulans: liposome delivery of the repair enzyme photolyase, sourced from plankton, that can absorb and assist in reversing the effects of UV induced skin damage

Hyaluronic acid has the ability to retain 1000x’s its weight in water which contributes significantly to the skin maintaining its youthful appearance

Evodia rutaecarpa fruit extract is derived from the Chinese Evodia plant and has been proven to calm and soothe irritated skin

L-ergothioneine is a powerful antioxidant that absorbs free radical chain initiators and inhibits ROS triggered by environmental exposure

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To Be Clear CELFIX Cosmeceuticals: DNA Youth Recovery

First and foremost, the product does not repair damaged DNA

It assists in speeding up the body’s natural process to repair damaged DNA

Liposome-delivered enzymes adhere to the damage, extract the damage, and allow the DNA to repair itself

This is what the body naturally does

However, the body can only repair 50% of the damage it receives in any given day

DNA Youth Recovery helps repair the other 50%

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How It Works Plant-derived enzymes mimic the body’s natural response

Enzymes are encapsulated in a liposomal delivery system which drives the enzymes into the nucleus of the skin cell

The cargo is released into the cell, searches and adheres to the damaged DNA strand only (search & destroy)

Damage is then extracted or cut out similar to the body’s natural response

DNA mimics clean strand and replicates to a healthy cell

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Who Needs CELFIX Cosmeceuticals: DNA Youth Recovery

Anyone concerned with overall skin health

Anyone overexposed to the sun, past and present

Anyone exposed to environmental pollutants

Anyone concerned with fines lines, wrinkles and UV spots

Anyone recovering from a non-invasive procedure

Everyone needs help repairing damaged DNA

DNA Youth Recovery is engineered to fit with all skin types and current protocols, therefore, anyone can use it

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Benefits CELFIX Cosmeceuticals: DNA Youth Recovery By assisting in DNA repair, it helps the skin recover from non-

invasive procedures Because it helps the skin repair the “other” 50% of damaged

DNA, it provides faster DNA recovery, which offers added protection/prevention to the UV damage suffered from sun exposure

Holds off collagen degradation in the lower layers of the skin, therefore, helping to reduce the appearance of fine lines and wrinkles

Has a non-comedogenic, paraben-free formulation Fits perfectly with all skincare regimens Attacks both past and present damage!!

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CELFIX Cosmeceuticals DNA Ceramide Renewal

Nourishing Cream

Skin Barrier Barrier function in the skin depends on ceramide lipids. Ceramides are fatty cells essential to a strong barrier

They are located in stratum corneum of skin and are an important part of the lipid barrier of the human skin which plays an essential role keeping the protective function of the skin against external insults and the hydration balance needed for its good conservation

Barrier is outer layer of skin and should be strong not necessarily thick

Protects the skin from the UV rays and environmental insults Building a better skin barrier:

– Apply topical ceramides– Accelerate keratinocyte maturation- late stage ceramide production– Stimulate keratinocyes to increase ceramides

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DNA Ceramide Renewal CELFIX Cosmeceuticals: DNA Ceramide

Renewal Nourishing Cream 50 ml / 1.7 oz.

Benefits Contains 1 DNA Repair Enzyme Builds upper skin barrier w/ ceramides

and antioxidants Strengthens lower collagen layer Reduce irritation and keeps skin moisturized Stronger protection from the inside out!

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DNA Ceramide Renewal One pump for face, throat and decollete

Once or twice daily, morning & night after cleansing and other treatments, before sunscreen

Patient Types:

Any patient post procedure

Men: post shave

Any patient w/ a compromised skin barrier

Any patient concerned with overall skin

health

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Key Ingredients Rosemary extract or ursolic acid is a natural component that provides a

boost to the skin’s natural ability to increase ceramide production Lactomide is an aqueous patented liposome dispersion containing a

naturally derived ceramide (Ceramide-3) as well as milk lipids. Lactomide improves the constitution and structure of the barrier and therefore has a positive effect on skin hydration and reversing the signs of aging

Arabidopsis thaliana: liposome delivery of the repair enzyme known as OGG1, sourced from mustard seed, recognizes DNA damage and helps the body’s natural process by initiating the cellular repair process

L-ergothioneine is a powerful antioxidant that absorbs free radical chain initiators and inhibits ROS triggered by environmental exposure

Evodia rutaecarpa fruit extract is derived from the Chinese Evodia plant and has been proven to calm and soothe irritated skin

Glycerin is a highly “hygroscopic” ingredient that helps to balance or maintain moisture levels in the skin

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Rosemary Extract Increases Ceramides

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eram

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Skin Lipids Increased Ceramides

30% Increase in 11 Days

Antioxidant ORAC Scores

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CELFIX Testimonial

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Tina S. Alster, MD, FAAD Director, Washington Institute of Dermatologic Laser Surgery Clinical Professor of Dermatology, Georgetown University Medical Center

“The impressive science-based technology of CELFIX DNA Youth Recovery makes it an important component of my patients’ anti-aging skin care regimens. The formulation can easily be incorporated into a variety of existing skin care protocols to enhance the skin’s appearance.”

CELFIX Testimonial

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Vivian Bucay, MD, FAAD Medical, Surgical & Cosmetic Dermatology San Antonio, TX

“As a stage IV melanoma survivor, the topic of DNA repair intrigues me. In clinical practice, I have found a product known as CELFIX DNA Youth Recovery (Carefree Skincare) to be very similar to the original Remergent DNA repair. An unpublished study performed in my clinic involving approximately 100 patients demonstrated that after three months of twice daily application, a 40-50 percent reduction in UV spots was achieved as measured by the VISIA Complexion Analysis.”

Clinical Analysis of CELFIX Products

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VISIA Complexion Analysis (Canfield Imaging Systems) Multi-spectral imaging, using

standard & UV photography Quantitative assessment of

sub-surface conditions Fixed positioning & lightening

to ensure accurateness of images between time points

20% Reduction in UV Spots in 4 Weeks

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Before: 342 UV Spots After: 4 Weeks: 271 UV Spots

Actual patient results using CELFIX products. Images taken by Vivian Bucay, MD, FAAD (Medical, Surgical & Cosmetic Dermatology – San Antonio, TX) using the VISIA Complexion Analysis System.

41% Reduction in UV Spots in 8 Weeks

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Before: 228 UV Spots After: 8 Weeks: 135 UV Spots

Actual patient results using CELFIX products. Images taken by Vivian Bucay, MD, FAAD (Medical, Surgical & Cosmetic Dermatology – San Antonio, TX) using the VISIA Complexion Analysis System.

70% Reduction in UV Spots in 12 Weeks

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Before: 217 UV Spots After: 12 Weeks: 64 UV Spots

Actual patient results using CELFIX products. Images taken by Vivian Bucay, MD, FAAD (Medical, Surgical & Cosmetic Dermatology – San Antonio, TX) using the VISIA Complexion Analysis System.

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CELFIX CosmeceuticalsDNA iQuad Infusion

Total Eye Complex

DNA iQuad Infusion CELFIX Cosmeceuticals: DNA iQuad Infusion

Total Eye Complex15 ml / 0.5 oz.

Benefits: 1 DNA Repair Enzyme Reduces appearance of lines & wrinkles Diminishes dark circles Treats photodamage Lessens the appearance of puffiness

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DNA iQuad Infusion cont. Matrixyl 3000, a combination of peptides that helps regulate

cell activity and works together to help restore and maintain the skin’s youthful appearance. Studies show a 45% reduction of wrinkles in 8 weeks.

Haloxyl is a combination of peptides that helps activate the elimination of blood originated pigments responsible for dark under-eye circles and puffiness while reinforcing firmness of the eye area.

Photolyase Liposomes, an organic DNA recovery enzyme derived from plankton which helps reverse photo damage and eliminate the appearance of UV spots on the skin.

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Key Ingredients

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Reduces Lines & Wrinkles

Diminishes Dark Circles

Lessens Puffiness

Combats Photodamage

Smoothes Skin Protects Moisturizes

Matrixyl 3000 X X Haloxyl X X Photolyase X X Caffeine X X X X Sunflower Seed Oil X XIvy Extract X Green Tea Extract X Sodium Hyaluronate X X XLicorice Extract X X Ergothioneine X Tocopherol X X XUbiquinone X X X X

45% Reduction of Wrinkles in 8 Weeks

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Baseline Week 8

Under-eye Circles Reduced in More Than 60% of Patients

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Dark circles significantly reduced by 19% in 8 weeks.

The Next Wave In The Skincare Revolution

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