changing the mindset: how to encourage faculty to think

Changing the Mindset: How to Encourage Faculty to Think About Products and Understand Commercial Needs

Emily Loughran (UCLA), Satish Rao (Columbia), Sunita Rajdev (UCSF), Brian Shedd (LSU) & Ben Dibling (UPenn)

March 3rd, 2017

• “Traditional” Missions of Academic Institutions– Research– Education– Service

• Expanded Missions….– Economic Development– “Impact” on a global scale

• Faculty Focused on Core Activities– Teaching and mentoring – Securing funding – Publishing – Securing tenure

• Common Barriers to Faculty Engagement– Awareness– Ease of Working with the Technology Transfer

Office – Time Commitment

How Does Successful Commercialization Impact the Mission?

– Increased funding support for research programs– Exposure of trainees to the commercial sector– Development of new products and services with

societal impact– Local and national economic growth

Speaker Contact Information

Ben Dibling – [email protected] Loughran – [email protected]

Satish Rao – [email protected] Radjev – [email protected]

Brian Shedd - [email protected]

D6: Changing the MindsetHow to Encourage Faculty to Think about Products and Understand Commercial Needs

Sunita Rajdev, PhDAssociate Director, Licensing

ITA

CTSI

QB3QB3: Startup infrastructure; incubator space; seed investment

Clinical and Translational Sciences Institute: Catalyst Accelerator

ITA: Entrepreneurship Center, IP management & Licensing, Strategic Research Partnerships

UCSF Innovation Engine

CDHI

Center for Digital Health & Innovation

Qb3

ITA

CDHI

CTSI

Companies

VCsUC System

Non-profitentities

UCSF Ecosystem

Some UCSF partnerships with translational focus:

• Industry Partnerships• GSK DPAc, Abbvie, Celgene, Daiichi-Sankyo, Pfizer CTI, MedImmune, Cisco, GE

• Non-Profit Partnerships• BioHub, Bluefield, Parker Institute of Cancer Immunotherapy

• UC-wide Collaborative Programs– UC CAI Program, UC Biomedical Research Acceleration, Integration &

Development (UC BRAID), UC Drug Discovery Consortium

Courses, Events & Seminars

Collaborations & Gap Funding

Community Networks

Innovation Ecosystem

CTSI Catalyst Program

REVIEW4 Panels: Rx, Dx,

Devices, D-Health; Review and feedback by panel of industry

experts; Identification of critical next steps

CONSULTATION

Mentoring by industry expert on

how best to achieve critical next steps

PITCH & AWARDS

Presentations; Awards of up to

$100K

INDUSTRY PARTNERSHIPS

Awards of up to $250K; larger collaborations

Catalyst - Unique Multi-Disciplinary Advisory Panel

• Leverages the biotechnology ecosystem of SF Bay area• Engages industry experts as reviewers and advisors on proposals• Panel consists of 200+ members, mainly volunteers• Experts provide customized input based on subject and project needs• New kind of private-public partnership

• Advisors from multiple sources with diverse expertise• Industry• Academia• Intellectual Property• Clinical/Regulatory

• Requirements:• 10 – 20 hours per year to review and consult

Therapeutics

Devices

Digital Health

Diagnostics

Thank [email protected]

Satish Rao, PhDAssociate Director, Physical Sciences Licensing

Entrepreneurship support - Programs

Medical Device: Coulter-Columbia

Therapeutics: TrX Clean tech: Powerbridge NY

Media: The Combine

Entrepreneurship support - Other resources

Executives Advisors Network

Venture Capital outreachExecutives-in-Residence

CTV internal fund

Translational Fellows Program

Business Leads Capital Space

Outreach and Processes

Visiting faculty department meetings

Postdoc lunch and learns

Standardized startup-friendly licenses

Negotiated discounted and deferred rates for outside

counsel and insurance providers

Lectures and Events on campus

CTV instructed classes –Intellectual Property for

Entrepreneurs, Hacking for Energy

Researcher outreach Streamlined startup licensing Education

Brian Shedd, PhDAssistant Director

EducationResources Student Support

• Technology Commercialization

• Entrepreneurship for Engineers

• Intellectual Property Seminars

• IP Protection & Commercialization

• Grant Writing Assistance• NSF I-Corps• Funding: PoC,

Seed/Angel, VC

• Student Accelerator• Mentorship• Internships• Certificate Programs• Networking &

Collaboration

A focal point for innovation housed within the College of Engineering to deliver value in 3 key areas

LSU LIFT2 Fund“Leverage Innovation for Technology Transfer”

Created by LSU Board of Supervisors in January of 2014 to help across all the campuses of the LSU

system

Gateway to Innovation, Research and Entrepreneurship

Support Services for Entrepreneurs at UCLA Technology Development Group

Emily Loughran


Table of Contents

• Office Structure and Existing Programs

• Proof of Concept Fund


New Ventures was formed in 2012 as a dedicated team within TDG to assist external startup companies that license IP from UCLA

Office Organization

New Ventures

LicensingIndustry

SponsoredResearch

Assisting Licensees

Deal Flow


New Ventures aims to make UCLA startup companies more successful by focusing on three key areas

Goals Activities

• Source opportunities from faculty• Diligence startup potential• Find entrepreneurs• Connect to “Startup in a Box” services (vendors)

Venture Creation

Connections to Funding

Company Growth

• Market to angels / VCs• Host SBIR / STTR workshops• Identify and help prepare for business plan / pitch

competitions• Manage Proof of Concept fund

• Couple with talent / mentors• Provide pitch coaching services• Connect with core facilities and UCLA assets that could

add value


Startup in a Box connects startups to lawyers, banks, HR services, CROs and accounting services

Example Firms that Participate in the Program

Example Schools Represented in the SIAB Program


New Ventures hosts First Look LA, a showcase for our newest startups, with 9 other local institutions and universities

Example Companies from Past FLLA

Life Sciences Physical Sciences

Key Components

• 2 sessions of NSF I-Corps ZAP! training

• Pitch Coach brought in by New Ventures

• 10 minute pitches on June 28, 2017 at CNSI in front of entrepreneurs and investors


We meet with these groups on a quarterly basis as the Entrepreneurship Council to ensure we are working to

synergistically grow entrepreneurship at UCLA

TDG is the hub of entrepreneurship at UCLA, and we work closely with other entrepreneurial groups on campus


Table of Contents

• Office Structure and Existing Programs

• Proof of Concept Fund


With the support of UCLA Chancellor Gene Block, UCLA has seeded a proof of concept

fund with $1.7 M from state funds“With the funding being used to provide proof of concept funds, pay entrepreneurs in residence, and support outreach to attract private sector investment, I am confident that UCLA can continue developing the next generation of businesses and industries that will keep our state economically healthy and at the cutting edge of innovation”

- UCLA Chancellor Gene Block


Licensing Officers identified projects for proof of concept funding

Target Startup Opportunities

Outlicensing/ Entrepreneur

Spinout

Program Management

Proof of Concept Funding

1 2 3 4

• Licensing Officers (TTOs) presented their top technologies– The top technologies were selected for 10 min

presentations to an internal committee – Presentations assessed market, competition, use of

funds, timeline, and aided in establishing reasonable milestones

– Top pitches were presented to an industry-specific Advisory Committee (one for therapeutics and one for medical devices)


Therapeutics Advisory Panel

Alice Chen, PhDPrincipal at Accelerator Corp.

Melissa Fitzgerald, PhDHead of Strategic Research Partnership at Pfizer

Vijay Murthy, PhDPrinciple, Venture Investments at J&J Innovation

Kanad Das, PhDDirector, Business Development at Merck

Michael Martin, PhDSenior Investment Director at Takeda Ventures


Medical Device Advisory Panel

Anne Pianca, MS/MBADirector of R&D at Boston Scientific

Widya Mulyasasmita, PhDNew Ventures at J&J California Innovation Center

Javad SeyedzadehRegulatory & Quality Strategic Advisor, Neural Analytics

Jim DreherFounder / Managing Partner at Option3

Paul GrandCEO, MedTech Innovator

Kathryn WillybiroLead for Critical Care Discoveries, Edward Lifesciences


The funding will support projects that have concrete milestones



Spinout

Program Management


1 2 3 4

• Projects across the University will be considered as long as the intellectual property is owned by UCLA

• Precise funding amount will be tied to milestones and vary per project, but may range from $50 – 250 K

• Funding will be internally managed, with preference towards deploying capital to outside firms rather than labs


Novel Antimicrobial Therapeutics:membrane-disrupting drug-peptide

conjugates

Prof. Andrea KaskoBioengineering

Prof. Gerard WongBioengineering

TOBRAMYCIN

+

DESIGNED PEPTIDE

=

PENTOBRA

Problem: There is an urgent need for new classes of antimicrobial agentsSolution: Renovate existing antibiotics by conjugating a designed cell-disrupting peptide that is specific for the underlying antibiotic molecule


Multi-frequency Harmonic Acoustography for Tumor Border Detection

Problem: Surgeons must accurately determine tumor margins, often resulting in over or under resectionSolution: Ultrasound-based method that can determine tumor margins intraoperatively

Warren Grundfest, MDProfessor in Bioengineering,

EE, Surgery

Maie St. John, MD, Ph.DAssistant Professor-in-

Residence, Head and Neck SurgeryCo-Director, UCLA Head and Neck

Cancer Program


Funded Therapeutics ProjectsLead PIs Department Invention

Andrea Kasko GerardWong Bioengineering Novel Antimicrobial Therapeutics: membrane-

disrupting drug-peptide conjugates

William Lowry/ Heather Christofk/ Mike Jung

MCDB; Biological Chemistry; Chem/Biochem

Hair follicle stem cell activation and hair growth by metabolic regulatory

Ohyun Kwon/ Jau-Nian Chen

Chem/Biochem; MCDB

A Novel Target and Small Molecule for Treating Cardiac Fibrillation


Funded Medical Device ProjectsLead PIs Department Invention

Wentai Liu Bioengineering Bioelectronic medicine – Gastrointestinal Therapeutics for Alleviating Post-Op Ileus

Warren Grundfest / Maie St. John

Bioengineering; Electrical Engin. / Head and Neck Surgery

Multi-frequency Harmonic Acoustography for Tissue Identification and Border

Dejan Markovic / Itzhak Fried

Electrical Engineering / Neurosurgery

Wireless Implantable System to RestoreMemory


Entrepreneurs in Residence will be responsible for program management



Spinout

Program Management


1 2 3 4

• Entrepreneurs in Residence (EIRs) were sourced to manage each project

• New Ventures will manage the funding process, timelines, communication, and review process

• New Ventures will align with the EIRs, faculty, advisory committee, and TTO to establish appropriate milestones and use of money

• New Ventures will have regular meetings with EIRs, TTOs, and funded PIs


The most successful startups are those founded by a serial entrepreneur or a venture creation firm



Spinout

Program Management


1 2 3 4

• The goal of proof of concept funding is to 1) license the IP to an established company or 2) to a startup managed by a successful serial entrepreneur or venture creation firm

• Projects need to be advanced to the point of attracting promising licensees

changing the mindset: how to encourage faculty to think

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