1.Presented by: PANKAJ KAPGATE M. V.Sc [Pharmacology] 2nd Yr. NAGPUR VETERINARY COLLEGE DEPARTMENT OF VETERINARY PHARMACOLOGY AND TOXICOLOGY WELCOMES CREDIT SEMINAR ON Under the guidance of DR. C.R. JANGDE

2. overview Introduction What Is Chonopharmacology Chronobiology Biologycal Rhythm Types Of Rhythm Biorythm Biologycal Clock Application And Uses Drug Delivery System Conclusion 3. What is Chronopharmacology ? It is the science concerned with the variations in the pharmacological actions of various drugs over a biological timings & endogenous periodicities. Introduction 4. Pharmacology- It is the science of drugs. Phamacon - (Drug), Logos (study) It deals with the interaction of administered Chem. molecule (Drug) with living systems. But most importantly those that are relevant to effective and safe use for medicinal purposes. 5. Chronobiology- Chronos (time), Bios (life), Logos (study). The science dealing with the phenomenon of biological rhythmicity in living organisms is called chronobiology (Halberg,1969). 6. Biological Rhythm- A determined rhythmic biological process or function. A biological rhythm is a self-sustaining oscillation with the duration of time between successive repetitions (i.e; the period) being rather non-varying under normal conditions. 7. Example- CIRCADIAN RHYTHM: Circadian (circa about or approximately; dies, day, or about 24 hour). Oscillations in the biological, physiological & behavioral functions of an organism with a periodicity of 24 hrs. 8. Continue Circadian rhythms are particularly important in medicine. A circadian clock in the brain coordinates daily physiological cycles. sleep/wake - digestion temperature - hormones Physiological day is about 24 hours . Clock is reset daily by the environment . day/night social schedules 9. Types of Rhythm- Ultradian (