Chapter 16 (Part 3)

Fatty acid Synthesis

ACP vs. Coenzyme A

Fatty Acid Synthesis Occurs in the Cytosol

Citrate synthaseCitrate Lyase

Malate dehydrogenase

Malate EnzymePyruvate

carboxylase

Acetyl-CoA CarboxylaseAcetyl-CoA + HCO3

- + ATP malonyl-CoA + ADP

Acetyl-CoA

Carboxylase

Regulation of Acetyl-CoA Carboxylase (ACCase)

Animal Fatty Acid Synthase

Further Processing of Fatty acids: Desaturation and Elongation

Allosteric regulation of fatty acid synthesis occurs at ACCase and the carnitine acyltransferase