chaperone enzyme provides new cancer treatment target & cancer in a single catastrophe
TRANSCRIPT
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María Carolina Portela FernándezUPB’s School of Health Sciences, Faculty of
MedicineIII Semester Student
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Chaperone enzyme Rad18
Escorts the DNA polymerase Pol eta
Repairs sunlight induced damage propperly
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Pol eta
Other DNA polymerases may take its place
The repair mechanisms are not accurate
e.g.: Xeroderma Pigmentosum
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Essential to prevent mutations in the most vulnerable cell cycle phase
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Cancer cells have high Cdc7
levels
Increases Pol eta+Rad18
BLOCK CHEMOTHERAPY AGENTS’ ACTION SUCH AS CIS-PLATINUM
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The team looked for DNA structural changes with
advanced sequencing techologies
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Most cells go into apoptosis
Few ones try to fix the mistake, causing cancer.
Most human cells may suffer one of these
catastrophes
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It would be interesting to do some research on the mechanisms
that cause these catastrophes as a contribution in the prevention of the cancer disease.
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Cancer epidemic, humankind has to
fight against it
Great interest in investigations about
its mechanisms.
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Science must discover how to
attack them
Cancer’s downfall D
ow
nfa
ll – Jam
es M
urp
hy
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Medical utility comes to
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1. MARTINEZ SÁNCHEZ, Lina María [y otros]. Biología molecular. 6 ed. Medellín: UPB. Fac. de Medicina, 2011. 292 p.
2. “Chaperone enzyme provides new target for cancer treatments” on ScienceDaily.com [available online at http://www.sciencedaily.com/releases/2011/01/110118143220.htm (January 30, 2011)]
3. “Cancer in a single catastrophe: Chromosome crisis common in cancer causation” on ScienceDaily.com [available online at http://www.sciencedaily.com/releases/2011/01/110106144735.htm (January 30, 2011)]
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