CIDER

Clinical Investigation Data Exploration Repository

CIDER

Clinical Investigation Data Exploration Repository• Joint venture of BJC & WUSM• Data repository to contain routine patient care

(inpatient and outpatient) data• Advanced Query functionality through web

interface• Restricted data access / Role Management• Data Interface to external systems like CSMS • Controlled Vocabulary support

Need for CIDER

• Clinical & Translational research goals– Rapidly convert novel advances in basic science to

Patient care– Get quick feedback on customized diagnostics and

therapeutics for further refinements back to the bench

• Need to analyze complex biomedical data– Clinical Information– Routine laboratory tests, imaging, biospecimens– Molecular profiling and genome annotation

Need for CIDER – cont’d

• Data sets must be co-analyzed & visualized to gain a comprehensive understanding of underlying processes occurring in multi-factorial diseases

• Easy access to this data for physicians, clinician-scientists, and bench scientists

• Reduce barrier between basic science and clinical research

Current challenges

• No easy way to access consolidated patient data

• Privacy and confidentiality risks

• No seamless and regulated data access

• HIPAA regulations

How CIDER addresses the challenges

• No easy way to access consolidated patient data - Consolidated repository

• Privacy and confidentiality risks - Secured data access based on user role and project privileges

• No seamless and regulated data access -

Seamless & regulated data access• HIPAA regulations - HIPAA training a must for

all CIDER users

Solution CIDER

CIDER Data Repository• Discrete Data from ClinDesk (IP Data)

o Demographics

o Encounters

o Labs

o Medications

o Vitals

o Allergies

o Microbiology

• Documents from ClinDesk, including Scanned Documents

(Hospital-based IP & OP Data)

o NLP (Natural Language Processing)

• AllScripts Data (WU Physician Offices OP Data)

• NextGen Data (BJC Medical Group Physician Offices OP Data)

• Diagnostic Images

• Other Sources (e.g.. MDL Discrete data)

CIDER Overall Timeline

8/1/2008 1/31/2011

10/1/2008 1/1/2009 4/1/2009 7/1/2009 10/1/2009 1/1/2010 4/1/2010 7/1/2010 10/1/2010 1/1/2011

3/31/2009v1.0

7/31/2009v2.0

1/31/2010v3.0

7/31/2010v4.0Today

3/31/2009CIDER GUI ApplicationMost Inpatient Discrete

DataData Integration APIsVocabulary Interface

(Early Adopters)

7/31/2009CIDER GUI Application

All Inpatient Discrete Data

Preliminary Outpatient Data

Document DataRule Based Engine(General Release)

1/31/2010CIDER GUI Application

Final Patient DataPrelim NLP

Prelim Image(General Release)

7/31/2010CIDER GUI Application

Final NLPFinal Image

(General Release)

Maintenance Releases

CIDER Overall Timeline

Release-1 Modules

• Manage Users / Manage Projects

• Query Module

• Vocabulary Interface

• Audit System

• Data Delivery (conversion and interface)

• Dashboard

• APIs to external systems like CSMS

REFERENCES

CDR

AllScripts

NextGen

Imaging

Research WorldHealth Care World

Data Repository

CIDER

IRB

CIDERData flow

Data Source

XSDs

CIDER Database (DB2)

OBJECT MODEL

CIDER-DATA TO CIDER-DOMAIN-MODEL

XSD - XML Schema Definition

Object Model – Graphical Representation of Data Elements and their Relationships

DB2 – XML Database

Via ETL Process

Data Source

XSDs

CIDER Database (DB2)

OBJECT MODEL

XSD - XML Schema Definition

Object Model – Graphical Representation of Data Elements and their Relationships

DB2 – XML Database

Via ETL Process

i-Query

X-Query

What data to query?

Categories

Generate Metadata

CIDER Query Module

CIDER Workflow

CIDER Technology

• Web based GUI (Graphical User Interface) which uses Java, Ajax, Flex and Web services technologies

• Hierarchical and real-time data in XML• Federated DB2 Databases on Linux• Advanced Query capabilities (Graphical)

using XQuery / SQL-XML• Multiple vocabulary support (SNOMED CT,

LOINC etc)

CIDER Architecture – cont’d