carsten krebs curriculum vitae - sites at penn...

CARSTEN KREBS Curriculum vitae

Personal Data Name: Carsten Krebs

Country of birth: Germany

Country of citizenship: Germany

Immigration status: Permanent resident of the United States

Education 10/1989 - 9/1991 Undergraduate studies in Chemistry at the Ruhr-Universität Bochum, Germany

10/1991 - 9/1993 Graduate studies in Chemistry at the Ruhr-Universität Bochum, Germany

10/1993 - 5/1994 Diploma thesis in the Department of Inorganic Chemistry I at the Ruhr-

Universität Bochum, Germany

Title: 'Synthesis of sulfur- and selenium functionalized macrocyclic ligands and

their coordination chemistry'

Supervisor: Professor K. Wieghardt

6/1994 - 2/1997 Ph.D. thesis at the Max Planck Institut für Strahlenchemie, Mülheim/Ruhr,

Germany

Title: 'Magnetic exchange interactions in linear tetranuclear transition metal

compounds',

Supervisor: Professor K. Wieghardt

2/1997 - 1/2002 Postdoctoral Fellow, Physics Department, Emory University, Atlanta, GA,

Supervisor: Professor B. H. Huynh

Appointments

5/1999 – 1/2002 Research Associate, Physics Department, Emory University, Atlanta, GA

1/2002 – 6/2007 Assistant Professor of Biochemistry and Molecular Biology

The Pennsylvania State University

1/2004 – 6/2007 Assistant Professor of Chemistry


7/2007 – 6/2012 Associate Professor of Chemistry and of Biochemistry and Molecular Biology


7/2012 - current Professor of Chemistry and of Biochemistry and Molecular Biology


Carsten Krebs - 1 - Curriculum vitae as of 2/16/2015

Awards

9/1991 cum laude for Undergraduate Studies

5/1994 summa cum for Graduate Studies and Diploma Thesis

2/1997 summa cum laude for Ph.D. Thesis

2005 - 2008 “Beckman Young Investigator” of the Beckman Foundation

2006 – 2011 “Camille Dreyfus Teacher Scholar” of the Dreyfus Foundation

2008 “Pfizer Award in Enzyme Chemistry” of the ACS Biochemistry Division

2012 “Early Career Award” of the Society of Biological Inorganic Chemistry (SBIC)

Professional Memberships American Chemical Society

Society of Biological Inorganic Chemistry

American Association for the Advancement of Science


Organization of Meetings

1) Organizer (with J. Martin Bollinger) of the 1st Penn State Bioinorganic Workshop

June 1st to 2nd 2010, Pennsylvania State University, University Park, PA-16802

2) Organizer (with J. Martin Bollinger, Jr., Squire J. Booker, and Michael T. Green) of the 29th

Summer Symposium in Molecular Biology, entitled “2nd Frontiers in Metallobiochemistry”

June 2nd to 5th 2010, Pennsylvania State University, University Park, PA-16802

3) Organizer (with J. Martin Bollinger, Jr., Squire J. Booker, and John H. Golbeck) of the 2nd Penn

State Bioinorganic Workshop, June 1st to 8th 2012, Pennsylvania State University, University

Park, PA-16802

4) Organizer (with Amie K. Boal, J. Martin Bollinger, Jr., Squire J. Booker, John H. Golbeck, and

Michael T. Green) of the 3rd Penn State Bioinorganic Workshop, May 28th to June 4th 2014,

Pennsylvania State University, University Park, PA-16802

5) Organizer (with Amie K. Boal, J. Martin Bollinger, Jr., Squire J. Booker, and Michael T. Green) of

the 33rd Summer Symposium in Molecular Biology, entitled “3rd Frontiers in

Metallobiochemistry”

June 5th to 7th 2014, Pennsylvania State University, University Park, PA-16802


List of publications Published1-56

1) Krebs, C.; Winter, M.; Weyhermüller, T.; Bill, E.; Wieghardt, K.; Chaudhuri, P. "Magnetic exchange coupling in a nearly linear iron(III)nickel(II)nickel(II)iron(III) complex" J. Chem. Soc., Chem. Commun. 1995, 1913-15. 2) Beissel, T.; Birkelbach, F.; Bill, E.; Glaser, T.; Kesting, F.; Krebs, C.; Weyhermüller, T.;

Wieghardt, K.; Butzlaff, C.; Trautwein, A. X. "Exchange and Double-Exchange Phenomena in Linear Homo- and Heterotrinuclear

Nickel(II,III,IV) Complexes Containing Six µ2-Phenolato or µ2-Thiophenolato Bridging Ligands" J. Am. Chem. Soc. 1996, 118, 12376-12390. 3) Bill, E.; Krebs, C.; Winter, M.; Gerdan, M.; Trautwein, A. X.; Flörke, U.; Haupt, H.-J.;

Chaudhuri, P. "A triangular iron(III) complex potentially relevant to iron(III)-binding sites in ferreascidin" Chem.--Eur. J. 1997, 3, 193-201. 4) Bossek, U.; Nühlen, D.; Bill, E.; Glaser, T.; Krebs, C.; Weyhermüller, T.; Wieghardt, K.; Lengen,

M.; Trautwein, A. X. "Exchange Coupling in an Isostructural Series of Face-Sharing Bioctahedral Complexes

[LMII(µ-X)3MIIL]BPh4 (M = Mn, Fe, Co, Ni, Zn; X = Cl, Br; L = 1,4,7-Trimethyl-1,4,7-triazacyclononane)"

Inorg. Chem. 1997, 36, 2834-2843. 5) Trautwein, A. X.; Wieghardt, K.; Mochizuki, K.; Kesting, F.; Weyhermüller, T.; Butzlaff, C.;

Paulsen, H.; Ding, X.-Q.; Grodzicki, M.; Hartung, R.; Birkelbach, F.; Winter, M.; Flörke, U.; Haupt, H.-J.; Lengen, M.; Bill, E.; Chaudhuri, P.; Beissel, T.; Glaser, T.; Krebs, C.; Jüstel, T.; Hildebrandt, P.

"Electronic properties of paramagnetic and exchange-coupled transition-metal centers in biomimetic systems" in

"Bioinorganic Chemistry" Trautwein, A. X., Ed.; Wiley-VCH Verlag GmbH, Weinheim, Germany, 1997, pp 741-759. 6) Bollinger, J. M., Jr.; Krebs, C.; Vicol, A.; Chen, S.; Ley, B. A.; Edmondson, D. E.; Huynh, B. H. "Engineering the Diiron Site of Escherichia coli Ribonucleotide Reductase Protein R2 to

Accumulate an Intermediate Similar to Hperoxo, the Putative Peroxodiiron(III) Complex from the Methane Monooxygenase Catalytic Cycle"

J. Am. Chem. Soc. 1998, 120, 1094-1095. 7) Valentine, A. M.; Tavares, P.; Pereira, A. S.; Davydov, R.; Krebs, C.; Hoffman, B. M.;

Edmondson, D. E.; Huynh, B. H.; Lippard, S. J. "Characterization of a Mixed-Valent Fe(III)Fe(IV) Form of Intermediate Q in the Reaction Cycle

of Soluble Methane Monooxygenase, an Analog of Intermediate X in Ribonucleotide Reductase R2 Assembly"

J. Am. Chem. Soc. 1998, 120, 2190-2191.


8) Tavares, P.; Pereira, A. S.; Krebs, C.; Ravi, N.; Moura, J. J. G.; Moura, I.; Huynh, B. H. "Spectroscopic Characterization of a Novel Tetranuclear Fe Cluster in an Iron-Sulfur Protein

Isolated from Desulfovibrio desulfuricans" Biochemistry 1998, 37, 2830-2842. 9) Pereira, A. S.; Small, W.; Krebs, C.; Tavares, P.; Edmondson, D. E.; Theil, E. C.; Huynh, B. H. "Direct Spectroscopic and Kinetic Evidence for the Involvement of a Peroxodiferric Intermediate

during the Ferroxidase Reaction in Fast Ferritin Mineralization" Biochemistry 1998, 37, 9871-9876. 10) Krebs, C.; Glaser, T.; Bill, E.; Weyhermüller, T.; Meyer-Klaucke, W.; Wieghardt, K. "A paramagnetic copper(III) complex containing an octahedral CuIIIS6 coordination polyhedron" Angew. Chem., Int. Ed. 1999, 38, 359-361. 11) Moënne-Loccoz, P.; Krebs, C.; Herlihy, K.; Edmondson, D. E.; Theil, E. C.; Huynh, B. H.;

Loehr, T. M. "The Ferroxidase Reaction of Ferritin Reveals a Diferric µ-1,2 Bridging Peroxide Intermediate

in Common with Other O2-Activating Non-Heme Diiron Proteins" Biochemistry 1999, 38, 5290-5295. 12) Hurshman, A. R.; Krebs, C.; Edmondson, D. E.; Huynh, B. H.; Marletta, M. A. "Formation of a Pterin Radical in the Reaction of the Heme Domain of Inducible Nitric Oxide

Synthase with Oxygen" Biochemistry 1999, 38, 15689-15696. 13) Krebs, C.; Huynh, B. H. "Intermediates in oxygen activation reactions of diiron enzymes" in "Iron Metabolism" Ferreira, G. C., Moura, J. J. G. and Franco, R., Ed.; Wiley-VCH Verlag GmbH, Weinheim,

Germany, 1999, pp 253-273. 14) Lee, D.; Du Bois, J.; Petasis, D.; Hendrich, M. P.; Krebs, C.; Huynh, B. H.; Lippard, S. J. "Formation of Fe(III)Fe(IV) Species from the Reaction between a Diiron(II) Complex and

Dioxygen: Relevance to Ribonucleotide Reductase Intermediate X" J. Am. Chem. Soc. 1999, 121, 9893-9894. 15) Pereira, A. S.; Tavares, P.; Krebs, C.; Huynh, B. H.; Rusnak, F.; Moura, I.; Moura, J. J. G. "Biochemical and Spectroscopic Characterization of Overexpressed Fuscoredoxin from

Escherichia coli" Biochem. Biophys. Res. Commun. 1999, 260, 209-215. 16) Lee, D.; Krebs, C.; Huynh, B. H.; Hendrich, M. P.; Lippard, S. J. "Valence-Delocalized Diiron(II,III) Cores Supported by Carboxylate-Only Bridging Ligands" J. Am. Chem. Soc. 2000, 122, 5000-5001. 17) Hwang, J.; Krebs, C.; Huynh, B. H.; Edmondson, D. E.; Theil, E. C.; Penner-Hahn, J. E. "A short Fe-Fe distance in peroxodiferric ferritin: control of Fe substrate versus cofactor

decay?" Science 2000, 287, 122-125.


18) Agar, J. N.; Krebs, C.; Frazzon, J.; Huynh, B. H.; Dean, D. R.; Johnson, M. K. "IscU as a Scaffold for Iron-Sulfur Cluster Biosynthesis: Sequential Assembly of [2Fe-2S] and

[4Fe-4S] Clusters in IscU" Biochemistry 2000, 39, 7856-7862. 19) Krebs, C.; Davydov, R.; Baldwin, J.; Hoffman, B. M.; Bollinger, J. M., Jr.; Huynh, B. H. "Mössbauer and EPR Characterization of the S = 9/2 Mixed-Valence Fe(II)Fe(III) Cluster in the

Cryoreduced R2 Subunit of Escherichia coli Ribonucleotide Reductase" J. Am. Chem. Soc. 2000, 122, 5327-5336. 20) Jovanovic, T.; Ascenso, C.; Hazlett, K. R. O.; Sikkink, R.; Krebs, C.; Litwiller, R.; Benson, L.

M.; Moura, I.; Moura, J. J. G.; Radolf, J. D.; Huynh, B. H.; Naylor, S.; Rusnak, F. "Neelaredoxin, an iron-binding protein from the syphilis spirochete, Treponema pallidum, is a

superoxide reductase" J. Biol. Chem. 2000, 275, 28439-28448. 21) Nasri, H.; Ellison, M. K.; Krebs, C.; Huynh, B. H.; Scheidt, W. R. "Highly Variable π-Bonding in the Interaction of Iron(II) Porphyrinates with Nitrite" J. Am. Chem. Soc. 2000, 122, 10795-10804. 22) Baldwin, J.; Krebs, C.; Ley, B. A.; Edmondson, D. E.; Huynh, B. H.; Bollinger, J. M., Jr. "Mechanism of Rapid Electron Transfer during Oxygen Activation in the R2 Subunit of

Escherichia coli Ribonucleotide Reductase. 1. Evidence for a Transient Tryptophan Radical" J. Am. Chem. Soc. 2000, 122, 12195-12206. 23) Krebs, C.; Chen, S.; Baldwin, J.; Ley, B. A.; Patel, U.; Edmondson, D. E.; Huynh, B. H.;

Bollinger, J. M., Jr. "Mechanism of Rapid Electron Transfer during Oxygen Activation in the R2 Subunit of

Escherichia coli Ribonucleotide Reductase. 2. Evidence for and Consequences of Blocked Electron Transfer in the W48F Variant"

J. Am. Chem. Soc. 2000, 122, 12207-12219. 24) Krebs, C.; Henshaw, T. F.; Cheek, J.; Huynh, B. H.; Broderick, J. B. "Conversion of 3Fe-4S to 4Fe-4S Clusters in Native Pyruvate Formate-Lyase Activating Enzyme:

Mössbauer Characterization and Implications for Mechanism" J. Am. Chem. Soc. 2000, 122, 12497-12506. 25) Krebs, C.; Agar, J. N.; Smith, A. D.; Frazzon, J.; Dean, D. R.; Huynh, B. H.; Johnson, M. K. "IscA, an Alternate Scaffold for Fe-S Cluster Biosynthesis" Biochemistry 2001, 40, 14069-14080. 26) Baldwin, J.; Voegtli, W. C.; Khidekel, N.; Moënne-Loccoz, P.; Krebs, C.; Pereira, A. S.; Ley, B.

A.; Huynh, B. H.; Loehr, T. M.; Riggs-Gelasco, P. J.; Rosenzweig, A. C.; Bollinger, J. M., Jr. "Rational Reprogramming of the R2 Subunit of Escherichia coli Ribonucleotide Reductase into a

Self-Hydroxylating Monooxygenase" J. Am. Chem. Soc. 2001, 123, 7017-7030.


27) Ghiladi, R. A.; Hatwell, K. R.; Karlin, K. D.; Huang, H.-w.; Moënne-Loccoz, P.; Krebs, C.; Huynh, B. H.; Marzilli, L. A.; Cotter, R. J.; Kaderli, S.; Zuberbühler, A. D.

"Dioxygen Reactivity of Mononuclear Heme and Copper Components Yielding A High-Spin Heme-Peroxo-Cu Complex"

J. Am. Chem. Soc. 2001, 123, 6183-6184. 28) Krebs, C.; Broderick, W. E.; Henshaw, T. F.; Broderick, J. B.; Huynh, B. H. "Coordination of Adenosylmethionine to a Unique Iron Site of the [4Fe-4S] of Pyruvate Formate-

Lyase Activating Enzyme: A Mössbauer Spectroscopic Study" J. Am. Chem. Soc. 2002, 124, 912-913. 29) Yun, D.; Krebs, C.; Gupta, G. P.; Iwig, D. F.; Huynh, B. H.; Bollinger, J. M., Jr. "Facile Electron Transfer during Formation of Cluster X and Kinetic Competence of X for

Tyrosyl Radical Production in Protein R2 of Ribonucleotide Reductase from Mouse" Biochemistry 2002, 41, 981-990. 30) Lee, D.; Pierce, B.; Krebs, C.; Hendrich, M. P.; Huynh, B. H.; Lippard, S. J. "Functional Mimic of Dioxygen-Activating Centers in Non-Heme Diiron Enzymes: Mechanistic

Implications of Paramagnetic Intermediates in the Reactions between Diiron(II) Complexes and Dioxygen"

J. Am. Chem. Soc. 2002, 124, 3993-4007. 31) Krebs, C.; Bollinger, J. M., Jr.; Theil, E. C.; Huynh, B. H. "Exchange coupling constant J of peroxodiferric reaction intermediates determined by

Mössbauer spectroscopy" J. Biol. Inorg. Chem. 2002, 7, 863-869. 32) Jameson, G. N. L.; Jin, W.; Krebs, C.; Pereira, A. S.; Tavares, P.; Liu, X.; Theil, E. C.; Huynh, B.

H. "Stoichiometric Production of Hydrogen Peroxide and Parallel Formation of Ferric Multimers

through Decay of the Diferric-Peroxo Complex, the First Detectable Intermediate in Ferritin Mineralization"

Biochemistry 2002, 41, 13435-13443. 33) Krebs, C.; Edmondson, D. E.; Huynh, B. H. "Demonstration of Peroxodiferric Intermediate in M-ferritin Ferroxidase Reaction using Rapid

Freeze-Quench Mössbauer, Resonance Raman, and XAS Spectroscopies" Methods in Enzymology 2002, 354, 436-454. 34) Price, J. C.; Barr, E. W.; Tirupati, B.; Bollinger, J. M., Jr.; Krebs, C. "The First Direct Characterization of a High-Valent Iron Intermediate in the Reaction of an α-

Ketoglutarate-Dependent Dioxygenase: A High-Spin Fe(IV) Complex in Taurine/α-Ketoglutarate Dioxygenase (TauD) from Escherichia coli"

Biochemistry 2003, 42, 7497-7508. 35) Chaudhuri, P.; Rentschler, E.; Birkelbach, F.; Krebs, C.; Bill, E.; Weyhermüller, T.; Flörke, U. "Ground spin state variation in carboxylate-bridged tetranuclear [Fe2Mn2O2]8+ cores and a

comparison with their [Fe4O2]8+ and [Mn4O2]8+ congeners" European Journal of Inorganic Chemistry 2003, 541-555.


36) Baldwin, J.; Krebs, C.; Saleh, L.; Stelling, M.; Huynh, B. H.; Bollinger, J. M., Jr.; Riggs-Gelasco, P. J.

"Structural Characterization of the Peroxodiiron(III) Intermediate Generated during Oxygen Activation by the W48A/D84E Variant of Ribonucleotide Reductase Protein R2 from Escherichia coli"

Biochemistry 2003, 42, 13269-13279. 37) Broderick, J. B.; Walsby, C.; Broderick, W. E.; Krebs, C.; Hong, W.; Ortillo, D.; Cheek, J.;

Huynh, B. H.; Hoffman, B. M. "Paramagnetic resonance in mechanistic studies of Fe-S/radical enzymes" ACS Symposium Series 2003, 858, 113-127. 38) Price, J. C.; Barr, E. W.; Glass, T. E.; Krebs, C.; Bollinger, J. M., Jr. "Evidence for Hydrogen Abstraction from C1 of Taurine by the High-Spin Fe(IV) Intermediate

Detected during Oxygen Activation by Taurine:α-Ketoglutarate Dioxygenase (TauD)" J. Am. Chem. Soc. 2003, 125, 13008-13009. 39) Hurshman, A. R.; Krebs, C.; Edmondson, D. E.; Marletta, M. A. "Ability of Tetrahydrobiopterin Analogues to Support Catalysis by Inducible Nitric Oxide

Synthase: Formation of a Pterin Radical Is Required for Enzyme Activity" Biochemistry 2003, 42, 13287-13303. 40) Tripp, B. C.; Bell, C. B., III; Cruz, F.; Krebs, C.; Ferry, J. G. "A Role for Iron in an Ancient Carbonic Anhydrase" J. Biol. Chem. 2004, 279, 6683-6687. 41) Mader Cosper, M.; Jameson, G. N. L.; Hernandez, H. L.; Krebs, C.; Huynh, B. H.; Johnson, M.

K. "Characterization of the Cofactor Composition of Escherichia coli Biotin Synthase" Biochemistry 2004, 43, 2007-2021. 42) Saleh, L.; Krebs, C.; Ley, B. A.; Naik, S.; Huynh, B. H.; Bollinger, J. M., Jr. "Use of a Chemical Trigger for Electron Transfer to Characterize a Precursor to Cluster X in

Assembly of the Iron-Radical Cofactor of Escherichia coli Ribonucleotide Reductase" Biochemistry 2004, 43, 5953-5964. 43) Riggs-Gelasco, P. J.; Price, J. C.; Guyer, R. B.; Brehm, J. H.; Barr, E. W.; Bollinger, J. M., Jr.;

Krebs, C. "EXAFS Spectroscopic Evidence for an Fe=O Unit in the Fe(IV) Intermediate Observed during

Oxygen Activation by Taurine:α-Ketoglutarate Dioxygenase" J. Am. Chem. Soc. 2004, 126, 8108-8109. 44) Cicchillo, R. M.; Baker, M. A.; Schnitzer, E. J.; Newman, E. B.; Krebs, C.; Booker, S. J. "Characterization of Escherichia coli L-Serine Dehydratase as an Iron-Sulfur Containing

Enzyme" J. Biol. Chem. 2004, 279, 32418-32425. 45) Cicchillo, R. M.; Lee, K.-H.; Baleanu-Gogonea, C.; Nesbitt, N. M.; Krebs, C.; Booker, S. J. "Escherichia coli Lipoyl Synthase Binds Two Distinct [4Fe-4S] Cluster per Polypeptide" Biochemistry 2004, 43, 11770-11781.


46) Krebs, C.; Price, J. C.; Baldwin, J.; Saleh, L.; Green, M. T.; Bollinger, J. M., Jr. "Rapid Freeze-Quench 57Fe Mössbauer Spectroscopy: Monitoring Changes of an Iron-

Containing Active Site during a Biochemical Reaction" Inorg. Chem. 2005, 44, 742-757. 47) Cicchillo, R. M.; Tu, L.; Stromberg, J. A.; Hoffart, L. M.; Krebs, C.; Booker, S. J. "Escherichia coli Quinolinate Synthetase Does Indeed Harbor a [4Fe-4S] Cluster" J. Am. Chem. Soc. 2005, 127, 7310-7311. 48) Price, J. C.; Barr, E. W.; Hoffart, L. M.; Krebs, C.; Bollinger, J. M., Jr. "Kinetic Dissection of the Catalytic Mechanism of Taurine:α-Ketoglutarate Dioxygenase (TauD)

from Escherichia coli" Biochemistry 2005, 44, 8138-8147. 49) Smith, A. D.; Jameson, G. N. L.; Dos Santos, P. C.; Agar, J. N.; Naik, S.; Krebs, C.; Frazzon, J.;

Dean, D. R.; Huynh, B. H.; Johnson, M. K. "NifS-Mediated Assembly of [4Fe-4S] Clusters in the N- and C-Terminal Domains of the NifU

Scaffold Protein" Biochemistry 2005, 44, 12955-12969. 50) Bollinger, J. M., Jr.; Price, J. C.; Hoffart, L. M.; Barr, E. W.; Krebs, C. "Mechanism of Oxygen Activation by Taurine:α-Ketoglutarate Dioxygenase (TauD) from

Escherichia coli" Eur. J. Inorg. Chem. 2005, 2005, 4245-4254. 51) Bollinger, J. M., Jr.; Krebs, C. "Stalking intermediates in oxygen activation by iron enzymes: Motivation and method" J. Inorg. Biochem. 2006, 100, 586-605. 52) Xing, G.; Hoffart, L. M.; Diao, Y.; Prabhu, K. S.; Arner, R. J.; Reddy, C. C.; Krebs, C.;

Bollinger, J. M., Jr. "A Coupled Dinuclear Iron Cluster that Is Perturbed by Substrate Binding in myo-Inositol

Oxygenase" Biochemistry 2006, 45, 5393-5401. 53) Xing, G.; Barr, E. W.; Diao, Y.; Hoffart, L. M.; Prabhu, K. S.; Arner, R. J.; Reddy, C. C.; Krebs,

C.; Bollinger, J. M., Jr. "Oxygen Activation by a Mixed-Valent, Diiron(II/III) Cluster in the Glycol Cleavage Reaction

Catalyzed by myo-Inositol Oxygenase" Biochemistry 2006, 45, 5402-5412. 54) Xing, G.; Diao, Y.; Hoffart, L. M.; Barr, E. W.; Prabhu, K. S.; Arner, R. J.; Reddy, C. C.; Krebs,

C.; Bollinger, J. M., Jr. "Evidence for C-H cleavage by an iron-superoxide complex in the glycol cleavage reaction

catalyzed by myo-inositol oxygenase" Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 6130-6135. 55) Heinnickel, M.; Agalarov, R.; Svensen, N.; Krebs, C.; Golbeck, J. H. "Identification of FX in the Heliobacterial Reaction Center as a [4Fe-4S] Cluster with an S = 3/2

Ground Spin State" Biochemistry 2006, 45, 6756-6764.


56) Stone, K. L.; Hoffart, L. M.; Behan, R. K.; Krebs, C.; Green, M. T. "Evidence for Two Ferryl Species in Chloroperoxidase Compound II" J. Am. Chem. Soc. 2006, 128, 6147-6153. 57) Kim, S. H.; Xing, G.; Bollinger, J. M. Jr.; Krebs, C.; Hoffman, B. M.

"Demonstration by 2H ENDOR Spectroscopy that myo-Inositol Binds via an Alkoxide Bridge to the Mixed-valent Diiron Center of myo-Inositol Oxygenase" J. Am. Chem. Soc., 2006, 128, 10374-10375.

58) Behan, R. K.; Stone, K. L.; Hoffart, L. M.; Krebs, C.; Green, M. T.

"Evidence for Basic Ferryls in Cytochromes P450" J. Am. Chem. Soc., 2006, 128, 11471-11474.

59) Hoffart, L. M.; Barr, E. W.; Guyer, R. B.; Bollinger, J. M., Jr.; Krebs, C. "Direct Spectroscopic Detection of a C-H-Cleaving High-Spin Fe(IV) Complex in a Prolyl-4-

Hydroxylase" Proc. Natl. Acad. Sci., U. S. A., 2006, 103, 14738-14743. 60) Galonić, D. P.; Barr, E. W.; Walsh, C. T.; Bollinger, J. M., Jr.; Krebs, C.

"Two Interconverting High-Spin Fe(IV) Intermediates in Aliphatic Chlorination by the Fe(II)- and α-Ketoglutarate-Dependent Halogenase CytC3"

Nature Chem. Biol., 2007, 3, 113-116. 61) Bollinger, J. M., Jr.; Krebs, C.

“Enzymatic C-H activation by metal-superoxo intermediates” Curr. Opin. Chem. Biol., 2007, 11, 151-158.

62) Behan, R. K.; Hoffart, L. M.; Stone, K. L.; Krebs, C.; Green, M. T.

"Reaction between Cytochrome P450BM3 and Peroxynitrite Yields Nitrosyl Complex" J. Am. Chem. Soc., 2007, 129, 5855-5859.

63) Ghiladi, R.; Chufan, E.; del Rio, D.; Solomon, E. I.; Krebs, C.; Huynh, B.-H.; Huang, H.-W.;

Moënne-Loccoz, P.; Kaderli, S.; Honecker, M.; Zuberbühler, A.; Marzilli, L.; Cotter, R.; Karlin, K. D. "Further Insights into the Spectroscopic Properties, Electronic Structure and Kinetics of Formation of the Heme-Peroxo-Copper Complex [(F8TPP)FeIII µ-(O2

2-)-CuII(TMPA)]" Inorg. Chem., 2007, 46, 3889-3902.

64) Sinnecker, S.; Svensen, N.; Barr, E. W.; Ye, S.; Bollinger, J. M., Jr.; Neese, F.; Krebs, C.

"Spectroscopic and Computational Evaluation of the Structure of the High-Spin Fe(IV)-Oxo Intermediates in Taurine:α-Ketoglutarate Dioxygenase from Escherichia coli and its His99Ala Ligand Variant" J. Am. Chem. Soc., 2007, 129, 6168-6179.

65) Jiang, W.; Yun, D.; Saleh, L.; Barr, E. W.; Xing, G.; Hoffart, L. M.; Maslak, M.-A.; Krebs, C.;

Bollinger, J. M., Jr. "A Stable Manganese(IV)/Iron(III) Cofactor Initiates Substrate Radical Production in Chlamydia trachomatis Ribonucleotide Reductase" Science, 2007, 316, 1188-1191.


66) Jiang, W.; Bollinger, J. M., Jr.; Krebs, C. "The active form of Chlamydia trachomatis Ribonucleotide Reductase R2 protein contains a heterodinuclear Mn(IV)/Fe(III) cluster with S = 1 ground state" J. Am. Chem. Soc., 2007, 129, 7504-7505.

67) Krebs, C.; Galonić Fujimori, D.; Barr, E. W.; Walsh, C. T.; Bollinger, J. M., Jr.

"Non-heme Fe(IV)-Oxo Intermediates" Acc. Chem. Res., 2007, 40, 484-492.

68) Jiang, W.; Hoffart, L. M.; Krebs, C.; Bollinger, J. M., Jr.

"Direct Detection of a Mn(IV)/Fe(IV) Intermediate in Assembly of the Mn(IV)/Fe(III) Cofactor of Chlamydia trachomatis Ribonucleotide Reductase" Biochemistry 2007, 46, 8709-8716.

69 Krebs, C.; Matthews, M. L.; Jiang, W.; Bollinger, J. M., Jr. "AurF from Streptomyces thioluteus and a Possible New Family of Manganese/Iron Oxygenases" Biochemistry 2007, 46, 10413-10418. 70) Wu, C.-H.; Jiang, W.; Krebs, C.; Stubbe, J.

"YfaE, a Ferredoxin Involved in Diferric-Tyrosyl Radical Maintenance in E. coli Ribonucleotide Reductase" Biochemistry 2007, 46, 11577-11588.

71) Eser, B.; Barr, E. W.; Frantom, P. A.; Saleh, L.; Bollinger, J. M., Jr.; Krebs, C.; Fitzpatrick, P. F. "Direct Spectroscopic Evidence for a High-Spin Fe(IV) Intermediate in Tyrosine Hydroxylase" J. Am. Chem. Soc., 2007, 129, 11334-11335. 72) Shen, G.; Balasubramanian, R.; Wang, T.; Hoffart, L. M.; Krebs, C.; Bryant, D. A.; Golbeck, J.

H. "The Cyanobacterial SufR Transcriptional Repressor Binds to the Promoter Region of the

sufBCDS Operon as a Homodimer and Coordinates a [4Fe-4S]1+,2+ Cluster" J. Biol. Chem., 2007, 282, 31909-31919. 73) Galonić Fujimori, D.; Barr, E. W.; Matthews, M. L.; Koch, G. M.; Yonce, J. R.; Walsh, C. T.,

Bollinger, J. M., Jr.; Krebs, C.; Riggs-Gelasco, P. J. "Spectroscopic Evidence for a High-Spin Fe(IV)-Oxo Intermediate in the α-Ketoglutarate-

Dependent Halogenase CytC3 from Streptomyces" J. Am. Chem. Soc., 2007, 129, 13408-13409. 74) Neidig, M. L.; Brown, C. D.; Light, K.; Galonić Fujimori, D.; Nolan, E. M.; Price, J. C.; Barr, E.

W.; Bollinger, J. M., Jr.; Krebs, C.; Walsh, C. T.; Solomon, E. I. "CD and MCD of CytC3 and Taurine Dioxygenase: Role of the Facial Triad in α-KG-dependent

Dioxygenases" J. Am. Chem. Soc., 2007, 129, 14224-14231. 75) Hristova, D.; Wu, C.-H.; Jiang, W.; Krebs, C.; Stubbe, J.

"Importance of the Maintenance Pathway in the Regulation of the Activity of Escherichia coli Ribonucleotide Reductase" Biochemistry, 2008, 47, 3989-3999.


76) Jiang, W.; Xie, J.; Nørgaard, H.; Bollinger, J. M., Jr.; Krebs, C. "Rapid and Quantitative Activation of Chlamydia trachomatis Ribonucleotide Reductase by

Hydrogen Peroxide" Biochemistry, 2008, 47, 4477-4483.

77) Li, X.; Fu, R.; Lee, S.; Krebs, C.; Davidson, V. L.; Liu, A.

"A Catalytic Di-Heme Bis-Iron(IV) Intermediate, Alternative to an Fe(IV)=O Porphyrin Radical" Proc. Natl. Acad. Sci., U. S. A., 2008, 105, 8597-8600. 78) Grove, T. L.; Lee, K.-H.; St. Clair, J.; Krebs, C.; Booker, S. J. "In vitro Characterization of AtsB, a Radical SAM Formylglycine Generating Enzyme that

Contains at Least Two [4Fe–4S] Clusters" Biochemistry, 2008, 47, 7523-7538.

79) Jiang, W.; Saleh, L.; Barr, E. W.; Xie, J.; Maslak-Gardner, M.; Krebs, C.; Bollinger, J. M., Jr. "Branched Activation- and Catalysis-Specific Pathways for Electron Relay to the

Manganese/Iron Cofactor in Ribonucleotide Reductase from Chlamydia trachomatis" Biochemistry, 2008, 47, 8477-8484.

80) Saunders, A. H.; Griffiths, A. E.; Lee, K.-H.; Cicchillo, R. M.; Tu, L.; Stromberg, J. A.; Krebs,

C.; Booker, S. J. "Characterization of Quinolinate Synthases from Escherichia coli, Mycobacterium tuberculosis,

and Pyrococcus horikoshii Indicates That [4Fe-4S] Clusters Are Common Cofactors throughout This Class of Enzymes" Biochemistry, 2008, 47, 10999-11012.

81) Jin, Z.; Heinnickel, M. L.; Krebs, C.; Shen, G.; Golbeck, J. H.; Bryant, D. A. "Biogenesis of iron-sulfur clusters in Photosystem I: holo-NfuA from the cyanobacterium

Synechococcus sp. PCC 7002 rapidly and efficiently transfers [4Fe-4S] clusters to APO-PsaC in vitro"

J. Biol. Chem., 2008, 283, 28426-28435. 82) Younker, J. M.; Krest, C. M.; Jiang, W.; Krebs, C.; Bollinger, J. M., Jr.; Green, M. T. "Structural Analysis of the Mn(IV)/Fe(III) Cofactor of Chlamydia trachomatis Ribonucleotide

Reductase by Extended X-ray Absorption Fine Structure Spectroscopy and Density Functional Theory Calculations"

J. Am. Chem. Soc., 2008, 130, 15022-150271. 83) Chatterjee, A.; Li, Y.; Zhang, Y.; Grove, T. L.; Lee, M.; Krebs, C.; Booker, S. J.; Begley, T. P.;

Ealick, S. E. "Reconstitution of ThiC in Thiamine Pyrimidine Biosynthesis Expands the Radical SAM

Superfamily" Nature Chem. Biol., 2008, 4, 758-765. 84) Jiang, W.; Yun, D.; Saleh, L.; Bollinger, J. M., Jr.; Krebs, C. "Formation and Function of the Manganese(IV)/Iron(III) Cofactor in Chlamydia trachomatis

Ribonucleotide Reductase" Biochemistry, 2008, 47, 13736-13744.


85) Bollinger, J. M., Jr.; Jiang, W.; Green, M. T.; Krebs, C. "The Manganese(IV)/Iron(III) Cofactor of Chlamydia trachomatis Ribonucleotide Reductase:

Structure, Assembly, Radical Initiation, and Evolution" Curr. Opin. Struct. Biol., 2008, 18, 650-657.

86) Bollinger, J. M., Jr.; Diao, Y.; Matthews, M. L.; Xing, G.; Krebs, C. "myo-Inositol Oxygenase: A Radical New Pathway for O2 and C-H Activation at a Nonheme

Diiron Cluster" Dalton Transactions, 2009, 905-914.

87) Matthews, M. L.; Krest, C. M.; Barr, E. W.; Vaillancourt, F. H.; Walsh, C. T.; Green, M. T.;

Krebs, C.; Bollinger, J. M., Jr. “Substrate-Triggered Formation and Remarkable Stability of the C- H Bond-Cleaving

Chloroferryl Intermediate in the Aliphatic Halogenase, SyrB2” Biochemistry, 2009, 48, 4331-4343.

88) Matthews, M. L.; Neumann, C. S.; Miles, L. A.; Grove, T. L.; Booker, S. J.; Krebs, C.; Walsh, C.

T.; Bollinger, J. M., Jr. "Substrate positioning controls the partition between halogenation and hydroxylation in the

aliphatic halogenase, SyrB2" Proc. Natl. Acad. Sci., U. S. A., 2009, 106, 17723-17728. 89) Korneeva Korboukh, V.; Li, N.; Barr, E. W.; Bollinger, J. M., Jr.; Krebs, C. "A Long-Lived, Substrate-Hydroxylating Peroxodi iron(III/III) Intermediate in the Amine

Oxygenase, AurF, from Streptomyces thioluteus" J. Am. Chem. Soc., 2009, 131, 13608-13609. 90) Lee, K.; Saleh, L.; Anton, B. P.; Madinger, C. L.; Benner, J. S.; Iwig, D. F.; Roberts, R. J.;

Krebs, C.; Booker, S. J. "Characterization of RimO, a New Member of the Methylthiotransferase Subclass of the Radical

SAM Superfamily" Biochemistry, 2009, 48, 10162-10174. 91) Bollinger, J. M., Jr.; Krebs, C. "Freeze-quench 57Fe- Mössbauer spectroscopy: trapping reactive intermediates" Photosynthesis Research, 2009, 102, 295-304. 92) Ye, S.; Price, J. C.; Barr, E. W.; Green, M. T.; Bollinger, J. M., Jr.; Krebs, C.; Neese, F. "Cryoreduction of the NO-Adduct of Taurine:α-Ketoglutarate Dioxygenase (TauD) Yields an

Elusive {FeNO}8 Species" J. Am. Chem. Soc., 2010, 132, 4739–4751. 93) Grove, T. L.; Ahlum, J. H.; Sharma, P.; Krebs, C.; Booker, S. J. "A Consensus Mechanism for Radical SAM-Dependent Dehydrogenation? BtrN Contains Two

[4Fe–4S] Clusters" Biochemistry, 2010, 49, 3783-3785. 94) Zhang, Y.; Zhu, X.; Torelli, A.; Lee, M.; Dzikovski, B.; Koralewski, R. M.; Wang, E.; Freed, J.;

Krebs, C.; Ealick, S. E.; Lin, H. "Diphthamide biosynthesis requires a SAM-dependent [4Fe-4S]-containing enzyme" Nature, 2010, 465, 891-896.


95) Jiang, W.; Xie, J.; Varano, P. T.; Krebs, C.; Bollinger, J. M., Jr. "Two Distinct Mechanisms of Inactivation of the Class Ic Ribonucleotide Reductase from

Chlamydia trachomatis by Hydroxyurea: Implications for the Protein Gating of Inter-subunit Electron Transfer"

Biochemistry, 2010, 49, 5340–5349. 96) Flashman, E.; Hoffart, L. M.; Hamed, R. B.; Bollinger, J. M., Jr.; Krebs, C.; Schofield, C. J. "Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen" FEBS Journal, 2010, 277, 4089–4099. 97) Song, W. J.; McCormick, M. S.; Behan, R. K.; Sazinsky, M. H.; Jiang, W.; Lin, J.; Krebs C.;

Lippard, S. J. "Active Site Threonine Facilitates Proton Transfer during Dioxygen Activation at the Diiron

Center of Toluene/o-Xylene Monooxygenase Hydroxylase" J. Am. Chem. Soc., 2010, 132, 13582–13585. 98) Li, N.; Korneeva Korboukh, V.; Krebs, C.; Bollinger, J. M., Jr. "Four-electron oxidation of p-hydroxylaminobenzoate to p-nitrobenzoate by a peroxodiferric

complex in AurF from Streptomyces thioluteus" Proc. Natl. Acad. Sci., U. S. A., 2010, 107, 15722–15727. 99) van der Donk, W. A.*; Krebs, C.; Bollinger, J. M., Jr. "Substrate activation by iron superoxo intermediates" Curr. Opin. Struct. Biol., 2010, 20, 673–683. 100) Bhave, D. P.; Hong, J. A.; Lee, M.; Jiang, W.; Krebs, C.; Carroll, K. S. "Spectroscopic Studies on the [4Fe-4S] Cluster in Adenosine 5’-Phosphosulfate Reductase from

Mycobacterium tuberculosis" J. Biol. Chem., 2011, 286, 1216-1226. 101) Panay, A. J.; Lee, M.; Krebs C.; Bollinger, J. M., Jr.; Fitzpatrick, P. F. "Evidence for a High Spin Fe(IV) Species in the Catalytic Cycle of a Bacterial Phenylalanine

Hydroxylase" Biochemistry, 2011, 50, 1928-1933. 102) Grove, T. L.; Benner, J. S.; Radle, M. I.; Ahlum, J. H.; Landgraf, B. J.; Krebs, C.; Booker, S. J. "A Radically Different Mechanism for S-adenosylmethionine-dependent Methyltransferases

Exhibited by the Antibiotic Resistance Protein Cfr and its Homologue RlmN" Science 2011, 332, 604-607. 103) Warui, D. M.; Li, N.; Nørgaard, H.; Krebs, C., Bollinger, J. M., Jr.; Booker, S. J. "Detection of formate, rather than carbon monoxide, as the stoichiometric co-product in

conversion of fatty aldehydes to alkanes by a cyanobacterial aldehyde decarbonylase" J. Am. Chem. Soc. 2011, 133, 3316-3319. 104) Krebs, C., Bollinger, J. M., Jr.; Booker, S. J. "Cyanobacterial alkane biosynthesis further expands the catalytic repertoire of the ferritin-like

"di-iron-carboxylate" proteins" Curr. Opin. Chem. Biol. 2011, 15, 291-303.


105) Li, N.; Nørgaard, H.; Warui, D. M.; Booker, S. J.; Krebs, C., Bollinger, J. M., Jr. "Conversion of Fatty Aldehydes to Alka(e)nes and Formate by a Cyanobacterial Aldehyde

Decarbonylase: Cryptic Redox by an Unusual Di-metal Oxygenase" J. Am. Chem. Soc. 2011, 133, 6158-6161. 106) Grove, T. L.; Radle, M. I.; Krebs, C.; Booker, S. J. "Cfr and RlmN Each Contain Only One [4Fe–4S] Cluster, which Is Required Both for Formation

of the Protein Methylcysteinyl Intermediate and Generation of the 5’-Deoxyadenosyl 5’-Radical" J. Am. Chem. Soc., 2011, 133, 19586-19589. 107) Bhave, D. P.; Hong, J. A.; Keller, R. L.; Krebs, C.; Carroll, K. S. "Iron-Sulfur Cluster Engineering Provides Insight into the Evolution of Substrate Specificity

among the Family of Sulfonucleotide Reductases" ACS Chemical Biology, 2012, 7, 305-314. 108) Dassama, L. M. K.; Boal, A. K., Krebs, C.; Rosenzweig, A. C.; Bollinger, J. M., Jr. "Evidence that the β Subunit of Chlamydia trachomatis Ribo-nucleotide Reductase is Active with

the Manganese Ion of its Manganese(IV)/Iron(III) Cofactor in Site 1" J. Am. Chem. Soc., 2012, 134, 2520-2523. 109) Dassama, L. M. K.; Yosca, T. H.; Conner, D. A.; Lee, M.; Blanc, B.; Streit, B. R.; Green, M. T.;

DuBois, J. L.; Krebs, C., Bollinger, J. M., Jr. "O2-evolving Chlorite Dismutase as a Tool to Study O2-Utilizing Enzymes" Biochemistry, 2012, 51, 1607-1616. 110) Ye, S.; Riplinger, C.; Hansen, A.; Krebs, C., Bollinger, J. M., Jr., Neese, F. "Electronic Structure Analysis of the Oxygen-Activation Mechanism by Fe(II)- and alpha-

Ketoglutarate (alpha KG)-Dependent Dioxygenases" Eur. J. Inorg. Chem., 2012, 18, 6555-6567. 111) Li, N.; Chang, W.-c.; Warui, D. M.; Booker, S. J.; Krebs, C.; Bollinger, J. M., Jr. “Evidence for Only Oxygenative Cleavage of Aldehydes to Alk(a/e)nes and Formate by

Cyanobacterial Aldehyde Decarbonylase” Biochemistry, 2012, 51, 7908-7916 112) Lanz, N. D.; Grove, T. L.; Gogonea, C.; Krebs, C.; Booker, S. J. “RlmN and AtsB as Models for the Overproduction and Characterization of Radical SAM

Proteins” Methods in Enzymology, 2012, 516, 125-152. 113) Dassama, L. M.K.; Jiang, W.; Varano, P.T.; Pandelia, M.E.; Conner, D.A.; Xie, J.J.; Bollinger

J.M., Jr.; Krebs, C. “Radical-Translocation Intermediates and Hurdling of Pathway Defects in “Super-oxidized”

(Mn-IV/Fe-IV) Chlamydia trachomatis Ribonucleotide Reductase” J. Am. Chem. Soc., 2012, 134, 20498-20506. 114) McCarty, R. M. ;Krebs, C.; Bandarian, V. “Spectroscopic, Steady-State Kinetic, and Mechanistic Characterization of the Radical SAM

Enzyme QueE, Which Catalyzes a Complex Cyclization Reaction in the Biosynthesis of 7‑Deazapurines”

Biochemistry, 2013, 52, 188-198.


115) Krebs, C.; Dassama, L. M. K.; Matthews, M. L.; Jiang, W.; Price, J. C.; Korboukh, V.; Li, N.; Bollinger, J. M., Jr.

“Novel Approaches for the Accumulation of Oxygenated Intermediates to Multi-Millimolar Concentrations”

Coordination Chemistry Reviews, 2013, 257, 234-243. 116) Grove, T. L.; Ahlum, J. H.; Qin, R. M.; Lanz, N. D.; Radle, M. I.; Krebs, C.; Booker, S. J.

“Further Characterization of Cys-Type and Ser-Type Anaerobic Sulfatase Maturating Enzymes Suggests a Commonality in the Mechanism of Catalysis” Biochemistry 2013, 52, 2874−2887.

117) Wörsdörfer, B.; Conner, D. A.; Yokoyama, K.; Livada, J.; Seyedsayamdost, M.; Jiang, W.; Stubbe, J.; Bollinger, J. M., Jr.; Krebs, C.

“Function of the Diiron Cluster of Escherichia coli Class Ia Ribonucleotide Reductase in Proton- Coupled Electron Transfer” J. Am. Chem. Soc. 2013, 135, 8585−8593.

118) Pandelia, M. E.; Li, N.; Nørgaard, H.; Warui, D. M.; Rajakovich, L. J.; Chang, W. C.; Booker, S. J.; Krebs, C.; Bollinger, J. M., Jr. “Substrate-Triggered Addition of Dioxygen to the Diferrous Cofactorof Aldehyde-Deformylating Oxygenase to Form a Diferric-PeroxideIntermediate” J. Am. Chem. Soc. 2013, 135, 15801−15812.

119) Dassama, L. M. K.; Krebs, C.; Bollinger, J. M., Jr.; Rosenzweig, A. C.; Boal, A. K. “Structural Basis for Assembly of the MnIV/FeIII Cofactor in the Class Ic Ribonucleotide Reductase from Chlamydia trachomatis” Biochemistry 2013, 52, 6424−6436.

120) Wörsdörfer, B.; Lingaraju, M.; Yennawar, N. H.; Boal, A. K.; Krebs, C.; Bollinger, J. M., Jr.; Pandelia, M. E. “Organophosphonate-degrading PhnZ reveals an emerging family of HD domain mixed-valent diiron oxygenases” Proc. Natl. Acad. Sci., U. S. A., 2013, 110, 18874-18879.

121) Wong, S. D.; Srnec, M.; Matthews, M. L.; Liu, L. V.; Kwak, Y.; Park, K.; Bell, C. B.; Alp, E. E.;

Zhao, J.; Yoda, Y.; Kitao, S.; Seto, M.; Krebs, C.; Bollinger, J. M., Jr.; Solomon, E. I. “Elucidation of the Fe(IV)=O intermediate in the catalytic cycle of the halogenase SyrB2” Nature 2013, 499, 320-324.

122) Wang, C.; Chang, W. C.; Guo, Y.; Huang, H.; Peck, S. C.; Pandelia, M. E.; Lin, G. M.; Liu, H.

W.; Krebs, C.; Bollinger, J. M., Jr. “Evidence that the Fosfomycin-Producing Epoxidase, HppE, Is a Non–Heme-Iron Peroxidase” Science 2013, 342, 991-995.

123) Snyder, R. A.; Bell, C. B.; Diao, Y.; Krebs, C.; Bollinger, J. M., Jr.; Solomon, E. I.

“Circular Dichroism, Magnetic Circular Dichroism, and Variable Temperature Variable Field Magnetic Circular Dichroism Studies of Biferrous and Mixed-Valent myo-Inositol Oxygenase: Insights into Substrate Activation of O2 Reactivity” J. Am. Chem. Soc. 2013, 135, 15851-15863.


124) Anton, B. P.; Chang, Y.C.; Brown, P.; Choi, H. P.; Faller, L. L.; Guleria, J.; Hu, Z.; Klitgord, N.; Levy-Moonshine, A.; Maksad, A.; Mazumdar, V.; McGettrick, M.; Osmani, L.; Pokrzywa, R.; Rachlin, J.; Swaminathan, R.; Allen, B.; Housman, G.; Monahan, C.; Rochussen, K.; Tao, K.; Bhagwat, A. S.; Brenner, S. E.; Columbus, L.; de Cre´cy-Lagard, V.; Ferguson, D.; Fomenkov, A.; Gadda, G.; Morgan, R. D.; Osterman, A. L.; Rodionov, D. A.; Rodionova, I. A.; Rudd, K. E.; Soll, D.; Spain, J.; Xu, S. Y.; Bateman, A.; Blumenthal, R. M.; Bollinger, J. M., Jr.; Chang, W. S.; Ferrer, M.; Friedberg, I.; Galperin, M. Y.; Gobeill, J.; Haft, D.; Hunt, J.; Karp, P.; Klimke, W.; Krebs, C.; Macelis, D.; Madupu, R.; Martin, M. J.; Miller, J. H.; O’Donovan, C.; Palsson, B.; Ruch, P.; Setterdahl, A.; Sutton, G.; Tate, J.; Yakunin, A.; Tchigvintsev, D.; Plata, G.; Hu, J.; Greiner, R.; Horn, D.; Sjölander, K.; Salzberg, S. L.; Vitkup, D.; Letovsky, S.; Segre, D.; DeLisi, C.; Roberts, R. J.; Steffen, M.; Kasif, S. “The COMBREX Project: Design, Methodology, and Initial Results” PLOS Biology 2013, 11(8), e1001638.

125) Dassama, L. M. K.; Silakov, A.; Krest, C. M.; Calixto, J. C.; Krebs, C.; Bollinger, J. M., Jr.;

Green, M. T. “A 2.8 Å Fe−Fe Separation in the Fe2

III/IV Intermediate, X, from Escherichia coli Ribonucleotide Reductase” J. Am. Chem. Soc. 2013, 135, 16758−16761.

126) Kwak, Y.; Jiang, W.; Dassama, L. M. K.; Park, K.; Bell, C. B., III.; Liu, L. V.; Wong, S. D.; Saito, M.; Kobayashi, Y.; Kitao, S.; Seto, M.; Yoda, Y.; Alp, E. E.; Zhao, J.; Bollinger, J. M. Jr.; Krebs, C.: Solomon, E. I. “Geometric and Electronic Structure of the Mn(IV)Fe(III) Cofactor in Class Ic Ribonucleotide Reductase: Correlation to the Class Ia Binuclear Non-Heme Iron Enzyme” J. Am. Chem. Soc. 2013, 135, 17573−17584.

127) Matthews, M. L.; Chang, W.-c.; Layne, A. P.; Miles, L. A.; Krebs, C.; Bollinger, J. M. Jr. “Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase” Nature Chem. Biol. 2014, 10, 209-215.

128) Chang, W.-c.; Guo, Y.; Wang, C.; Butch. S. E.; Rosenzweig, A. C.; Boal, A. K.; Krebs, C.; Bollinger, J. M. Jr. “Mechanism of the C5 Stereoinversion Reaction in the Biosynthesis of Carbapenem Antibiotics” Science 2014, 343, 1140-1144.

129) Ludwig, M; Pandelia, M.-E.; Chw, C. Y.; Zhang, B.; Golbeck, J. H.; Krebs, C.; Bryant, D. A. “ChlR Protein of Synechococcus sp PCC 7002 Is a Transcription Activator That Uses an Oxygen-sensitive [4Fe-4S] Cluster to Control Genes involved in Pigment Biosynthesis” J. Biol. Chem. 2014, 289, 16624-16639.

130) Lanz, N. D.; Pandelia, M.-E.; Kakar, E. S.; Lee, K. H.; Krebs, C.; Booker, S. J. “Evidence for a Catalytically and Kinetically Competent Enzyme-Substrate Cross-Linked Intermediate in Catalysis by Lipoyl Synthase” Biochemistry 2014, 53, 4557-4572.

131) Pandelia, M.-E.; Lanz, N. D.; Booker, S. J.; Krebs, C. “Mössbauer Spectroscopy of Fe/S proteins” Biochim. Biophys. Acta 2014, http://dx.doi.org/10.1016/j.bbamcr.2014.12.005.


http://dx.doi.org/10.1016/j.bbamcr.2014.12.005

132) Warui, D. M.; Pandelia, M.-E.; Rajakovich, L. J.; Krebs, C.; Bollinger, J. M. Jr.; Booker, S. J. “Efficient Delivery of Long-Chain Fatty Aldehydes from the Nostoc punctiforme Acyl-Acyl Carrier Protein Reductase to Its Cognate Aldehyde-Deformylating Oxygenase” Biochemistry 2015, 54, 1006-1015. 133) Bollinger, J. M. Jr.; Chang, W-c.; Matthews, M. L.; Martinie, R. J.; Boal, A. K.; Krebs, C. “Mechanisms of 2-Oxoglutarate-Dependent Oxygenases: The Hydroxylation Paradigm and Beyond” in “2-Oxoglutarate-Dependent Oxygenases” Hausinger, R. P. and Schofield, C. J.; The Royal Society of Chemistry, London, 2015, 95-122.


Invited talks (Conferences and meetings) 1) "Spectroscopic Characterization of A High-Spin Fe(IV) Complex in Taurine/α-Ketoglutarate

Dioxygenase (TauD) from Escherichia coli" 227th National Meeting of the American Chemical Society, Anaheim, CA March 28th to April 1st 2004

2) "Spectroscopic Characterization of A High-Spin Fe(IV) Complex in Taurine/α-Ketoglutarate Dioxygenase (TauD) from Escherichia coli" 7th European Biological Inorganic Chemistry Conference (EUROBIC-7), Garmisch-Partenkirchen, Germany August 29th to September 2nd 2004

3) "Spectroscopic Characterization of A High-Spin Fe(IV) Complex in Taurine/α-Ketoglutarate Dioxygenase (TauD) from Escherichia coli" Gordon Conference “Metals in Biology”, Ventura, CA January 23rd to January 27th 2005

4) "Spectroscopic Characterization of A High-Spin Fe(IV) Complex in Taurine/α-Ketoglutarate Dioxygenase (TauD) from Escherichia coli" 2005 Meeting of the American Society of Biochemistry and Molecular Biology (ASBMB) April 2nd to April 6th 2005, San Diego, CA

5) “Oxygen Activation by the α-Ketoglutarate-Dependent Dioxygenases” 12th International Conference on Biological Inorganic Chemistry (ICBIC-12), Ann Arbor, MI July 31st to August 6th 2005

6) “Oxygen Activation by the α-Ketoglutarate-Dependent Dioxygenases” 2005 Pacifichem, Honolulu, HI December 15th to December 20th 2005

7) "Oxygen Activation by Taurine:α-Ketoglutarate Dioxygenase" 2006 Meeting of Priority Program 1071 of the DFG (Deutsche Forschungsgemeinschaft) on “Radicals in Enzymatic Catalysis”, Schloss Rauischholzhausen, Germany March 6th to March 8th 2006

8) "Oxygen Activation by the α-Ketoglutarate-Dependent Dioxygenases" 231st National Meeting of the American Chemical Society, Atlanta, GA March 26th to March 30th 2006

9) “Mechanism of Oxygen Activation by the α-Ketoglutarate-Dependent Dioxygenases” Annual meeting of the “Inorganic Biochemistry Discussion Group” of the UK, Manchester, UK January 3rd to January4th 2008

10) “Mechanism of Oxygen Activation by the Mononuclear Non-Heme Enzymes” Gordon Conference “Protein Cofactors, Radicals, and Quinones”, Ventura, CA January 20th to January 25th 2008


11) “Mechanism of Oxygen Activation by the Mononuclear Non-Heme Enzymes” Symposium “Dioxygen Activation by Metalloenzymes and Models”, Nagoya, Japan March 20th to March 21st 2008

12) “Mechanism of Oxygen Activation by Isopenicillin N Synthase” Gordon Conference “Enzymes, Coenzymes, and Metabolic Pathways”, Biddeford, ME July 13th to July 18th 2008

13) “Mechanism of Oxygen Activation by the Mononuclear Non-Heme Enzymes” 236th National Meeting of the American Chemical Society, Philadelphia, PA August 17th to 21st 2008

14) “Mechanism of Oxygen Activation by the Mononuclear Non-Heme Enzymes” 2008 Beckman Young Investigator Meeting, Beckman Center, Irvine, CA August 29th to 30th 2008

15) “A Heterobinuclear Mn/Fe Cofactor in Chlamydia trachomatis ribonucleotide reductase” Gordon Conference “Metals in Biology”, Ventura, CA January 25th to January 29th 2009

16) “Formation and function of the heterodinuclear Mn/Fe cofactor in Chlamydia trachomatis ribonucleotide reductase” 14th International Conference on Biological Inorganic Chemistry (ICBIC-14), Nagoya, Japan July 25th to 30th 2009

17) “Formation and function of the heterodinuclear Mn/Fe cofactor in Chlamydia trachomatis ribonucleotide reductase” International Symposium on “Molecular Coordination Chemistry” Max Planck Institute for Bioinorganic Chemistry, Mülheim a.d. Ruhr, Germany November 7th to 9th 2010

18) “Mechanism of the unusual six-electron oxidation of para-aminobenzoate to para-nitrobenzoate by the non-heme-diiron enzyme AurF from Streptomyces thioluteus” 2010 Pacifichem, Honolulu, HI December 15th to December 21st 2010

19) “Mechanistic Studies Aldehyde-Deformylating Oxygenases” Gordon Conference “Isotopes in Biological & Chemical Sciences”, Galveston, TX February 5th to 10th 2012

20) “Mechanistic Studies Aldehyde-Deformylating Oxygenases” Gordon Conference “Protein Cofactors, Radicals & Quinones”, South Hadley, MA July 29th to August 3rd 2012

21) “New cofactors, hot intermediates, and unexpected reactivities: exploring the mechanistic diversity of non-heme-iron enzymes” Award lecture for my Early Career Award from the Society of Biological Inorganic Chemistry given at the 16th International Conference on Biological Inorganic chemistry (ICBIC-16), Grenoble, France July 22th to 26th 2013


22) “Mechanism of the C5 stereoinversion reaction catalyzed by the Fe(II)-and 2-oxoglutarate-

dependent enzyme,CarC, in the biosynthesis of bio-synthesis of carbapenem antibiotics” 248th ACS National Meeting and Exposition, San Francisco, CA August 10-14, 2014

23) “3rd Bioinorganic Workshop” Physical Biosciences Principal Investigators’ Research Meeting, U.S. Department of Energy, Annapolis, MD September 21-24, 2014


Invited talks (Seminars) 1) “Valence Delocalization in Polynuclear Iron Complexes”

Department of Physics, Emory University, Atlanta, GA April 1997

2) “Oxygen Activation by Non-Heme Diiron Enzymes” Max Planck Institut für Strahlenchemie, Mülheim, Germany June 1998

3) “Oxygen Activation by Non-Heme Diiron Enzymes” Department of Physics, Emory University, Atlanta, GA October 1998

4) “Oxygen Activation by Non-Heme Diiron Enzymes” Department of Chemistry, Georgia Tech University, Atlanta, GA October 2000

5) “Oxygen Activation by Non-Heme Diiron Enzymes” Department of Chemistry, University of Arizona, Tucson, AZ November 2000

6) “Oxygen Activation by Non-Heme Diiron Enzymes” Department of Biochemistry and Molecular Biology, The Pennsylvania State University, PA January 2001

7) “Oxygen Activation by Non-Heme Diiron Enzymes” Department of Chemistry, Tufts University, Medford, MA January 2001

8) “Oxygen Activation by Non-Heme Diiron Enzymes” Department of Chemistry, Concordia University, Montréal, Quebec March 2001

9) “Biosynthesis of Iron-Sulfur Clusters” Max-Planck Institut für Strahlenchemie, Mülheim, Germany July 20th 2002

10) “Oxygen Activation by Mononuclear Non-Heme Fe-Enzymes” Department of Chemistry, The Pennsylvania State University December 12th 2003

11) “Mechanism of Oxygen Activation by Taurine:α-Ketoglutarate Dioxygenase” Department of Chemistry, University of Puerto Rico, Río Piedras Campus, San Juan, Puerto Rico June 7th 2004

12) “Mechanism of Oxygen Activation by Taurine:α-Ketoglutarate Dioxygenase” Max-Planck Institut for Bioinorganic Chemistry, Mülheim a.d. Ruhr, Germany August 11th 2004


13) “Mechanism of Oxygen Activation by Taurine:α-Ketoglutarate Dioxygenase” Department of Physics, University of Lübeck, Germany August 17th 2004

14) “Mechanism of Oxygen Activation by Taurine:α-Ketoglutarate Dioxygenase” Department of Chemistry, Technical University of Vienna, Austria September 3rd 2004

15) “Mechanism of Oxygen Activation by Taurine:α-Ketoglutarate Dioxygenase” Department of Chemistry, University of California, San Diego, CA April 1st 2005

16) “Mechanism of Oxygen Activation by Taurine:α-Ketoglutarate Dioxygenase” Department of Chemistry, Christian Albrechts Universität Kiel, Germany April 22nd 2005

17) “Mechanism of Oxygen Activation by Taurine:α-Ketoglutarate Dioxygenase” Department of Chemistry, Ruprecht Karl Universität Heidelberg, Germany April 25th 2005

18) “Mechanism of Oxygen Activation by Taurine:α-Ketoglutarate Dioxygenase” Department of Chemistry, Danmarks Tekniske Universitet, Lyngby, Denmark November 25th 2005

19) “Mechanism of Oxygen Activation by Taurine:α-Ketoglutarate Dioxygenase” Department of Chemistry, Ursinus College, Collegeville, PA February 28th 2006

20) “Mechanism of Oxygen Activation by the α-Ketoglutarate-Dependent Dioxygenases” Department of Physics, Emory University, Atlanta, GA March 24th 2006

21) “Mechanism of Oxygen Activation by the α-Ketoglutarate-Dependent Dioxygenases” Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA November 20th 2006

22) “A Heterobinuclear Mn/Fe Cofactor in Chlamydia trachomatis ribonucleotide reductase” Department of Chemistry, University of Minnesota, Minneapolis MN April 3rd 2008

23) “Mechanism of Oxygen Activation by the Mononuclear Non-Heme Enzymes” Department of Chemistry and Biochemistry, University of California, Irvine CA April 25th 2008

24) “Formation and function of the heterodinuclear Mn/Fe cofactor in Chlamydia trachomatis ribonucleotide reductase” Department of Chemistry, Cornell University, Ithaca NY March 18th 2010


25) “Formation and function of the heterodinuclear Mn/Fe cofactor in Chlamydia trachomatis ribonucleotide reductase” Department of Chemistry, Carnegie Mellon University, Pittsburgh PA September 2nd 2010

26) “Formation and function of the heterodinuclear Mn/Fe cofactor in Chlamydia trachomatis ribonucleotide reductase” Department of Chemistry, California Institute of Technology, Pasadena CA November 1st 2010

27) “Formation and function of the heterodinuclear Mn/Fe cofactor in Chlamydia trachomatis ribonucleotide reductase” Department of Chemistry, Marquette University, Milwaukee, WI January 28th 2011

28) “Formation and function of the heterodinuclear Mn/Fe cofactor in Chlamydia trachomatis ribonucleotide reductase” Department of Chemistry, Northwestern University, Evanston, IL April 7th 2011

29) “Formation and function of the heterodinuclear Mn/Fe cofactor in Chlamydia trachomatis ribonucleotide reductase” Department of Chemistry, University of Delaware, Newark, DE May 4th 2011


Research Support

Research support completed

Title: “The Mechanism of Oxygen Activation by Taurine:α-Ketoglutarate Dioxygenase”

Innovative Biotechnology Research Fund, The Huck Institutes for Life Sciences

06/01/2002 – 06/30/2003; $ 39,500 ($ 19,750 available to Krebs)

Role: co-P.I. (together with J. Martin Bollinger, Jr.)

Title: “BioMetals Center”

Tobacco Settlement Formula, 417-12HY 89HE TSF (P.I.: Dr. James R. Connor)

06/01/2002 – 05/31/2004; $ 198,500 ($ 32,500 available to Krebs)

Role: co-investigator

Title: “Oxygen Activation by the Y73F Variant of Taurine:α-Ketoglutarate Dioxygenase”

President’s Fund for Undergraduate Research, The Pennsylvania State University

11/1/2003 - 5/31/2004; $ 1,500

Role: P.I.

Title: “Center for Metallobiochemistry: A Systems Approach to Metalloprotein Bioassembly”

The Huck Institutes of Life Sciences Planning Grant (P.I. John H. Golbeck)

1/1/2004 - 12/31/2007; $100,000 ($ 20,000 available to Krebs)


Title: “Oxygen Activation by Prolyl-4-Hydroxylase”


12/1/2004 - 6/30/2005; $ 1,500

Role: P.I.

Title: “Oxygen Activation by Prolyl-4-Hydroxylase”


11/1/2005 - 5/31/2006; $ 1,500

Role: P.I.


Title: “Mechanism of Oxygen Activation by Mononuclear Non-Heme Fe Enzymes”

American Chemical Society - Petroleum Research Fund (ACS-PRF) type G starter grant

9/1/2004 - 8/31/2006; $35,000

Role: P.I.

Title: “Center for Metallobiochemistry: A Systems Approach to Metalloprotein Bioassembly”

Tobacco Settlement Formula (P.I. John H. Golbeck)

1/1/2005 - 12/31/2006; $317,188 ($63,438 available to Krebs)


Title: “Regulation of Oxygen Homeostasis: Determination of the Molecular Mechanisms and

Approaches to Controlled Modulation Thereof for Therapeutic Applications”

GlaxoSmithKline


Role: co-P.I. (with J. Martin Bollinger, Jr.)

Title: ”Mechanism of Taurine:α-Ketoglutarate Dioxygenase”

National Institutes of Health NIGMS GM-69657

1/1/2004 - 12/31/2010; $1,324,680 ($662,340 available to Krebs)

Role: P.I. (J. Martin Bollinger, Jr., co-investigator)

Title: “Molecular Mechanism and Controlled Modulation of Oxygen Homeostasis”

“Beckman Young Investigator Award” from the Arnold and Mabel Beckman Foundation

9/1/2005 - 8/31/2009; $ 264,000

Role: P.I.

Title: “Oxygen Activation by Isopenicillin N Synthase”

American Chemical Society, Petroleum Research Fund – Type AC grant


Role: co-P.I. (with J. Martin Bollinger, Jr.)


Title: “An Integrative Approach to Metalloenzyme-Catalyzed C-H Activation”

National Science Foundation (joint program with the Deutsche Forschungsgesesellschaft)


Role: co-P.I. (with J. Martin Bollinger, Jr., Sharon Hammes-Schiffer, and Frank Neese)

Title: “Mechanism of Iron-Containing Enzymes”

“Camille Dreyfus Teacher Scholar Award” from the Dreyfus Foundation

5/1/2006 - 4/30/2011; $ 75,000

Role: P.I.

Title: “Non-Heme Fe(IV)-oxo Intermediates: Structure and Function”

National Science Foundation MCB-642058

7/1/2007 - 6/30/2010; $ 595,000 ($297,500 available to Krebs)


Title: “Structure and Mechanism of myo-Inositol Oxygenase”

National Institutes of Health NIDDK-74641


Role: co-investigator (P.I.: J. Martin Bollinger, Jr.)

Title: “Bioinorganic Workshop in 2012”

National Science Foundation

5/1/2012 – 6/30/2012; $15,000

Role: co-P.I. (together with J. Martin Bollinger, Jr., Squire J. Booker, and Michael T. Green)

Title: ”Oxygen Activation and Radical Transfer in Ribonucleotide Reductase from Pathogens”



Role: co-P.I. (together with J. Martin Bollinger, Jr. and Michael T. Green)


Title: Administrative supplement to ”Oxygen Activation and Radical Transfer in Ribonucleotide

Reductase from Pathogens”


6/1/2010 - 5/31/2013 $269,358 ($67,340 available to Krebs)

Role: co-P.I. (together with J. Martin Bollinger, Jr., Harry B. Gray, and Jay Winkler)

Title: “Structure and function of Intermediates Involved in Metalloenzymatic N-oxygenation and

Oxidation Reactions”

National Science Foundation CHE-1058931



Research support in progress

Title: “Identification of the dinuclear metallo-cofactor and elucidation of the reaction mechanism of the

aldehyde decarbonylase from the alkane-producing cyanobacterium Nostoc punctiforme”

National Science Foundation MCB-1122079


Role: co-P.I. (together with J. Martin Bollinger, Jr. and Squire J. Booker)

Title: “Bioinorganic Workshops in 2012 and 2014 and Bioinorganic Symposium in 2014”

National Institutes of Health NIGMS

6/1/2012 - 7/31/2014; $6,000

Role: co-P.I. (together with J. Martin Bollinger, Jr., Squire J. Booker, and Michael T. Green)

Title: “Functionalization of unactivated sp2-hybridized carbon atoms”

National Institutes of Health

7/1/2012 – 6/30/2016; $1,063,752

Role: co-P.I. ( together with J. Martin Bollinger, Jr., Squire J. Booker)

Title: “Mechanism of Taurine: alpha-Ketoglutarate Dioxygenase”


7/1/2013 – 6/30/2017; $2,056,953



Title: "Mapping the hydrolase-oxygenase boundaries and range of catalytic capabilities in the HD-

domain dinuclear metalloenzyme superfamily"

National Science Foundation

8/1/2013 – 7/31/2017; $1,036,746


Title: “Diphthamide Biosynthesis”


07/05/2014-03/31/2015; $4,206

Role: co-P.I. (Cornell University- NIH Prime)

Research support pending

Title: “Mechanistic Determination of the Non-heme Iron Enzyme Hyoscyamine-6-hydroxylase”


09/01/2014-08/31/2017; $154,662

Dr. Christopher Pollock Fellowship- Ruth L. Kirschstein National Research Service Award

Role: co-Sponsor

Title: “Mechanisms of oxacycle-and-olefin-installing iron/2-(oxo)glutarate oxygenases”


07/01/2015-06/30/2019; $2,312,153

Role: co-P.I. (together with J. Martin Bollinger, Jr. and Amie Boal)

Title: “Metallocofactor Assembly and Function in Novel Class I Ribonucleotide Reductase”


07/01/2015-06/31/2020; $1,863,152

Role: co-P.I. (together with Amie Boal and J. Martin Bollinger, Jr.)

Title: “Mechanisms of Radical Translocation in Class I Ribonucleotide Reductases”


07/01/2015-06/30/2018; $154,662

Dr. Elizabeth Blaesi Fellowshi- Ruth L. Kirschstein National Research Service Award

Role: co-Sponsor


Title: “Enzymes and Mechanisms in the Conversion of Abundant Fatty Acids to Diesel-Fuel

Hydrocarbons in Cyanobacteria”

U.S. Department of Energy

09/01/2015-08/31/2018; $616,846

Role: Principal Investigator

Graduate students supervised John C. Price * Ph.D. completed 9/2005 Biochemistry, Microbiology, and Mol. Biol.

Wei Jiang * Ph.D. completed 9/2008 Biochemistry, Microbiology, and Mol. Biol.

Jiajia Xie * M.S. completed 10/2008 Biochemistry, Microbiology, and Mol. Biol.

Lee M. Hoffart * left without degree Biochemistry, Microbiology, and Mol. Biol.

Gretchen M. Koch * M.S. completed 7/2009 Biochemistry, Microbiology, and Mol. Biol.

Yinghui Diao * Ph.D. completed 4/2011 Biochemistry, Microbiology, and Mol. Biol.

Megan L. Matthews * Ph.D. completed 5/2011 Chemistry

Denise Conner * left without degree Chemistry

Michael Lee * left without degree Biochemistry, Microbiology, and Mol. Biol.

Rebecca Keller * M.S. completed 6/2012 Biochemistry, Microbiology, and Mol. Biol.

Ning Li * Ph.D. completed 6/2012 Biochemistry, Microbiology, and Mol. Biol.

Esta Tamanaha * Ph.D. completed 1/2013 Biochemistry, Microbiology, and Mol. Biol.

Laura Dassama * Ph.D. completed 2/2013 Biochemistry, Microbiology, and Mol. Biol.

Grodon Zrelak * M.S. completed 5/2013 Chemistry

Andrew Layne * left without degree Chemistry

Chen Wang * Ph.D. completed 10/2014 Biochemistry, Microbiology, and Mol. Biol.

Lauren Rajakovich * Ph.D. in progress Biochemistry, Microbiology, and Mol. Biol.

Susan Butch * Ph.D. in progress Chemistry

Jovan Livada * Ph.D. in progress Chemistry

Ryan Martinie * Ph.D. in progress Chemistry

* co-advised with J. Martin Bollinger, Jr.


Postdoctoral scholars supervised (all co-advised with J. Martin Bollilnger, Jr.) Chivukula Sastri 5/2007 - 7/2008

J. Allen Easton 8/2007 - 7/2009

Viktoria Korboukh 8/2007 - 2/2010

Priti Singh 7/2008 - 4/2010

Gang Xing 7/2008 - 10/2010

Wei Jiang 10/2008 - 6/2010

Hanne Nørgaard 10/2009 - 9/2012

Bigna Wörsdörfer 3/2011 – 12/2013

Laura Dassama 2/2013 – 7/2013

Yisong (Alex) Guo 6/2012 – 12/2013

Viviane Hajj 9/2012 – 9/2014

Bennett R. Streit 9/2011 – 10/2014

Wei-chen Chang 8/2011 – current

Maria-Eirini Pandelia 2/2012 - current

Bo Zhang 8/2013 - current

Chris Pollock 12/2013 – current

Manas Ghosh 5/2014 – current

Juan Pan 9/2014 – current

Elizabeth Blaesi 9/2014 - current


Teaching Undergraduate

BMB 401 General Biochemistry (2 credits) FA05 FA06

BMB 474 Properties of Biological Macromolecules (2 credits) SP03

BMB 497B Metals in Biology (1 credit) SP05 SP06 SP07

CHEM 110 General Chemistry (3 credits) FA09 FA10

CHEM 412 Transition Metal Chemistry (3 credits) FA12** FA13 FA14

Graduate

BMMB 597A “Biophysics” module (1 credit) of FA02

“Core Concepts in Biochemistry and Molecular Biology”

BMMB 597B Bioinorganic Chemistry (3 credits) FA03* FA04* FA06*

FA07* FA08* FA09*

FA11* FA12 FA13*

FA14*

* class taught together with Michael T. Green

** class taught together with J. Martin Bollinger, Jr.

1 credit corresponds to 15 50-minute lectures


carsten krebs curriculum vitae - sites at penn...

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