Cell Development II

Cell Signaling and Disease Models

CS Cell Social MediaM

BKA

Group Members

• Nishi Bryska, UNC Charlotte• Sharon Bullock, UNC Charlotte• Katie Crump, VCU-IRACDA• Teshell Greene, VCU-IRACDA• Derek Kendig, VCU-IRACDA• Michelle Pass, UNC CharlotteFacilitator: Suann Yang, Presbyterian College

Context of the Teachable Unit

• General biology major’s class (cell biology section)

• Target class size is 60 students, with 10 working groups of 6 students each

• Co-requisite coursework: general chemistry• A one semester course, 2 lectures at end of the

semester. • 5 hours class time total, 10 hours out of class

time.

Learning GoalsStudents should understand 1. How a signal is transduced, relayed, and

amplified to lead to a biological response.2. The regulation and termination of a biological

signal and response in normal and diseased states.

3. How cell signaling regulates homeostasis.

Tidbit ObjectivesStudents should be able to:

1. Describe how a message is communicated.2. Diagram a signaling pathway.3. Predict how disturbing the components of

the pathway will affect cell signaling response.

Prior Knowledge Gained• Cell signaling terms – Protein-protein interactions– Receptor– Ligand and how it interacts with receptors– Signal relay and response

• Cell membranes are selectively permeable• Extracellular signals elicit cellular responses• Basics of regulation

Generic Signal PathwaySignal

Receiver

Relay/Transducer

Response

Mom

Group Work (4 mins)

Diagram a Signaling Model Using The Shapes Provided

-Take shapes out of the envelope

-Use shapes to model the pathway

Cytosol

Extracellular Fluid

Response

Group Work (4 mins)

Diagram a Signaling Model Using The Shapes Provided

-Take shapes out of the envelope

-Use shapes to model the pathway

Hint:Orange = same type of molecule

Cytosol

Extracellular Fluid

.Response

Real World Scenario

For upcoming polls please enter the site http://www.pollev.com into your web browser or set

your phone up to text message the number ‘37607’ as the phone number.

Poll: Do you know someone with diabetes?

Diversity of People with Diabetes

Clinical Scenario

In diabetes the response of one important pathway is to transport glucose from the extracellular fluid (ECF)/blood into the cytosol of cells.

This pathway becomes disrupted as part of diabetes.

Cytosol

Extracellular Fluid

SugarInsulin Receptor

Insulin

Cytosol

Extracellular Fluid

SugarInsulin Receptor

Insulin

Response

Cytosol

Extracellular Fluid

SugarInsulin Receptor

Insulin

Response

Cytosol

Extracellular Fluid

SugarInsulin Receptor

Insulin

Response

Cytosol

Extracellular Fluid

SugarInsulin Receptor

Insulin Sugar

Sugar

Response

Cytosol

Extracellular Fluid

SugarInsulin Receptor

Insulin

Response

Cytosol

Extracellular Fluid

SugarInsulin Receptor

Insulin Sugar

Sugar

Response

Type II DiabetesThe process of glucose accumulation in the

extracellular fluid or blood is due to insulin resistance (inactivation of receptor)

Glucose level

Acknowledgements

HHMI SI and Dr. Kathrin Stanger-HallSuann YangCell Development I (Group 1)Evolution Group (Group 4)Dean of the College of Arts & Sciences at UNC

CharlotteDr. Nichols-Casebolt at VCU and the Office of

Research