Chelerythrine shows promising antitumour activity

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<ul><li><p>Inpharma 1229 - 18 Mar 2000</p><p>Chelerythrine shows promisingantitumour activity</p><p>The protein kinase C inhibitor chelerythrine may be auseful antitumor agent, report researchers from the US.</p><p>In a series of in vitro experiments, the researchersinvestigated the antitumour activity of chelerythrineagainst 9 human tumour cell lines. Chelerythrinedemonstrated cytotoxic activity in all tumour cell lines.</p><p>In a series of in vivo experiments, the researchersinoculated Sprague-Dawley nude mice with thep53-deficient radiotherapy- and chemotherapy-resistanthuman epidermoid cancer cell line SQ-20B. Micereceived intraperitoneal injections of chelerythrine 2.5mg/kg/day on days 8, 10 and 12 after tumourimplantation, chelerythrine 5 mg/kg/day on days 8, 10and 12 or on days 8, 11 and 14, or PBS on days 8, 10 and12 (controls).</p><p>Tumour growth was delayed in all chelerythrine,compared with PBS, recipients. In addition, throughoutthe study, bodyweights of chelerythrine recipients didnot fall below 90% of bodyweight at baseline. Notreatment-related deaths occurred.Chmura SJ, et al. In vitro and in vivo activity of protein kinase C inhibitorchelerythrine chloride induces tumor cell toxicity and growth delay in vivo.Clinical cancer research: an official journal of the American Association forCancer Research 6: 737-742, Feb 2000 800818517</p><p>1</p><p>Inpharma 18 Mar 2000 No. 12291173-8324/10/1229-0001/$14.95 Adis 2010 Springer International Publishing AG. All rights reserved</p></li></ul>