2001 hydroxycarboxylic acids

hydroxycarboxylic acids (ether carboxylic acids) (acyclic compounds) and estersP 0280

02 - 082New Synthetic Technology for Efficient Construction of α-Hydroxy-β-amino Amides via the Passerini Reaction. — Title investigationis presented with a view to the preparation of P1-α-protease inhibitors. Bestresults are obtained in the presence of pyridine or pyridine-derived bases.Synthetic value of this novel method is demonstrated by a concise synthesis ofbestatin. — (SEMPLE, J. EDWARD; OWENS, TIMOTHY D.; NGUYEN,KHANH; LEVY, ODILE E.; Org. Lett. 2 (2000) 18, 2769-2772; Dep. Med.Chem., Corvas Int., Inc., San Diego, CA 92121, USA; EN)

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